Stereoselective Biotransformation of the Selective Serotonin Reuptake Inhibitor Citalopram and Its Demethylated Metabolites by Monoamine Oxidases in Human Liver

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.

1995 • 601 citations

The pharmacological effect of citalopram resides in the (S)-(+)-enantiomer

1992 • 321 citations

Monoamine oxidase—I

1974 • 318 citations

A Double-Blind, Placebo-Controlled Study of Citalopram With and Without Lithium in the Treatment of Therapy-Resistant Depressive Patients

1996 • 168 citations

Use of in vitro human metabolism studies in drug development

1994 • 142 citations

Interactions of monoamine oxidase with substrates and inhibitors

1989 • 141 citations

Adrenaline and amine oxidase

1937 • 132 citations

Analysis of Enantiomers of Citalopram and Its Demethylated Metabolites in Plasma of Depressive Patients Using Chiral Reverse-Phase Liquid Chromatography

1995 • 126 citations

Neuroendocrine Effects of a 20-mg Citalopram Infusion in Healthy Males A Placebo-Controlled Evaluation of Citalopram as 5-HT Function Probe

1996 • 109 citations

Pharmacology and pharmacokinetics of citalopram and other SSRIs

1996 • 109 citations

Tyramine oxidase

1937 • 96 citations

Selective inhibitors of monoamine oxidase (MAO‐A and MAO‐B) as probes of its catalytic site and mechanism

1995 • 91 citations

Characterization of the enzyme responsible for the metabolism of sumatriptan in human liver

1994 • 85 citations

Screening of unsubstituted cyclic compounds as inhibitors of monoamine oxidases

1994 • 77 citations

Determination of the enantiomers of citalopram, its demethylated and propionic acid metabolites in human plasma by chiral HPLC

1995 • 72 citations

High-performance liquid chromatographic determination of citalopram and four of its metabolites in plasma and urine samples from psychiatric patients

1984 • 67 citations

Non-response to citalopram in depressive patients: pharmacokinetic and clinical consequences of a fluvoxamine augmentation

1996 • 67 citations

Xen0biotic Oxidation Catalyzed by Aldehyde Dehydrogenases

1989 • 66 citations

Monoamine oxidases: old friends hold many surprises

1995 • 65 citations

Enzymatic basis of the debrisoquine/sparteine-type genetic polymorphism of drug oxidation

1987 • 63 citations

Xenobiotic Metabolism in Brain

1995 • 55 citations

GC and GC-MS procedures for simultaneous phenotyping with dextromethorphan and mephenytoin

1988 • 44 citations

Determination of plasma levels of citalopram and its demethylated and deaminated metabolites by gas chromatography and gas chromatography—mass spectrometry

1993 • 40 citations

Inhibition by SKF-525A of the aldehyde oxidase-mediated metabolism of the experimental antitumour agent acridine carboxamide

1993 • 27 citations

Inhibition of rat brain monoamine oxidase enzymes by fluoxetine and norfluoxetine

1996 • 23 citations

Hepatic microsomal oxygenation of aldehydes to car☐ylic acids

1990 • 22 citations

Chronic administration of citalopram inhibited El mouse convulsions and decreased monoamine oxidase-A activity.

1994 • 16 citations

Metabolism of diltiazem. III. Oxidative deamination of diltiazem in rat liver microsomes.

1990 • 14 citations

Extrahepatic Microsomal Forms: Brain Cytochrome P450

1993 • 14 citations

On the stereospecificity of monoamine oxidase

1982 • 11 citations

Oxidation of tolualdehydes to toluic acids catalyzed by cytochrome P450-dependent aldehyde oxygenase in the mouse liver.

1995 • 10 citations

Pharmacogenetic variability in brain and muscle.

1994 • 6 citations

Metabolic Formation of Dimethylamine and Methylamine from Basic Drugs Containing N-Methyl Group: A Newly Established Chromatographic Assay and Its Application to the Determination of Deaminase Activity.

1993 • 4 citations