Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

1992 • 3,863 citations

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

1991 • 1,814 citations

Human cyclooxygenase-2 cDNA.

1992 • 1,493 citations

Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.

1994 • 1,322 citations

Traitement statistique des erreurs dans la determination des structures cristallines

1952 • 1,284 citations

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

1994 • 1,263 citations

Preparation and analysis of protein crystals

1982 • 976 citations

Protein Data Bank

1984 • 731 citations

A fast algorithm for rendering space-filling molecule pictures

1988 • 616 citations

Different Intracellular Locations for Prostaglandin Endoperoxide H Synthase-1 and −2

1995 • 574 citations

The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase

1995 • 483 citations

The aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases.

1990 • 429 citations

A Single Amino Acid Difference between Cyclooxygenase-1 (COX-1) and −2 (COX-2) Reverses the Selectivity of COX-2 Specific Inhibitors

1996 • 411 citations

Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase.

1994 • 410 citations

Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin.

1994 • 366 citations

Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system

1994 • 339 citations

Extension of molecular replacement: a new search strategy based on Patterson correlation refinement

1990 • 315 citations

Fatty Acid Substrate Specificities of Human Prostaglandin-endoperoxide H Synthase-1 and −2

1995 • 294 citations

Specificity of expression and effects of eicosanoid mediators in normal physiology and human diseases ¹

1995 • 275 citations

Characterization of the Genomic Structure, Chromosomal Location and Promoter of Human Prostaglandin H Synthase-2 Gene

1994 • 272 citations

Tyrosine 385 of prostaglandin endoperoxide synthase is required for cyclooxygenase catalysis

1990 • 229 citations

Synthesis and Use of Iodinated Nonsteroidal Antiinflammatory Drug Analogs as Crystallographic Probes of the Prostaglandin H₂ Synthase Cyclooxygenase Active Site^,

1996 • 162 citations

Regulation of prostaglandin endoperoxide synthase (cyclooxygenase) isozyme expression

1995 • 134 citations

Tyrosyl radicals and their role in hydroperoxide-dependent activation and inactivation of prostaglandin endoperoxide synthase

1992 • 122 citations

Electron spin resonance investigation of tyrosyl radicals of prostaglandin H synthase. Relation to enzyme catalysis.

1991 • 96 citations

Mutation of serine‐516 in human prostaglandin G/H synthase‐2 to methionine or aspirin acetylation of this residue stimulates 15‐R‐HETE synthesis

1994 • 94 citations

The Kinetic Factors That Determine the Affinity and Selectivity for Slow Binding Inhibition of Human Prostaglandin H Synthase 1 and 2 by Indomethacin and Flurbiprofen

1996 • 86 citations

Crystallography of Biological Macromolecules at Ultra-Low Temperature

1990 • 77 citations

Complex heterocyclic structures ‐ a challenge for computer‐assisted molecular modeling

1988 • 32 citations

Tracking conformational states in allosteric transitions of phosphorylase

1992 • 25 citations

The 3.1 A X-ray crystal structure of the integral membrane enzyme prostaglandin H2 synthase-1.

1995 • 13 citations

Chapter 10 The eicosanoids: cyclooxygenase, lipoxygenase, and epoxygenase pathways

1991 • 11 citations