Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts

The versatility and universality of calcium signalling

2000 • 5,407 citations

Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation

1998 • 5,369 citations

Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density

1997 • 5,058 citations

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

1998 • 4,184 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

Bone Resorption by Osteoclasts

2000 • 3,797 citations

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

1999 • 3,340 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

Modulation of Osteoclast Differentiation and Function by the New Members of the Tumor Necrosis Factor Receptor and Ligand Families

1999 • 2,238 citations

Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis*

2000 • 2,226 citations

Calcium oscillations increase the efficiency and specificity of gene expression

1998 • 1,870 citations

The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

1990 • 1,763 citations

Therapeutic Approaches to Bone Diseases

2000 • 1,732 citations

Reaching a Genetic and Molecular Understanding of Skeletal Development

2002 • 1,564 citations

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

1997 • 1,533 citations

TNF-α induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand

2000 • 1,330 citations

NFAT Signaling

2002 • 1,316 citations

T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ

2000 • 1,302 citations

TRAF6 is a signal transducer for interleukin-1

1996 • 1,287 citations

c-Fos: a Key Regulator of Osteoclast-Macrophage Lineage Determination and Bone Remodeling

1994 • 1,253 citations

The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway

1999 • 1,163 citations

Requirement for NF-κB in osteoclast and B-cell development

1997 • 994 citations

Identification of a Putative Regulator of Early T Cell Activation Genes

1988 • 933 citations

RANK-L and RANK: T Cells, Bone Loss, and Mammalian Evolution

2002 • 802 citations

Partners in transcription: NFAT and AP-1

2001 • 757 citations

The Osteoclast Differentiation Factor Osteoprotegerin-Ligand Is Essential for Mammary Gland Development

2000 • 731 citations

Bcl2 Regulation by the Melanocyte Master Regulator Mitf Modulates Lineage Survival and Melanoma Cell Viability

2002 • 728 citations

RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-β

2002 • 704 citations

Osteoclast differentiation factor is a ligand for osteoprotegerin/ osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci USA 95: 3597-602

1998 • 669 citations

Commitment and Differentiation of Osteoclast Precursor Cells by the Sequential Expression of C-Fms and Receptor Activator of Nuclear Factor κb (Rank) Receptors

1999 • 666 citations

Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum

1998 • 639 citations

Severe osteopetrosis, defective interleukin‐1 signalling and lymph node organogenesis in TRAF6‐deficient mice

1999 • 639 citations

Involvement of receptor activator of nuclear factor κB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis

2000 • 600 citations

The transcription factor NF-ATc is essential for cardiac valve formation

1998 • 580 citations

Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression

1996 • 535 citations

Osteopetrosis in mice lacking haematopoietic transcription factor PU.1

1997 • 531 citations

Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA

1998 • 510 citations

The TRAF Family of Signal Transducers Mediates NF-κB Activation by the TRANCE Receptor

1998 • 458 citations

Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis

2001 • 450 citations

Large Scale Gene Expression Analysis of Osteoclastogenesisin Vitro and Elucidation of NFAT2 as a Key Regulator

2002 • 371 citations

Directed evolution of green fluorescent protein by a new versatile PCR strategy for site-directed and semi-random mutagenesis

2000 • 341 citations

The Transcription Factor NF-ATc1 Regulates Lymphocyte Proliferation and Th2 Cytokine Production

1998 • 340 citations

Fosl1 is a transcriptional target of c-Fos during osteoclast differentiation

2000 • 323 citations

Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun

2000 • 316 citations

Regulation of the differentiation and function of osteoclasts

2000 • 308 citations

Enforced Expression of Bcl-2 in Monocytes Rescues Macrophages and Partially Reverses Osteopetrosis in op/op Mice

1997 • 292 citations

Frequency and predictors of osteoporotic fractures after cardiac or liver transplantation: a follow-up study

2001 • 262 citations

THE DELETERIOUS EFFECTS OF LONG-TERM CYCLOSPORINE A, CYCLOSPORINE G, AND FK506 ON BONE MINERAL METABOLISM IN VIVO

1994 • 250 citations

Genetic control of skeletal development

2001 • 231 citations

Phosphatidylinositol 3-Kinase in Interleukin 1 Signaling

1997 • 231 citations

Linking osteopetrosis and pycnodysostosis: Regulation of cathepsin K expression by the microphthalmia transcription factor family

2001 • 215 citations

Linkage of M-CSF Signaling to Mitf, TFE3, and the Osteoclast Defect in Mitfmi/mi Mice

2001 • 155 citations

Early Events in M-CSF Receptor Signaling

2000 • 128 citations

Regulation of the Murine Nfatc1 Gene by NFATc2

2002 • 124 citations

Conditional requirement for the Flk-1 receptor in the in vitro generation of early hematopoietic cells

1999 • 119 citations

T lymphocytes play a critical role in the development of cyclosporin A-induced osteopenia.

1996 • 111 citations

Characterization of the mouse tartrate-resistant acid phosphatase (trap) gene promoter

1995 • 90 citations

Tissue-specific and Ubiquitous Promoters Direct the Expression of Alternatively Spliced Transcripts from the Calcitonin Receptor Gene

2001 • 65 citations

Recombinant human tumor necrosis factor alpha induces calcium oscillation and calcium-activated chloride current in human neutrophils. The role of calcium/calmodulin-dependent protein kinase.

1993 • 55 citations

Carbonic anhydrase II is an AP‐1 target gene in osteoclasts

2001 • 52 citations

NF-ATc Isoforms Are Differentially Expressed and Regulated in Murine T and Mast Cells

1999 • 29 citations