The T cell enigma in lupus

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

Phosphorylated CREB binds specifically to the nuclear protein CBP

1993 • 2,039 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

Murine Models of Systemic Lupus Erythematosus

1985 • 1,572 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

1991 • 1,185 citations

Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation

1994 • 742 citations

Presentation of two bone marrow elements: The ‘tart cell’ and the ‘LE’ cell

2001 • 579 citations

Characteristics of a soluble nuclear antigen precipitating with sera of patients with systemic lupus erythematosus

2001 • 551 citations

Evidence for impaired t cell dna methylation in systemic lupus erythematosus and rheumatoid arthritis

1990 • 546 citations

Genetic control of autoimmune disease

1980 • 520 citations

Characteristics of a Soluble Nuclear Antigen Precipitating with Sera of Patients with Systemic Lupus Erythematosus

1966 • 452 citations

Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn)

1991 • 395 citations

Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production.

1991 • 349 citations

Suppressor T-cell abnormality in idiopathic systemic lupus erythematosus

1976 • 314 citations

T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif.

1994 • 291 citations

Clinical and Immunologic Effects of Monthly Administration of Intravenous Cyclophosphamide in Severe Systemic Lupus Erythematosus

1988 • 283 citations

Activators of protein kinase C down-regulate and phosphorylate the T3/T-cell antigen receptor complex of human T lymphocytes.

1985 • 267 citations

The basis of autoimmunity: Part I mechanisms of aberrant self-recognition

1995 • 247 citations

CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line.

1994 • 232 citations

Phenotypic, functional, and molecular genetic comparisons of the abnormal lymphoid cells of C3H-lpr/lpr and C3H-gld/gld mice.

1986 • 224 citations

THE PRECIPITIN REACTION BETWEEN DNA AND A SERUM FACTOR IN SYSTEMIC LUPUS ERYTHEMATOSUS

1959 • 213 citations

The basis of autoimmunity: part II genetic predisposition

1995 • 205 citations

The apoptosis-1/Fas protein in human systemic lupus erythematosus.

1994 • 200 citations

The Role of Autoantibodies in Autoimmune Disease

1993 • 184 citations

Protein kinase C and T cell activation

1990 • 183 citations

Phenotypic and functional similarities between 5‐azacytidine‐treated t cells and a t cell subset in patients with active systemic lupus erythematosus

1992 • 178 citations

TCR/CD3 complex-mediated signal transduction pathway in T cells and T cell lines from patients with systemic lupus erythematosus.

1995 • 168 citations

Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn.

1992 • 151 citations

Transient modulation and internalization of T4 antigen induced by phorbol esters.

1986 • 137 citations

Abnormal tyrosine phosphorylation on T-cell receptor in lymphoproliferative disorders

1986 • 127 citations

CD8+ Lymphocytes from patients with systemic lupus erythematosus sustain, rather than suppress, spontaneous polyclonal IgG production and synergize with CD4+ cells to support autoantibody synthesis

1990 • 120 citations

Inquiry into Murine and Human Lupus

1995 • 111 citations

CD28-induced T cell activation. Evidence for a protein-tyrosine kinase signal transduction pathway.

1992 • 92 citations

Mechanisms of autoimmune disease induction

1995 • 91 citations

Deficient type I protein kinase A isozyme activity in systemic lupus erythematosus T lymphocytes.

1994 • 90 citations

In Vitro Tyrosine Phosphorylation of PLC-γ1 and PLC-γ2 by SRC-Family Protein Tyrosine Kinases

1993 • 89 citations

Phosphorylation of CD4 and CD8 molecules following T cell triggering.

1987 • 87 citations

Functional analysis of T cell subsets from mice bearing the lpr gene.

1985 • 87 citations

T cell-antigen-presenting cell interactions in human systemic lupus erythematosus. Evidence for heterogeneous expression of multiple defects.

1993 • 73 citations

Abnormal adenosine-induced immunosuppression and cAMP metabolism in T lymphocytes of patients with systemic lupus erythematosus

1982 • 73 citations

Regulation of apoptosis in immune cells

1995 • 72 citations

Overexpression of src family gene for tyrosine-kinase p59fyn in CD4-CD8- T cells of mice with a lymphoproliferative disorder.

1989 • 68 citations

In vitro correction of the interleukin 2 defect of autoimmune mice

1983 • 60 citations

A defect in the protein kinase C system in T cells from patients with systemic lupus erythematosus

1991 • 58 citations

Impaired responsiveness of lymphocytes in patients with systemic lupus erythematosus.

1974 • 51 citations

Assessment of in vivo frequency of mutated T cells in patients with systemic lupus erythematosus.

1992 • 50 citations

Impaired T cell capping and receptor regeneration in active systemic lupus erythematosus. Evidence for a disorder intrinsic to the T lymphocyte.

1983 • 50 citations

Early events of human T lymphocyte activation are associated with type I protein kinase A activity.

1993 • 45 citations

Interleukin 2 responses of lpr and normal L3T4-/Lyt-2- T cells induced by TPA plus A23187.

1987 • 43 citations

Impaired T-cell activation in patients with systemic lupus erythematosus

1989 • 42 citations

CD28 signal transduction: tyrosine phosphorylation and receptor association of phosphoinositide‐3 kinase correlate with Ca²⁺‐independent costimulatory activity

1994 • 42 citations

Rapid T cell receptor modulation accompanies lack of in vitro mitogenic responsiveness of double negative T cells to anti-CD3 monoclonal antibody in MRL/Mp-lpr mice.

1988 • 41 citations

The role of L3T4⁺ cells in the pathogenesis of lupus in lpr‐bearing mice. I. Defects in the production of interleukins 2 and 3

1987 • 41 citations

B-cell and T-cell function in systemic lupus erythematosus

1993 • 40 citations

T- and B-Cell Abnormalities in Systemic Lupus

1993 • 39 citations

Antigen-stimulated changes in cyclic nucleotide levels in the mouse.

1975 • 39 citations

Lpr T cell hyporesponsiveness to mitogens linked to deficient receptor-stimulated phosphoinositide hydrolysis.

1988 • 38 citations

Impaired immunoregulation in systemic lupus erythematosus: defective adenosine-induced suppressor T lymphocyte generation.

1983 • 37 citations

Defective cAMP-dependent phosphorylation of intact T lymphocytes in active systemic lupus erythematosus.

1990 • 34 citations

Enhanced CD3‐mediated T lymphocyte proliferation in patients with systemic lupus erythematosus

1991 • 31 citations

Defective CD2 pathway T cell activation in systemic lupus erythematosus

1991 • 31 citations

Systemic lupus erythematosus*

1993 • 30 citations

Human T lymphocyte cAMP‐dependent protein kinase: subcellular distributions and activity ranges of type I and type II isozymes

1992 • 29 citations

Impaired generation of polyclonal T cell-mediated cytolytic activity despite normal polyclonal T cell proliferation in systemic lupus erythematosus

1992 • 29 citations

T lymphocyte immune dysfunctions in systemic lupus erythematosus.

1990 • 25 citations

Lymphocyte abnormalities in human lupus

1992 • 24 citations

B7/BB1 provides an important costimulatory signal for CD3-mediated T lymphocyte proliferation in patients with systemic lupus erythematosus (SLE)

1994 • 23 citations

Intact antigen receptor-mediated generation of inositol phosphates and increased intracellular calcium in CD4 CD8 T lymphocytes from MRL lpr mice.

1990 • 22 citations

Lymphokines in autoimmunity: Relationship between interleukin-2 and interferon-γ production in systemic lupus erythematosus

1984 • 22 citations

Functionally anergic lpr and gld B220+ T cell receptor (TCR)-alpha/beta+ double-negative T cells express CD28 and respond to costimulation with phorbol myristate acetate and antibodies to CD28 and the TCR.

1993 • 22 citations

Impaired mobility of human t lymphocyte surface molecules during inactive systemic lupus erythematosus. relationship to a defective camp pathway

1988 • 20 citations

Constitutive turnover of inositol-containing phospholipids in B220+ T cells from autoimmune-prone MRL-lpr/lpr mice.

1990 • 19 citations

Increase in Potential Activities of Protein Phosphatases PP1 and PP2A in Lymphoid Tissues of Autoimmune MRL/Mp J-lpr/lpr Mice1

1992 • 17 citations

Antigen Induced Alterations in Splenic Prostaglandin and Cyclic Nucleotide Levels in NZB Mice

1977 • 17 citations

The Effect of Circulating Serum Factors from Patients with Systemic Lupus Erythematosus on Protein Kinase A (PKA) Activity and PKA-Dependent Protein Phosphorylation in T Lymphocytes

1993 • 15 citations

Abnormal antigen receptor-initiated signal transduction in lpr T lymphocytes

1994 • 15 citations

Co-stimulation via CD28 induces activation of a refractory subset of MRL-Ipr/Ipr T lymphocytes

1993 • 13 citations

Enhancement of the impaired autologous mixed leukocyte reaction in patients with systemic lupus erythematosus.

1985 • 13 citations

T Lymphocytes from Patients with Systemic Lupus Erythematosus Show Increased Response to Interleukin-2 after Costimulation with OKT3 Monoclonal Antibody and Phorbol Esters

1994 • 10 citations

Low responsiveness to the anti Leu 4 antibody by T cells from patients with active systemic lupus erythematosus.

1989 • 10 citations

Increases in Protein Phosphatase 2B Activity in Lymphoid Tissues and T-Lymphocytes of Autoimmune MRL/MpJ-lpr/lpr Mice1

1993 • 10 citations

Cyclic AMP level of lymphocytes in patients with systemic lupus erythematosus and its relation to disease activity

1989 • 10 citations

Regulation of antigen induced changes in cyclic nucleotide levels in NZB/WF1 Mice

1978 • 9 citations

Biochemical and molecular abnormalities in the pathogenesis of systemic lupus erythematosus.

1991 • 2 citations