Drosophila Jun mediates Ras-dependent photoreceptor determination

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

1986 • 6,284 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

The protein Id: A negative regulator of helix-loop-helix DNA binding proteins

1990 • 2,273 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1990 • 1,605 citations

Fos and jun: The AP-1 connection

1988 • 1,597 citations

Transposition of Cloned P Elements into Drosophila Germ Line Chromosomes

1982 • 1,560 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

Human Proto-Oncogene c- jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1

1987 • 1,353 citations

Development of the Drosophila retina, a neurocrystalline lattice

1976 • 1,028 citations

Comparison of the consensus sequence flanking translational start sites inDrosophilaand vertebrates

1987 • 966 citations

Bone and haematopoietic defects in mice lacking c-fos

1992 • 939 citations

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase

1991 • 869 citations

12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region.

1987 • 699 citations

The DNA Binding Domain of the Rat Liver Nuclear Protein C/EBP Is Bipartite

1989 • 661 citations

Pleiotropic effects of a null mutation in the c-fos proto-oncogene

1992 • 643 citations

Isolation and characterization of the c-fos(rat) cDNA and analysis of post-translational modification in vitro.

1987 • 630 citations

Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

1991 • 626 citations

Parallel Association of Fos and Jun Leucine Zippers Juxtaposes DNA Binding Domains

1989 • 607 citations

Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters

1988 • 597 citations

The pathway to signal achievement

1993 • 563 citations

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos

1993 • 555 citations

Neuronal differentiation in the Drosophila ommatidium

1987 • 532 citations

Nuclear factor of activated T cells contains Fos and Jun

1992 • 495 citations

Making a difference: The role of cell-cell interactions in establishing separate identities for equivalent cells

1992 • 452 citations

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

1993 • 451 citations

A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity

1991 • 436 citations

The Drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates

1990 • 430 citations

Functional antagonism between c-Jun and MyoD proteins: A direct physical association

1992 • 424 citations

Sevenless , a Cell-Specific Homeotic Gene of Drosophila , Encodes a Putative Transmembrane Receptor with a Tyrosine Kinase Domain

1987 • 421 citations

A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways

1994 • 417 citations

Raf functions downstream of Rasl in the Sevenless signal transduction pathway

1992 • 323 citations

Signalling by the sevenless protein tyrosine kinase is mimicked by Rasl activation

1992 • 315 citations

seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye

1990 • 313 citations

Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor

1991 • 298 citations

A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase

1992 • 288 citations

Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila

1987 • 279 citations

The homeo domain protein rough is expressed in a subset of cells in the developing Drosophila eye where it can specify photoreceptor cell subtype.

1990 • 267 citations

Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein

1992 • 258 citations

Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye

1991 • 255 citations

Suppression of oncogene-induced transformation by a deletion mutant of c-jun.

1993 • 227 citations

Cellular interactions in the developing Drosophila eye

1988 • 218 citations

Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases

1991 • 209 citations

A multifaceted approach to neural development

1989 • 194 citations

Transformation suppressor activity of a Jun transcription factor lacking its activation domain

1991 • 190 citations

rough, a Drosophila homeobox gene required in photoreceptors R2 and R5 for inductive interactions in the developing eye

1988 • 189 citations

The fat facets gene is required for Drosophila eye and embryo development

1992 • 187 citations

Control of photoreceptor cell fate by the sevenless protein requires a functional tyrosine kinase domain

1988 • 177 citations

Expression of a truncated viral trans-activator selectively impedes lytic infection by its cognate virus

1988 • 169 citations

The cellular dynamics of pattern formation in the eye of Drosophila

1985 • 166 citations

Induction of cell fate in the Drosophila retina: the bride of sevenless protein is predicted to contain a large extracellular domain and seven transmembrane segments.

1990 • 164 citations

Transforming but not immortalizing oncogenes activate the transcription factor PEA1.

1988 • 160 citations

Induction in the developing compound eye of Drosophila: Multiple mechanisms restrict R7 induction to a single retinal precursor cell

1991 • 155 citations

cis-acting DNA sequence requirements for P-element transposition.

1989 • 132 citations

Signal transduction and the fate of the R7 photoreceptor in Drosophila

1991 • 128 citations

The Drosophila Fos-related AP-1 protein is a developmentally regulated transcription factor.

1990 • 123 citations

Control of cell fate determination by p21ras/Ras1, an essential component of torso signaling in Drosophila.

1993 • 110 citations

Torso, a receptor tyrosine kinase required for embryonic pattern formation, shares substrates with the sevenless and EGF-R pathways in Drosophila.

1993 • 99 citations

Ectopic expression of seven-up causes cell fate changes during ommatidial assembly

1993 • 90 citations

Prepattern in the developing Drosophila eye revealed by an activated torso--sevenless chimeric receptor.

1992 • 80 citations

Reprogramming cell fate in the developing Drosophila retina: transformation of R7 cells by ectopic expression of rough.

1990 • 78 citations

Drosophila homolog of the mammalian jun oncogene is expressed during embryonic development and activates transcription in mammalian cells.

1990 • 54 citations

Dynamics of Drosophila eye development and temporal requirements of sevenless expression

1989 • 54 citations

Transformation and transactivation suppressor activity of the c-Jun leucine zipper fused to a bacterial repressor.

1992 • 44 citations

Transcriptional Regulation by the AP-1 Family of Enhancer-binding Proteins: A Nuclear Target for Signal Transduction

1988 • 37 citations

A unique mutation in the Enhancer of split gene complex affects the fates of the mystery cells in the developing Drosophila eye

1992 • 34 citations

Isolation of temperature-sensitive mutations of the tyrosine kinase receptor sevenless (sev) in Drosophila and their use in determining its time of action.

1991 • 27 citations

Genetic dissection of signal transduction mediated by the sevenless receptor tyrosine kinase inDrosophila

1993 • 10 citations