Diacylglycerol production in Xenopus laevis oocytes after microinjection of p21ras proteins is a consequence of activation of phosphatidylcholine metabolism.

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

1987 • 1,197 citations

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1986 • 999 citations

The p21 ras C-terminus is required for transformation and membrane association

1984 • 590 citations

Ras -Transformed Cells: Altered Levels of Phosphatidylinositol-4,5-Bisphosphate and Catabolites

1986 • 450 citations

Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production

1986 • 406 citations

Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus.

1984 • 403 citations

Regulation of phosphatidylcholine biosynthesis

1984 • 401 citations

RAS proteins can induce meiosis in xenopus oocytes

1985 • 341 citations

Elevated levels of diacylglycerol and decreased phorbol ester sensitivity in ras-transformed fibroblasts

1987 • 330 citations

Signal transduction via phosphatidylcholine cycles

1989 • 314 citations

Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene

1987 • 303 citations

Direct identification of palmitic acid as the lipid attached to p21ras.

1986 • 157 citations

Identification of a precursor in the biosynthesis of the p21 transforming protein of harvey murine sarcoma virus

1982 • 151 citations

Deregulation of hamster fibroblast proliferation by mutated ras oncogenes is not mediated by constitutive activation of phosphoinositide-specific phospholipase C.

1988 • 143 citations

Rapid Stimulation of Diacylglycerol Production in Xenopus Oocytes by Microinjection of H- ras p21

1987 • 134 citations

Involvement of functional protein kinase C in the mitogenic response to the H-ras oncogene product.

1987 • 131 citations

Posttranslational processing of p21 ras proteins involves palmitylation of the C-terminal tetrapeptide containing cysteine-186

1985 • 120 citations

Elevated phosphocholine concentration in ras-transformed NIH 3T3 cells arises from increased choline kinase activity, not from phosphatidylcholine breakdown.

1989 • 106 citations

Separation of phospholipids by high-performance liquid chromatography: All major classes, including ethanolamine and choline plasmalogens, and most minor classes, including lysophosphatidylethanolamine

1986 • 95 citations

Mutant but not normal p21 ras elevates inositol phospholipid breakdown in two different cell systems.

1988 • 53 citations

Phosphatidylinositol kinase is activated in membranes derived from cells treated with epidermal growth factor.

1987 • 53 citations

Complete co-purification of choline kinase and ethanolamine kinase from rat kidney and immunological evidence for both kinase activities residing on the same enzyme protein(s) in rat tissues

1985 • 53 citations

Transforming activity of ras proteins translocated to the plasma membrane by a myristoylation sequence from the src gene product.

1988 • 39 citations

Evidence for the existence of a single enzyme catalyzing the phosphorylation of choline and ethanolamine in primate lung

1978 • 36 citations

Diethylstilbestrol treatment increases the amount of choline kinase in rooster liver

1982 • 26 citations