Synthetic antioxidants: Biochemical actions and interference with radiation, toxic compounds, chemical mutagens and chemical carcinogens

The aging process.

1981 • 1,871 citations

The Role of Glutathione and Glutathione S-Transferases in the Metabolism of Chemical Carcinogens and Other Electrophilic Agents

1979 • 1,179 citations

Some current perspectives on chemical carcinogenesis in humans and experimental animals: Presidential Address.

1978 • 938 citations

Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens

1980 • 854 citations

Advances in Prostaglandin and Thromboxane Research

1976 • 840 citations

Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity.

1980 • 757 citations

Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid.

1983 • 623 citations

Radioprotectors and anticarcinogens

1983 • 613 citations

Carcinogenicity of Butylated Hydroxyanisole in F344 Rats<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref><xref ref-type="fn" rid="fn4">4</xref>

1983 • 574 citations

Inhibition of neoplasia by minor dietary constituents.

1983 • 479 citations

The mechanism of NADPH-dependent lipid peroxidation. The propagation of lipid peroxidation.

1979 • 390 citations

Inhibition of Carcinogenic and Toxic Effects of Polycyclic Hydrocarbons by Phenolic Anti-oxidants and Ethoxyquin<xref ref-type="fn" rid="FN2">2</xref>

1972 • 352 citations

Polynuclear aromatic hydrocarbons : chemistry and biological effects

1980 • 340 citations

Free Radical Theory of Aging: Effect of Free Radical Reaction Inhibitors on the Mortality Rate of Male LAF1 Mice

1968 • 339 citations

Elevation of hepatic glutathione S-transferase activities and protection against mutagenic metabolites of benzo(a)pyrene by dietary antioxidants.

1978 • 338 citations

Chromosome Aberrations and Sister Chromatid Exchanges in Chinese Hamster Cells Exposed to Various Chemicals 2

1977 • 330 citations

Glutathione <italic>S</italic>-Transferase Activity: Enhancement by Compounds Inhibiting Chemical Carcinogenesis and by Dietary Constituents<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1982 • 325 citations

Inhibition of Chemical Carcinogenesis

1978 • 321 citations

THE MUTAGENIC ACTIVITY OF 61 AGENTS AS DETERMINED BY THE MICRONUCLEUS, SALMONELLA, AND SPERM ABNORMALITY ASSAYS

1979 • 283 citations

Promoting activities of butylated hydroxyanisole and butylated hydroxytoluene on 2-stage urinary bladder carcinogenesis and inhibition of γ-glutamyl transpeptidase-positive foci development in the liver of rats

1983 • 272 citations

Inhibition of the mutagenicity of bay-region diol epoxides of polycyclic aromatic hydrocarbons by naturally occurring plant phenols: Exceptional activity of ellagic acid

1982 • 269 citations

Aflatoxin B1-2,3-oxide as a probable intermediate in the covalent binding of aflatoxins B1 and B2 to rat liver DNA and ribosomal RNA in vivo.

1977 • 252 citations

Tumorigenicity studies with diol-epoxides of benzo(a)pyrene which indicate that (+/-)-trans-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene is an ultimate carcinogen in newborn mice.

1978 • 239 citations

Chemical Mutagens in the Human Environment

1968 • 224 citations

Phospholipid Degradation and Cellular Edema Induced by Free Radicals in Brain Cortical Slices

1982 • 221 citations

Liver response tests. III. Liver enlargement and stimulation of microsomal processing enzyme activity

1965 • 211 citations

The effects of antioxidants on skin tumor initiation and aryl hydrocarbon hydroxylase.

1977 • 201 citations

Elevation of extrahepatic glutathione S-transferase and epoxide hydratase activities by 2(3)-tert-butyl-4-hydroxyanisole.

1979 • 200 citations

Inhibition of the mutagenicity of bay-region diol-epoxides of polycyclic aromatic hydrocarbons by phenolic plant flavonoids

1983 • 196 citations

Effect of the prostaglandin synthetase inhibitor indomethacin on 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis in rats fed different levels of fat.

1983 • 194 citations

Role of Selenium in The Chemoprevention of Cancer

1979 • 193 citations

The major metabolite of aflatoxin B1 in the rat is a glutathione conjugate

1978 • 193 citations

Effect of dietary vitamin E on dimethylhydrazine-induced colonic tumors in mice.

1980 • 189 citations

Lung injury induced by butylated hydroxytoluene: cytodynamic and biochemical studies in mice.

1977 • 186 citations

Mechanism of inhibition of tumour growth by aspirin and indomethacin

1978 • 178 citations

Synergistic effect of vitamin E and selenium in the chemoprevention of mammary carcinogenesis in rats.

1983 • 171 citations

Protective effects of ellagic acid and other plant phenols on benzo[a]pyrene-induced neoplasia in mice

1983 • 171 citations

Inhibition of Chemical Carcinogen-Induced Pulmonary Neoplasia by Butylated Hydroxyanisole

1973 • 167 citations

Studies on the Mechanisms Involved in Multistage Carcinogenesis in Mouse Skin

1982 • 163 citations

Antioxidants and carcinogenesis: butylated hydroxytoluene, but not diphenyl-p-phenylenediamine, inhibits cancer induction by N-2-fluorenylacetamide and by N-hydroxy-N-2-fluorenylacetamide in rats

1973 • 157 citations

Inhibitors of chemical carcinogens.

1980 • 152 citations

Inhibition of carcinogen-induced neoplasia by sodium cyanate, tert-butyl isocyanate, and benzyl isothiocyanate administered subsequent to carcinogen exposure.

1981 • 150 citations

Structure-activity relationships for inhibition of prostaglandin cyclooxygenase by phenolic compounds

1980 • 149 citations

Carcinogen-Induced Chromosomal Breakage Decreased by Antioxidants

1973 • 149 citations

PROLONGATION OF LIFE: ROLE OF FREE RADICAL REACTIONS IN AGING

1969 • 145 citations

Chemoprotective Effects of Two Dithiolthiones and of Butylhydroxyanisole Against Carbon Tetrachloride and Acetaminophen Toxicity

2007 • 142 citations

Enhancing effects of phenobarbitone and butylated hydroxytoluene on 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat

1977 • 138 citations

Nutrition and cancer : etiology and treatment

1981 • 135 citations

Antimutagenic effects of 2(3)-tert-butyl-4-hydroxyanisole and of antimicrobial agents.

1978 • 132 citations

Butylated hydroxytoluene (BHT): A review

1982 • 132 citations

Differential inhibitory effects of vitamin E and other antioxidants on prostaglandin synthetase, platelet aggregation and lipoxidase

1977 • 130 citations

Effect of Ethoxyquin on the Longevity of C3H Mice

1971 • 129 citations

Enhancement of Urethan Tumorigenesis in Mouse Lung by Butylated Hydroxytoluene2

1977 • 127 citations

Hydroxyl radical scavengers inhibit human natural killer cell activity

1984 • 126 citations

Antioxidants reduce the mutagenic effect of malonaldehyde and β-propiolactone

1979 • 125 citations

Increased synthesis of glutathione S-transferases in response to anticarcinogenic antioxidants. Cloning and measurement of messenger RNA.

1983 • 124 citations

Major Effect on Susceptibility to Urethan-lnduced Pulmonary Adenoma by a Single Gene in BALB/cBy Mice<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1983 • 121 citations

Biochemical mechanisms of liver injury

1979 • 120 citations

Oral Mucosal Carcinogenesis in Hamsters: Inhibition by Vitamin E<xref ref-type="fn" rid="fn2">2</xref>

1982 • 120 citations

Inhibition of cell-cell communication by tumor promoters.

1982 • 119 citations

Effects of antiinflammatory agents on mouse skin tumor promotion, epidermal DNA synthesis, phorbol ester-induced cellular proliferation, and production of plasminogen activator.

1977 • 117 citations

Comparative effects of dietary administration of 2(3)-tert-butyl-4-hydroxyanisole and 3,5-di-tert-butyl-4-hydroxytoluene on several hepatic enzyme activities in mice and rats.

1982 • 114 citations

Protection against cocarcinogenesis by antioxidants

1966 • 111 citations

Lung Damage in Mice Following Intraperitoneal Injection of Butylated Hydroxytoluene

1972 • 110 citations

Effect of Antioxidants on Life-Span of C57BL Mice

1971 • 109 citations

Inhibition of Tumor Induction and Development

1981 • 108 citations

Inhibitory effect of antioxidants ethoxyquin and 2(3)-tert-butyl-4-hydroxyanisole on hepatic tumorigenesis in rats fed ciprofibrate, a peroxisome proliferator.

1984 • 107 citations

Dependence of specific metabolism of benzo(a)pyrene on the inducer of hydroxylase activity.

1974 • 105 citations

Enhancement of Glutathione <italic>S</italic>-Transferase Activity of the Mouse Forestomach by Inhibitors of Benzo[<italic>a</italic>]pyrene-Induced Neoplasia of the Forestomach<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1981 • 104 citations

Effect of 2(3)-tert-butyl-4-hydroxyanisole administration on the activities of several hepatic microsomal and cytoplasmic enzymes in mice

1979 • 99 citations

Inhibitory effect of butylated hydroxytoluene (BHT) on intestinal carcinogenesis in rats by azoxymethane

1977 • 96 citations

Effect of retinoic acid, butylated hydroxytoluene, selenium and sorbic acid on azo-dye hepatocarcinogenesis

1980 • 96 citations

Inhibition by 2(3)-tert-butyl-4-hydroxyanisole and other antioxidants of epidermal ornithine decarboxylase activity induced by 12-O-tetradecanoylphorbol-13-acetate.

1983 • 93 citations

Prostagland in synthetase dependent benzo(a)pyrene oxidation: Products of the oxidation and inhibition of their formation by antioxidants

1977 • 91 citations

Butylated Hydroxytoluene Inactivated Lipid-Containing Viruses

1975 • 89 citations

Use of Spin Labels to Evaluate Effects of Cold Shock and Osmolality on Sperm

1978 • 86 citations

Assessment of the use of the Salmonella mutagenesis assay to determine the influence of antioxidants on carcinogen‐induced mutagenesis

1979 • 85 citations

Effects of antioxidants on cyclooxygenase and lipoxygenase activities in intact human platelets: Comparison with indomethacin and etya

1983 • 84 citations

Formation of mutagens in sugar-ammonia model systems

1979 • 83 citations

Effect of Vitamin E on Carcinogenicity of Methylcholanthrene.

1962 • 83 citations

Enhancement of liver microsome epoxide hydratase activity in rodents by treatment with 2(3)-tert-butyl-4-hydroxyanisole.

1978 • 83 citations

Suppression of tumor promoter phorbolmyristate acetate-induced chromosome breakage by antioxidants and inhibitors of arachidonic acid metabolism

1983 • 82 citations

The inhibitory effects of ethoxyquin on the carcinogenic action of aflatoxin B1 in rats

1983 • 82 citations

Inhibition of ultraviolet light-induced erythema by antioxidants

1979 • 79 citations

Effects of Butylated Hydroxyanisole on the Metabolism of Benzo[a]pyrene by Mouse Liver Microsomes2

1977 • 78 citations

Free radical theory of aging: Beneficial effect of antioxidants on the life span of male NZB mice; role of free radical reactions in the deterioration of the immune system with age and in the pathogenesis of systemic lupus erythematosus

1980 • 78 citations

Free Radical Theory of Aging: Effect of Free‐Radical‐Reaction Inhibitors on the Immune Response†

1977 • 78 citations

Enhancing Effect of Vitamin E on Murine Intestinal Tumorigenesis by 1 ,2-Dimethylhydrazine Dihydrochloride<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1983 • 77 citations

Screening of antioxidants and other compounds for antimutagenic properties towards benzo[a]pyrene-induced mutagenicity in strain TA98 of Salmonella typhimurium

1982 • 76 citations

Perturbations of the dynamics of lipid alkyl chains in membrane systems: Effect on the activity of membrane-bound enzymes

1974 • 75 citations

Enhancement of bleomycin—iron free radical damage to DNA by antioxidants and their inhibition of lipid peroxidation

1981 • 75 citations

Elevation of quinone reductase activity by anticarcinogenic antioxidants

1982 • 75 citations

Effect of the antioxidant butylated hydroxytoluene (BHT) on the metabolism of the carcinogens N-2-fluorenylacetamide and N-hydroxy-N-2-fluorenylacetamide

1973 • 74 citations

Enhancement of tumor formation in mouse lung by dietary butylated hydroxytoluene

1981 • 73 citations

THE EFFECT OF THE LEVEL OF DIETARY FAT ON THE TOXICITY OF PHENOLIC ANTIOXIDANTS

1959 • 73 citations

The effects of antioxidants on the metabolism and mutagenicity of benzo[a]pyrene in vitro

1977 • 72 citations

Stimulation of DNA Synthesis in Mouse Lung Following Intraperitoneal Injection of Butylated Hydroxytoluene

1974 • 71 citations

Antiinflammatory effects of free radical scavengers and antioxidants

1980 • 71 citations

Dose-dependent reduction of N-2-fluorenylacetamide-induced liver cancer and enhancement of bladder cancer in rats by butylated hydroxytoluene.

1984 • 70 citations

Effects of drug metabolism inhibitors on butylated hydroxytoluene-induced pulmonary toxicity in mice

1980 • 70 citations

Tumor Promotion by Phorbol Esters in Skin: Evidence for a Memory Effect

1983 • 69 citations

Induction of squamous cell carcinoma in the forestomach of F344 rats treated with butylated hydroxyanisole.

1982 • 68 citations

Inhibition of the A-23187-stimulated leukotriene and prostaglandin biosynthesis of rat basophil leukemia (RBL-1) cells by nonsteroidal anti-inflammatory drugs, antioxidants, and calcium channel blockers

1983 • 68 citations

Butylated hydroxyanisole-stimulated NADPH oxidase activity in rat liver microsomal fractions.

1983 • 68 citations

Dietary vitamin E intake and mammary carcinogenesis in rats

1982 • 67 citations

Enhancement of glutathione S-transferase activity of the esophagus by phenols, lactones, and benzyl isothiocyanate.

1982 • 66 citations

Biochemical studies on the mechanisms by which dietary antioxidants suppress mutagenic activity

1979 • 66 citations

Hydrogen peroxide contracts airway smooth muscle: A possible endogenous mechanism

1981 • 66 citations

Effects of butylated hydroxytoluene on the ultrastructure of rat hepatocytes.

1967 • 65 citations

Binding of (3H)benzo(a)pyrene to DNA in cultured human bronchus.

1976 • 64 citations

Vitamin E and hepatotoxic agents

1970 • 64 citations

Inhibition of the mono-oxygenase system by butylated hydroxyanisole and butylated hydroxytoluene

1974 • 64 citations

Lipid peroxidation during enzymatic iodination of rat liver endoplasmic reticulum

1972 • 64 citations

Effect of phenolic antioxidants on the mutagenicity of aflatoxin B1

1980 • 64 citations

Effects of Administration to Mice of Butylated Hydroxyanisole by Oral Intubation on Benzo[ a ]pyrene-Induced Pulmonary Adenoma Formation and Metabolism of Benzo[ a ]pyrene 2

1978 • 63 citations

Mutagenicity screening of feed additives in the microbial system

1980 • 63 citations

Long-term studies on chemically induced liver enlargement in the rat I. Sustained induction of microsomal enzymes with absence of liver damage on feeding phenobarbitone or butylated hydroxytoluene

1977 • 63 citations

Inhibition of hepatic mixed function oxidase activity by propyl gallate

1974 • 62 citations

Prevention of butylated hydroxytoluene-induced lung damage in mice by cedar terpene administration

1979 • 61 citations

Induction of rat hepatic epoxide hydratase by dietary antioxidants

1979 • 60 citations

Liver response tests. IV. Application to short-term feeding studies with butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA)

1965 • 59 citations

Ultrastructural and biochemical changes in the liver of monkeys given butylated hydroxytoluene and butylated hydroxyanisole

1972 • 59 citations

PHOTOSENSITIZATION OF HUMAN DIPLOID CELL CULTURES BY INTRACELLULAR FLAVINS AND PROTECTION BY ANTIOXIDANTS

1976 • 58 citations

Modification of the acute toxicity of mutagenic and carcinogenic chemicals in the mouse by prefeeding with antioxidants

1973 • 58 citations

Vitamin E and hepatotoxic agents

1969 • 57 citations

Systemic Protection by Antioxidants Against Uvl-Induced Erythema

1978 • 57 citations

Effects of dietary broccoli and butylated hydroxyanisole on liver-mediated metabolism of benzo[a]pyrene

1983 • 56 citations

Butylated Hydroxytoluene Protects Chickens Exposed to Newcastle Disease Virus

1977 • 55 citations

Effects of butylated hydroxytoluene on the enzyme activity and ultrastructure of rat hepatocytes

1970 • 54 citations

Butylate hydroxytoluene pretreatment protects against cytotoxicity and reduces covalent binding of aflatoxin B1 in primary hepatocyte cultures

1981 • 54 citations

Toxicity of butylated hydroxytoluene in mouse following oral administration

1978 • 53 citations

Enhancing effect of butylated hydroxytoluene on the development of liver altered foci and neoplasms induced by N-2-fluorenylacetamide in rats

1984 • 52 citations

Effect of butylated hydroxytoluene and other antioxidants on mouse lung metabolism

1977 • 51 citations

Inhibition in vivo of the formation of adducts between metabolites of benzo(a)pyrene and DNA by butylated hydroxyanisole.

1981 • 51 citations

Glutathione conjugation and DNA-binding of (±)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene and (±)-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in isolated rat hepatocytes

1982 • 50 citations

Mutagenicity testing of some approved food additives with the Salmonella/microsome assay.

1980 • 50 citations

The BHT content of human adipose tissue

1970 • 49 citations

Enhancement of Lung Tumor Formation in Mice by Dietary Butylated Hydroxy toluene: Dose-Time Relationships and Cell Kinetics<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1983 • 49 citations

Diet, nutrition, and cancer: Interim dietary guidelines

1983 • 48 citations

Effects of Cytokinins and Antioxidants on the Susceptibility of Membranes to Ozone Damage

1982 • 48 citations

A comparison of the effects of pretreatment with phenobarbitone and 3-methylcholanthrene on the metabolism of aflatoxin B1 by rat liver microsomes and isolated hepatocytes in vitro

1981 • 48 citations

Effects of dietary constituents on ultraviolet light-mediated carcinogenesis.

1978 • 48 citations

Amelioration of teratogenesis. I. Modification of hydroxyurea‐induced teratogenesis by the antioxidant propyl gallate

1981 • 47 citations

Ethoxyquin as an inducer and inhibitor of phenobarbital-type cytochrome P-450 in rat liver microsomes

1977 • 47 citations

Enhancement of adenoma formation in mouse lung by butylated hydroxytoluene

1979 • 47 citations

Protection against reactive oxygen species by NAD(P)H:quinone reductase induced by the dietary antioxidant butylated hydroxyanisole (BHA)

1984 • 47 citations

Inhibitory Effects of Butylated Hydroxyanisole on Methylazoxymethanol Acetate-Induced Neoplasia of the Large Intestine and on Nicotinamide Adenine Dinucleotide-Dependent Alcohol Dehydrogenase Activity in Mice<xref ref-type="fn" rid="fn2">2</xref>

1979 • 47 citations

Influence of butylated hydroxytoluene (BHT) on the viability of ram spermatozoa undergoing cold shock

1983 • 47 citations

Review: Putative mutagens and carcinogens in foods III. Butylated hydroxytoluene (BHT)

1983 • 47 citations

Simultaneous inhibition of liver carcinogenicity and enhancement of bladder carcinogenicity of N-2-fluorenylacetamide by butylated hydroxytoluene

1983 • 46 citations

THE EFFECT OF THE ANTIOXIDANTS, BUTYLATED HYDROXY ANISOLE, BUTYLATED HYDROXY TOLUENE AND PROPYL GALLATE ON GROWTH, LIVER AND SERUM LIPIDS AND SERUM SODIUM LEVELS OF THE RAT

1961 • 46 citations

Effects of low levels of butylated hydroxytoluene on the prothrombin index of male rats

1978 • 45 citations

Lung growth in mice after a single dose of butylated hydroxytoluene

1975 • 45 citations

Inhibition of Promutagen Activation by the Antioxidants Butylated Hydroxyanisole and Butylated Hydroxytoluene

1979 • 45 citations

Interaction of butylated hydroxytoluene (BHT) with phospholipid bilayer membranes: Effect on 22Na permeability and membrane fluidity

1977 • 44 citations

Progress report on multigeneration reproduction studies in rats fed butylated hydroxytoluene (BHT)

1965 • 44 citations

Biochemical parameters of BHT-induced cell growth in mouse lung

1976 • 43 citations

In vitro effects of synthetic antioxidants and vitamin E on arachidonic acid metabolism and thromboxane formation in human platelets and on platelet aggregation

1981 • 42 citations

Inhibition of chemically induced mammary carcinogenesis in rats by long-term exposure to butylated hydroxytoluene (BHT): interrelations among BHT concentration, carcinogen dose, and diet.

1986 • 42 citations

Modification of lung tumor development in A/J mice

1981 • 42 citations

Effect of micronutrients, antioxidants and related compounds on the mutagenicity of 3,2′-dimethyl-4-aminobiphenyl, a colon and breast carcinogen

1983 • 42 citations

Liver response tests. VI. Application to a comparative study of food antioxidants and hepatotoxic agents

1965 • 41 citations

Neoplastic Effects of Oral Administration of (±)-<italic>trans</italic>-7 ,8-Dihydroxy-7,8-dihydrobenzo[<italic>a</italic>]pyrene and Their Inhibition by Butylated Hydroxyanisole<xref ref-type="fn" rid="FN2">2</xref>

1979 • 41 citations

Effects of butylated hydroxytoluene alone or with diethylnitrosamine in mice

1974 • 41 citations

Direct and indirect involvement of radical scavengers during prostaglandin biosynthesis.

1980 • 41 citations

Structural features required for inhibition of cyanide-insensitive electron transfer by propyl gallate

1981 • 41 citations

Selective Protective Effect of Butylated Hydroxytoluene Against 1,2-Dimethylhydrazine Carcinogenesis in BALB/c Mice<xref ref-type="fn" rid="FN2">2</xref>

1979 • 40 citations

Effects of the Food Additive Butylated Hydroxytoluene on Monolayer Cultures of Primate Cells

1967 • 40 citations

Studies on the mechanism of inhibition of 2-acetylaminofluorene toxicity by butylated hydroxytoluene

1976 • 39 citations

Antioxidants and the mutagenicity of benzo(a) pyrene and some derivatives

1978 • 39 citations

Butylhydroxyanisol (BHA), Butylhydroxytoluene (BHT) and Ethoxyquin (EMQ) Tested for Mutagenicity

1977 • 38 citations

Antioxidant effects on the prostaglandin endoperoxide synthetase product profile.

1981 • 38 citations

Inhibition of carcinogenic effect of bracken fern (pteridium aquilinum) by various chemicals

1977 • 38 citations

Mechanisms of Protection Against the Damage Produced in Biological Systems by Oxygen-Derived Radicals

2008 • 37 citations

Cell culture as a test system for toxicity

1971 • 37 citations

Differential effects of antioxidants, steroids and other compounds on benzo(a)pyrene 3-hydroxylase activity in various tissues of rat

1979 • 37 citations

Evidence that the effectiveness of antioxidants as inhibitors of 7,12-dimethylbenz(a) anthracene-induced mammary tumors is a function of dietary fat composition.

1981 • 37 citations

Effects of monocyclic compounds on biomembranes

1977 • 36 citations

On the mechanism of covalent binding of butylated hydroxytoluene to microsomal protein

1983 • 36 citations

Inhibition by retinol and butylated hydroxyanisole of carcinogen-mediated increases in guanylate cyclase activity and guanosine 3':5'-monophosphate accumulation.

1977 • 35 citations

Hydroperoxide-dependent activation of p-phenetidine catalyzed by prostaglandin synthase and other peroxidases

1983 • 34 citations

Inhibition of Chemically Induced Mammary Carcinogenesis in Rats by Short-Term Exposure to Butylated Hydroxytoluene (BHT): Interrelationships Among BHT Concentration, Carcinogen Dose, and Diet234

1984 • 34 citations

Cytotoxicity of butylated hydroxytoluene and butylated hydroxyanisole in cultured heart cells

1978 • 34 citations

Selective Sex-Related Modification of Diethylnitrosamine-lnduced Carcinogenesis in BALB/c Mice by Concomitant Administration of Butylated Hydroxytoluene2

1978 • 34 citations

Studies on the pathogenesis of butylated hydroxytoluene-induced lung damage in mice

1978 • 34 citations

Effects of 2- and 3-tert-butyl-4-hydroxyanisole on glutathione S-transferase and epoxide hydrolase activities and sulfhydryl levels in liver and forestomach of mice.

1981 • 32 citations

Inhibition of Chemical Carcinogenesis by Phenols, Coumarins, Aromatic Isothiocyanates, Flavones, and Indoles

1981 • 32 citations

Liver response tests. V. Effect of dietary restriction on a short-term feeding study with butylated hydroxytoluene (BHT)

1965 • 32 citations

Effect of inducers of drug-metabolizing enzymes on diethylnitrosamine metabolism and toxicity

1971 • 32 citations

Dose-response relationships for the binding of benzo(a)pyrene metabolites to DNA and protein in lung, liver, and forestomach of control and butylated hydroxyanisole-treated mice.

1983 • 31 citations

Short time interval effects of butylated hydroxyanisole on the metabolism of benzo(a)pyrene.

1980 • 31 citations

Adenoma Development in Mouse Lung Following Treatment with Possible Promoting Agents

1982 • 31 citations

Vitamin K deficiency in male rats fed diets containing butylated hydroxytoluene (BHT)

1979 • 30 citations

Effects of dietary antioxidants on the biotransformation and porphyrinogenic action of hexachlorobenzene in two strains of rats

1981 • 30 citations

Antioxidants increase the formation of 6-oxo- PGF1α by ram seminal vesicle microsomes

1981 • 29 citations

The enzyme-catalysed conversion of anti-benzo[alpyrene-7,8-diol 9,10-oxide into a glutathione conjugate

1980 • 29 citations

Inhibition of prostaglandin synthesis in mouse 3T3 fibroblasts and human platelets by substituted phenols

1977 • 29 citations

Phenolic antioxidants and the inhibition of hepatotoxicity from n-dimethylnitrosamine formed in situ in the rat stomach

1977 • 29 citations

Protective effect of butylated hydroxytoluene against induction of gastric cancer by N‐methyl‐N′‐nitro‐N‐nitrosoguanidine in wistar rats

1983 • 29 citations

Effect of butylated hydroxytoluene on glutathione S-transferase and glutathione peroxidase activities in rat liver

1983 • 29 citations

Induction by butylated hydroxytoluene of rat liver γ-glutamyl transpeptidase activity in comparison to expression in carcinogen-induced altered lesions

1984 • 29 citations

Preventive Effects of Phylloquinone on Hemorrhagic Death Induced by Butylated Hydroxytoluene in Male Rats

1979 • 29 citations

Species differences in the haemorrhagic response to butylated hydroxytoluene

1980 • 28 citations

Antimicrobial activity of some alkyl esters of gallic acid (3,4,5,-trihydroxybenzoic acid) against Escherichia coli NCTC 5933 with particular reference to n-propyl gallate.

1981 • 28 citations

Toxicity of 3,3′,4,4′‐ and 2,2′,5,5′‐tetrabromobiphenyl: Correlation of activity with aryl hydrocarbon hydroxylase induction and lack of protection by antioxidants

1983 • 28 citations

Influence of lipid peroxidation on lipoprotein secretion by isolated hepatocytes

1981 • 28 citations

Radiosensitizing Property of Butylated Hydroxytoluene inDrosophilaSperm

1973 • 27 citations

Effects of Carbon Tetrachloride on Isolated Rat Liver Cells: Stimulation of Lipid Peroxidation and Inhibitory Action of Free-Radical Scavengers

1978 • 27 citations

Comparison of effects of dietary administration of butylated hydroxytoluene or a polymeric antioxidant on the hepatic and intestinal cytochrome P-450 mixed-function-oxygenase system of rats

1980 • 27 citations

In Vivo Collagen Accumulation in an Experimental Model of Pulmonary Fibrosis

1980 • 26 citations

Chemiluminescent measurement of free radicals and antioxidant molecular-protection inside living rat-mitochondria

1980 • 26 citations

Effect of antioxidants and antitoxicants of isoniazid on the formation of lung tumours in mice by isoniazid and hydrazine sulphate

1982 • 26 citations

Species and strain differences in the butylated hydroxytoluene (BHT)-producing induction of hepatic drug oxidation enzymes.

1980 • 26 citations

Cytogenetic activity of some common antioxidants and their interaction with x-rays

1979 • 26 citations

Reversibility of hepatic changes caused by ethoxyquin

1974 • 26 citations

Mechanism of FANFT cooxidation by prostaglandin endoperoxide synthetase.

1980 • 25 citations

Comparison of the effect of butylated hydroxytoluene on N-nitrosomethylurea and 7,12-dimethylbenz[a]anthracene-induced mammary tumors

1981 • 25 citations

The influence of wheat germ oil on the production of tumors in rats by methylcholanthrene.

1946 • 25 citations

Effect of butylated hydroxytoluene on the life span of Drosophila bipectinata

1983 • 25 citations

Radiosensitization ofDrosophilaSperm by Commonly Used Food Additives–Butylated Hydroxyanisole and Butylated Hydroxytoluene

1974 • 25 citations

Protective role of dietary butylated hydroxyanisole against chemical-induced acute liver damage in mice

1983 • 25 citations

Inhibition of Clostridium botulinum by antioxidants, phenols, and related compounds

1982 • 25 citations

Effect of butylated hydroxyanisole, alpha-angelica lactone, and beta-naphthoflavone on benzo(alpha)pyrene:DNA adduct formation in vivo in the forestomach, lung, and liver of mice.

1982 • 24 citations

Inhibitory action of BHA on carcinogenesis in F1 and F2 descendants of mice exposed to DMBA during pregnancy

1982 • 24 citations

Effects of dietary and in vitro 2(3)-t-butyl-4-hydroxy-anisole and other phenols on hepatic enzyme activities in mice

1982 • 24 citations

Effect of tumor promoters on lipid peroxidation in mouse skin

1982 • 24 citations

Inhibition of Clostridium botulinum Types A and B by Phenolic Antioxidants

1979 • 24 citations

Study on toxicity of butylated hydroxyanisole (BHA) in pregnant gilts and their foetuses

1982 • 23 citations

Nitrous acid mutagenesis of duplex DNA as a three-component system

1979 • 23 citations

Effects of dietary butylated hydroxytoluene and phenobarbital on the activities of ornithine decarboxylase and thymidine kinase in rat liver and lung

1978 • 23 citations

Butylated hydroxytoluene: Tumor-promoting activity in anin vitro two-stage carcinogenesis assay

1982 • 22 citations

Involvements of cyclic nucleotide systems in enlarged mice lungs produced by butylated hydroxytoluene

1978 • 22 citations

Influence of gallic acid esters on drug-metabolizing enzymes of rat liver

1982 • 22 citations

Effect of coumarin, BHT and phenobarbitone onprotein synthesis in the rat liver

1969 • 22 citations

Metabolic Activation of 7,8-Dihydroxy-7,8-dihydrobenzo[a]-pyrene during Prostaglandin Biosynthesis

1982 • 21 citations

The effects of butylated hydroxyanisole and butylated hydroxytoluene on renal function in the rat. I. Effects on fluid and electrolyte excretion

1980 • 21 citations

The carcinogenic effect of butylated hydroxyanisole on the stratified epithelium of the stomach in rat versus pig

1983 • 21 citations

Collagen production rates following acute lung damage induced by butylated hydroxytoluene

1982 • 21 citations

Interaction of antioxidants with ozone and herbicide stress

1980 • 20 citations

Effects of butylated hydroxyanisole in Drosophila melanogaster

1976 • 20 citations

Effect of Various Levels of Dietary Butylated Hydroxyanisole on Methylazoxymethanol Acetate-Induced Colon Carcinogenesis in CF1 Mice<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1983 • 20 citations

Induction of rat hepatic UDP-glucuronosyltransferases by dietary ethoxyquin

1980 • 20 citations

Strain differences in butylated hydroxytoluene-induced deaths in male mice

1981 • 20 citations

Differential effects of dietary and intraperitoneal administration of antioxidants on the activities of several hepatic enzymes of mice.

1982 • 19 citations

Bioassay of butylated hydroxytoluene (BHT) for possible carcinogenicity.

1979 • 19 citations

Inhibition by butylated hydroxytoluene of excision repair synthesis and semiconservative DNA synthesis

1978 • 19 citations

Enhancement of epoxide hydratase activity in rat lung, kidney and liver by dietary antioxidants

1980 • 19 citations

THE LOCAL ANTINOCICEPTIVE AND TOPICAL ANTI‐INFLAMMATORY EFFECTS OF PROPYL GALLATE IN RODENTS

1976 • 19 citations

Effects of butylated hydroxyanisole on the metabolism of benzo(a)pyrene by mouse lung microsomes.

1984 • 19 citations

Differential effects of dietary BHA on hepatic enzyme activities and benzo[a]pyrene metabolism in male and female NMRI mice

1982 • 18 citations

The effects of butylated hydroxytoluene on the cell cycle and chromosome morphology of phytohaemagglutinin-stimulated leucocyte cultures

1974 • 18 citations

Effect of butylated hydroxytoluene and paraquat on urethan tumorigenesis in mouse lung

1978 • 18 citations

Hydroxylation of benzo[a]pyrene and binding of (−)trans 5-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene metabolites to deoxyribonucleic acid catalyzed by purified forms of rabbit liver microsomal cytochrome P-450

1980 • 17 citations

Regioselective inhibition of benzo[a]pyrene metabolism by butylated hydroxyanisole

1983 • 17 citations

Protective effects of antioxidants on bitterweed (Hymenoxys odorata DC) toxicity in sheep.

1982 • 17 citations

The effect of butylated hydroxytoluene (BHT) on the rat thyroid

1982 • 17 citations

Modification of Polycyclic Aromatic Hydrocarbon Carcinogenesis

1981 • 17 citations

The Antiviral Effectiveness of Butylated Hydroxytoluene on Herpes Cutaneous Infections in Hairless Mice

1982 • 17 citations

Effects of butylated hydroxyanisole on the aryl hydrocarbon hydroxylase of rats and mice

1981 • 16 citations

Inhibitory Effect of an Anti-oxidant, Butylated Hydroxyanisole, on the Primary in Vitro Immune Response

1977 • 16 citations

Stimulation of DNA Synthesis in Mouse and Rat Lung Following Administration of Butylated Hydroxytoluene

1978 • 16 citations

The effects of butylated hydroxytoluene on the in vitro metabolism, DNA-binding and mutagenicity of aflatoxin B1 in the rat

1984 • 16 citations

Inhibitory actions of butylated hydroxytoluene on isolated ileal, atrial, and perfused heart preparations

1979 • 15 citations

Effects of butylated hydroxytoluene on Tetrahymena pyriformis

1976 • 15 citations

Modifications of chronic hepatotoxicity of pyrrolizidine (Senecio) alkaloids by butylated hydroxyanisole and cysteine

1982 • 15 citations

Feedstuffs Antioxidants, Toxicity Studies on the Antioxidant 6-Ethoxy-1,2-dihydro-2,2,4-trimethylquinoline

1959 • 15 citations

Carcinogenesis Bioassay of Propyl Gallate in F344 Rats and B6C3FJ Mice

1983 • 15 citations

Effects of butylated hydroxyanisole on Tetrahymena pyriformis

1976 • 15 citations

The effects of butylated hydroxytoluene on radiation and chemically-induced genetic damage in Drosophila melanogaster

1983 • 15 citations

Effects of dietary butylated hydroxytoluene on functional and biochemical properties of platelets and plasma preceding the occurrence of haemorrhage in rats

1984 • 15 citations

Ethoxyquin feeding to rats increases liver microsome-catalyzed formation of benzo(a)pyrene diol epoxide — DNA adduct

1978 • 15 citations

The influence of butylated hydroxytoluene-induced cell proliferation on mouse lung damage after x rays or fission neutrons.

1982 • 15 citations

Butylated hydroxyanisole as a possible mutagenic agent

1982 • 15 citations

Inhibition of carcinogenic effects of diethylnitrosamine (den) and 4-nitroquinoline-n-oxide (nqo) by antioxidants. Abstr.

1972 • 14 citations

Elevation of conjugation capacity in isolated hepatocytes from BHA-treated mice

1982 • 14 citations

A Comparison of Induction of Microsomal Glutathione S-Transferase Activity in the Liver of the Mouse and Rat by Dietary 2(3)-tert-Butyl-4-hydroxyanisole (BHA).

1982 • 14 citations

Enhanced hepatotoxicity of dimethylnitrosamine by pretreatment of rats with the antioxidant ethoxyquin

1977 • 14 citations

Effect of 2(3)-tert-butyl-4-hydroxyanisole on benzo[a]pyrene metabolism and DNA-binding of benzo[a]pyrene metabolites in isolated mouse hepatocytes

1982 • 14 citations

Dietary antioxidant effects on the hepatic mixed-function oxidase system of rainbow trout (Salmo gairdneri)

1983 • 13 citations

Anticellular and Immunosuppressive Activities of Foodborne Phenolic Compounds

1981 • 13 citations

Radiosensitization of EL4 lymphoma cells by a commonly used food additive-butylated hydroxytoluene (BHT)

1973 • 13 citations

Effect of dietary antioxidants on benzo[a]pyrene metabolism in rat liver microsomes

1983 • 13 citations

Effect of butylated hydroxytoluene on the lipid composition of rat liver

1981 • 12 citations

Modification of Radiation Lethality by Previous Treatment with Butylated Hydroxytoluene

1975 • 12 citations

Differential protective effects of antioxidants against cell killing and mutagenesis of Salmonella typhimurium by .GAMMA. radiation.

1981 • 12 citations

Effect of butylated hydroxyanisole on the metabolism of benzo[a]-pyrene and the binding of metabolites to DNA, in vitro and in vivo, in the forestomach, lung, and liver of mice

1982 • 11 citations

Antioxidants and carcinogen metabolism

1982 • 11 citations

Effects of butylated hydroxytoluene (BHT) on the level of glutathione and the activity of glutathione-S-transferase in rat liver.

1981 • 11 citations

Use of the Ames test in assessing the relation of dietary lipid and antioxidants to N-2-fluorenylacetamide activation.

1980 • 11 citations

EFFECTS OF ETHOXYQUIN ON AFLATOXIN–PRODUCING STRAINS OF Aspergillus parasiticus AND A. flavus

1978 • 11 citations

Ultrastructural hepatic changes in rats after oral administration of ethoxyquin (EMQ)

1978 • 11 citations

Chemical Dissection of the Primary and Secondary in Vitro Antibody Responses with Butylated Hydroxyanisole and Gallic Acid

1979 • 11 citations

Interactions of ionizing radiation, nitrosamines, sulfonoxyalkanes and antioxidants as they affect carcinogenesis and survival in mice

1978 • 11 citations

Inhibition of mutagenesis in Chinese hamster v-79 cells by antioxidants

1980 • 11 citations

Inhibition of differentiation of mouse myeloid leukemia cells by phenolic antioxidants and alpha-tocopherol.

1981 • 10 citations

Restoration by cyclic guanosine monophosphate and extracellular calcium of butylated hydroxyanisole-suppressed primary murine thymus-dependent antibody response

1981 • 10 citations

The Influence of Butylated Hydroxytoluene-Induced Cell Proliferation on Mouse Lung Damage after X Rays or Fission Neutrons

1982 • 10 citations

Protection from mutagenic effects of antischistosomal and other drugs.

1978 • 10 citations

Evidence from in Vitro Murine Immunologic Assays That Some Phenolic Food Additives May Function as Antipromoters by Lowering Intracellular Cyclic GMP Levels

1982 • 10 citations

Differentiation induction of murine erythroleukemia cells by butylated hydroxytoluene

1984 • 9 citations

Elevation of hepatic epoxide hydratase activity by ethoxyquin is due to increased synthesis of the enzyme

1980 • 9 citations

Modification of the mutagenic activity of propane sultone by some phenolic antioxidants

1981 • 9 citations

Kinetics of growth and accumulation of aflatoxin B₁ by Aspergillus parasiticus in the presence of butylated hydroxyanisole, isoprothiolane, and nystatin

1984 • 8 citations

ANTIOXIDANTS AS AGENTS REDUCING THE TOXICITY OF INDOMETHACIN

1978 • 8 citations

Effects of butylated hydroxyanisole and butylated hydroxytoluene on 7,12-dimethylbenz[a]anthracene—DNA adduct formation in mouse embryo cell cultures

1983 • 8 citations

Protection with butylated hydroxytoluene and other compounds against intoxication and mortality caused by hexachlorophene

1984 • 8 citations

Inhibition of bradykinin by gallates

1970 • 8 citations

Mutagenicity of disulfiram and ethoxyquin

1982 • 7 citations

Effect of dietary butylated hydroxyanisole on methylazoxymethanol acetate-induced toxicity in mice

1982 • 7 citations

Vitamin K content of liver and feces from vitamin K-deficient and butylated hydroxytoluene (BHT)-treated male rats

1983 • 7 citations

Toxicity of nitrite and dimethylamine in rats

1983 • 7 citations

Mammary gland prostaglandin synthesis: effect of dietary lipid and propyl gallate.

1980 • 7 citations

Effect of lipid peroxidation and its inhibitors (BHA, BHT) on the drug metabolizing enzymes in rat liver microsomes.

1974 • 6 citations

Reactive forms of aromatic amines and amides: chemical and structural features in relation to carcinogenesis.

1983 • 6 citations

Metabolism of (±)-trans-7,8-dihydroxy-7,8-dihydro-benzo[a]pyrene in mouse liver microsomes and the effect of 2(3)-tert-butyl-4-hydroxy-anisole

1982 • 6 citations

Recessive lethals induced by ethyl methanesulfonate and diethyl sulfate in Drosophila melanogaster post-meiotic male cells pre-treated with butylated hydroxytoluene

1983 • 6 citations

Modification of Paracetamol Toxicity by Antioxidants

1976 • 6 citations

Comparative effects of antioxidants on the toxicity of mixed pyrrolizidine alkaloids fromSenecio jacobaeain mice

1982 • 6 citations

Effect of urethane, dimethylnitrosamine, paraquat, and butylated hydroxytoluene on the activities of glycolytic key enzymes in mouse lung

1981 • 6 citations

Effect of butylated hydroxytoluene on Newcastle disease virus.

1980 • 6 citations

The mechanism of action of lymphokines VII. Modulation of the action of macrophage migration inhibitory factor by antioxidants and drugs affecting thromboxane synthesis

1983 • 5 citations

Respiration of Gametangia of the Aquatic Phycomycete Allomyces macrogynus

1983 • 5 citations

Effects of prostaglandins and some anti-inflammatory drugs on the binding of 7,12-dimethylbenz[a]anthracene to the DNA of murine epidermal cells in culture

1979 • 5 citations

The effects of anti-inflammatory agents on skin tumor initiation and aryl hydrocarbon hydroxylase.

1977 • 5 citations

Effect of dietary butylated hydroxyanisole on the mouse hepatic monooxygenase system of nuclear and microsomal fractions

1983 • 4 citations

Inhibition of norepinephrine uptake into synaptic vesicles by butylated hydroxytoluene

1982 • 4 citations

Tumour promotion by BHT

1982 • 4 citations

Propyl gallate as a local anesthetic agent.

1971 • 4 citations

Inhibition of the appearance of benzidine-positive cells in induced Friend leukemia cells by butyrated hydroxyanisole

1982 • 3 citations

[Role of lipid peroxidation in retinal damage during hyperbaric oxygenation and the potential of chemical protection with antioxidants].

1983 • 3 citations

Inhibitory effect of the antioxidant butylated hydroxyanisole on the activation of the carcinogen benzo(a)pyrene.

1979 • 3 citations

Inhibition of a mixed function oxidase system and consequent increase in potency of carbaryl by butylated hydroxyanisole in the- housefly

1977 • 3 citations

Alterations in metabolism of cytidine components in rat liver after oral administration of butylated hydroxytoluene (in vivo study)

1979 • 3 citations

Radioprotecting effect of propylgalate and butylated hydroxyanisol.

1981 • 2 citations

Structural factors that enhance or attenuate the carcinogenicity of polycyclic aromatic hydrocarbons.

1983 • 1 citations

Butyl hydroxyl toluene (BHT) a lipid-soluble antioxidant in the treatment of experimental paraquat intoxication.

1979 • 1 citations