The dual role of the cAMP-dependent protein kinase C alpha subunit in T-cell receptor-triggered T-lymphocytes effector functions.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Selected methods in cellular immunology

1981 • 1,915 citations

Purification and Characterization of a Protein Inhibitor of Adenosine 3',5'-Monophosphate-dependent Protein Kinases

1971 • 892 citations

The distribution and dissociation of cyclic adenosine 3':5'-monophosphate-dependent protein kinases in adipose, cardiac, and other tissues.

1975 • 758 citations

Fluorescence ratio imaging of cyclic AMP in single cells

1991 • 686 citations

Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor.

1985 • 676 citations

CREM gene: Use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription

1991 • 655 citations

Phosphorothioate analogs of oligodeoxynucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus.

1987 • 530 citations

Cyclic nucleotide-dependent protein kinases

1991 • 487 citations

Hybrid antibodies can target sites for attack by T cells

1985 • 479 citations

A c- myb Antisense Oligodeoxynucleotide Inhibits Normal Human Hematopoiesis in Vitro

1988 • 439 citations

A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a protein

1990 • 391 citations

Human promyelocytic leukemia HL-60 cell proliferation and c-myc protein expression are inhibited by an antisense pentadecadeoxynucleotide targeted against c-myc mRNA.

1988 • 374 citations

Intracellular distribution of microinjected antisense oligonucleotides.

1991 • 362 citations

Evidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinase.

1986 • 286 citations

Regulation of actin microfilament integrity in living nonmuscle cells by the cAMP-dependent protein kinase and the myosin light chain kinase.

1988 • 279 citations

Isolation of cDNA clones coding for the catalytic subunit of mouse cAMP-dependent protein kinase.

1986 • 275 citations

Phosphorylation of a Cyclic Adenosine 3′ : 5′-Monophosphate-dependent Protein Kinase from Bovine Cardiac Muscle

1974 • 253 citations

Amino acid sequence of the regulatory subunit of bovine type I cAMP-dependent protein kinase

1984 • 253 citations

Inhibition of intracellular cAMP-dependent protein kinase using mutant genes of the regulatory type I subunit.

1987 • 248 citations

Serine esterase in cytolytic T lymphocytes

1986 • 240 citations

Characterization of a bipartite activator domain in transcription factor CREB

1990 • 228 citations

Specific assays for cytokine production by T cells

1989 • 228 citations

cdc2 Gene Expression at the G ₁ to S Transition in Human T Lymphocytes

1990 • 220 citations

Adenosine 3':5'-monophosphate dependent protein kinase from bovine heart. Characterization of the catalytic subunit

1977 • 218 citations

Genetic characterization of a brain-specific form of the type I regulatory subunit of cAMP-dependent protein kinase.

1988 • 212 citations

Role for cyclin A in the dependence of mitosis on completion of DMA replication

1991 • 212 citations

Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase.

1986 • 201 citations

The tissue-specific extinguisher locus TSE1 encodes a regulatory subunit of cAMP-Dependent protein kinase

1991 • 192 citations

Complete amino acid sequence of the catalytic subunit of bovine cardiac muscle cyclic AMP-dependent protein kinase.

1981 • 188 citations

The catalytic subunit of cAMP-dependent protein kinase induces expression of genes containing cAMP-responsive enhancer elements

1988 • 186 citations

Inhibition of c-myc expression by phosphorothioate antisense oligonucleotide identifies a critical role for c-myc in the growth of human breast cancer.

1991 • 177 citations

Dynamics of the distribution of cyclic AMP-dependent protein kinase in living cells.

1990 • 165 citations

[9] Assay of protein kinases using peptides with basic residues for phosphocellulose binding

1991 • 149 citations

Gene regulation: Biology of antisense RNA and DNA

1992 • 146 citations

Antigen receptor-regulated exocytosis in cytotoxic T lymphocytes.

1987 • 128 citations

Primary structure of the regulatory subunit of type II cAMP-dependent protein kinase from bovine cardiac muscle.

1982 • 128 citations

Oligodeoxynucleotides: Antisense inhibitors of gene expression

1990 • 124 citations

Antimessenger oligodeoxyribonucleotides: an alternative to antisense RNA for artificial regulation of gene expression — a review

1988 • 123 citations

Locus of inhibitory action of cAMP-dependent protein kinase in the antigen receptor-triggered cytotoxic T lymphocyte activation pathway.

1988 • 92 citations

An antisense oligodeoxynucleotide targeted against the type II beta regulatory subunit mRNA of protein kinase inhibits cAMP-induced differentiation in HL-60 leukemia cells without affecting phorbol ester effects.

1990 • 85 citations

A sensitive immunochemical assay for biologically active MuIFN-γ

1987 • 79 citations

Inhibition of lymphocyte mediated cytotoxicity by perforin antisense oligonucleotides.

1990 • 73 citations

[11] Inhibitor protein of the cAMP-dependent protein kinase: Characteristics and purification

1983 • 41 citations

Mechanistic, Functional and Immunopharmacological Implications of Biochemical Studies of Antigen Receptor-Triggered Cytolytic T-Lymphocyte Activation*

1988 • 35 citations

Modulation of cytolytic T lymphocyte functions by an inhibitor of serine/threonine phosphatase, okadaic acid. Enhancement of cytolytic T lymphocyte-mediated cytotoxicity.

1991 • 34 citations

Cyclic AMP-Dependent Protein Kinase as a Part of the Possible Down-regulating Pathway in the Antigen Receptor-Regulated Cytotoxic T Lymphocyte Conjugate Formation and Granule Exocytosis

1988 • 19 citations

Similar molecular requirements for antigen receptor-triggered secretion of interferon and granule enzymes by cytolytic T lymphocytes

1989 • 17 citations