Enantiomeric antidepressant drugs should be considered on individual merit

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1994 • 2,716 citations

The pharmacological effect of citalopram resides in the (S)-(+)-enantiomer

1992 • 321 citations

Clinical Pharmacokinetics of Mirtazapine

2000 • 307 citations

Venlafaxine oxidation in vitro is catalysed by CYP2D6

1996 • 226 citations

Fluoxetine

1994 • 177 citations

Chiral switches

2000 • 140 citations

Interaction of the enantiomers of fluoxetine and norfluoxetine with human liver cytochromes P450.

1993 • 131 citations

Intellectual property and chirality of drugs

1999 • 121 citations

Steady-state pharmacokinetics of the enantiomers of citalopram and its metabolites in humans

1997 • 117 citations

Identification of three cytochrome P450 isozymes involved in N-demethylation of citalopram enantiomers in human liver microsomes

1997 • 109 citations

Neuroendocrine Effects of a 20-mg Citalopram Infusion in Healthy Males A Placebo-Controlled Evaluation of Citalopram as 5-HT Function Probe

1996 • 109 citations

The stereoselective metabolism of fluoxetine in poor and extensive metabolizers of sparteine

1999 • 101 citations

Replacement of (R)-methadone by a double dose of (R, S)-methadone in addicts: interindividual variability of the (R)/(S) ratios and evidence of adaptive changes in methadone pharmacokinetics

1996 • 96 citations

Citalopram: a comprehensive review

2001 • 95 citations

Genetic Analysis of the CYP2D6 Locus in a Hong Kong Chinese Population

2000 • 94 citations

Genetic Polymorphism of Drug Metabolising Enzymes in African Populations: Implications for the Use of Neuroleptics and Antidepressants

1997 • 93 citations

Stereoselective Biotransformation of the Selective Serotonin Reuptake Inhibitor Citalopram and Its Demethylated Metabolites by Monoamine Oxidases in Human Liver

1998 • 92 citations

Identification of the human cytochromes p450 responsible for in vitro formation of R- and S-norfluoxetine.

2001 • 90 citations

The α2-selective adrenoceptor antagonist org 3770 (mirtazapine, Remeron®) enhances noradrenergic and serotonergic transmission

1995 • 83 citations

Identification of human cytochrome P450 isoforms involved in the stereoselective metabolism of mianserin enantiomers.

1996 • 65 citations

Concentrations of the Enantiomers of Fluoxetine and Norfluoxetine After Multiple Doses of Fluoxetine in Cytochrome P4502D6 Poor and Extensive Metabolizers

2001 • 59 citations

The potential therapeutic role of the enantiomers and metabolites of mianserin.

1983 • 56 citations

Stereoselective disposition of mianserin is related to debrisoquin hydroxylation polymorphism

1994 • 54 citations

A Comparison of the Physicochemical and Biological Properties of Mirtazapine and Mianserin

1997 • 54 citations

Trimipramine: Pharmacological reevaluation and comparison with clozapine

1991 • 51 citations

Steady State Plasma Levels of the Enantiomers of Trimipramine and of Its Metabolites in CYP2D6-, CYP2C19- and CYP3A4/5-Phenotyped Patients

2000 • 46 citations

The CYP2D6 Genotype and Plasma Concentrations of Mianserin Enantiomers in Relation to Therapeutic Response to Mianserin in Depressed Japanese Patients

1997 • 41 citations

Adrenoreceptor interactions of the enantiomers and metabolites of mianserin: are they responsible for the antidepressant effect?

1985 • 32 citations

Comparison of the effects of mianserin and its enantiomers and metabolites on a behavioral screen for antidepressant activity

1991 • 29 citations

Marked Increase of Venlafaxine Enantiomer Concentrations as a Consequence of Metabolic Interactions: A Case Report

2000 • 29 citations

Stereoselective Interaction of Mianserin with 5-HT3 Receptors

1993 • 24 citations

Steady State Concentrations of the Enantiomers of Mianserin and Desmethylmianserin in Poor and in Homozygous and Heterozygous Extensive Metabolizers of Debrisoquine

1998 • 20 citations

Determination of the enantiomers of mianserin, desmethylmianserin, and 8‐hydroxymianserin in the plasma and urine of mianserin‐treated patients

1994 • 19 citations

Paroxetine increases serum trimipramine concentration. A report of two cases

1995 • 19 citations

Influence of electrical stimulation of the substantia nigra on spontaneous activity of raphe neurons in the anesthetized rat

1979 • 14 citations

Pharmacokinetic Consequences of a Citalopram Treatment Discontinuation

1999 • 11 citations

Deleted Work

1955 • 0 citations