Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice.

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Murine Models of Systemic Lupus Erythematosus

1985 • 1,572 citations

Heterogeneity of Cytokine Secretion Patterns and Functions of Helper T Cells

1989 • 1,122 citations

Prognostic factors in lupus nephritis

1983 • 755 citations

The Immunology and Pathology of NZB Mice

1968 • 664 citations

Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells.

1983 • 654 citations

Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation.

1990 • 622 citations

Evidence for impaired t cell dna methylation in systemic lupus erythematosus and rheumatoid arthritis

1990 • 546 citations

Isolation of CD4-CD8-mycobacteria-reactive T lymphocyte clones from rheumatoid arthritis synovial fluid

1989 • 543 citations

The Regulatory Role of Macrophages in Antigenic Stimulation

1972 • 506 citations

Acquisition of immunologic self-tolerance

1989 • 484 citations

Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity.

1988 • 413 citations

In vivo treatment of (NZB X NZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon.

1987 • 396 citations

Heterogeneity of mouse helper T cells. Evidence from bulk cultures and limiting dilution cloning for precursors of Th1 and Th2 cells.

1990 • 386 citations

Spontaneous release of a factor with properties of T cell growth factor from a continuous line of primate tumor T cells.

1981 • 368 citations

DNA methylation, biochemistry, and biological significance

1984 • 343 citations

Lupus nephritis

1977 • 300 citations

Monoclonal antibody to a novel lymphocyte function-associated antigen (LFA-1): mechanism of blockade of T lymphocyte-mediated killing and effects on other T and B lymphocyte functions.

1981 • 292 citations

A systemic lupus erythematosus (SLE)‐like disease in mice induced by abnormal T‐B cell cooperation. Preferential formation of autoantibodies characteristic of SLE

1982 • 267 citations

Mapping of antigenic and functional epitopes on the alpha- and beta-subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1.

1983 • 255 citations

Antigen presenting function of class II MHC expressing pancreatic beta cells

1988 • 255 citations

IL-4 plays a dominant role in the differential development of Tho into Th1 and Th2 cells.

1992 • 223 citations

Bcl-2 maintains B cell memory

1991 • 219 citations

The role of macrophages in the induction of antibody in x-irradiated animals.

1967 • 211 citations

Biological Effects of 5-Azacytidine in Eukaryotes

1974 • 198 citations

The recombinant 65-kD heat shock protein of Mycobacterium bovis Bacillus Calmette-Guerin/M. tuberculosis is a target molecule for CD4+ cytotoxic T lymphocytes that lyse human monocytes.

1988 • 189 citations

The Autologous Mixed-Lymphocyte Reaction

1981 • 181 citations

Phenotypic and functional similarities between 5‐azacytidine‐treated t cells and a t cell subset in patients with active systemic lupus erythematosus

1992 • 178 citations

Drug-induced systemic lupus erythematosus: A critical review

1975 • 173 citations

Ultraviolet radiation-induced metallothionein-I gene activation is associated with extensive DNA demethylation

1983 • 159 citations

Effect of an inhibitor of DNA methylation on T cells. II. 5-azacytidine induces self-reactivity in antigen-specific T4+ cells

1986 • 149 citations

Procainamide inhibits DNA methyltransferase in a human T cell line.

1991 • 136 citations

Allosuppressor- and allohelper-T cells in acute and chronic graft-vs.-host (GVH) disease. III. Different Lyt subsets of donor T cells induce different pathological syndromes.

1983 • 135 citations

CD8+ Lymphocytes from patients with systemic lupus erythematosus sustain, rather than suppress, spontaneous polyclonal IgG production and synergize with CD4+ cells to support autoantibody synthesis

1990 • 120 citations

Lupus prone (SWR x NZB)F1 mice produce potentially nephritogenic autoantibodies inherited from the normal SWR parent.

1985 • 107 citations

Mechanisms of lysis by cytotoxic T lymphocyte clones. Lytic activity and gene expression in cloned antigen-specific CD4+ and CD8+ T lymphocytes.

1991 • 105 citations

Drug-induced Lupus: Clinical and Serological Studies

1982 • 95 citations

Quantitative changes in T cell DNA methylation occur during differentiation and ageing

1990 • 91 citations

CD4+ T cell-mediated killing of MHC class II-positive antigen-presenting cells. I. Characterization of target cell recognition by in vivo or in vitro activated CD4+ killer T cells.

1990 • 86 citations

Specific lysis of Listeria monocytogenes‐infected macrophages by class II‐restricted L3T4⁺ T cells

1987 • 82 citations

Gene Activation by 5-Azacytidine

1984 • 74 citations

CD4+ cells treated with DNA methylation inhibitors induce autologous B cell differentiation

1990 • 66 citations

Biochemistry of azacitidine: a review.

1987 • 65 citations

Effect of cyclosporin A, silica quartz dust, and protease inhibitors on virus-induced demyelination

1986 • 50 citations

5-Azacytidine Hydrolysis Kinetics Measured by High-Pressure Liquid Chromatography and 13C-NMR Spectroscopy

1979 • 46 citations

Effect of an inhibitor of DNA methylation on T cells. I. 5-Azacytidine induces T4 expression on T8+ T cells.

1986 • 46 citations

Increased immunoglobulin response to γ-interferon by lymphocytes from patients with systemic lupus erythematosus

1988 • 38 citations

Inducer T-cell-mediated killing of antigen-presenting cells

1986 • 30 citations

N‐acetylprocainamide is a less potent inducer of t cell autoreactivity than procainamide

1988 • 30 citations

The implications of procainamide metabolism to its induction of lupus

1981 • 25 citations

Induction of graft versus host-associated immunodeficiency by CD4+ T cell clones.

1990 • 24 citations

5‐Azacytidine inhibits the lpr gene‐induced lymphadenopathy and acceleration of lupus‐like syndrome in MRL/MpJ‐lpr/lpr mice

1990 • 22 citations

Characterization of B cell growth in systemic lupus erythematosus. Effects of recombinant 12‐kDa B cell growth factor, interleukin 4 and transforming growth factor‐β

1990 • 18 citations

The Autologous Mixed-Lymphocyte Reaction

1982 • 16 citations

The comparative effects of 5-azacytidine and dihydro-5-azacytidine on 4 S and 5 S nuclear RNA.

1980 • 11 citations

T-cell repertoire.

1988 • 2 citations

Evidence that macrophages are programmed to die after activating autologous, cloned, antigen-specific, CD4 + T cells

1993 • 1 citations