DNA methylation, methyltransferases, and cancer

The Hallmarks of Cancer

2000 • 27,569 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Surfing the p53 network

2000 • 6,487 citations

DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

1999 • 5,748 citations

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

1998 • 3,363 citations

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

1998 • 2,686 citations

Cancer-epigenetics comes of age

1999 • 2,379 citations

The regulation of E2F by pRB-family proteins

1998 • 2,297 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

Cytosine methylation and the ecology of intragenomic parasites

1997 • 1,906 citations

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

1999 • 1,865 citations

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

1998 • 1,852 citations

Methylation-Induced Repression— Belts, Braces, and Chromatin

1999 • 1,823 citations

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

1994 • 1,669 citations

DNA hypermethylation in tumorigenesis: epigenetics joins genetics

2000 • 1,628 citations

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

1994 • 1,542 citations

Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines.

1997 • 1,465 citations

Aberrant CpG-island methylation has non-random and tumour-type–specific patterns

2000 • 1,344 citations

Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA

1992 • 1,331 citations

Identification and Characterization of a Family of Mammalian Methyl-CpG Binding Proteins

1998 • 1,317 citations

MeCP2 Is a Transcriptional Repressor with Abundant Binding Sites in Genomic Chromatin

1997 • 1,258 citations

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

1994 • 1,205 citations

Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene

1999 • 1,168 citations

DNA methylation in health and disease

2000 • 1,055 citations

A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei

1992 • 1,027 citations

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci

2000 • 1,024 citations

Number of CpG islands and genes in human and mouse.

1993 • 986 citations

DNA methyltransferase Dnmt1 associates with histone deacetylase activity

2000 • 960 citations

Aberrant methylation of p16 ^INK4a is an early event in lung cancer and a potential biomarker for early diagnosis

1998 • 953 citations

Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a

2000 • 943 citations

DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters

2000 • 938 citations

Hhal methyltransferase flips its target base out of the DNA helix

1994 • 936 citations

DNA hypomethylation leads to elevated mutation rates

1998 • 935 citations

MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex

1999 • 898 citations

Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21 ^WAF1

1997 • 895 citations

Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells

1988 • 891 citations

PCNA: structure, functions and interactions

1997 • 886 citations

The PHD finger: Implications for chromatin-mediated transcriptional regulation

1995 • 857 citations

Hypomethylation of DNA from Benign and Malignant Human Colon Neoplasms

1985 • 844 citations

Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis.

1994 • 840 citations

The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors

1999 • 830 citations

Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation

1999 • 806 citations

Association of Transcriptionally Silent Genes with Ikaros Complexes at Centromeric Heterochromatin

1997 • 792 citations

De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells

1996 • 784 citations

Effects of DNA methylation on DNA-binding proteins and gene expression

1993 • 732 citations

The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome

1999 • 714 citations

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.

1995 • 713 citations

Maintenance of genomic methylation requires a SWI2/SNF2-like protein

1999 • 689 citations

Replication-Dependent Marking of DNA by PCNA Facilitates CAF-1-Coupled Inheritance of Chromatin

1999 • 674 citations

Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas.

1995 • 635 citations

Hsp90 & Co. – a holding for folding

1999 • 631 citations

Recombinant Human DNA (Cytosine-5) Methyltransferase

1999 • 624 citations

Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.

1996 • 585 citations

Requirement for PCNA in DNA Mismatch Repair at a Step Preceding DNA Resynthesis

1996 • 569 citations

Functional requirement of p23 and Hsp90 in telomerase complexes

1999 • 538 citations

Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation

2000 • 494 citations

Reduced genomic 5-methylcytosine content in human colonic neoplasia.

1988 • 491 citations

DNA methylation in Drosophila melanogaster

2000 • 482 citations

CpG methylation is maintained in human cancer cells lacking DNMT1

2000 • 453 citations

Chromosomal imbalance maps of malignant solid tumors: a cytogenetic survey of 3185 neoplasms.

1997 • 434 citations

The DNA (cytosine-5) methyltransferases

1994 • 425 citations

Cloning, expression and chromosome locations of the human DNMT3 gene family

1999 • 412 citations

Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells

1998 • 408 citations

The p150 and p60 subunits of chromatin assemblyfactor I: A molecular link between newly synthesized histories and DNA replication

1995 • 373 citations

Inactivation of glutathione S-transferase P1 gene by promoter hypermethylation in human neoplasia.

1998 • 366 citations

Two DNA methyltransferases from murine erythroleukemia cells: purification, sequence specificity, and mode of interaction with DNA.

1983 • 361 citations

The Human ARF Cell Cycle Regulatory Gene Promoter Is a CpG Island Which Can Be Silenced by DNA Methylation and Down-Regulated by Wild-Type p53

1998 • 357 citations

Chromatin Assembly Coupled to DNA Repair: A New Role for Chromatin Assembly Factor I

1996 • 333 citations

tsg101: A Novel Tumor Susceptibility Gene Isolated by Controlled Homozygous Functional Knockout of Allelic Loci in Mammalian Cells

1996 • 332 citations

Eukaryotic DNA methylation as an evolutionary device

1999 • 328 citations

In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis

1999 • 321 citations

Hypermethylation of the DAP-Kinase CpG Island Is a Common Alteration in B-Cell Malignancies

1999 • 319 citations

Increased Cytosine DNA-Methyltransferase Activity During Colon Cancer Progression

1993 • 315 citations

Creation of genomic methylation patterns

1996 • 313 citations

Loss of methylation activates Xist in somatic but not in embryonic cells.

1995 • 300 citations

DNA Methyltransferase Contributes to Delayed Ischemic Brain Injury

2000 • 300 citations

Isolation and Initial Characterization of a Novel Zinc Finger Gene, DNMT3L, on 21q22.3, Related to the Cytosine-5- Methyltransferase 3 Gene Family

2000 • 293 citations

De Novo Methylation of CpG Island Sequences in Human Fibroblasts Overexpressing DNA (Cytosine-5-)-Methyltransferase

1996 • 290 citations

An embryonic-like methylation pattern of classical satellite DNA is observed in ICF syndrome

1993 • 281 citations

Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins

1999 • 274 citations

A candidate mammalian DNA methyltransferase related to pmt1p of fission yeast

1998 • 274 citations

Hypomethylation of pericentromeric DNA in breast adenocarcinomas

1998 • 263 citations

Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia.

1998 • 260 citations

In Vivo Activity of Murine De Novo Methyltransferases, Dnmt3a and Dnmt3b

1999 • 260 citations

Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.

1993 • 255 citations

ATRX encodes a novel member of the SNF2 family of proteins: mutations point to a common mechanism underlying the ATR-X syndrome

1996 • 250 citations

DNA methylation and expression of LINE-1 and HERV-K provirus sequences in urothelial and renal cell carcinomas

1999 • 250 citations

DNA tumor virus transforming proteins and the cell cycle

1993 • 242 citations

Expression of DNA methyltransferase gene in mature and immature neurons as well as proliferating cells in mice

1994 • 228 citations

Conserved plant genes with similarity to mammalian de novo DNA methyltransferases

2000 • 228 citations

Purification of PCNA as a nucleotide excision repair protein

1992 • 228 citations

Methylation hot spots in the 5' flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene.

1997 • 214 citations

DNA hypomethylation and unusual chromosome instability in cell lines fromICF syndrome patients

2000 • 209 citations

The solution structure of the domain from MeCP2 that binds to methylated DNA

1999 • 202 citations

Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G0/G1 to S phase transition in normal and tumor cells

2000 • 197 citations

Hypermethylation of the APC (adenomatous Polyposis Coli) gene promoter region in human colorectal carcinoma

1997 • 195 citations

Suppression of crossing-over by DNA methylation in Ascobolus

1998 • 190 citations

Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes.

1994 • 190 citations

Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila

1999 • 187 citations

Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome

2000 • 182 citations

A 1-kb Alu-mediated germ-line deletion removing BRCA1 exon 17.

1997 • 177 citations

DNA demethylation and pericentromeric rearrangements of chromosome 1

1997 • 176 citations

CpG methylated minichromosomes become inaccessible for V(D)J recombination after undergoing replication.

1992 • 168 citations

Cell cycle-dependent phosphorylation of the ATRX protein correlates with changes in nuclear matrix and chromatin association

2000 • 154 citations

Emerin deletion reveals a common X-chromosome inversion mediated by inverted repeats

1997 • 154 citations

A sex chromosome rearrangement in a human XX male caused by Alu—Alu recombination

1987 • 154 citations

Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein

1998 • 151 citations

Satellite DNA hypomethylation vs. overall genomic hypomethylation in ovarian epithelial tumors of different malignant potential

1999 • 151 citations

Multiple domains are involved in the targeting of the mouse DNA methyltransferase to the DNA replication foci

1998 • 150 citations

MBD2‐MBD3 complex binds to hemi‐methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase

2000 • 145 citations

Retinoblastoma protein meets chromatin

1999 • 143 citations

Abnormal methylation pattern in constitutive and facultative (X inactive chromosome) heterochromatin of ICF patients

1994 • 141 citations

Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation.

1996 • 138 citations

Growth regulation of mouse DNA methyltransferase gene expression

1991 • 137 citations

Histone deacetylation is required for the maturation of newly replicated chromatin.

1983 • 132 citations

Methylation of deoxycytidine incorporated by excision-repair synthesis of DNA

1982 • 117 citations

Chromosomal localization of human satellites 2 and 3 by a FISH method using oligonucleotides as probes

1994 • 114 citations

ICF syndrome: a new case and review of the literature

1994 • 111 citations

Progressive Region-Specific De Novo Methylation of the p16 CpG Island in Primary Human Mammary Epithelial Cell Strains during Escape from M₀ Growth Arrest

1999 • 111 citations

Baculovirus-mediated expression and characterization of the full-length murine DNA methyltransferase

1997 • 99 citations

New 5′ Regions of the Murine and Human Genes for DNA (Cytosine-5)-methyltransferase

1996 • 96 citations

Transcriptional repression of BRCA1 by aberrant cytosine methylation, histone hypoacetylation and chromatin condensation of the BRCA1 promoter

2000 • 93 citations

Lsh, an SNF2/helicase family member, is required for proliferation of mature T lymphocytes

2000 • 93 citations

Complementation of methylation deficiency in embryonic stem cells by a DNA methyltransferase minigene

1996 • 90 citations

Cytoplasmic 8 S glucocorticoid receptor binds to actin filaments through the 90-kDa heat shock protein moiety

1991 • 90 citations

The mouse DNA methyltransferase 5'-region. A unique housekeeping gene promoter.

1992 • 77 citations

Localization of the ICF Syndrome to Chromosome 20 by Homozygosity Mapping

1998 • 57 citations

Chromosome instability in ICF syndrome: Formation of micronuclei from multibranched chromosomes 1 demonstrated by fluorescence in situ hybridization

1995 • 50 citations

A rise in nuclear calcium translocates annexins IV and V to the nuclear envelope

1996 • 46 citations

Variable immunodeficiency with abnormal condensation of the heterochromatin of chromosomes 1, 9, and 16

1988 • 41 citations

Assignment of human satellite 1 DNA as revealed by fluorescent in situ hybridization with oligonucleotides

1994 • 39 citations

Characterization of a Novel 23-Kilodalton Protein of Unactive Progesterone Receptor Complexes

1994 • 38 citations

Variability of clinical and immunological phenotype in immunodeficiency-centromeric instability-facial anomalies syndrome

1995 • 36 citations

Molecular Cloning and Characterization of Annexin V‐Binding Proteins with Highly Hydrophilic Peptide Structure

1996 • 35 citations

Transcriptional silencing of human Alu sequences and inhibition of protein binding in the box B regulatory elements by 5′‐CG‐3′ methylation

1995 • 34 citations

Subcellular localization of annexin V in human foreskin fibroblasts: nuclear localization depends on growth state

1996 • 30 citations

A human modifier of methylation for class I HLA genes (MEMO-1) maps to chromosomal bands 1p35-36.1

1996 • 26 citations

Hypersensitivity to radiation-induced non-apoptotic and apoptotic death in cell lines from patients with the ICF chromosome instability syndrome

2000 • 22 citations

Nuclear matrix-associated DNA methylase

1985 • 21 citations

Mammalian DNA cytosine‐5 methyltransferase interacts with p23 protein

1996 • 20 citations

Nuclear Matrix Localization of Annexin V in Chicken Liver

1996 • 13 citations

Metastatic rat carcinoma cells express a new retrotransposon

1999 • 8 citations

Different Effects of Histone H1 on de Novo DNA Methylation in Vitro Depend on both the DNA Base Composition and the DNA Methyltransferase

1996 • 5 citations

Information

1995 • 4 citations

Survey of quality control practices of microbiology media

1999 • 3 citations

Illustration, Design, Comics, and Picture Books

1996 • 1 citations