Abnormal inside-out signal transduction-dependent activation of glycoprotein IIb-IIIa in a patient with impaired pleckstrin phosphorylation

A murine monoclonal antibody that completely blocks the binding of fibrinogen to platelets produces a thrombasthenic-like state in normal platelets and binds to glycoproteins IIb and/or IIIa.

1983 • 780 citations

Detection of activated platelets in whole blood using activation- dependent monoclonal antibodies and flow cytometry

1987 • 736 citations

Human platelets possess an inducible and saturable receptor specific for fibrinogen.

1979 • 713 citations

Integrin cytoplasmic domains mediate inside-out signal transduction

1994 • 682 citations

The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von Willebrand factor binding to platelets.

1985 • 594 citations

An Abnormal Platelet Glycoprotein Pattern in Three Cases of Glanzmann's Thrombasthenia

1974 • 445 citations

The tetrapeptide analogue of the cell attachment site of fibronectin inhibits platelet aggregation and fibrinogen binding to activated platelets.

1985 • 437 citations

A β ₃ Integrin Mutation Abolishes Ligand Binding and Alters Divalent Cation-Dependent Conformation

1990 • 418 citations

Determination of ATP and ADP in blood platelets: A modification of the firefly luciferase assay for plasma

1972 • 330 citations

Affinity modulation of the alpha IIb beta 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor.

1990 • 285 citations

Inhibition of fibrinogen binding to stimulated human platelets by a monoclonal antibody.

1983 • 280 citations

Occupancy of an adhesive glycoprotein receptor modulates expression of an antigenic site involved in cell adhesion.

1988 • 280 citations

Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex

1991 • 270 citations

Induction of the fibrinogen receptor on human platelets by intracellular mediators.

1987 • 240 citations

Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia.

1992 • 234 citations

Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signaling through integrin and agonist receptors.

1994 • 233 citations

Detection of thromboxane B2 in peripheral blood of patients with Prinzmetal's angina

1979 • 164 citations

Sphingosine inhibition of agonist-dependent secretion and activation of human platelets implies that protein kinase C is a necessary and common event of the signal transduction pathways.

1987 • 156 citations

Effects of chymotrypsin and adenosine diphosphate on the exposure of fibrinogen receptors on normal human and Glanzmann's thrombasthenic platelets.

1981 • 144 citations

Comparison of fibrinogen association with normal and thrombasthenic platelets on exposure to ADP or chymotrypsin

1979 • 138 citations

Protein kinase C and cyclic AMP regulate reversible exposure of binding sites for fibrinogen on the glycoprotein IIB-IIIA complex of human platelets

1991 • 92 citations

Regulation of glycoprotein IIb-IIIa receptor function studied with platelets permeabilized by the pore-forming complement proteins C5b-9.

1992 • 84 citations

Glanzmann thrombasthenia: new insights from an historical perspective.

1994 • 79 citations

Interaction of disintegrins with the αIIbβ3 receptor on resting and activated human platelets

1994 • 76 citations

Long range propagation of conformational changes in integrin αIIbβ3

1994 • 63 citations

Fibrinogen binding to purified platelet glycoprotein IIb-IIIa (integrin alpha IIb beta 3) is modulated by lipids.

1992 • 53 citations

Heterogeneous defects of platelet secretion and responses to weak agonists in patients with bleeding disorders

1988 • 50 citations

Regulation of Platelet Anchorage and Signaling by Integrin αIIbβ3

1993 • 44 citations

Platelet secretion defect associated with impaired liberation of arachidonic acid and normal myosin light chain phosphorylation

1984 • 41 citations

Ca+2 mobilization and fibrinogen binding of platelets refractory to adenosine diphosphate stimulation.

1985 • 36 citations

Activation of the fibrinogen receptor on human platelets exposed to alpha chymotrypsin

1991 • 33 citations

Impairment of Phosphatidylinositol Metabolism in a Patient with a Bleeding Disorder Associated with Defects of Initial Platelet Responses

1988 • 25 citations

High concentrations of exogenous arachidonate inhibit calcium mobilization in platelets by stimulation of adenylate cyclase

1988 • 21 citations

Studies on platelet protein phosphorylation in patients with impaired responses to platelet agonists.

1990 • 17 citations

Identification of a unique type of thrombopathy of human platelets: defect in the exposure of active fibrinogen receptors in a patient with Friedreich's ataxia.

1988 • 10 citations

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