Chronic deletion, escape from deletion and activation of mouse mammary tumor virus superantigen-reactive T cells in C57BL/10 mice

The Staphylococcal Enterotoxins and Their Relatives

1990 • 1,914 citations

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

1988 • 1,036 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

1988 • 901 citations

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

1991 • 695 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction

1991 • 523 citations

The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens

1988 • 491 citations

An endogenous retrovirus mediating deletion of αβ T cells?

1991 • 278 citations

Clonal deletion of V β814-bearing T cells in mice transgenic for mammary tumour virus

1991 • 277 citations

Superantigens: Bacterial and Viral Proteins that Manipulate the Immune System

1993 • 236 citations

Specificity and flexibility in thymic selection

1994 • 221 citations

Contribution of Virus-specific CD8+ Cytotoxic T Cells to Virus Clearance or Pathologic Manifestations of Influenza Virus Infection in a T Cell Receptor Transgenic Mouse Model

1998 • 208 citations

Requirement for Cotolerogenic Gene Products in the Clonal Deletion of I-E Reactive T Cells

1990 • 193 citations

Identification of a Naturally Occurring Ligand for Thymic Positive Selection

1997 • 193 citations

Positive selection of CD4+ thymocytes controlled by MHC class II gene products

1988 • 174 citations

Thymic depletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic mice.

1992 • 149 citations

The Human T Cell Receptor in Health and Disease

1992 • 149 citations

The level of CD8 expression can determine the outcome of thymic selection

1992 • 134 citations

CD8 surface levels alter the fate of alpha/beta T cell receptor-expressing thymocytes in transgenic mice.

1992 • 119 citations

Non‐Deletional Mechanisms of Peripheral and Central Tolerance: Studies with Transgenic Mice with Tissue‐Specific Expression of a Foreign MHC Class I Antigen

1991 • 107 citations

Influence of Viral Superantigens on Vβ‐and Vα Specific Positive and Negative Selection

1993 • 83 citations

Influence of T cell receptor V alpha expression on Mlsa superantigen-specific T cell responses.

1992 • 75 citations

Mouse Mammary Tumor Virus: Immunological Interplays between Virus and Host **This article was accepted for publication on 1 October 1996.

1997 • 68 citations

The use of mammary tumor virus (Mtv)-negative and single-Mtv mice to evaluate the effects of endogenous viral superantigens on the T cell repertoire.

1995 • 64 citations

Capacity of unprimed CD4+ and CD8+ T cells expressing V beta 11 receptors to respond to I-E alloantigens in vivo.

1989 • 53 citations

A characteristic Mls-1a response precedes Mls-1a anergy in vivo.

1991 • 53 citations

Major histocompatibility complex-specific recognition of Mls-1 is mediated by multiple elements of the T cell receptor.

1993 • 50 citations

Response of mature unprimed CD8+ T cells to Mlsa determinants.

1990 • 47 citations

The induction of peripheral tolerance by the chronic activation and deletion of CD4+V beta 5+ cells.

1994 • 45 citations

Processing and major histocompatibility complex binding of the MTV7 superantigen

1994 • 43 citations

Co-segregation of a gene encoding a deletion ligand for Tcrb-V3+ T cells with Mtv-3

1991 • 43 citations

Expression of major histocompatibility complex class I antigens at low levels in the thymus induces T cell tolerance via a non‐deletional mechanism

1992 • 42 citations

CD8+ T cells respond clonally to Mls-1a-encoded determinants.

1990 • 41 citations

CD4 expression is differentially required for deletion of MLS-1a-reactive T cells.

1992 • 41 citations

Expression of the V beta 5.1 gene by murine peripheral T cells is controlled by MHC genes and skewed to the CD8+ subset.

1990 • 40 citations

A signaling pathway coupled to T cell receptor ligation by MMTV superantigen leading to transient activation and programmed cell death

1995 • 38 citations

Skewed T cell receptor V_α repertoire among superantigen reactive murine T cells

1993 • 36 citations

A functionally compromised intermediate in extrathymic CD8+ T cell deletion

1995 • 34 citations

Evaluation of the functional equivalence of major histocompatibility complex class II A and E complexes.

1992 • 31 citations

Influence of the T cell receptor alpha-chain on T cell reactivity and tolerance to Mls-1 in T cell receptor beta-chain transgenic mice.

1993 • 29 citations

A transcriptionally defective long terminal repeat within an endogenous copy of mouse mammary tumor virus proviral DNA

1988 • 28 citations

I-E-independent deletion of V beta 17a+ T cells by Mtv-3 from the nonobese diabetic mouse.

1992 • 26 citations

MHC class II A alpha and E alpha molecules determine the clonal deletion of V beta 6+ T cells. Studies with recombinant and transgenic mice.

1989 • 24 citations

CD8+ T cell response to Mls-1a determinants involves major histocompatibility complex class II molecules.

1991 • 19 citations

Persistence of V beta 6+ T cells in Mls-1a mice. A role for the third complementarity-determining region (CDR3) of the T cell receptor beta chain in superantigen recognition.

1995 • 15 citations

Phosphatidylinositol synthesis is a proximal event in intracellular signaling coupled to T cell receptor ligation. Differential induction by conventional antigen and retroviral superantigen.

1994 • 15 citations

Disrupted development of thymocytes expressing a transgenic TCR upon CD4 overexpression

1995 • 12 citations

Are There Cellular Superantigens?

1993 • 10 citations

Down-modulation of CD2 delays deletion of superantigen-responsive T cells

1998 • 8 citations

Evidence for an Endogenous Superantigen Deleting Human Vβ2 Positive T‐Lymphocytes

1995 • 4 citations

Efficient presentation of endogenous superantigen by H-2Aq

1998 • 4 citations

T cell repertoire formation displays characteristics of qualitative models of thymic selection

1997 • 3 citations

CD4 regulates the efficiency of an endogenous superantigen‐induced clonal deletion of TCRVβ11⁺ cells in the periphery

1997 • 2 citations