Systematically applied chemicals that damage lung tissue

Lysosomes in biology and pathology

1977 • 2,068 citations

Casarett and Doull's Toxicology: The Basic Science of Poisons

1981 • 622 citations

Superoxide- and singlet oxygen-catalyzed lipid peroxidation as a possible mechanism for paraquat (methyl viologen) toxicity

1974 • 540 citations

Bipyridylium quaternary salts and related compounds. V. Pulse radiolysis studies of the reaction of paraquat radical with oxygen. Implications for the mode of action of bipyridyl herbicides

1973 • 518 citations

Lung Tumors in Mice: Application to Carcinogenesis Bioassay

1975 • 443 citations

Association between Maternal Diabetes and the Respiratory-Distress Syndrome in the Newborn

1976 • 436 citations

The toxic actions of pyrrolizidine (senecio) alkaloids.

1970 • 380 citations

Separation and purification of multiple forms of microsomal cytochrome P-450. Activities of different forms of cytochrome P-450 towards several compounds of environmental interest.

1977 • 367 citations

Evidence for the Clara cell as a site of cytochrome P450-dependent mixed-function oxidase activity in lung

1977 • 359 citations

The role of catalytic superoxide formation in the O2 inhibition of nitroreductase

1975 • 306 citations

Mitomycin C: Current status and new developments

1979 • 296 citations

Accidental Poisoning by Paraquat: Report of Two Cases in Man

1966 • 294 citations

Evidence for energy-dependent accumulation of paraquat into rat lung

1974 • 294 citations

Lead encephalo-myelopathy of the suckling rat and its implications on the porphyrinopathic nervous diseases

1966 • 289 citations

Biochemical Mechanisms in Chemical-Induced Lung Injury: Roles of Metabolic Activation

1980 • 246 citations

The pulmonary toxicity of antineoplastic agents.

1982 • 237 citations

Synthetic antioxidants: Biochemical actions and interference with radiation, toxic compounds, chemical mutagens and chemical carcinogens

1984 • 233 citations

Pulmonary Fibrosis—A possible mechanism

1979 • 213 citations

Protection by zinc against cadmium toxicity

1972 • 211 citations

Paraquat accumulation: Tissue and species specificity

1976 • 202 citations

Paraquat toxicity: proposed mechanism of action involving lipid peroxidation.

1976 • 196 citations

Drug-induced lysosomal storage disorders.

1979 • 194 citations

Prediction of BCNU Pulmonary Toxicity in Patients with Malignant Gliomas

1980 • 189 citations

Paraquat

1976 • 187 citations

Lung injury induced by butylated hydroxytoluene: cytodynamic and biochemical studies in mice.

1977 • 186 citations

Carcinogenic effects of metals.

1978 • 178 citations

Cytotoxic drug-induced pulmonary disease: Update 1980

1980 • 178 citations

The conversion of pyrrolizidine alkaloids to N-oxides and to dihydropyrrolizine derivatives by rat-liver microsomes in vitro

1971 • 178 citations

Protection from Oxygen Toxicity with Endotoxin

1980 • 173 citations

Review of the Toxicology of Paraquat (1, 1′-Dimethyl-4, 4′-bipyridinium Chloride)

1979 • 169 citations

Pharmacology and the future of man

1974 • 167 citations

Reduction of paraquat toxicity by superoxide dismutase

1974 • 165 citations

The pathogenesis and structure of paraquat‐induced pulmonary fibrosis in rats

1974 • 164 citations

Studies on the mechanism of the lung toxicity of paraquat: Comparison of tissue distribution and some biochemical parameters in rats and rabbits

1974 • 163 citations

Increases in rat liver cyclic AMP concentrations prior to the initiation of DNA synthesis following partial hepatectomy or hormone infusion

1972 • 160 citations

Proliferation of type II alveolar cells: A review of common responses in toxic lung injury

1976 • 159 citations

Metabolism of phospholipids in the lung.

1976 • 150 citations

The toxicological properties of impurities in malathion

1978 • 149 citations

Alpha‐naphthyl‐thiourea‐induced pulmonary oedema in the rat: A topographical and electron‐microscope study

1972 • 147 citations

Changes in pulmonary structure and function induced by monocrotaline intoxication

1981 • 144 citations

Embolic pneumopathy induced by oleic acid. A systematic morphologic study.

1977 • 142 citations

The Infant of the Diabetic Mother

1959 • 141 citations

Pulmonary Toxicity Associated with Bischloroethylnitrosourea (BCNU)

1979 • 140 citations

Hepatotoxicity and pulmonary toxicity of pennyroyal oil and its constituent terpenes in the mouse

1982 • 139 citations

Effect of impurities on the mammalian toxicity of technical malathion and acephate

1977 • 139 citations

Lack of metabolism as the biochemical basis of bleomycin-induced pulmonary toxicity.

1983 • 133 citations

Pulmonary toxicity of antineoplastic agents

1983 • 133 citations

Butylated hydroxytoluene (BHT): A review

1982 • 132 citations

Enhancement of oxygen toxicity by the herbicide paraquat.

1973 • 131 citations

Lesions in the liver and lungs of rats given pyrrole derivatives of pyrrolizidine alkaloids

1970 • 128 citations

Evidence for cytochrome P-450 mediated metabolism in the bronchiolar damage by naphthalene

1982 • 127 citations

Cyclophosphamide therapy and interstitial pulmonary fibrosis

1976 • 126 citations

Handling of Bioactive Materials by the Lung

1974 • 124 citations

Hepato- and pneumotoxicity of pyrrolizidine alkaloids and derivatives in relation to molecular structure

1976 • 121 citations

Teratogenic effects of cadmium in rats

1973 • 121 citations

Immunologic and Infectious Reactions in the Lung.

1977 • 120 citations

Dose-response study of hemorrhagic death by dietary butylated hydroxytoluene (BHT) in male rats

1978 • 119 citations

Lung Metabolism and Biochemistry

1974 • 118 citations

Cyclic adenosine 3':5'-monophosphate and the induction of deoxyribonucleic acid synthesis in liver.

1975 • 115 citations

Morphology of a naphthalene-induced bronchiolar lesion.

1977 • 115 citations

In vitro stimulation by paraquat of reactive oxygen-mediated lipid peroxidation in rat lung microsomes

1981 • 115 citations

Pulmonary and generalized lysosomal storage induced by amphiphilic drugs.

1984 • 112 citations

Lung Damage in Mice Following Intraperitoneal Injection of Butylated Hydroxytoluene

1972 • 110 citations

The pulmonary clara cell as a target for toxic chemicals requiring metabolic activation; studies with carbon tetrachloride.

1980 • 110 citations

Potentiation of Butylated Hydroxytoluene-induced Acute Lung Damage by Oxygen

1983 • 108 citations

In vivo studies on the relationship between target organ alkylation and the pulmonary toxicity of a chemically reactive metabolite of 4-ipomeanol.

1978 • 107 citations

Pulmonary toxicity of bleomycin.

1976 • 105 citations

Ultrastructure of pulmonary bleomycin toxicity

1973 • 103 citations

Pulmonary toxicity of mitomycin

1980 • 100 citations

Adverse Reactions to Sulfisoxazole, Sulfamethoxazole, and Nitrofurantoin

1971 • 99 citations

In vivo oxidation of reduced nicotinamide-adenine dinucleotide phosphate by paraquat and diquat in rat lung

1977 • 99 citations

THE LUNG: STRUCTURE, FUNCTION AND DISEASE

1979 • 98 citations

Alkylation as the Mechanism by which the Hepatotoxic Pyrrolizidine Alkaloids Act on Cell Nuclei

1962 • 97 citations

EFFECT OF CHOLESTEROL SYNTHESIS INHIBITION IN NORMOCHOLESTEREMIC YOUNG MEN*

1959 • 95 citations

The relevance of pentose phosphate pathway stimulation in rat lung to the mechanism of paraquat toxicity

1976 • 95 citations

Utilization of glycogen for phospholipid synthesis in fetal rat lung

1982 • 94 citations

Interstitial Pneumonia from Mitomycin

1978 • 94 citations

The nitrosoureas and pulmonary toxicity

1981 • 91 citations

Alterations in pulmonary alveoli after a single injection of monocrotaline.

1967 • 89 citations

Localization of Metabolic Activation and Deactivation Systems in the Lung: Significance to the Pulmonary Toxicity of Xenobiotics

1983 • 87 citations

In vitro studies on the metabolic activation of the pulmonary toxin, 4-ipomeanol, by rat lung and liver microsomes.

1978 • 87 citations

Diquat intoxication

1981 • 85 citations

Superoxide and hydrogen peroxide production and NADPH oxidation stimulated by nitrofurantoin in lung microsomes: Possible implications for toxicity

1979 • 85 citations

Pulmonary Toxicity of Antineoplastic Drugs

1981 • 85 citations

THE DEVELOPMENT AND USE OF ALPHA-NAPHTHYL THIOUREA (ANTU) AS A RAT POISON

1945 • 82 citations

Acute pulmonary injury in rats by nitrofurantoin and modification by vitamin E, dietary fat, and oxygen.

1979 • 81 citations

Pulmonary metabolism of xenobiotics

1976 • 80 citations

Sclerosing alveolitis induced by cyclophosphamide. Ultrastructural observations on alveolar injury and repair.

1975 • 79 citations

Adenosine 3',5'-monophosphate concentrations and isoproterenol-induced synthesis of deoxyribonucleic acid in mouse parotid gland.

1972 • 79 citations

Electron microscopy of butylated hydroxytoluene-induced lung damage in mice

1977 • 79 citations

Hepatic metabolism and pulmonary toxicity of monocrotaline using isolated perfused liver and lung

1984 • 78 citations

Drug-induced lipidosis and the alveolar macrophage

1981 • 78 citations

Paraquat and NADPH-dependent lipid peroxidation in lung microsomes.

1981 • 77 citations

Role of metabolic activation in the pathogenesis of chemically induced pulmonary disease: mechanism of action of the lung-toxic furan, 4-ipomeanol.

1976 • 77 citations

Species and strain differences in target organ alkylation and toxicity by 4-ipomeanol

1979 • 76 citations

The toxicity of diquat

1970 • 76 citations

New aspects of the toxicology and pharmacology of pyrrolizidine alkaloids

1979 • 76 citations

Effects of beryllium on deoxyribonucleic acid-synthesizing enzymes in regenerating rat liver

1970 • 75 citations

Pulmonary edema and emphysema in cattle after intraruminal and intravenous administration of 3-methylindole.

1975 • 75 citations

Pulmonary oedema induced by ANTU, or by high or low oxygen concentrations in rat--an electron microscopic study.

1972 • 73 citations

Toxicological properties of phosphorothioate and related esters present as impurities in technical organophosphorus insecticides

1981 • 72 citations

Oleic-acid-induced lung injury in the rat. Failure of indomethacin treatment or complement depletion to ablate lung injury.

1981 • 72 citations

Preferential effects of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on pulmonary glutathione reductase and glutathione/glutathione disulfide ratios: possible implications for lung toxicity.

1984 • 72 citations

Stimulation of DNA Synthesis in Mouse Lung Following Intraperitoneal Injection of Butylated Hydroxytoluene

1974 • 71 citations

Pulmonary ultrastructure after oral and intravenous dosage of paraquat to rats

1977 • 71 citations

Methotrexate-Induced Diffuse Interstitial Pulmonary Fibrosis

1979 • 70 citations

Effects of drug metabolism inhibitors on butylated hydroxytoluene-induced pulmonary toxicity in mice

1980 • 70 citations

Studies on the mechanism of toxicity and of development of tolerance to the pulmonary toxin, alpha-naphthylthiourea (ANTU).

1976 • 69 citations

In vitro metabolic activation of the pulmonary toxin, 4-ipomeanol, in nonciliated bronchiolar epithelial (Clara) and alveolar type II cells isolated from rabbit lung.

1982 • 69 citations

Nitrofurantoin: Evidence for the Oxidant Injury of Lung Parenchymal Cells^1,2

1983 • 68 citations

Pulmonary oedema in rats given monocrotaline pyrrole

1972 • 68 citations

Epithelial-Mesenchymal Associations of Cells in Human Pulmonary Fibrosis and in BHT-Oxygen-Induced Fibrosis in Mice

1981 • 68 citations

Amiodarone pneumonitis: three further cases with a review of published reports.

1984 • 66 citations

Enhanced Acute Lung Damage Following Corticosteroid Treatment

1984 • 64 citations

Early damage indicators in the lungs. IV. Biochemical and cytologic response of the lung to lavage with metal salts

1979 • 64 citations

Potentiation of bleomycin-induced lung injury by exposure to 70% oxygen. Morphologic assessment.

1982 • 64 citations

The effect of a pyrrolizidine alkaloid, monocrotaline, and a pyrrole, dehydroretronecine, on the biochemical functions of the pulmonary endothelium.

1978 • 62 citations

Potentiating effects of oxygen in lungs damaged by methylcyclopentadienyl manganese tricarbonyl, cadmium chloride, oleic acid, and antitumor drugs

1983 • 61 citations

Prevention of butylated hydroxytoluene-induced lung damage in mice by cedar terpene administration

1979 • 61 citations

Molecular studies of the induction of cellular phospholipidosis by cationic amphiphilic drugs.

1984 • 61 citations

1,1-Dichloroethylene-Induced Pulmonary Injury

1982 • 60 citations

Pulmonary toxicity of antineoplastic agents: Anaesthetic and postoperative implications

1983 • 59 citations

Investigation of the acute toxicity of some trimethyl and triethyl phosphorothioates with particular reference to those causing lung damage

1982 • 58 citations

Metabolism of trace amounts of vanadium 48 in rat organs and liver subcellular particles

1966 • 58 citations

Morphology of Experimental Respiratory Carcinogenesis

1971 • 57 citations

Amiodarone lung toxicity: A human and experimental study

1984 • 56 citations

Hyperoxia, but not thoracic X-irradiation, potentiates bleomycin- and cyclophosphamide-induced lung damage in mice.

1982 • 56 citations

Toxicology and the Newborn

1985 • 55 citations

Pulmonary histiocytosis simulating desquamative interstitial pneumonia in rats receiving oral iprindole

1972 • 53 citations

Tissue uptake of paraquat and diquat

1977 • 53 citations

3-methylindole-induced pulmonary injury in goats.

1977 • 53 citations

The acute toxicity of thioureas and related compounds to wild and domestic Norway rats.

1947 • 53 citations

Toxicity of butylated hydroxytoluene in mouse following oral administration

1978 • 53 citations

Isotope effects on the metabolism and pulmonary toxicity of butylated hydroxytoluene in mice by deuteration of the 4-methyl group

1983 • 52 citations

Alveolar type II and Clara cells: isolation and xenobiotic metabolism.

1984 • 51 citations

Hypoxic protection in paraquat poisoning.

1976 • 51 citations

Protective role of endogenous pulmonary glutathione and other sulfhydryl compounds against lung damage by alkylating agents

1982 • 50 citations

Fatal pulmonary fibrosis following 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy

1978 • 49 citations

Paraquat Poisoning: New Aspects of Therapy

1976 • 49 citations

Delay in Pulmonary Glycogen Degradation in Fetuses of Streptozotocin Diabetic Rats

1982 • 48 citations

3-methylindole-induced pulmonary edema and emphysema in sheep.

1978 • 48 citations

Long-term morphologic and biochemical features of experimentally induced lung fibrosis in the mouse.

1982 • 47 citations

Distribution, excretion, and binding of radioactivity in the rat after intraperitoneal administration of the lung-toxic furan, 614C94-ipomeanol*1

1975 • 47 citations

Review: Putative mutagens and carcinogens in foods III. Butylated hydroxytoluene (BHT)

1983 • 47 citations

Cellular responses to trialkylphosphorothioate-induced injury in rat lung

1982 • 46 citations

Beryllium disease: A clinical perspective

1980 • 46 citations

Fetal Lung Lecithin Metabolism in the Glucose-Intolerant Rhesus Monkey Pregnancy

1976 • 46 citations

Effect of monocrotaline ingestion on liver, kidney, and lung of rats

1981 • 45 citations

Lung growth in mice after a single dose of butylated hydroxytoluene

1975 • 45 citations

Pulmonary intra-alveolar histiocytosis induced by drugs

1973 • 45 citations

An impurity of malathion alters the morphology of rat lung bronchiolar epithelium

1983 • 44 citations

Potentiation of Bleomycin-induced Lung Injury by Exposure to 70% Oxygen

2015 • 44 citations

Prolonged survival after paraquat

1981 • 44 citations

Metabolism of α-naphthylthiourea by rat liver and rat lung microsomes

1980 • 44 citations

Biological fate of butylated hydroxytoluene (BHT); Binding in vitro of BHT to liver microsomes.

1979 • 43 citations

Biochemical parameters of BHT-induced cell growth in mouse lung

1976 • 43 citations

Toxicology of trialkylphosphorothioates with particular reference to lung toxicity

1984 • 43 citations

Pulmonary toxicity of butylated hydroxytoluene and related alkylphenols: Structural requirements for toxic potency in mice*1

1982 • 43 citations

Acute toxicity of ammonium metavanadate in mice

1982 • 42 citations

Pulmonary Alveolar Reaction to Nickel Carbonyl

1968 • 42 citations

Functional delay in lung maturation in fetuses of diabetic rabbits

1980 • 41 citations

Mitomycin C in advanced adenocarcinoma and large cell carcinoma of the lung.

1978 • 41 citations

Pulmonary toxicity of methylcyclopentadienyl manganese tricarbonyl: Nonciliated bronchiolar epithelial (Clara) cell necrosis and alveolar damage in the mouse, rat, and hamster

1982 • 41 citations

Alterations in granular (type II) pneumocyte ultrastructure by streptozotocin-induced diabetes in the rat.

1978 • 41 citations

Evidence for lipid peroxidation by paraquat in the perfused rat lung.

1983 • 41 citations

Toxic effects of methylcyclopentadienyl manganese tricarbonyl (MMT) in rats: Role of metabolism

1980 • 40 citations

The effect of bcnu (carmustine) on tissue glutathione reductase activity

1983 • 40 citations

The toxicology of paraquat, diquat and morfamquat

1978 • 40 citations

Vanadium retention in rat tissues following acute exposures to different dose levels

1980 • 40 citations

Toxicity studies of methylcyclopentadienyl manganese tricarbonyl (MMT)

1979 • 39 citations

Mitomycin-associated lung disease.

1983 • 39 citations

ACUTE TOXICITY OF THIOUREA TO RATS IN RELATION TO AGE, DIET, STRAIN AND SPECIES VARIATION

1945 • 38 citations

Potentiation of butylated-hydroxytoluene-induced acute lung damage by oxygen. Effects of prednisolone and indomethacin.

1983 • 38 citations

Reduction in rabbit serum and pulmonary angiotensin converting enzyme activity after subacute bleomycin treatment

1981 • 38 citations

Intraalveolar foam cells associated with lipidosis-like alterations in lung and liver of rats treated with tricyclic psychotropic drugs

1975 • 38 citations

Toxicity and metabolism of malathion and its impurities in isolated rat hepatocytes: Role of glutathione

1982 • 37 citations

Pulmonary toxicity, hepatic, and extrahepatic metabolism of 2-methylnaphthalene in mice

1981 • 36 citations

On the mechanism of covalent binding of butylated hydroxytoluene to microsomal protein

1983 • 36 citations

Potentiation of Bleomycin Toxicity by Oxygen

1982 • 36 citations

Alveolar Injury in Acute Carbon Tetrachloride Intoxication

1971 • 35 citations

The Influence of Hyperoxia on the Acute Toxicity of Paraquat and Diquat

1979 • 35 citations

Citalopram‐induced Generalized Lipidosis in Rats

1983 • 35 citations

Inhibition of glutathione reductase by nitrofurantoin.

1960 • 35 citations

Biochemical indices of cyclophosphamide-induced lung toxicity

1984 • 35 citations

Lack of in vivo lipid peroxidation in experimental paraquat poisoning

1980 • 35 citations

Effect of glutathione status on covalent binding and pneumotoxicity of 3-methylindole in goats

1983 • 34 citations

Acute target organ toxicity of 1-nitronaphthalene in the rat

1984 • 34 citations

Lung Maturation in Fetuses of Diabetic Rats

1980 • 33 citations

Effect of Ingested Vanadium on Cholesterol and Phospholipid Metabolism in the Rabbit.

1956 • 33 citations

Age and Species Variation in the Acute Toxicity of Alpha-Naphthyl Thiourea.

1946 • 33 citations

Pulmonary fibrosis and nitrofurantoin.

1973 • 33 citations

The effects of anorectic agents on the pulmonary pressure and morphology of rat lungs after chronic administration.

1972 • 33 citations

Renal toxicity due to reactive metabolites formed in situ in the kidney: investigations with 4-ipomeanol in the mouse.

1981 • 32 citations

Effect of chlorphentermine on the lipids of rat lungs.

1976 • 32 citations

Lung damage induced by butylated hydroxytoluene in mice. Biochemical, cellular, and morphologic characterization.

1984 • 32 citations

Biochemical, cytological, and histological alterations in rat lung following acute beryllium aerosol exposure

1984 • 32 citations

Prevention of acute paraquat toxicity in rats by superoxide dismutase.

1978 • 32 citations

Ultrastructural evidence of pulmonary capillary endothelial damage from paraquat

1982 • 31 citations

Adenoma Development in Mouse Lung Following Treatment with Possible Promoting Agents

1982 • 31 citations

Role of metabolic activation, covalent binding, and glutathione depletion in pulmonary toxicity produced by an impurity of malathion

1984 • 31 citations

The effect of superoxide dismutase on paraquat mortality in mice and rats

1982 • 31 citations

Potentiation of chemically induced lung fibrosis by thorax irradiation

1980 • 31 citations

Disintegration of lung peroxisomes during differentiation of type II cells to type I cells in butylated hydroxytoluene-administered mice

1983 • 31 citations

The metabolism and disposition of 3-methylindole in goats

1979 • 31 citations

Metabolic activation of 4-ipomeanol by avian tissue microsomes

1982 • 30 citations

Interaction of 4-methylbenzaldehyde with rabbit pulmonary cytochrome p-450 in the intact animal, microsomes, and purified systems

1979 • 30 citations

In vivo study of the mechanism of protective effects of ascorbic acid and reduced glutathione in paraquat poisoning

1980 • 30 citations

Biochemical markers of bleomycin toxicity: clearance of [14C]-5-hydroxytryptamine and [3H]norepinephrine by rabbit lung in vivo.

1981 • 30 citations

The enhancement of paraquat toxicity in rats by 85% oxygen: lethality and cell-specific lung damage.

1981 • 30 citations

Melphalan-Induced Pulmonary Interstitial Fibrosis

1980 • 29 citations

The covalent binding of 3-methylindole metabolites to bovine tissue

1980 • 29 citations

Mode of action of the delayed toxicity of O,O,S-trimethyl phosphorothioate in the rat

1982 • 29 citations

Covalent binding of metabolites of 4-ipomeanol to rabbit pulmonary and hepatic microsomal proteins and to the enzymes of the pulmonary cytochrome P-450-dependent monooxygenase system.

1983 • 28 citations

Influence of maternal diabetes on lipid metabolism in neonatal rat lung

1979 • 28 citations

Oral toxicity of methylcyclopentadienyl manganese tricarbonyl (MMT) in rats

1974 • 28 citations

In vivo studies on the target tissue metabolism, covalent binding, glutathione depletion, and toxicity of 4-ipomeanol in birds, species deficient in pulmonary enzymes for metabolic activation

1982 • 28 citations

Pulmonary Ossification Associated with Long-Term Busulfan Therapy in Chronic Myeloid Leukemia

1972 • 28 citations

Morphometric Evaluation of Ultrastructural Changes in Type II Alveolar Cells of Rat Lung Produced by Bromhexine

1971 • 27 citations

Toxic effects of cadmium on the developing rat lung. I. Altered pulmonary surfactant and the induction of respiratory distress syndrome

1979 • 27 citations

Health hazards of pyrrolizidine alkaloids: A short review

1982 • 27 citations

Effect of dose level and pregnancy on the distribution and toxicity of intravenous lead in rats

1982 • 27 citations

Effect of drug metabolism inducer and inhibitor on O,O,S-trimethyl phosphorothioate-induced delayed toxicity in rats

1983 • 26 citations

Effects of the Clara cell toxin, 4-ipomeanol, on pulmonary function in rats

1983 • 26 citations

Correlation of biochemical and morphological changes induced by chemical injury to the lung

1979 • 25 citations

Early bronchiolar damage following paraquat poisoning in mice

1979 • 25 citations

Ascorbic acid and paraquat: Oxygen depletion with concurrent oxygen activation*1

1982 • 24 citations

Morphologic Disturbance of Lung Maturation in Fetuses of Alloxan Diabetic Rabbits^1–3

1980 • 24 citations

Enhanced oxygen toxicity following treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea

1984 • 24 citations

Biotransformation and excretion of methylcyclopentadienyl manganese tricarbonyl in the rat.

1980 • 23 citations

BCNU (1,3-Bis-(2-chloroethyl)-1-nitrosurea) lung. Drug-induced pulmonary changes

1984 • 23 citations

A comparative ultrastructural and biochemical study between the effects of chlorphentermine and phentermine on rat lung

1977 • 23 citations

Binding of radioactivity from (14C)thiourea to rat lung protein.

1976 • 22 citations

Tissue distribution and binding of radioactivity from 14C-thiourea in the rat.

1974 • 22 citations

Changes in Histone Phosphorylation and Adenosine 3′:5′-Cyclic Monophosphate during the Initiation of Deoxyribonucleic Acid Synthesis and Mitosis in Rat Kidney

1974 • 22 citations

Involvements of cyclic nucleotide systems in enlarged mice lungs produced by butylated hydroxytoluene

1978 • 22 citations

Pulmonary toxicity of 2-methylnaphthalene: Lack of a relationship between toxicity, dihydrodiol formation and irreversible binding to cellular macromolecules in DBA/2J mice

1983 • 21 citations

The effect of bleomycin and oxygen on rat lung

1984 • 21 citations

Collagen production rates following acute lung damage induced by butylated hydroxytoluene

1982 • 21 citations

Strain differences in butylated hydroxytoluene-induced deaths in male mice

1981 • 20 citations

Animal model of human disease. Diffuse interstitial pulmonary fibrosis. Pulmonary fibrosis in mice induced by treatment with butylated hydroxytoluene and oxygen.

1981 • 19 citations

Selective inhibition of rat pulmonary monooxygenase by O, O, S-trimethyl phosphorothioate treatment

1983 • 19 citations

Fenfluramine-induced ultrastructural alterations in tissues of rats and guinea pigs

1974 • 19 citations

Comparison of the subacute effects of cadmium exposure upon nucleic acid, cyclic adenosine 3′, 5′-monophosphate and polyamine metabolism in lung and kidney cortex

1976 • 19 citations

Nonciliated bronchiolar epithelial (Clara) cell necrosis induced by organometallic carbonyl compounds☆

1982 • 19 citations

Biological Factors Involved in Poisoning Rats with Alpha-Naphthyl Thiourea (ANTU).

1946 • 19 citations

Effects of bis-chloronitrosourea (BCNU) on pulmonary and serum angiotensin converting enzyme activity in rats

1983 • 18 citations

Sequential and dose‐dependent alterations in rat bronchiolar epithelium during O,O,S‐trimethyl phosphorothioate induced delayed toxicity

1984 • 18 citations

Pulmonary toxicity of antineoplastic drugs

1981 • 18 citations

Induction of feather malformations in chick embryos by cadmium: Protection by zinc

1983 • 18 citations

Effects of paraquat aerosol on mouse lung.

1979 • 18 citations

Biochemical and morphologic investigation of the influence of chlorphentermine and subsequent withdrawal on newborn rat lung

1979 • 18 citations

Altered phosphorylation of lung proteins following administration of Butylated Hydroxytoluene (BHT) to mice

1979 • 18 citations

Adverse reactions to sulfosoxazole, sulfamethoxazole, and nitrofurantoin. Manifestations and specific reaction rates during 2,118 courses of therapy

1971 • 17 citations

Fetal zinc deficiency as a mechanism for cadmium induced toxicity to the developing rat lung and pulmonary surfactant

1982 • 17 citations

Pulmonary fibrosis: A complication of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy

1981 • 17 citations

Metabolic interactions of hydrocarbons with mammalian lung.

1981 • 17 citations

Drug-induced lung disease.

1978 • 17 citations

Metabolic aspects of methylcyclopentadienyl manganese tricarbonyl in rats

1974 • 17 citations

Mechanisms of pyrrolizidine alkaloid toxicity

1972 • 17 citations

In Vitro Covalent Binding of 3-[14C]Methylindole Metabolites in Goat Tissues

1984 • 17 citations

Influence of lead on hepatic, renal and pulmonary nucleic acid, polyamine, and cyclic adenosine 3′:5′-monophosphate metabolism in neonatal rats

1977 • 16 citations

Stimulation of DNA Synthesis in Mouse and Rat Lung Following Administration of Butylated Hydroxytoluene

1978 • 16 citations

Lung injury and delayed toxicity produced by O,S,S-trimethyl phosphorodithioate, an impurity of malathion

1984 • 16 citations

Toxic effects of cadmium on the developing rat lung. II. Glycogen and phospholipid metabolism

1982 • 16 citations

Acute toxicity of oral diquat (1,1′-ethylene-2,2′-bipyridinium) in cynomolgus monkeys

1979 • 16 citations

Concentration of 3-Methylindole (3MI) and distribution of radioactivity from 14C3MI in goat tissues associated with acute pulmonary edema

1982 • 16 citations

Potentiation of alpha-naphthyl thiourea-induced lung injury by prostaglandin E1 and platelet depletion.

1984 • 16 citations

Cloforex-induced pulmonary changes in rats.

1972 • 15 citations

Sequential changes in hepatic polyamine, deoxyribonucleic acid, and cyclic adenosine 3′,5′-monophosphate metabolism after subacute exposure to cadmium in rats

1977 • 15 citations

Prevention of butylated hydroxytoluene-induced lung damage by diethyldithiocarbamate and carbon disulfide in mice

1984 • 15 citations

Chlorimipramine-induced phospholipidosis: Biochemical and pharmacokinetic observations in the rat

1983 • 15 citations

Effect of AY-9944, a cholesterol biosynthesis inhibitor, on fetal lung development and on the development of type II alveolar epithelial cells.

1973 • 15 citations

Glycogen accumulation in alveolar type II cells in 3-methylindole--induced pulmonary edema in goats.

1981 • 15 citations

Innate and drug-induced resistance to acute lung damage caused in rats by alpha-naphthyl thiourea (ANTU) and related compounds.

1976 • 14 citations

Amiodarone and pulmonary fibrosis

1983 • 14 citations

Biochemical evidence for pulmonary endothelial cell injury after carbon tetrachloride administration in mice.

1982 • 14 citations

Lipid accumulation in liver, spleen, lungs and kidneys of miniature-pigs after chloroquine treatment

1982 • 14 citations

Studies on organophosphorus impurities in technical malathion: Inhibition of carboxylesterases and the stability of isomalathion

1984 • 14 citations

Fatty change of the granular pneumocyte in CCl4 intoxication.

1966 • 14 citations

Increased incorporation of fatty acids into phospholipids of lungs and livers of rabbits under the influence of bromhexine and ambroxol

1977 • 14 citations

Inhalation Toxicology and Lung Edema Receptor Sites

1970 • 13 citations

Lung surfactant in the hyperinsulinemic fetal monkey

1983 • 13 citations

Comparison of ratios of covalent binding to total metabolism of the pulmonary toxin, 4-ipomeanol, In vitro in pulmonary and hepatic microsomes, and the effects of pretreatments with phenobarbital or 3-methylcholanthrene

1980 • 12 citations

Role of drug metabolism in protection against chlorphentermine-induced pulmonary phospholipidosis in adult rat

1981 • 12 citations

Alterations in newborn and adult rat lung morphology and phospholipid levels after chlorcyclizine or chlorphentermine treatment

1982 • 12 citations

Intrabronchial instillation of paraquat in rats: lung morphology and retention study.

1981 • 12 citations

The infant of the diabetic mother.

1969 • 12 citations

Preventive effect of cysteine on butylated hydroxytoluene-induced pulmonary toxicity in mice

1984 • 12 citations

Correlative morphological and biochemical studies on monocrotaline-induced pulmonary alterations in rats

1984 • 12 citations

Delayed Pulmonary Phosphatidylglycerol Synthesis and Reversal by Prenatal Dexamethasone in Fetal Rats of Streptozotocin-Diabetic Mothers

1983 • 11 citations

Effects of maternal diabetes on the levels, synthetic rates and activities of synthetic enzymes of surface-active phospholipids in perinatal rat lung

1983 • 11 citations

Cadmium-induced pulmonary injury in mouse: A relationship with serum antitrypsin activity

1982 • 11 citations

Chlorphentermine-induced alterations in pulmonary phospholipid content in rats

1983 • 11 citations

Generalized lipidosis in newborn rats and guinea pigs induced during prenatal development by administration of amphiphilic drugs to pregnant animals

1982 • 11 citations

Morphological alterations of rat lung bronchiolar epithelium produced by various trialkyl phosphorothioates

1984 • 11 citations

Effects of Maternal Diabetes on the Development of Carbohydrate-Metabolizing Enzymes, Glycogen Deposition and Surface Active Phospholipid Levels in Fetal Rat Lung

1983 • 11 citations

Imipramine and chloroquine induced alterations in phospholipid content of rat lung

1983 • 10 citations

Prevention of chlorphentermine-induced pulmonary phospholipidosis in rats by phenobarbital.

1985 • 10 citations

Modification by phenobarbital of chlorphenterm1ne‐induced changes in lung morphology and drug‐metabolizing enzymes in newborn rats

1981 • 10 citations

The relationship between paraquat accumulation and covalent binding in rat lung slices.

1983 • 10 citations

Effects of chlorocyclizine on pulmonary lipid metabolism in rats

1983 • 9 citations

Toxicity of minimal amounts of cadmium to the developing rat lung and pulmonary surfactant

1981 • 9 citations

Effects of Nitrofurantoin on the Glutathione Redox Status and Related Enzymes in the Isolated, Perfused Rabbit Lung

1982 • 9 citations

Resistance to toxic thioureas in rats treated with anti-thyroid compounds.

1949 • 9 citations

Disposition of the pulmonary toxin, bleomycin.

1979 • 9 citations

Toxicological properties of O,O,S‐trialkyl phosphorothioates

1983 • 9 citations

Protective effects of butylated hydroxyanisole, ethoxyquin, and disulfiram on acute pyrrolizidine alkaloids poisoning in mice.

1982 • 8 citations

Effects of parenteral vanadium administration on pulmonary metabolism of rats

1982 • 8 citations

Alveolar injury in acute carbon tetrachloride intoxication

1971 • 8 citations

Neonatal toxicity in rats following in utero exposure to chlorphentermine or phentermine

1982 • 7 citations

The role of hyperoxygenation in facilitating the induction of pulmonary histiocytosis by low doses of chlorphentermine

1980 • 7 citations

Effects of monocrotaline treatment on norepinephrine removal by isolated, perfused rat lungs

1984 • 7 citations

Early metabolic alterations in pulmonary tissue following administration of toxic agents.

1978 • 7 citations

Ascorbic acid potentiates the substrate‐specific inhibition of mixed‐function oxidation and the stimulation of NADPH oxidation caused by paraquat

1984 • 7 citations

Ascorbic acid nutritional status does not affect the biochemical response to paraquat*1

1984 • 7 citations

Effect of endotoxin on thiourea induced pulmonary edema and pleural effusion.

1981 • 7 citations

14C-Thiourea binding in the rat lung.

1979 • 6 citations

Comparative effects of antioxidants on the toxicity of mixed pyrrolizidine alkaloids fromSenecio jacobaeain mice

1982 • 6 citations

Drug-induced pulmonary disease

1979 • 6 citations

Lack of Lung Damage in Mice Following Administration of Tertiary Butylhydroquinone

1984 • 6 citations

Enzymatic Changes in Alveolar Macrophages of Rats Exposed to Lead and Nickel by Inhalation

1983 • 5 citations

Chlorcyclizine-Induced Pulmonary Phospholipidosis in Rats

1983 • 5 citations

Effects of 3-methylcholanthrene on covalent binding and toxicity of 4-ipomeanol in inducible and non-inducible (B6D2) mice

1983 • 5 citations

Role of age in amphiphilic drug-induced pulmonary morphological and metabolic responses.

1984 • 5 citations

Chlorphentermine inhibits oxidative energy metabolism in rat lung slices

1982 • 5 citations

Reappraisal of the use of a single dose of lead for the study of cell proliferation in kidney, liver, and lung

1977 • 4 citations

Effect of pretreatment with butylated hydroxytoluene (BHT) on binding of 14C-BHT to lung microsomes.

1980 • 4 citations

Effects of hyperoxia on pulmonary metabolism of newborn rats and modification by chlorphentermine

1981 • 4 citations

The action of isoproterenol on phenylthiourea induced pulmonary edema.

1975 • 3 citations

In vivo incorporation of3H-choline in alveolar type-II pneumocytes in mice treated with butylated hydroxytoluene (BHT)

1981 • 3 citations

Modification by Hyperoxia of Chlorphentermine- or Phentermine-Induced Effects on Newborn Rat Lung Morphology and Metabolism

1981 • 3 citations

Induction and reversal of pulmonary lipid histiocytosis in rats following oral administration of anorectics cloforex and chlorphentermine

1981 • 3 citations

Biochemical changes induced by α-naphthylthiourea in albino rats

1978 • 3 citations

Protective effect of drug metabolism inducer and inhibitor on O,O,S-trimethyl phosphorothioate induced delayed toxicity in rats.

1984 • 2 citations