Role of metabolic activation, covalent binding, and glutathione depletion in pulmonary toxicity produced by an impurity of malathion

Tissue sulfhydryl groups

1959 • 25,130 citations

A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250

1977 • 2,970 citations

Chloroform toxicity in mice: Correlation of renal and hepatic necrosis with covalent binding of metabolites to tissue macromolecules

1973 • 177 citations

Metabolism and Binding of Aromatic Hydrocarbons in the Lung

1973 • 148 citations

Effect of impurities on the mammalian toxicity of technical malathion and acephate

1977 • 139 citations

Evidence for cytochrome P-450 mediated metabolism in the bronchiolar damage by naphthalene

1982 • 127 citations

In vivo studies on the relationship between target organ alkylation and the pulmonary toxicity of a chemically reactive metabolite of 4-ipomeanol.

1978 • 107 citations

The scientific basis of toxicity assessment

1980 • 82 citations

Metabolism of polycyclic hydrocarbons by rat-lung preparations

1974 • 75 citations

Carcinogenic polynuclear hydrocarbons bind to macromolecules in cultured human bronchi

1974 • 53 citations

Protective role of endogenous pulmonary glutathione and other sulfhydryl compounds against lung damage by alkylating agents

1982 • 50 citations

An impurity of malathion alters the morphology of rat lung bronchiolar epithelium

1983 • 44 citations

Identification and toxicological evaluation of impurities in technical malathion and fenthion

1980 • 43 citations

Effect of drug metabolism inducer and inhibitor on O,O,S-trimethyl phosphorothioate-induced delayed toxicity in rats

1983 • 26 citations

Biochemical and physiological investigations into the delayed toxicity produced by O,O,S-trimethyl phosphorothioate in rats

1983 • 22 citations

Effects of phenobarbital and 3-methylcholanthrene on the in vivo distribution, metabolism and covalent binding of 4-ipomeanol in the rat; implications for target organ toxicity

1982 • 19 citations

Sequential and dose‐dependent alterations in rat bronchiolar epithelium during O,O,S‐trimethyl phosphorothioate induced delayed toxicity

1984 • 18 citations

Phenobarbital pretreatment protects against morphologic changes in rat bronchiolar epithelium caused by an impurity of malathion.

1983 • 15 citations