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Alkylation as the Mechanism by which the Hepatotoxic Pyrrolizidine Alkaloids Act on Cell Nuclei

Data up to Jan 2025

Published1962
Citations97
References19

Total Citations Per Year

Abstract

References (19)

Structure and Mechanism in Organic Chemistry

1953 • 1,447 citations

Structure and mechanism in organic chemistry

1954 • 411 citations

Senecio Alkaloids: Primary Liver Tumours in Rats as a Result of Treatment with (1) A Mixture of Alkaloids from S. Jacobaea Lin.; (2) Retrorsine; (3) Isatidine

1954 • 144 citations

The chronic pathological effects on the liver of the rat of the pyrrolizidine alkaloids heliotrine, lasiocarpine, and their N‐oxides

1959 • 81 citations

Hepatotoxic Action of Pyrrolizidine (Senecio) Alkaloids in Relation to their Structure

1957 • 51 citations

The mutagenic activity of some pyrrolizidine alkaloids inDrosophila

1960 • 47 citations

Chromosome Breakage by Pyrrolizidine Alkaloids and Modification of the Effect by Cysteine

1961 • 39 citations

Hepatotoxic Activity of Semi-Synthetic Analogues of Pyrrolizidine Alkaloids

1960 • 31 citations

Alkyl–oxygen heterolysis in carboxylic esters and related compounds

1955 • 28 citations

The Alkaloids of Heliotropium supinum L., with Observations on Viridifloric Acid

1959 • 22 citations

The Alkaloids of Crotalaria goreensis Guill. et Perr.: 7β-Hydroxy-1-methylene-8β- and 7β-Hydroxy-1-methylene-8α-pyrrolizidine

1961 • 19 citations

Alkaloids of Crotalaria trifoliastrum Willd. and C. aridicola Domin. I. Methyl Ethers of Supinidine and Retronecine

1962 • 19 citations

The effect of pyrrolizidine alkaloids on liver enzyme systems

1960 • 16 citations

LIVER DAMAGE IN ACUTE HELIOTRINE POISONING

1958 • 14 citations

Action of Pyrrolizidine Alkaloids on the Neuro-Muscular Junction

1959 • 12 citations

SOME PHARMACOLOGICAL PROPERTIES OF PYRROLIZIDINE ALKALOIDS AND THEIR RELATIONSHIP TO CHEMICAL STRUCTURE

1958 • 12 citations

The molecular structure and absolute configuration of thelepogine methiodide

1960 • 11 citations

Alkaloids of the Gramineae: Thelepogon elegans

1962 • 10 citations

Pyridine Nucleotide Metabolism in Heliotrine Poisoning

1961 • 7 citations

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Alkylation as the Mechanism by which the Hepatotoxic Pyrrolizidine Alkaloids Act on Cell… (1962) – Nature | Metascience Observatory Explorer