Subcellular Localization of Prostaglandin Endoperoxide H Synthases-1 and -2 by Immunoelectron Microscopy

PERIODATE-LYSINE-PARAFORMALDEHYDE FIXATIVE A NEW FIXATIVE FOR IMMUNOELECTRON MICROSCOPY

1974 • 3,882 citations

Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

1994 • 3,477 citations

15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

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1996 • 1,987 citations

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1991 • 1,814 citations

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

1996 • 1,773 citations

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1991 • 1,709 citations

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1996 • 1,328 citations

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1994 • 1,263 citations

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1996 • 1,212 citations

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

1994 • 994 citations

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1994 • 826 citations

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1997 • 814 citations

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1990 • 777 citations

Prostaglandin Endoperoxide H Synthases-1 and -2

1996 • 721 citations

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1995 • 694 citations

Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2

1996 • 618 citations

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1991 • 607 citations

Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence.

1988 • 604 citations

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1995 • 574 citations

Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C.

1993 • 521 citations

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1996 • 474 citations

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1995 • 469 citations

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1994 • 462 citations

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1996 • 460 citations

A calcium-dependent mechanism for associating a soluble arachidonoyl-hydrolyzing phospholipase A2 with membrane in the macrophage cell line RAW 264.7.

1990 • 447 citations

The aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases.

1990 • 429 citations

Use of poly(vinylpyrrolidone) and poly(vinyl alcohol) for cryoultramicrotomy

1989 • 403 citations

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1993 • 397 citations

Lipopolysaccharide induces prostaglandin H synthase-2 protein and mRNA in human alveolar macrophages and blood monocytes.

1994 • 310 citations

Fatty Acid Substrate Specificities of Human Prostaglandin-endoperoxide H Synthase-1 and −2

1995 • 294 citations

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1990 • 229 citations

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1993 • 224 citations

Signals and structural features involved in integral membrane protein targeting to the inner nuclear membrane.

1995 • 216 citations

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1993 • 215 citations

N-glycosylation of prostaglandin endoperoxide synthases-1 and -2 and their orientations in the endoplasmic reticulum.

1993 • 211 citations

Prostaglandin Biosynthesis and its Compartmentation in Vascular Smooth Muscle and Endothelial Cells

1986 • 195 citations

5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation.

1995 • 192 citations

The Highly Stereoselective Oxidation of Polyunsaturated Fatty Acids by Cytochrome P450BM-3

1996 • 176 citations

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1997 • 175 citations

Subcellular localization of prostaglandin-forming cyclooxygenase in Swiss mouse 3T3 fibroblasts by electron microscopic immunocytochemistry.

1980 • 174 citations

The amino-terminal domain of the lamin B receptor is a nuclear envelope targeting signal.

1993 • 161 citations

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1995 • 149 citations

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1993 • 134 citations

The first membrane spanning region of the lamin B receptor is sufficient for sorting to the inner nuclear membrane.

1993 • 133 citations

Role of the 5-Lipoxygenase–activating Protein (FLAP) in Murine Acute Inflammatory Responses

1997 • 133 citations

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1994 • 133 citations

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1996 • 133 citations

The orientation of prostaglandin endoperoxide synthases-1 and -2 in the endoplasmic reticulum.

1994 • 129 citations

Interaction between peroxidase and cyclooxygenase activities in prostaglandin-endoperoxide synthase. Interpretation of reaction kinetics.

1994 • 122 citations

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1991 • 115 citations

Selective Inhibition of Prostaglandin Endoperoxide Synthase-1 (Cyclooxygenase-1) by Valerylsalicylic Acid

1995 • 112 citations

Differential Allosteric Regulation of Prostaglandin H Synthase 1 and 2 by Arachidonic Acid

1997 • 111 citations

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1995 • 108 citations

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1993 • 100 citations

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1996 • 96 citations

"Cytosolic" phospholipase A2 is in the nucleus of subconfluent endothelial cells but confined to the cytoplasm of confluent endothelial cells and redistributes to the nuclear envelope and cell junctions upon histamine stimulation.

1996 • 95 citations

Arachidonate 12-lipoxygenase of platelet-type in human epidermal cells

1993 • 83 citations

5-Lipoxygenase-activating protein (FLAP)

1995 • 73 citations

Prostaglandin H synthase: Implications for membrane structure

1994 • 68 citations

A23187-induced translocation of 5-lipoxygenase in osteosarcoma cells.

1992 • 65 citations

Amino-terminal topology of thromboxane synthase in the endoplasmic reticulum.

1993 • 34 citations

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1996 • 25 citations

Immunoelectron microscopy of the outer membrane of rat hepatocyte nuclear envelopes in relation to the rough endoplasmic reticulum.

1983 • 24 citations

Chromatin structure of simian virus 40-pBR322 recombinant plasmids in COS-1 cells.

1983 • 24 citations

Inappropriate transcription from the 5′ end of the murinedihydrofolate reductasegene masks transcriptional regulation

1994 • 18 citations