A signaling pathway coupled to T cell receptor ligation by MMTV superantigen leading to transient activation and programmed cell death

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Oxidative stress as a mediator of apoptosis

1994 • 2,210 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

Activation in vitro of NF-κB" by phosphorylation of its inhibitor IκB"

1990 • 1,202 citations

TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced “Acidic” sphingomyelin breakdown

1992 • 1,058 citations

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.

1990 • 960 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

Peripheral Selection of the T Cell Repertoire

1991 • 666 citations

T Cell Deletion in High Antigen Dose Therapy of Autoimmune Encephalomyelitis

1994 • 530 citations

The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules

1992 • 438 citations

Activation of T Cells by a Tyrosine Kinase Activation Domain in the Cytoplasmic Tail of CD3 ε

1992 • 430 citations

Suppression of human immunodeficiency virus expression in chronically infected monocytic cells by glutathione, glutathione ester, and N-acetylcysteine.

1991 • 330 citations

Genetic and Mutational Analysis of the T-Cell Antigen Receptor

1990 • 275 citations

Cytoplasmic phospholipase A2 activity and gene expression are stimulated by tumor necrosis factor: dexamethasone blocks the induced synthesis.

1993 • 208 citations

Regulation of Lymphocyte Function by Protein Phosphorylation

1993 • 203 citations

Increased membrane permeability of apoptotic thymocytes: A flow cytometric study

1993 • 200 citations

Activation-driven T cell death. I. Requirements for de novo transcription and translation and association with genome fragmentation.

1989 • 194 citations

Autocrine production of extracellular catalase prevents apoptosis of the human CEM T-cell line in serum-free medium.

1993 • 187 citations

Murine CD8+ T cells that specifically delete autologous CD4+ T cells expressing Vβ8 TCR: a role of the Qa-1 molecule

1995 • 175 citations

Glucocorticoid-induced apoptosis in the thymus.

1992 • 167 citations

TNF induces c-fos via a novel pathway requiring conversion of arachidonic acid to a lipoxygenase metabolite.

1991 • 159 citations

A flow-cytometric method for the separation and quantitation of normal and apoptotic thymocytes

1992 • 132 citations

Retinoic acids inhibit activation-induced apoptosis in T cell hybridomas and thymocytes.

1992 • 129 citations

Release of arachidonic acid from human lymphocytes in response to mitogenic lectins.

1979 • 91 citations

Effector T‐Cell Induction and T‐Cell Memory versus Peripheral Deletion of T Cells

1993 • 87 citations

The effects of chronic infection with a superantigen-producing virus.

1992 • 83 citations

N-(2-mercaptoethyl)-1,3-propanediamine (WR-1065) protects thymocytes from programmed cell death.

1992 • 78 citations

Exogenous and Endogenous Mouse Mammary Tumor Virus Superantigens

1993 • 77 citations

Oligoclonal expansion of major histocompatibility complex class I-restricted cytolytic T lymphocytes during a primary immune response in vivo: direct monitoring by flow cytometry and polymerase chain reaction.

1993 • 76 citations

[30] Assay of guanylyl cyclase catalytic activity

1991 • 65 citations

Efficiency of antigen presentation differs in mice differing at the Mls locus

1983 • 62 citations

N-(2-mercaptoethyl)-1,3-propanediamine (WR-1065) protects thymocytes from programmed cell death.

1992 • 62 citations

Phytohemagglutinin stimulation of guanylate cyclase in human lymphocytes.

1981 • 61 citations

Activation of Polyphosphoinositide Hydrolysis in T Cells by H-2 Alloantigen But Not MLS Determinants

1990 • 59 citations

Resistance to killing by tumor necrosis factor in an adipocyte cell line caused by a defect in arachidonic acid biosynthesis.

1991 • 57 citations

A characteristic Mls-1a response precedes Mls-1a anergy in vivo.

1991 • 53 citations

The measurement of oxygen-derived free radicals and related substances in medicine.

1990 • 53 citations

Receptor diversity of insulin-specific T cell lines from C57BL (H-2b) mice.

1987 • 50 citations

T‐Cell Receptor Repertoire Selection by Mouse Mammary Tumor Viruses and MHC Molecules

1993 • 48 citations

Experimental autoimmune encephalomyelitis-resistant mice have highly encephalitogenic myelin basic protein (MBP)-specific T cell clones that recognize a MBP peptide with high affinity for MHC class II.

1995 • 36 citations

Distinct structural specificities for functional coupling of the epidermal growth factor receptor to calcium-signalling versus phospholipase A2 responses

1991 • 34 citations

Disappearance of Specifically MLC‐Responsive Lymphocytes in CBA Mice Injected with Cells from the H‐2‐Compatible, M‐Antigen‐Incompatible Strain C3H

1975 • 30 citations

Differential induction of interferon gamma gene expression after activation of CD4+ T cells by conventional antigen and Mls superantigen.

1991 • 30 citations

Specifically Decreased MLC Response of Lymphocytes from CBA Mice Injected with Cells from the H-2-Compatible, M-Antigen-Incompatible Strain C3H.

1975 • 27 citations

Superantigen staphylococcal enterotoxin B-induced T-helper cell activation is independent of CD4 molecules and phosphatidylinositol hydrolysis.

1992 • 25 citations

Phosphatidylinositol synthesis is a proximal event in intracellular signaling coupled to T cell receptor ligation. Differential induction by conventional antigen and retroviral superantigen.

1994 • 15 citations

Alloreactivity of an OVA-specific T-cell clone

1987 • 13 citations

ABROGATION OF LETHAL GRAFT‐VERSUS‐HOST REACTION DIRECTED AGAINST NON‐H‐2 ANTIGENS: ROLE OF Mls^a AND K/I REGION ANTIGENS IN THE INDUCTION OF UNRESPONSIVENESS BY ALLOIMMUNIZATION

1986 • 11 citations

Are There Cellular Superantigens?

1993 • 10 citations

[8] Phospholipase A2 assays with fluorophore-labeled lipid substrates

1991 • 8 citations

Mls‐1 Superantigen: Molecular Characterization and Functional Analysis

1993 • 7 citations