Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

X-PLOR Version 3.1: A System for X-ray Crystallography and NMR

1992 • 3,488 citations

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

1993 • 1,655 citations

Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.

1994 • 1,579 citations

Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.

1994 • 1,322 citations

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

1994 • 1,263 citations

Prostaglandin synthase 2

1996 • 1,212 citations

Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.

1994 • 1,026 citations

NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro

1994 • 826 citations

Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2

1996 • 618 citations

The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase

1995 • 483 citations

Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs.

1994 • 462 citations

The aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases.

1990 • 429 citations

Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase

1995 • 414 citations

A Single Amino Acid Difference between Cyclooxygenase-1 (COX-1) and −2 (COX-2) Reverses the Selectivity of COX-2 Specific Inhibitors

1996 • 411 citations

Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase.

1994 • 410 citations

MERLOT, an integrated package of computer programs for the determination of crystal structures by molecular replacement

1988 • 348 citations

Higher oxidation states of prostaglandin H synthase

1988 • 254 citations

Metal Ions in Biological Systems

2023 • 245 citations

Anti-inflammatory and safety profile of DuP 697, a novel orally effective prostaglandin synthesis inhibitor.

1990 • 230 citations

Data collection and processing

2013 • 199 citations

Prostaglandin endoperoxide synthases-1 and -2

1995 • 192 citations

Stoichiometry and kinetics of the interaction of prostaglandin H synthase with anti-inflammatory agents.

1985 • 185 citations

Involvement of Arginine 120, Glutamate 524, and Tyrosine 355 in the Binding of Arachidonate and 2-Phenylpropionic Acid Inhibitors to the Cyclooxygenase Active Site of Ovine Prostaglandin Endoperoxide H Synthase-1

1996 • 178 citations

Synthesis and Use of Iodinated Nonsteroidal Antiinflammatory Drug Analogs as Crystallographic Probes of the Prostaglandin H₂ Synthase Cyclooxygenase Active Site^,

1996 • 162 citations

Tyrosyl radicals and their role in hydroperoxide-dependent activation and inactivation of prostaglandin endoperoxide synthase

1992 • 122 citations

From indomethacin to a selective COX-2 inhibitor: Development of indolalkanoic acids as potent and selective cyclooxygenase-2 inhibitors

1996 • 104 citations

3,4-diarylthiophenes are selective COX-2 inhibitors

1995 • 34 citations

Structure and conformation of the cis and trans isomers of 1-(p-chlorobenzylidene)-2-methyl-5-methoxyindenylacetic acid

1970 • 14 citations