Autoimmunity caused by disruption of central T cell tolerance. A murine model of drug-induced lupus.

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Murine Models of Systemic Lupus Erythematosus

1985 • 1,572 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells

1988 • 917 citations

Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus.

1993 • 637 citations

Positive Selection of Thymocytes

1995 • 604 citations

Positive selection of lymphocytes

1994 • 563 citations

A solid-phase immunoenzymatic technique for the enumeration of specific antibody-secreting cells

1983 • 561 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

Kinetic analysis of deoxyribonuclease I cleavages in the nucleosome core: Evidence for a DNA superhelix

1978 • 383 citations

Clonal Deletion Versus Clonal Anergy: The Role of the Thymus in Inducing Self Tolerance

1990 • 380 citations

Effects of Cyclosporine A on T Cell Development and Clonal Deletion

1988 • 354 citations

Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice.

1993 • 350 citations

A Nondeletional Mechanism of Thymic Self Tolerance

1989 • 322 citations

The central role of chromatin in autoimmune responses to histones and DNA in systemic lupus erythematosus.

1994 • 307 citations

Antibodies to Histones in Drug-Induced and Idiopathic Lupus Erythematosus

1978 • 285 citations

A systemic lupus erythematosus (SLE)‐like disease in mice induced by abnormal T‐B cell cooperation. Preferential formation of autoantibodies characteristic of SLE

1982 • 267 citations

Anti-nucleosome antibodies complexed to nucleosomal antigens show anti-DNA reactivity and bind to rat glomerular basement membrane in vivo.

1994 • 267 citations

A differential-avidity model for T-cell selection

1994 • 239 citations

Genesis and evolution of antichromatin autoantibodies in murine lupus implicates T-dependent immunization with self antigen.

1993 • 234 citations

Transformation of Lupus-Inducing Drugs to Cytotoxic Products by Activated Neutrophils

1994 • 233 citations

Review: Nephritogenic autoantibodies in lupus: Current concepts and continuing controversies

1996 • 207 citations

Nucleosome‐restricted antibodies are detected before anti‐dsdna and/or antihistone antibodies in serum of mrl‐mp lpr/lpr and +/+ mice, and are present in kidney eluates of lupus mice with proteinuria

1994 • 207 citations

Enzyme amplification — A general method applied to provide an immunoassisted assay for placental alkaline phosphatase

1985 • 178 citations

A role for clonal inactivation in T cell tolerance to Mis-1a

1990 • 166 citations

Structure and specificity of T cell receptors expressed by potentially pathogenic anti-DNA autoantibody-inducing T cells in human lupus.

1995 • 165 citations

Drug-induced lupus

2015 • 160 citations

Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities.

1990 • 146 citations

Presence of nucleosome‐restricted antibodies in patients with systemic lupus erythematosus

1995 • 144 citations

Drug-induced anti-histone autoantibodies display two patterns of reactivity with substructures of chromatin.

1991 • 134 citations

Autoantibodies in chronic graft versus host result from cognate T-B interactions.

1990 • 133 citations

Subnucleosome structures as substrates in enzyme-linked immunosorbent assays

1990 • 127 citations

Intermittent Intravenous Procaine Amide to Treat Ventricular Arrhythmias

1973 • 125 citations

The T cell enigma in lupus

1996 • 106 citations

Autoantibodies associated with lupus induced by diverse drugs target a similar epitope in the (H2A-H2B)-DNA complex.

1992 • 104 citations

Immunological function of a defined T-cell population tolerized to low-affinity self antigens

1995 • 97 citations

Reactivity and possible significance of hydroxylamine and nitroso metabolites of procainamide.

1985 • 96 citations

Heterogeneity and clinical significance of glomerular-binding antibodies in systemic lupus erythematosus.

1996 • 92 citations

Selecting the T Cell Receptor Repertoire

1994 • 71 citations

T Lymphocytes Ignore Procainamide, but Respond to Its Reactive Metabolites in Peritoneal Cells: Demonstration by the Adoptive Transfer Popliteal Lymph Node Assay

1993 • 57 citations

Isotype-restricted hyperimmunity in a murine model of the toxic oil syndrome.

1992 • 55 citations

Specificities and genetic characteristics of nucleosome-reactive antibodies from autoimmune mice

1996 • 54 citations

Clonal analysis of autoantibody-producing cell precursors in the preimmune B cell repertoire.

1988 • 52 citations

Cytotoxicity of oxidative metabolites of procainamide.

1987 • 48 citations

IgG but not other classes of anti-[(H2A-H2B)-DNA] is an early sign of procainamide-induced lupus.

1995 • 46 citations

V beta gene repertoires in aging mice.

1992 • 46 citations

Metabolism of procainamide to the cytotoxic hydroxylamine by neutrophils activated in vitro.

1989 • 42 citations

Selective production of autoantibodies in graft-vs-host-induced and spontaneous murine lupus. Predominant reactivity with histone regions accessible in chromatin.

1988 • 40 citations

Effects of cyclosporine A on T cell development and clonal deletion

1988 • 31 citations

Immunomodulatory effects of procainamide metabolites: their implications in drug-related lupus.

1989 • 30 citations

Mechanism of hypersensitivityreactions: proposed involvement of reactive metabolites generated by activated leukocytes

1989 • 30 citations

Positive Selection of Thymocytes

1995 • 28 citations

Spectropolarimetric analysis of the core histone octamer and its subunits

1990 • 26 citations

Persistence of allospecific helper T cells is required for maintaining autoantibody formation in lupus-like graft-versus-host disease

1990 • 25 citations

Pseudoautoimmunity in normal mice: Anti-histone antibodies elicited by immunization versus induction during graft-versus-host reaction

1990 • 24 citations

A metabolite of the lupus-inducing drug procainamide prevents anergy induction in T cell clones.

1997 • 24 citations

Genetic, Immunologic and Biotransformation Studies of Patients on Procainamide

1993 • 22 citations

Self-reactive T cells are present in the peripheral lymphoid tissues of cyclosporin A-treated mice

1992 • 20 citations

Procainamide hydroxylamine lymphocyte toxicity—I. Evidence for participation by hemoglobin

1989 • 18 citations

Study of procainamide hapten-specific antibodies in rabbits and humans

1993 • 16 citations

Electrochemical Determination of N-oxidized Procainamide Metabolites and Functional Assessment of Effects on Murine Cells in Vitro

1988 • 16 citations

Intrathymic Injection of Polynucleosomes Delays Autoantibody Production in BXSB Mice

1996 • 14 citations

T-cell maturation and clonal deletion in cyclosporine-induced autoimmunity

1991 • 12 citations

Determination of metabolically derived nitroprocainamide in the urine of procainamide-dosed humans and rats by liquid chromatography with electrochemical detection.

1991 • 11 citations

Role of Xenobiotic Metabolism

1994 • 8 citations

Characterization of tumour necrosis factor α release by human granulocytes in response to procainamide challenge

1995 • 3 citations