Conversion of the substrate specificity of mouse proteinase granzyme B

On the size of the active site in proteases. I. Papain

1967 • 5,150 citations

Evolutionary families of peptidases

1993 • 897 citations

Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase. Studies with peptide substrates related to the alpha 1-protease inhibitor reactive site.

1979 • 602 citations

A sensitive new substrate for chymotrypsin

1979 • 584 citations

Inhibition of restriction endonuclease Nel I cleavage by phosphorothioate groups and its application to oligonucleotide-directed mutagenesis

1986 • 560 citations

Converting Trypsin to Chymotrypsin: The Role of Surface Loops

1992 • 461 citations

A family of serine esterases in lytic granules of cytolytic T lymphocytes

1987 • 393 citations

A natural killer cell granule protein that induces DNA fragmentation and apoptosis.

1992 • 379 citations

Redesigning Trypsin: Alteration of Substrate Specificity

1985 • 357 citations

IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha.

1991 • 324 citations

Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

1991 • 255 citations

Novel Serine Proteases Encoded by Two Cytotoxic T Lymphocyte-Specific Genes

1986 • 246 citations

The inducible cytotoxic T-lymphocyte-associated gene transcript CTLA-1 sequence and gene localization to mouse chromosome 14

1986 • 197 citations

Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity.

1991 • 185 citations

Electrostatic complementarity within the substrate-binding pocket of trypsin.

1988 • 162 citations

Cloning of two genes that are specifically expressed in activated cytotoxic T lymphocytes.

1986 • 91 citations

Activation of recombinant murine cytotoxic cell proteinase-1 requires deletion of an amino-terminal dipeptide.

1993 • 81 citations

Comparative molecular model building of two serine proteinases from cytotoxic T lymphocytes

1988 • 80 citations

Substrate specificity of two chymotrypsin-like proteases from rat mast cells. Studies with peptide 4-nitroanilides and comparison with cathepsin G

1980 • 73 citations

Purification, characterization, cloning, and expression of a glutamic acid-specific protease from Bacillus licheniformis ATCC 14580.

1992 • 73 citations

Relocating a Negative Charge in the Binding Pocket of Trypsin

1993 • 68 citations

CTLA-1 and CTLA-3 serine esterase transcripts are detected mostly in cytotoxic T cells, but not only and not always.

1987 • 59 citations

Isolation and complete structure of the lymphocyte serine protease granzyme G, a novel member of the granzyme multigene family in murine cytolytic T lymphocytes. Evolutionary origin of lymphocyte proteases

1989 • 56 citations

A serine protease (CCP1) is sequestered in the cytoplasmic granules of cytotoxic T lymphocytes.

1987 • 41 citations

Substitution of valine for glycine-558 in the congenital dysthrombin thrombin Quick II alters primary substrate specificity

1989 • 34 citations

Chapter 1 Why Purify Enzymes?

2009 • 32 citations

[1] Why purify enzymes?

1990 • 25 citations