Steady State Concentrations of the Enantiomers of Mianserin and Desmethylmianserin in Poor and in Homozygous and Heterozygous Extensive Metabolizers of Debrisoquine

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.

1993 • 652 citations

Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification

1990 • 451 citations

The genetic polymorphism of debrisoquine/sparteine metabolism — Clinical aspects

1990 • 367 citations

Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test.

1994 • 301 citations

Clinical significance of the sparteine/debrisoquine oxidation polymorphism

1989 • 292 citations

High-performance liquid chromatographic assays for bufuralol 1′-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver

1987 • 262 citations

Pharmacokinetics of Citalopram in Relation to the Sparteine and the Mephenytoin Oxidation Polymorphisms

1993 • 214 citations

Pharmacokinetic-Pharmacodynamic Relationship of the Selective Serotonin Reuptake Inhibitors???

1996 • 212 citations

The relationship between paroxetine and the sparteine oxidation polymorphism

1992 • 204 citations

Pharmacokinetics of Desipramine Coadministered With Sertraline or Fluoxetine

1994 • 191 citations

Pharmacokinetics of the selective serotonin reuptake inhibitor paroxetine: Nonlinearity and relation to the sparteine oxidation polymorphism

1992 • 150 citations

The antipsychotic clozapine is metabolized by the polymorphic human microsomal and recombinant cytochrome P450 2D6.

1992 • 116 citations

Clinical Pharmacokinetics of Imipramine and Desipramine

1990 • 112 citations

Simultaneous determination of plasma levels of fluvoxamine and of the enantiomers of fluoxetine and norfluoxetine by gas chromatography-mass spectrometry

1996 • 80 citations

Dextromethorphan and Mephenytoin Phenotyping of Patients Treated with Thioridazine or Amitriptyline

1992 • 68 citations

Identification of human cytochrome P450 isoforms involved in the stereoselective metabolism of mianserin enantiomers.

1996 • 65 citations

Quinidine inhibits the 2-hydroxylation of imipramine and desipramine but not the demethylation of imipramine

1989 • 63 citations

Drug metabolism in epileptics: in vivo and in vitro correlations.

1978 • 62 citations

Lack of effect of mianserin on the symptoms of diabetic neuropathy

1992 • 59 citations

Plasma levels of the enantiomers of thioridazine, thioridazine 2-sulfoxide, thioridazine 2-sulfone, and thioridazine 5-sulfoxide in poor and extensive metabolizers of dextromethorphan and mephenytoin*

1996 • 58 citations

Stereoselective disposition of mianserin is related to debrisoquin hydroxylation polymorphism

1994 • 54 citations

Clinical Pharmacokinetics of Citalopram and Other Selective Serotonergic Reuptake Inhibitors (SSRI)

1992 • 40 citations

Pharmacokinetic Fluvoxamine - Clomipramine Interaction with Favorable Therapeutic Consequences in Therapy-resistant Depressive Patient

1996 • 37 citations

Pharmacological aspects of mianserin

1983 • 32 citations

Moclobemide treatment causes a substantial rise in the sparteine metabolic ratio. Danish University Antidepressant Group.

1993 • 30 citations

Extremely Long Plasma Half-Life of Amitriptyline in a Woman with the Cytochrome P450IID6 29/29-Kilobase Wild-Type Allele—A Slowly Reversible Interaction with Fluoxetine

1991 • 23 citations

Determination of the Enantiomers of Mianserin and its Metabolites in Plasma by Capillary Electrophoresis After Liquid--Liquid Extraction and On-Column Sample Preconcentration

1997 • 23 citations

Activation of mianserin and its metabolites by human liver microsomes

1989 • 21 citations

Influence of Quinidine on the Pharmacokinetics of Trimipramine and on Its Effect on the Waking EEG of Healthy Volunteers

1992 • 20 citations

Variability in the elimination of mianserin in elderly patients.

1989 • 19 citations

Determination of the enantiomers of mianserin, desmethylmianserin, and 8‐hydroxymianserin in the plasma and urine of mianserin‐treated patients

1994 • 19 citations

Steady-State Plasma Concentrations of Mianserin and Its Major Active Metabolite, Desmethylmianserin

1993 • 15 citations

Plasma Concentrations of Mianserin after Single Dose and at Steady-State in Depressed Elderly Patients

1987 • 15 citations

Debrisoquine hydroxylation phenotypes of patients with high versus low to normal serum antidepressant concentrations.

1992 • 15 citations

Metabolic Interaction between Fluoxetine and Clomipramine: A Case Report

1996 • 8 citations

Debrisoquine Hydroxylation Phenotypes of

1992 • 7 citations

Prediction of Plasma Concentrations of Mianserin and Desmethylmianserin at Steady State from Those After an Initial Dose of Mianserin

1993 • 5 citations