The Human T Cell Receptor in Health and Disease

Structure of the human class I histocompatibility antigen, HLA-A2

1987 • 3,453 citations

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1987 • 2,403 citations

Interaction of Staphylococcus aureus toxin "superantigens" with human T cells.

1989 • 1,000 citations

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

1988 • 940 citations

A procedure forin vitroamplification of DNA segments that lie outside the boundaries of known sequences

1988 • 814 citations

Evidence for the Effects of a Superantigen in Rheumatoid Arthritis

1991 • 632 citations

Junctional sequences of T cell receptor γδ genes: Implications for γδ T cell lineages and for a novel intermediate of V-(D)-J joining

1989 • 572 citations

Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy

1988 • 555 citations

Thymus cell migration: Quantitative aspects of cellular traffic from the thymus to the periphery in mice

1980 • 551 citations

Human lymphocytes bearing T cell receptor gamma/delta are phenotypically diverse and evenly distributed throughout the lymphoid system.

1989 • 547 citations

A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation

1987 • 483 citations

The Structure, Function, and Molecular Genetics of the gamma/delta T Cell Receptor

1989 • 476 citations

T cell stimulation by staphylococcal enterotoxins. Clonally variable response and requirement for major histocompatibility complex class II molecules on accessory or target cells.

1988 • 427 citations

Limited heterogeneity of rearranged T-cell receptor Vα transcripts in brains of multiple sclerosis patients

1990 • 395 citations

A superantigen encoded in the open reading frame of the 3′ long terminal repeat of mouse mammary tumour virus

1991 • 394 citations

Two tandemly organized human genes encoding the T-cell γ constant-region sequences show multiple rearrangement in different T-cell types

1985 • 382 citations

Correlations between T-cell specificity and the structure of the antigen receptor

1986 • 375 citations

The toxicity of staphylococcal enterotoxin B in mice is mediated by T cells.

1990 • 347 citations

A maternally inherited superantigen encoded by a mammary tumour virus

1991 • 335 citations

Diversity and rearrangement of the human T cell rearranging γ genes: Nine germ-line variable genes belonging to two subgroups

1986 • 329 citations

Linkage of Mls genes to endogenous mammary tumour viruses of inbred mice

1991 • 307 citations

The human t cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene

1984 • 306 citations

Murine T-cell receptor mutants with deletions of beta-chain variable region genes.

1986 • 304 citations

Cross-linking of human T cell receptor proteins: association between the T cell idiotype β subunit and the T3 glycoprotein heavy subunit

1985 • 303 citations

Residues of the variable region of the T-cell-receptor β-chain that interact with S. aureus toxin superantigens

1990 • 301 citations

An endogenous retrovirus mediating deletion of αβ T cells?

1991 • 278 citations

Diversity and structure of human T-cell receptor alpha-chain variable region genes.

1987 • 274 citations

Clonal dominance among T-lymphocyte infiltrates in arthritis.

1988 • 268 citations

Sequences and repertoire of the human T cell receptor α and β chain variable region genes in thymocytes

1987 • 226 citations

A susceptibility locus for multiple sclerosis is linked to the T cell receptor β chain complex

1989 • 219 citations

T cell recognition as the target for immune intervention in autoimmune disease

1989 • 218 citations

Human γ-chain genes are rearranged in leukaemic T cells and map to the short arm of chromosome 7

1985 • 205 citations

Implications of a Fab-like structure for the T-cell receptor

1989 • 193 citations

Biology of the Human γ T‐Cell Receptor

1991 • 185 citations

Specific recognition of staphylococcal enterotoxin A by human T cells bearing receptors with the Vγ9 region

1990 • 175 citations

Rearrangement of two distinct T-cell γ-chain variable-region genes in human DNA

1986 • 174 citations

New subgroups in the human T cell rearranging V gamma gene locus.

1987 • 170 citations

Superantigenicity of streptococcal M protein.

1990 • 170 citations

Characterization and expression of the human alpha beta T cell receptor by using a framework monoclonal antibody.

1987 • 162 citations

Sequences and diversity of human T cell receptor beta chain variable region genes.

1986 • 140 citations

Diversity and structure of human T cell receptor delta chain genes in peripheral blood gamma/delta-bearing T lymphocytes.

1989 • 137 citations

Selective stimulation of human T cells with streptococcal erythrogenic toxins A and B.

1991 • 137 citations

Human T-cell-receptor delta chain: genomic organization, diversity, and expression in populations of cells.

1988 • 136 citations

Induction of specific clonal anergy in human T lymphocytes by Staphylococcus aureus enterotoxins.

1990 • 132 citations

Staphylococcal exotoxin activation of T cells. Role of exotoxin-MHC class II binding affinity and class II isotype.

1991 • 130 citations

Identification of a diversity segment of human T-cell receptor β-chain, and comparison with the analogous murine element

1984 • 121 citations

Diversity and organization of human T cell receptor delta variable gene segments.

1989 • 107 citations

The human T cell receptor beta-chain gene complex contains at least 57 variable gene segments. Identification of six V beta genes in four new gene families.

1991 • 105 citations

Generation of diversity in T cell receptor repertoire specific for pigeon cytochrome c.

1987 • 104 citations

Dominance of one T-cell receptor in the H–2Kb/TNP response

1987 • 98 citations

Allelic variations in the human T cell receptor V beta 6.7 gene products.

1990 • 85 citations

Characterization of a third form of the human T cell receptor gamma/delta.

1988 • 83 citations

Inherited polymorphism of the human T-cell antigen receptor detected by a monoclonal antibody.

1986 • 81 citations

Properties of a panel of monoclonal antibodies which react with the human T cell antigen receptor on the leukemic line HPB-ALL and a subset of normal peripheral blood T lymphocytes.

1986 • 80 citations

Flow cytometric and immunohistochemical characterization of the gamma/delta T-lymphocyte population in normal human lymphoid tissue and peripheral blood.

1990 • 80 citations

Structure of t cell antigen receptor β chain in synovial fluid cells from patients with rheumatoid arthritis

1988 • 78 citations

T cell receptor alpha chain genes are located on chromosome 14 at 14q11-14q12 in humans.

1985 • 77 citations

The genetic contribution to human T-cell receptor repertoire.

1991 • 76 citations

Surprisingly uneven distribution of the T cell receptor V beta repertoire in wild mice.

1990 • 69 citations

Delineation of a defect in T cell receptor beta genes of NZW mice predisposed to autoimmunity.

1986 • 68 citations

Activation of MHC class I-restricted CD8+ CTL by microbial T cell mitogens. Dependence upon MHC class II expression of the target cells and V beta usage of the responder T cells.

1990 • 68 citations

Allelic sequence variations in the hypervariable region of a T-cell receptor beta chain: correlation with restriction fragment length polymorphism in human families and populations.

1989 • 67 citations

Helper T cell-dependent human B cell differentiation mediated by a mycoplasmal superantigen bridge.

1990 • 61 citations

Dominant T‐Cell Receptor β‐Chain Gene Rearrangements Indicate Clonal Expansion in the Rheumatoid Joint

1990 • 57 citations

T-cell receptor α chain V region polymorphism linked to primary autoimmune hypothyroidism but not Graves' Disease

1987 • 56 citations

Insertion/deletion-related polymorphisms in the human T cell receptor beta gene complex.

1989 • 47 citations

T-cell receptor genes and insulin-dependent diabetes mellitus (IDDM): no evidence for linkage from affected sib pairs.

1990 • 38 citations

Molecular genotypes of the human T cell receptor gamma-chain.

1988 • 26 citations