Developmental specificity of immunoglobulin heavy chain switch region recombination activities

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

1993 • 984 citations

Establishment and Characterization of BALB/c Lymphoma Lines with B Cell Properties

1979 • 677 citations

IMMUNE REGULATION BY CD40 AND ITS LIGAND GP39

1996 • 653 citations

Mechanism and Regulation of Immunoglobulin Isotype Switching

1993 • 516 citations

Immunoglobulin gene expression in transformed lymphoid cells.

1983 • 400 citations

Shutdown of Class Switch Recombination by Deletion of a Switch Region Control Element

1993 • 340 citations

Methods in molecular genetics

1995 • 319 citations

Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus

1982 • 278 citations

DNA sequences at immunoglobulin switch region recombination sites

1993 • 275 citations

A class switch control region at the 3′ end of the immunoglobulin heavy chain locus

1994 • 267 citations

B lymphocyte differentiation induced by lipopolysaccharide. I. Generation of cells synthesizing four major immunoglobulin classes.

1975 • 250 citations

CD40 and Its Ligand in Host Defense

1996 • 236 citations

Immunoglobulin Class Switching: Molecular and Cellular Analysis

1990 • 224 citations

Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching.

1986 • 220 citations

A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon.

1993 • 206 citations

Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50.

1995 • 201 citations

STF-IL-4: a novel IL-4-induced signal transducing factor.

1994 • 183 citations

MECHANISM AND DEVELOPMENTAL PROGRAM OF IMMUNOGLOBULIN GENE REARRANGEMENT IN MAMMALS

1989 • 144 citations

B Lymphocyte Differentiation Induced by Lipopolysaccharide

1975 • 138 citations

Replacement of germ-line epsilon promoter by gene targeting alters control of immunoglobulin heavy chain class switching.

1993 • 114 citations

Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement

1983 • 105 citations

Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes.

1985 • 99 citations

Directed Ig class switch recombination in activated murine B cells.

1987 • 94 citations

Interleukin 4 signals through two related pathways.

1995 • 90 citations

A V(D)J recombinase-inducible B-cell line: role of transcriptional enhancer elements in directing V(D)J recombination.

1993 • 81 citations

Transcriptional regulatory elements stimulate recombination in extrachromosomal substrates carrying immunoglobulin switch-region sequences.

1992 • 74 citations

Strand specificity in the transcriptional targeting of recombination at immunoglobulin switch sequences.

1995 • 73 citations

B cell lineage-specific activator protein (BSAP). A player at multiple stages of B cell development.

1996 • 48 citations

Regulation of germ-line epsilon transcription and induction of epsilon switching in cloned EBV-transformed and malignant human B cell lines by cytokines and CD4+ T cells.

1992 • 45 citations

Synthesis, assembly and secretion of gamma globulin by mouse myeloma cells

1971 • 41 citations

Molecular basis of heavy-chain class switching and switch region deletion in an Abelson virus-transformed cell line.

1984 • 39 citations

Regulation and Targeting of Recombination in Extrachromosomal Substrates Carrying Immunoglobulin Switch Region Sequences

1994 • 38 citations

A V(D)J Recombinase-Inducible B-Cell Line: Role of Transcriptional Enhancer Elements in Directing V(D)J Recombination

1993 • 29 citations

A λ1 transgene under the control of a heavy chain promoter and enhancer does not undergo somatic hypermutation

1994 • 27 citations

Regulation and targeting of recombination in extrachromosomal substrates carrying immunoglobulin switch region sequences.

1994 • 25 citations

Class-switching from mu to gamma 3 or gamma 2b production at pre-B cell stage.

1986 • 20 citations

Targeting and Regulation of Immunoglobulin Gene Somatic Hypermutation and lsotype Switch Recombination

1995 • 14 citations

[21]Extrachromosomal substrates to study immunoglobulin heavy chain class switch recombination in mammalian B cells

1996 • 3 citations