Target Specificity of Immunoglobulin Class Switch Recombination Is Not Determined by Nucleotide Sequences of S Regions

Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis

1988 • 1,734 citations

pEF-BOS, a powerful mammalian expression vector

1990 • 1,641 citations

SRα Promoter: an Efficient and Versatile Mammalian cDNA Expression System Composed of the Simian Virus 40 Early Promoter and the R-U5 Segment of Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat

1988 • 1,351 citations

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

1993 • 984 citations

The SCID but Not the RAG-2 Gene Product Is Required for Sμ–Sε Heavy Chain Class Switching

1996 • 411 citations

Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching.

1986 • 344 citations

Shutdown of Class Switch Recombination by Deletion of a Switch Region Control Element

1993 • 340 citations

Ku80 is required for immunoglobulin isotype switching

1998 • 330 citations

Organization of the constant-region gene family of the mouse immunoglobulin heavy chain

1982 • 323 citations

B cells from p50/NF-kappa B knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switching.

1996 • 304 citations

Organization of immunoglobulin heavy chain genes and allelic deletion model.

1978 • 297 citations

Ku70 Is Required for Late B Cell Development and Immunoglobulin Heavy Chain Class Switching

1998 • 293 citations

Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes.

1988 • 285 citations

Mitogen- and IL-4-regulated expression of germ-line Ig γ2b transcripts: Evidence for directed heavy chain class switching

1988 • 277 citations

DNA sequences at immunoglobulin switch region recombination sites

1993 • 275 citations

Switch Transcripts in Immunoglobulin Class Switching

1995 • 248 citations

Menage á trois: Double strand break repair, V(D)J recombination and DNA-PK

1995 • 245 citations

Circular DNA is excised by immunoglobulin class switch recombination

1990 • 244 citations

Switch circular DNA formed in cytokine-treated mouse splenocytes: Evidence for intramolecular DNA deletion in immunoglobulin class switching

1990 • 240 citations

Induction of RNA-stabilized DMA conformers by transcription of an immunoglobulin switch region

1990 • 237 citations

Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching.

1986 • 220 citations

The Immunoglobulin Class Switch: Beyond “Accessibility”

1997 • 217 citations

S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process.

1994 • 214 citations

Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch.

1980 • 213 citations

High frequency class switching of an lgM⁺ B lymphoma clone CH12F3 to lgA⁺ cells

1996 • 212 citations

Immunoglobulin class switching

1984 • 208 citations

Circular DNA is a product of the immunoglobulin class switch rearrangement

1990 • 202 citations

RNA: DNA complex formation upon transcription of immunoglobulin switch regions: implications for the mechanism and regualtion of class switch recombination

1995 • 200 citations

The role of gene deletion in the immunoglobulin heavy chain switch

1980 • 164 citations

Nucleotide sequences of switch regions of immunoglobulin C epsilon and C gamma genes and their comparison.

1982 • 157 citations

Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination

1990 • 120 citations

Replacement of germ-line epsilon promoter by gene targeting alters control of immunoglobulin heavy chain class switching.

1993 • 114 citations

Interleukin 5 (IL-5) provides a signal that is required in addition to IL-4 for isotype switching to immunoglobulin (Ig) G1 and IgE.

1992 • 108 citations

Deletions in the constant region locus can account for switches in immunoglobulin heavy chain expression

1980 • 106 citations

IgA class switch in I alpha exon-deficient mice. Role of germline transcription in class switch recombination.

1996 • 90 citations

Transcriptional regulatory elements stimulate recombination in extrachromosomal substrates carrying immunoglobulin switch-region sequences.

1992 • 74 citations

Strand specificity in the transcriptional targeting of recombination at immunoglobulin switch sequences.

1995 • 73 citations

Immunoglobulin heavy chain switch region recombination within a retroviral vector in murine pre-B cells.

1987 • 59 citations

Isolation of cDNA encoding a binding protein specific to 5'-phosphorylated single-stranded DNA with G-rich sequences

1993 • 57 citations

Frequent but biased class switch recombination in the Sμ flanking regions

1998 • 51 citations

IL-10 selectively regulates murine Ig isotype switching

1996 • 47 citations

Effect of downregulation of germline transcripts on immunoglobulin A isotype differentiation.

1993 • 39 citations

Iα exon-replacement mice synthesize a spliced HPRT–Cα transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice

1999 • 38 citations

Regulation of class switch recombination of the immunoglobulin heavy chain genes

1995 • 32 citations

The complete murine immunoglobulin class switch region of the alpha heavy chain gene-hierarchic repetitive structure and recombination breakpoints.

1993 • 31 citations

Efficient Recombination of a Switch Substrate Retrovector in CD40-Activated B Lymphocytes: Implications for the Control of CH Gene Switch Recombination

1998 • 30 citations

Antigen receptor cross-linking differentially regulates germ-line CH ribonucleic acid expression in murine B cells.

1995 • 28 citations

Analysis of immunoglobulin Sgamma3 recombination breakpoints by PCR: implications for the mechanism of isotype switching

1997 • 24 citations

Extrachromosomal Eukaryotic DNA Substrates for Switch Recombination: Analysis of Isotype and Cell Specificity

1994 • 22 citations

Developmental specificity of immunoglobulin heavy chain switch region recombination activities

1997 • 22 citations

Chicken immunoglobulin μ-chain gene: germline organization and tandem repeats characteristic of class switch recombination

1996 • 16 citations