DFF45/ICAD Can Be Directly Processed by Granzyme B during the Induction of Apoptosis

Caspases: Enemies Within

1998 • 6,923 citations

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1998 • 3,169 citations

Caspases: Intracellular Signaling by Proteolysis

1997 • 2,114 citations

A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

1997 • 2,054 citations

X-linked IAP is a direct inhibitor of cell-death proteases

1997 • 1,961 citations

Caspase-3 Is Required for DNA Fragmentation and Morphological Changes Associated with Apoptosis

1998 • 1,927 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

1998 • 1,651 citations

Substrate Specificities of Caspase Family Proteases

1997 • 871 citations

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

1994 • 844 citations

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B

1995 • 720 citations

The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis

1998 • 534 citations

Caspase-3 Is the Primary Activator of Apoptotic DNA Fragmentation via DNA Fragmentation Factor-45/Inhibitor of Caspase-activated DNase Inactivation

1999 • 482 citations

How do cytotoxic lymphocytes kill their targets?

1998 • 398 citations

Granzyme B Directly and Efficiently Cleaves Several Downstream Caspase Substrates: Implications for CTL-Induced Apoptosis

1998 • 316 citations

ICE-LAP6, a Novel Member of the ICE/Ced-3 Gene Family, Is Activated by the Cytotoxic T Cell Protease Granzyme B

1996 • 304 citations

Granzyme B Is Inhibited by the Cowpox Virus Serpin Cytokine Response Modifier A

1995 • 238 citations

Target Cell Lysis by CTL Granule Exocytosis Is Independent of ICE/Ced-3 Family Proteases

1997 • 237 citations

Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells.

1995 • 216 citations

Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation.

1997 • 212 citations

CrmA, a Poxvirus-encoded Serpin, Inhibits Cytotoxic T-lymphocyte-mediated Apoptosis

1995 • 207 citations

Mitochondria-dependent and -independent Regulation of Granzyme B–induced Apoptosis

1999 • 190 citations

Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor 45

1998 • 179 citations

Granule-mediated Killing: Pathways for Granzyme B–initiated Apoptosis

1997 • 178 citations

Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B.

1996 • 175 citations

Granzyme B Mimics Apical Caspases

1998 • 171 citations

Activation of the Apoptotic Endonuclease DFF40 (Caspase-activated DNase or Nuclease)

1999 • 168 citations

Efficient Nuclear Targeting of Granzyme B and the Nuclear Consequences of Apoptosis Induced by Granzyme B and Perforin Are Caspase-dependent, but Cell Death Is Caspase-independent

1998 • 166 citations

Cleavage of DFF-45/ICAD by Multiple Caspases Is Essential for Its Function during Apoptosis

1998 • 163 citations

Granzyme A Initiates an Alternative Pathway for Granule-Mediated Apoptosis

1999 • 163 citations

Cytotoxic T Lymphocyte-assisted Suicide

1998 • 161 citations

Cleavage of FLICE (caspase‐8) by granzyme B during cytotoxic T lymphocyte‐induced apoptosis

1997 • 158 citations

Cleavage of CPP32 by Granzyme B Represents a Critical Role for Granzyme B in the Induction of Target Cell DNA Fragmentation

1996 • 148 citations

Granzyme B-induced loss of mitochondrial inner membrane potential (Delta Psi m) and cytochrome c release are caspase independent.

1999 • 133 citations

Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3

1996 • 101 citations

Differential inhibition of the Fas- and granule-mediated cytolysis pathways by the orthopoxvirus cytokine response modifier A/SPI-2 and SPI-1 protein.

1996 • 100 citations

Granzyme B-Induced Loss of Mitochondrial Inner Membrane Potential (ΔΨm) and Cytochrome c Release Are Caspase Independent

1999 • 99 citations

Caspase Dependence of Target Cell Damage Induced by Cytotoxic Lymphocytes

1998 • 91 citations

DNA Fragmentation Factor 45-deficient Cells Are More Resistant to Apoptosis and Exhibit Different Dying Morphology than Wild-type Control Cells

1999 • 83 citations

Activation of an interleukin 1 converting enzyme-dependent apoptosis pathway by granzyme B.

1996 • 83 citations

Conversion of the substrate specificity of mouse proteinase granzyme B

1994 • 74 citations

Production of Fully Active Recombinant Murine Granzyme B in Yeast

1998 • 59 citations

The 5′ Flanking Region of the Human Granzyme H Gene Directs Expression to T/Natural Killer Cell Progenitors and Lymphokine-Activated Killer Cells in Transgenic Mice

1999 • 22 citations