Review: Nephritogenic autoantibodies in lupus: Current concepts and continuing controversies

Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains.

1978 • 1,619 citations

IMMUNOLOGICAL STUDIES CONCERNING THE NEPHRITIS OF SYSTEMIC LUPUS ERYTHEMATOSUS

1967 • 881 citations

Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation.

1990 • 672 citations

Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus.

1993 • 637 citations

PATHOGENESIS OF THE GLOMERULONEPHRITIS OF NZB/W MICE

1968 • 622 citations

Basement Membrane Proteins: Structure, Assembly, and Cellular Interactions

1992 • 584 citations

Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus.

1994 • 555 citations

Genetic and Structural Evidence for Antigen Selection of Anti-DNA Antibodies

1994 • 464 citations

Textbook of Rheumatology

1994 • 434 citations

Induction of various autoantibodies by mutant gene lpr in several strains of mice.

1984 • 390 citations

Endogenous circulating DNA in systemic lupus erythematosus. Occurrence as multimeric complexes bound to histone.

1990 • 367 citations

Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci.

1992 • 339 citations

In vitro demonstration of a particular affinity of glomerular basement membrane and collagen for DNA. A possible basis for a local formation of DNA-anti-DNA complexes in systemic lupus erythematosus.

1976 • 308 citations

The central role of chromatin in autoimmune responses to histones and DNA in systemic lupus erythematosus.

1994 • 307 citations

Anti‐dsdna and complement profiles as prognostic guides in systemic lupus erythematosus

1979 • 280 citations

Antibody to nuclear ribonucleoprotein penetrates live human mononuclear cells through Fc receptors

1978 • 274 citations

Restricted subpopulations of DNA antibodies in kidneys of mice with systemic lupus

1980 • 268 citations

Anti-nucleosome antibodies complexed to nucleosomal antigens show anti-DNA reactivity and bind to rat glomerular basement membrane in vivo.

1994 • 267 citations

Anti-DNA antibodies bind directly to renal antigens and induce kidney dysfunction in the isolated perfused rat kidney.

1989 • 265 citations

Murine monoclonal anti-DNA antibodies bind directly to glomerular antigens and form immune deposits.

1987 • 249 citations

Activation-induced death of mature T cells in the regulation of immune responses

1995 • 248 citations

Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB x NZW)F1 mice.

1992 • 246 citations

Immune Complexes, Complement, and Anti-DNA in Exacerbations of Systemic Lupus Erythematosus (SLE)

1981 • 244 citations

Genesis and evolution of antichromatin autoantibodies in murine lupus implicates T-dependent immunization with self antigen.

1993 • 234 citations

Cross-reactivity of human and murine anti-DNA antibodies with heparan sulfate. The major glycosaminoglycan in glomerular basement membranes.

1986 • 230 citations

Association of circulating retroviral gp70-anti-gp70 immune complexes with murine systemic lupus erythematosus.

1979 • 223 citations

Anti-DNA antibodies form immune deposits at distinct glomerular and vascular sites

1992 • 217 citations

Human IgG anti-DNA antibodies deposit in kidneys and induce proteinuria in SCID mice

1995 • 215 citations

Nucleosome‐restricted antibodies are detected before anti‐dsdna and/or antihistone antibodies in serum of mrl‐mp lpr/lpr and +/+ mice, and are present in kidney eluates of lupus mice with proteinuria

1994 • 207 citations

Murine monoclonal anti-DNA antibodies penetrate cells, bind to nuclei, and induce glomerular proliferation and proteinuria in vivo.

1992 • 178 citations

Clinical and serological differences between systemic lupus erythematosus patients with antibodies to Ro versus patients with antibodies to Ro and La.

1982 • 168 citations

Significance of enzyme linked immunosorbent assay (ELISA) for antibodies to double stranded and single stranded DNA in patients with lupus nephritis: correlation with severity of renal histology.

1993 • 158 citations

IgG autoantibodies against C1q are correlated with nephritis, hypocomplementemia, and dsDNA antibodies in systemic lupus erythematosus.

1991 • 156 citations

Histones have high affinity for the glomerular basement membrane. Relevance for immune complex formation in lupus nephritis.

1989 • 151 citations

Apoptosis, fas and systemic autoimmunity: the MRL-Ipr/Ipr model

1994 • 151 citations

Comparison of pathogenic and non-pathogenic murine antibodies to DNA: antigen binding and structural characteristics

1994 • 150 citations

IgG3 production in MRL/lpr mice is responsible for development of lupus nephritis.

1991 • 142 citations

Detection of cross-reactive anti-DNA antibody idiotypes on renal tissue-bound immunoglobulins from lupus patients.

1985 • 140 citations

Polyreactive autoantibodies are nephritogenic in murine lupus nephritis.

1987 • 139 citations

Failure to detect circulating DNA--anti-DNA complexes by four radioimmunological methods in patients with systemic lupus erythematosus.

1977 • 137 citations

Predictive value of IgG autoantibodies against C1q for nephritis in systemic lupus erythematosus.

1993 • 134 citations

Mutational analysis of an autoantibody: differential binding and pathogenicity.

1994 • 130 citations

Cryoglobulinemia induced by a murine IgG3 rheumatoid factor: skin vasculitis and glomerulonephritis arise from distinct pathogenic mechanisms.

1990 • 122 citations

Low-molecular weight C1q-binding immunoglobulin G in patients with systemic lupus erythematosus consists of autoantibodies to the collagen-like region of C1q.

1988 • 115 citations

Immunogenic DNA-related factors. Nucleosomes spontaneously released from normal murine lymphoid cells stimulate proliferation and immunoglobulin synthesis of normal mouse lymphocytes.

1990 • 112 citations

Binding of a monoclonal anti-DNA autoantibody to identical protein(s) present at the surface of several human cell types involved in lupus pathogenesis.

1985 • 109 citations

Glomerular binding activity in MRL lpr serum consists of antibodies that bind to a DNA/histone/type IV collagen complex.

1995 • 109 citations

PROGNOSTIC INDICES IN LUPUS NEPHRITIS

1976 • 102 citations

A role for immunogenic dna in the pathogenesis of systemic lupus erythematosus

1990 • 101 citations

Anti-DNA antibodies can bind to the glomerulus via two distinct mechanisms

1992 • 100 citations

Anti-DNA antibodies and lupus nephritis: the complexity of crossreactivity

1990 • 99 citations

Cross-reactions of anti-DNA antibodies and the central dogma of lupus nephritis

1985 • 98 citations

Apoptosis, nucleosomes, and nephritis in systemic lupus erythematosus

1995 • 97 citations

The Origin, Sequence, Structure, and Consequences of Developing Anti‐DNA Antibodies

1994 • 95 citations

Isolation of DNA from DNA/anti-DNA antibody immune complexes in systemic lupus erythematosus.

1981 • 86 citations

Precipitating antibodies to ribosomes in the serum of patients with systemic lupus erythematosus

1967 • 85 citations

Molecular analysis of anti‐DNA antibodies

1994 • 74 citations

The effect of normalization of serum complement and anti-DNA antibody on the course of lupus nephritis

1978 • 72 citations

Genetic studies of autoimmunity in New Zealand mice. III. Associations among anti-DNA antibodies, NTA, and renal disease in (NZB x NZW)F1 x NZW backcross mice.

1981 • 71 citations

Idiotype restriction in murine lupus; high frequency of three public idiotypes on serum IgG in nephritic NZB/NZW F1 mice.

1987 • 68 citations

Cross-reactive binding patterns of monoclonal antibodies to DNA are often caused by DNA/anti-DNA immune complexes

1989 • 68 citations

Clearance of circulating DNA-anti-DNA immune complexes in mice.

1982 • 66 citations

Relationships among antinuclear antibodies from autoimmune MRL mice reacting with histone H2A-H2B dimers and DNA

1993 • 63 citations

Induction of Immune-Mediated Glomerulonephritis in Normal Mice Immunized with Bacterial DNA

1993 • 61 citations

Collagen autoantibodies in patients with vasculitis and systemic lupus erythematosus

1991 • 58 citations

Histones interact with anionic phospholipids with high avidity; its relevance for the binding of histone–antihistone immune complexes

1994 • 56 citations

Induction of different types of glomerulonephritis by monoclonal antibodies derived from an MRL/lpr lupus mouse.

1993 • 54 citations

Relationship between Renal Pathology and the Size of Circulating Immune Complexes in Patients with Systemic Lupus Erythematosus

1987 • 53 citations

Molecular analysis of spontaneous nephrotropic anti-laminin antibodies in an autoimmune MRL-lpr/lpr mouse.

1993 • 53 citations

Autoantibodies to the collagen-like region of C1Q deposit in glomeruli via C1Q in immune deposits

1991 • 52 citations

Cloning and cDNA sequence analysis of nephritogenic monoclonal antibodies derived from an MRL/lpr lupus mouse

1993 • 51 citations

Ligand recognition by murine anti-DNA autoantibodies. II. Genetic analysis and pathogenicity.

1996 • 49 citations

Sjögren's syndrome and cutaneous B cell lymphoma revealed by anetoderma

1993 • 48 citations

Independently derived murine glomerular immune deposit-forming anti-DNA antibodies are encoded by near-identical VH gene sequences.

1993 • 44 citations

Antibody to a cryptic, solid phase ClQ antigen in membranoproliferative nephritis

1989 • 43 citations

Production and analysis of IgG monoclonal anti-DNA antibodies from systemic lupus erythematosus (SLE) patients

1993 • 42 citations

Higher anti-heparan sulphate reactivity during systemic lupus erythematosus (SLE) disease exacerbations with renal manifestations; a long term prospective analysis

1993 • 35 citations

Autoantibodies to histone, DNA and nucleosome antigens in canine systemic lupus erythematosus

1995 • 35 citations

A comparison of assays used for the detection of antibodies to DNA

1990 • 34 citations

Murine lupus glomerulotropic monoclonal antibodies exhibit differing specificities but bind via a common mechanism.

1995 • 34 citations

Serologic markers of lupus nephritis in patients: use of a tissue-based ELISA and evidence for immunopathogenic heterogeneity

1994 • 33 citations

The Influence of Variable-Region Somatic Mutations on the Specificity and Pathogenicity of Murine Monoclonal Anti-DNA Antibodies

1995 • 33 citations

Interaction of DNA with connective tissue matrix proteins reveals preferential binding to type V collagen.

1985 • 32 citations

Systemic lupus erythematosus

1992 • 31 citations

Rheumatoid factor, cryoglobulinemia, anti-DNA, and renal disease in patients with systemic lupus erythematosus.

1991 • 29 citations

Anti-RNA polymerase I antibodies: potential role in the induction and progression of murine lupus nephritis.

1987 • 28 citations

The Influence of DNA Size on the Binding of Anti-DNA Antibodies in the Solid and Fluid Phase

1994 • 28 citations

Chronic graft versus host disease-associated autoimmune manifestations are independently regulated by different MHC class II loci.

1994 • 26 citations

Glomerular uptake of nucleosomes: Evidence for receptor-mediated mesangial cell binding

1995 • 23 citations

Human anti-fibronectin antibodies in systemic lupus erythematosus: occurrence and antigenic specificity

1994 • 21 citations

Detection of glomerular-binding immune elements in murine lupus using a tissue-based ELISA

1993 • 19 citations

Vitamin B12 Content of Aqueous Humour

1968 • 15 citations

Entrapment of anti-DNA antibodies in the kidney of patients with systemic lupus erythematosus

1982 • 13 citations

Serum glomerular binding activity is highly correlated with renal disease in MRL/lprmice

1993 • 12 citations

Interaction of fibronectin with DNA/anti-DNA complexes from systemic lupus erythematosus: Role of activated complement Cl in modulation of the interactions

1988 • 9 citations

Are the clonotypes of serum IgG anti-DNA antibodies associated with lupus nephritis in humans?

1990 • 2 citations

Are the clonotypes of serum IgG anti-DNA antibodies associated with lupus nephritis in humans?

1990 • 2 citations