LY294002 and rapamycin co‐operate to inhibit T‐cell proliferation

Cancer Cell Cycles

1996 • 5,379 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

2002 • 2,904 citations

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

2000 • 1,431 citations

The CD28 Signaling Pathway Regulates Glucose Metabolism

2002 • 1,331 citations

Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice

2002 • 910 citations

lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin

1994 • 903 citations

TOR controls translation initiation and early G1 progression in yeast.

1996 • 728 citations

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

1997 • 719 citations

IMMUNOPHARMACOLOGY OF RAPAMYCIN

1996 • 651 citations

cell cycle and death control: long live Forkheads

2002 • 583 citations

The Forkhead Transcription Factor FoxO Regulates Transcription of p27Kip1 and Bim in Response to IL-2

2002 • 580 citations

Biology of the Interleukin-2 Receptor

1998 • 489 citations

Control of Cell Cycle Exit and Entry by Protein Kinase B-Regulated Forkhead Transcription Factors

2002 • 435 citations

Phosphatidylinositol 3-Kinase Couples the Interleukin-2 Receptor to the Cell Cycle Regulator E2F

1997 • 411 citations

Cytokines and immunodeficiency diseases

2001 • 380 citations

Essential Role of Phosphoinositide 3-Kinase δ in Neutrophil Directional Movement

2003 • 364 citations

Rapamycin Inhibition of the G1 to S Transition Is Mediated by Effects on Cyclin D1 mRNA and Protein Stability

1998 • 338 citations

The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine

2002 • 326 citations

Rapamycin Resistance Tied to Defective Regulation of p27^Kip1

1996 • 213 citations

Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes.

1994 • 211 citations

Regulation of quiescence in lymphocytes

2003 • 210 citations

CD28 Costimulation Mediates T Cell Expansion Via IL-2-Independent and IL-2-Dependent Regulation of Cell Cycle Progression

2000 • 199 citations

CD28 Costimulation Mediates Down-Regulation of p27kip1and Cell Cycle Progression by Activation of the PI3K/PKB Signaling Pathway in Primary Human T Cells

2002 • 191 citations

Establishment of an interleukin 2-dependent human T cell line from a patient with T cell chronic lymphocytic leukemia who is not infected with human T cell leukemia/lymphoma virus

1987 • 165 citations

Naïve cytotoxic T lymphocytes spontaneously acquire effector function in lymphocytopenic recipients: A pitfall for T cell memory studies?

1999 • 146 citations

p70^s6k Integrates Phosphatidylinositol 3-Kinase and Rapamycin-Regulated Signals for E2F Regulation in T Lymphocytes

1999 • 138 citations

Selective role of PI3Kδ in neutrophil inflammatory responses

2003 • 136 citations

Individuality: the barrier to optimal immunosuppression

2003 • 113 citations

Phosphoinositide 3-kinases in T lymphocyte activation

2001 • 111 citations

CD28 induces cell cycle progression by IL-2-independent down-regulation of p27kip1 expression in human peripheral T lymphocytes

1999 • 74 citations

CD28-costimulation activates cyclic AMP-responsive element-binding protein in T lymphocytes.

1997 • 57 citations

A Late, Prolonged Activation of the Phosphatidylinositol 3-Kinase Pathway Is Required for T Cell Proliferation

2004 • 44 citations

Characterization of Intercellular Adhesion Molecule-1 Regulation by Epstein-Barr Virus-encoded Latent Membrane Protein-1 Identifies Pathways That Cooperate with Nuclear Factor κB to Activate Transcription

2001 • 43 citations

Selective pharmacological inhibitors reveal differences between Thy-1- and T cell receptor-mediated signal transduction in mouse T lymphocytes

2001 • 24 citations