Drug-induced lipidosis and the alveolar macrophage

Superoxide, hydrogen peroxide, and singlet oxygen in lipid peroxidation by a xanthine oxidase system.

1975 • 969 citations

Studies on Pulmonary Alveolar Macrophages from the Normal Rabbit: A Technique to Procure Them in a High State of Purity

1961 • 726 citations

Analysis of proteins and respiratory cells obtained from human lungs by bronchial lavage.

1974 • 654 citations

Trace elements in fly ash. Dependence of concentration on particle size

1974 • 641 citations

Membrane models with phospholipids

1968 • 536 citations

In Vitro Methods in Cell-Mediated Immunity

1971 • 507 citations

Toxic Trace Elements: Preferential Concentration in Respirable Particles

1974 • 400 citations

Origin, Kinetics, and characteristics of pulmonary macrophages in the normal steady state.

1979 • 363 citations

Lipidosis induced by amphiphilic cationic drugs

1978 • 353 citations

An enzymatic protective mechanism against lipid peroxidation damage to lungs of ozone‐exposed rats

1972 • 350 citations

The Pulmonary-Alveolar Macrophage

1979 • 331 citations

The type II epithelial cell of the lung. I. Method of isolation.

1974 • 313 citations

SOME ELECTRON MICROSCOPICAL OBSERVATIONS ON LIQUID-CRYSTALLINE PHASES IN LIPID-WATER SYSTEMS

1962 • 300 citations

Antibiotic uptake by alveolar macrophages.

1980 • 288 citations

Drug-Induced Phospholipidoses

1975 • 286 citations

Alveolar macrophage-derived chemotactic factor: kinetics of in vitro production and partial characterization.

1980 • 233 citations

Mechanism for the inflammatory response in primate lungs. Demonstration and partial characterization of an alveolar macrophage-derived chemotactic factor with preferential activity for polymorphonuclear leukocytes.

1977 • 215 citations

Pulmonary Alveolar Macrophage DEFENDER AGAINST BACTERIAL INFECTION OF THE LUNG

1974 • 202 citations

Drug-induced lysosomal storage disorders.

1979 • 194 citations

The alteration of superoxide dismutase, catalase, glutathione peroxidase, and NAD(P)H cytochrome c reductase in guinea pig polymorphonuclear leukocytes and alveolar macrophages during hyperoxia.

1976 • 189 citations

Metal toxicity for rabbit alveolar macrophages in vitro

1975 • 180 citations

Lipid Peroxidation by Human Blood Phagocytes

1974 • 177 citations

Elastase Release from Human Alveolar Macrophages: Comparison Between Smokers and Nonsmokers

1977 • 172 citations

Inhibition of lysosomal phospholipase A and phospholipase C by chloroquine and 4,4'-bis(diethylaminoethoxy) alpha, beta-diethyldiphenylethane.

1980 • 169 citations

Inhibition of lipid peroxidation in isolated inner membrane of rat liver mitochondria by superoxide dismutase

1973 • 161 citations

Influence of Ozone on Pulmonary Cells

1968 • 152 citations

The uptake and intracellular accumulation of aminoglycoside antibiotics in lysosomes of cultured rat fibroblasts

1978 • 152 citations

Microbicidal cationic proteins in rabbit alveolar macrophages: a potential host defense mechanism

1980 • 150 citations

Drugs affecting the synthesis of glycerides and phospholipids in rat liver. The effects of clofibrate, halofenate, fenfluramine, amphetamine, cinchocaine, chlorpromazine, demethylimipramine, mepyramine and some of their derivatives

1975 • 147 citations

Gentamicin-induced lysosomal phospholipidosis in cultured rat fibroblasts. Quantitative ultrastructural and biochemical study.

1979 • 141 citations

Lung Defense Mechanisms

1976 • 137 citations

Effects of physical training in intermittent claudication

1978 • 135 citations

The Pulmonary-Alveolar Macrophage

1979 • 134 citations

A comparison of the metabolic response to phagocytosis in human granulocytes and monocytes.

1976 • 134 citations

Recovery of free cells from rat lungs by repeated washings.

1968 • 121 citations

The binding of drugs to different polar lipids in vitro

1979 • 121 citations

Silicosis and fibrogenesis: Fact and artifact

1979 • 120 citations

Bronchopulmonary Lavage in Normal Subjects and Patients with Obstructive Lung Disease

1967 • 120 citations

Studies on drug-induced lipidosis: subcellular localization of phospholipid and cholesterol in the liver of rats treated with chloroquine or 4,4'-bis (diethylaminoethoxy)alpha, beta-diethyldiphenylethane.

1980 • 107 citations

NMR-Studies on the molecular basis of drug-induced phospholipidosis—II. Interaction between several amphiphilic drugs and phospholipids

1976 • 106 citations

Enhanced synthesis de novo of phosphatidylinositol in lymphocytes treated with cationic amphiphilic drugs

1975 • 106 citations

Bronchopulmonary lavage of small laboratory animals.

1977 • 98 citations

Alveolar macrophages. I. a simple technique for the preparation of high numbers of viable alveolar macrophages from small laboratory animals

1979 • 98 citations

Effect of Trace Metals on Phagocytosis by Alveolar Macrophages

1975 • 90 citations

The Pulmonary Macrophage in Acute Leukemia

1974 • 87 citations

Aryl hydrocarbon hydroxylase activity in pulmonary macrophages and lymphocytes from lung cancer and noncancer patients.

1977 • 84 citations

The ultrastructure of rat lung changes induced by an anorectic drug (Chlorphentermine)

1972 • 78 citations

Alveolar macrophage adhesion: wash electrolyte composition and free cell yield.

1973 • 74 citations

Cellular distribution and clearance of aerosolized dipalmitoyl lecithin

1975 • 73 citations

Elastase secretion by peritoneal exudative and alveolar macrophages.

1977 • 73 citations

Lysosomal alterations in cultured macrophages exposed to anorexigenic and psychotropic drugs.

1976 • 70 citations

Chlorphentermine-induced lipidosislike ultrastructural alterations in lungs and adrenal glands of several species

1974 • 70 citations

Cytotoxic effects of vanadium on rabbit alveolar macrophages in vitro

1974 • 69 citations

NMR-Studies on the molecular basis of drug-induced phospholipidosis

1973 • 68 citations

Normal rabbit alveolar macrophages. I. The phagocytosis of tubular myelin.

1976 • 68 citations

A study of the dynamics of imipramine accumulation in the isolated perfused rabbit lung.

1975 • 67 citations

Effects of heavy metal ions on selected oxidative metabolic processes in rat alveolar macrophages

1980 • 66 citations

The induction of fibrogenesis by silica-treated alveolar macrophages

1973 • 65 citations

Pulmonary alveolar macrophage. Oxidative metabolism of isolated cells and mitochondria and effect of cadmium ion on electron- and energy-transfer reactions

1971 • 64 citations

Role of lysozyme in the microbicidal activity of rat alveolar macrophages

1977 • 62 citations

Oxygen-induced synthesis of superoxide dismutase and catalase in pulmonary macrophages of neonatal rats.

1977 • 60 citations

Chloroquine accumulation in isolated rat liver lysosomes

1976 • 58 citations

The Effects of Asbestos on Macrophages

1978 • 57 citations

Nitrogen Dioxide Effects on Alveolar Macrophages

1972 • 56 citations

Drug-induced phospholipidosis

1974 • 55 citations

Pulmonary histiocytosis simulating desquamative interstitial pneumonia in rats receiving oral iprindole

1972 • 53 citations

Mixed-function oxidases and the alveolar macrophage

1972 • 53 citations

Defense Mechanisms of the Lungs

1975 • 53 citations

Nitrogen Dioxide Inhibition of Viral-Induced Resistance in Alveolar Monocytes

1970 • 53 citations

Bronchoalveolar lavage.

1980 • 48 citations

Active uptake of propranolol by isolated rabbit alveolar macrophages and its inhibition by other basic amines.

1980 • 46 citations

Induction of aryl hydrocarbon hydroxylase in human lymphocytes and pulmonary alveolar macrophages - a comparison

1973 • 45 citations

Pulmonary intra-alveolar histiocytosis induced by drugs

1973 • 45 citations

Activation of Alveolar Macrophages after Lower Respiratory Tract Infection

1975 • 45 citations

NO₂Gas and NO₂^-Effects on Alveolar Macrophage Phagocytosis and Metabolism

1973 • 44 citations

Electron microscopy of chlorphentermine lung

1973 • 43 citations

Cadmium-induced depression of the respiratory burst in mouse pulmonary alveolar macrophages, peritoneal macrophages and polymorphonuclear neutrophils

1977 • 40 citations

Drug-induced foam cell reactions in rats

1974 • 40 citations

Interaction of asbestos with alveolar cells

1974 • 38 citations

The effect of tobacco smoke on the metabolism and function of rat alveolar macrophages

1978 • 38 citations

Intraalveolar foam cells associated with lipidosis-like alterations in lung and liver of rats treated with tricyclic psychotropic drugs

1975 • 38 citations

The Pulmonary Macrophage Response to Irritants

1969 • 37 citations

Oxidative metabolic responses of rabbit pulmonary alveolar macrophages

1979 • 37 citations

The effects of macrophages isolated from the lungs of guinea pigs dusted with silica on collagen biosynthesis by guinea pig fibroblasts in cell culture

1975 • 36 citations

Hydroxyl radical formation in phagocytic cells of the rat

1979 • 36 citations

Alterations in the surface-related phenomena of alveolar macrophages following inhalation of crocidolite asbestos and quartz dusts: An overview

1979 • 35 citations

Pinocytosis by Human Alveolar Macrophages COMPARISON OF SMOKERS AND NONSMOKERS

1974 • 34 citations

The Relation of Age to the Numbers of Lung Free Cells, Lung Weight, and Body Weight in Rats

1968 • 33 citations

Effect of chlorphentermine on the lipids of rat lungs.

1976 • 32 citations

Drug-Induced Foam Cell Reactions in Rats, II. Chemical Analysis of Lipids Stored in Lungs and Foam Cells after Treatment with Chlorphentermine, 5-[p-(Fluoren-9-ylidenemethyl)phenyl]-2-piperidineethanol (RMI 10.393) and 1-Chloramitriptyline

1975 • 31 citations

Effects of chloroquine and 4,4'-bis(diethylaminoethoxy)α,β-diethyldiphenylethane on the incorporation of [3H]glycerol into the phospholipids of rat liver lysosomes and other subcellular fractions, in vivo

1980 • 29 citations

Studies on the persistence of basic amines in the rabbit lung.

1979 • 29 citations

Electrophysiological effects of droperidol in different cardiac tissues

1976 • 28 citations

Metabolism of foreign compounds by alveolar macrophages of rabbits

1972 • 28 citations

Uptake of Propranolol by the Lung and Its Displacement by Other Drugs: Involvement of the Alveolar Macrophage

1980 • 28 citations

Pulmonary alveolar proteinosis developing from desquamative interstitial pneumonia in long term toxicity studies of iprindole in the rat

1973 • 28 citations

The Alveolar Macrophage and its Role in Toxicology

1973 • 24 citations

Comparison of Aryl Hydrocarbon Hydroxylase Induction in Cultured Blood Lymphocytes and Pulmonary Macrophages

1977 • 23 citations

Macrophage metabolism: Activation of NADPH oxidation by phagocytosis

1971 • 23 citations

A comparative ultrastructural and biochemical study between the effects of chlorphentermine and phentermine on rat lung

1977 • 23 citations

Effect of O2 exposure on metabolism of the rabbit alveolar macrophage.

1974 • 21 citations

Augmentation in antioxidant defense mechanisms in rat alveolar macrophages following induction of phospholipidosis with chlorphentermine

1980 • 20 citations

Comparative toxicity of aminoglycoside antibiotics towards the lysosomes in a cell culture model

1980 • 20 citations

Fenfluramine-induced ultrastructural alterations in tissues of rats and guinea pigs

1974 • 19 citations

The effect of hyperoxia on phagocytosis and pinocytosis in isolated pulmonary macrophages.

1978 • 19 citations

Biochemical characteristics of rat alveolar macrophages with chlorphentermine-induced phospholipidosis: Variations with increasing cell size

1979 • 18 citations

The pulmonary macrophage.

1976 • 18 citations

Biochemical and morphologic investigation of the influence of chlorphentermine and subsequent withdrawal on newborn rat lung

1979 • 18 citations

Chlorphentermine uptake by isolated perfused rabbit lung

1980 • 18 citations

Cytochrome P-450 content and mixed-function oxidation by microsomes from rabbit alveolar macrophages.

1977 • 17 citations

Investigation of alveolar macrophages from rats exposed to coal dust.

1975 • 17 citations

Uptake and metabolism of chlorpromazine by rat and rabbit lungs.

1980 • 16 citations

Recovery of alveolar macrophages from rhesus and cynomolgus macaques by lung lavage.

1979 • 16 citations

Tissue Culture in Pneumoconiosis

1977 • 16 citations

Palmitic acid-1-14C incorporation and turnover in lung phospholipids of rats treated with chlorphentermine, RMI 10.393 and Ro 4-4318

1976 • 15 citations

The effect of phenobarbital on chlorphentermine-induced alveolar foam cells in rats

1977 • 15 citations

Effects of prolonged administration of chlorphentermine on the rat lung.

1974 • 14 citations

Tobacco smoke

1979 • 13 citations

Effects of ozone and photochemical oxidants on interferon production by rabbit alveolar macrophages

1980 • 13 citations

Society of Toxicology Meeting

1972 • 12 citations

Histochemical study on the pathogenesis of chlorocyclizine-induced pulmonary lipidosis

1979 • 12 citations

Iprindole-Induced Phospholipidosis in Rat Alveolar Macrophages: Alterations in Oxygen Consumption and Release of Oxidants

1981 • 11 citations

Changes in lysosomal properties of alveolar macrophages of rats treated with chlorphentermine

1978 • 11 citations

Chlorphentermine-induced ultrastructural alterations in foetal tissues

1972 • 10 citations

Foam cell response in the lung and lymphatic tissues during long-term high-level treatment with erythromvcin

1978 • 10 citations

Patterns of benzo[a]pyrene metabolism in normal human pulmonary alveolar macrophages

1979 • 10 citations

Chemiluminescence from rat alveolar macrophages following induction of phospholipidosis with chlorphentermine

1980 • 8 citations

Lung phospholipids: Biochemical and histologic changes induced by the cholesterol biosynthesis inhibitor AY-9944

1967 • 8 citations

Cumene hydroperoxide-mediated lipid peroxidation in rat alveolar macrophages following induction of phospholipidosis with chlorphentermine

1980 • 5 citations

Chlorphentermine uptake by rabbit lung slices

1980 • 4 citations

Lysosomal stabilizing effect of chlorphentermine in the rabbit alveolar macrophage

1979 • 3 citations