Heterogeneity and clinical significance of glomerular-binding antibodies in systemic lupus erythematosus.

The 1982 revised criteria for the classification of systemic lupus erythematosus

1982 • 14,553 citations

Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains.

1978 • 1,619 citations

IMMUNOLOGICAL STUDIES CONCERNING THE NEPHRITIS OF SYSTEMIC LUPUS ERYTHEMATOSUS

1967 • 881 citations

Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus.

1993 • 637 citations

PATHOGENESIS OF THE GLOMERULONEPHRITIS OF NZB/W MICE

1968 • 622 citations

Basement Membrane Proteins: Structure, Assembly, and Cellular Interactions

1992 • 584 citations

Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus.

1994 • 555 citations

Induction of various autoantibodies by mutant gene lpr in several strains of mice.

1984 • 390 citations

Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci.

1992 • 339 citations

The central role of chromatin in autoimmune responses to histones and DNA in systemic lupus erythematosus.

1994 • 307 citations

Restricted subpopulations of DNA antibodies in kidneys of mice with systemic lupus

1980 • 268 citations

Anti-nucleosome antibodies complexed to nucleosomal antigens show anti-DNA reactivity and bind to rat glomerular basement membrane in vivo.

1994 • 267 citations

Anti-DNA antibodies bind directly to renal antigens and induce kidney dysfunction in the isolated perfused rat kidney.

1989 • 265 citations

Murine monoclonal anti-DNA antibodies bind directly to glomerular antigens and form immune deposits.

1987 • 249 citations

Immune Complexes, Complement, and Anti-DNA in Exacerbations of Systemic Lupus Erythematosus (SLE)

1981 • 244 citations

Genesis and evolution of antichromatin autoantibodies in murine lupus implicates T-dependent immunization with self antigen.

1993 • 234 citations

Cross-reactivity of human and murine anti-DNA antibodies with heparan sulfate. The major glycosaminoglycan in glomerular basement membranes.

1986 • 230 citations

Anti-DNA antibodies form immune deposits at distinct glomerular and vascular sites

1992 • 217 citations

Review: Nephritogenic autoantibodies in lupus: Current concepts and continuing controversies

1996 • 207 citations

Nucleosome‐restricted antibodies are detected before anti‐dsdna and/or antihistone antibodies in serum of mrl‐mp lpr/lpr and +/+ mice, and are present in kidney eluates of lupus mice with proteinuria

1994 • 207 citations

Histones have high affinity for the glomerular basement membrane. Relevance for immune complex formation in lupus nephritis.

1989 • 151 citations

Comparison of pathogenic and non-pathogenic murine antibodies to DNA: antigen binding and structural characteristics

1994 • 150 citations

Presence of nucleosome‐restricted antibodies in patients with systemic lupus erythematosus

1995 • 144 citations

Subnucleosome structures as substrates in enzyme-linked immunosorbent assays

1990 • 127 citations

Immunogenic DNA-related factors. Nucleosomes spontaneously released from normal murine lymphoid cells stimulate proliferation and immunoglobulin synthesis of normal mouse lymphocytes.

1990 • 112 citations

Binding of a monoclonal anti-DNA autoantibody to identical protein(s) present at the surface of several human cell types involved in lupus pathogenesis.

1985 • 109 citations

Glomerular binding activity in MRL lpr serum consists of antibodies that bind to a DNA/histone/type IV collagen complex.

1995 • 109 citations

Autoantibodies associated with lupus induced by diverse drugs target a similar epitope in the (H2A-H2B)-DNA complex.

1992 • 104 citations

PROGNOSTIC INDICES IN LUPUS NEPHRITIS

1976 • 102 citations

Apoptosis, nucleosomes, and nephritis in systemic lupus erythematosus

1995 • 97 citations

A monoclonal anti-double-stranded DNA autoantibody binds to a 94-kDa cell-surface protein on various cell types via nucleosomes or a DNA-histone complex.

1989 • 91 citations

The effect of normalization of serum complement and anti-DNA antibody on the course of lupus nephritis

1978 • 72 citations

Genetic studies of autoimmunity in New Zealand mice. III. Associations among anti-DNA antibodies, NTA, and renal disease in (NZB x NZW)F1 x NZW backcross mice.

1981 • 71 citations

Cross-reactive binding patterns of monoclonal antibodies to DNA are often caused by DNA/anti-DNA immune complexes

1989 • 68 citations

Molecular analysis of spontaneous nephrotropic anti-laminin antibodies in an autoimmune MRL-lpr/lpr mouse.

1993 • 53 citations

IgG but not other classes of anti-[(H2A-H2B)-DNA] is an early sign of procainamide-induced lupus.

1995 • 46 citations

Glomerular immune deposits in murine lupus models may contain histones

1992 • 44 citations

A role for histones and ubiquitin in lupus nephritis?

1994 • 38 citations

Autoantibodies to histone, DNA and nucleosome antigens in canine systemic lupus erythematosus

1995 • 35 citations

Murine lupus glomerulotropic monoclonal antibodies exhibit differing specificities but bind via a common mechanism.

1995 • 34 citations

Serologic markers of lupus nephritis in patients: use of a tissue-based ELISA and evidence for immunopathogenic heterogeneity

1994 • 33 citations

The Influence of Variable-Region Somatic Mutations on the Specificity and Pathogenicity of Murine Monoclonal Anti-DNA Antibodies

1995 • 33 citations

Chronic graft versus host disease-associated autoimmune manifestations are independently regulated by different MHC class II loci.

1994 • 26 citations

Ultrastructural localization of DNA in immune deposits of human lupus nephritis.

1993 • 23 citations

Detection of glomerular-binding immune elements in murine lupus using a tissue-based ELISA

1993 • 19 citations

Serum glomerular binding activity is highly correlated with renal disease in MRL/lprmice

1993 • 12 citations

Cross-reactive binding patterns of monoclonal antibodies to DNA are often caused by DNA/anti-DNA immune complexes

1989 • 3 citations