The nitrosoureas and pulmonary toxicity

A clinical review of bleomycin—a new antineoplastic agent

1973 • 860 citations

Streptozocin Alone Compared with Streptozocin plus Fluorouracil in the Treatment of Advanced Islet-Cell Carcinoma

1980 • 638 citations

Pulmonary oxygen toxicity: a review.

1971 • 619 citations

Pulmonary Effects of Radiation Therapy

1977 • 575 citations

The pathogenesis of bleomycin-induced pulmonary fibrosis in mice.

1974 • 469 citations

Experimental evaluation of potential anticancer agents VIII. Effects of certain nitrosoureas on intracerebral L1210 leukemia.

1963 • 369 citations

Pancreatic Islet Cell Carcinoma

1973 • 347 citations

Combination chemotherapy trials in metastatic carcinoid tumor and the malignant carcinoid syndrome.

1979 • 280 citations

Oxygen toxicity

1980 • 238 citations

Factors influencing postoperative morbidity and mortality in patients treated with bleomycin.

1978 • 221 citations

Clinical trials with 1,3-bis(2-chloroethyl)-1-nitrosourea, NSC-409962.

1965 • 216 citations

Prediction of BCNU Pulmonary Toxicity in Patients with Malignant Gliomas

1980 • 189 citations

Studies on bleomycin

1967 • 186 citations

Interstitial Pneumonitis Associated with Bleomycin Therapy

1972 • 179 citations

Cytotoxic drug-induced pulmonary disease: Update 1980

1980 • 178 citations

The Toxicity of Oxygen

1972 • 175 citations

1,3-Bis(2-Chloroethyl)-1-Nitrosourea (Bcnu) And Other Nitrosoureas In Cancer Treatment: A Review

1973 • 167 citations

Large-dose bleomycin therapy and pulmonary toxicity. A possible role of prior radiotherapy.

1976 • 154 citations

Cytotoxic drug-induced lung disease

1977 • 154 citations

Pulmonary Toxicity Associated with Bischloroethylnitrosourea (BCNU)

1979 • 140 citations

Interrelationships of some chemical, physicochemical, and biological activities of several 1-(2-haloethyl)-1-nitrosoureas.

1974 • 139 citations

Case records of the massachusetts general hospital. Case 41–1979

1980 • 131 citations

Clinical, radiologic, and histopathologic studies on pulmonary toxicity induced by treatment with bleomycin (NSC-125066).

1972 • 127 citations

Bleomycin Hypersensitivity Pneumonitis

1978 • 126 citations

Ultrastructure of pulmonary bleomycin toxicity

1973 • 103 citations

Pulmonary toxicity after radiation and bleomycin: A review

1979 • 86 citations

Synthesis of chlorozotocin, the 2-chloroethyl analog of the anticancer antibiotic streptozotocin

1975 • 85 citations

Experimental evaluation of potential anticancer agents. VI. Anatomical distribution of leukemic cells and failure of chemotherapy.

1961 • 79 citations

BCNU and X-ray therapy of intracerebral 9L rat tumors

1979 • 74 citations

Pulmonary toxicity in long-term administration of BCNU.

1976 • 67 citations

Central nervous system leukemia and solid tumors of childhood:Treatment with 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU)

1966 • 65 citations

Pulmonary complications after bleomycin, irradiation and surgery for esophageal cancer

1978 • 64 citations

Fatal Pulmonary Reaction From Low Doses of Bleomycin

1976 • 64 citations

Effectiveness of the nitrosoureas as a function of their lipid solubility in the chemotherapy of experimental rat brain tumors.

1974 • 62 citations

Carbamoylation of amino acid, peptides, and proteins by nitrosoureas.

1975 • 57 citations

Fatal pulmonary reaction from low doses of bleomycin. An idiosyncratic tissue response

1976 • 56 citations

1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU)-induced Pulmonary Fibrosis

1980 • 52 citations

Fatal pulmonary fibrosis following 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy

1978 • 49 citations

Nitrosoureas: 1,3-bis(2-chloroethyl)-1-nitrosourea (NSC-409962; BCNU) and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC-79037; CCNU)--clinical brochure.

1968 • 49 citations

Toxicology and pharmacology of the nitrosoureas.

1973 • 49 citations

A Review of Studies on the Mechanism of Action of Nitrosoureas

1976 • 48 citations

A new effective four-drug combination of CCNU (1-[2-chloroethyl]-3-cyclohexyl-1-nitrosourea) (NSC-79038), vinblastine, prednisone, and procarbazine for the treatment of advanced Hodgkin's disease

1980 • 45 citations

The Pulmonary Changes of Bleomycin Toxicity

1973 • 42 citations

Chemistry and structure-activity studies of the nitrosoureas.

1976 • 41 citations

Adenocarcinoma of the cervix. A clinicopathologic study of 47 cases

1966 • 34 citations

Experimentally induced bleomycin sulfate pulmonary toxicity: histopathologic and ultrastructural study in the pheasant.

1977 • 33 citations

Pulmonary Fibrosis after Prolonged Therapy with 1,3-Bis (2-chloroethyl)-nitrosourea

1977 • 30 citations

Comparison of biochemical and biological effects of four nitrosoureas with differing carbamoylating activities.

1978 • 27 citations

CCNU and bleomycin in the treatment of cancer: A southwest oncology group study

1975 • 27 citations

Interstitial pulmonary fibrosis as a complication of prolonged methyl-CCNU therapy.

1978 • 26 citations

Large-dose bleomycin therapy and pulmonary toxicity. A possible role of prior radiotherapy

1976 • 26 citations

CCNU nephrotoxicity following sustained remission in oat cell carcinoma.

1979 • 22 citations

Treatment of grade III and IV astrocytomas with BCNU alone and in combination with VM-26 following surgery and radiation therapy.

1979 • 20 citations

Pulmonary toxicity of bischloronitrosourea:Report of a case with transient response to corticosteroid therapy

1979 • 20 citations

CCNU (NSC-79037): preclinical toxicologic evaluation of a single intravenous infusion in dogs and monkeys.

1974 • 19 citations

Pulmonary fibrosis following low-dose 1,3-bis (2-chloro-ethyl)-1-nitrosourea (BCNU) therapy

1980 • 17 citations

Multiple pulmonary lesions in a patient treated with BCNU (1,3-BIS(2-chloroethyl)-1-nitrosourea) for glioblastoma multiforme

1979 • 15 citations

Case Report Irreversible pulmonary toxicity after single course of BCNU

1980 • 15 citations

Distribution of 14C-Lomustine (14C-CCNU)-Derived Radioactivity following Intravenous Administration of Three Potential Clinical Formulations to Rabbits

1974 • 11 citations

Nitrosourea-associated pulmonary fibrosis.

1979 • 11 citations

Case 41-1980

1980 • 9 citations

Progrediente Lungenfibrose unter Kombinationstherapie mit BCNU

1978 • 9 citations

Pulmonary toxicity from carmustine (BCNU): A case report

1979 • 6 citations

Clinical, radiologic, and histopathologic studies on pulmonary toxicity induced by treatment with bleomycin (NSC125066)

1972 • 5 citations

Sequential and adjuvant chemotherapy for malignant astrocytoma of the brain

1978 • 5 citations

PROGRESSIVE PULMONARY FIBROSIS DURING COMBINATION CHEMOTHERAPY WITH BCNU

1978 • 3 citations