Early Events in M-CSF Receptor Signaling

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

1997 • 2,747 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

Signal Transduction through MAP Kinase Cascades

1998 • 1,762 citations

Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

1997 • 1,448 citations

Three-dimensional structure of the tyrosine kinase c-Src

1997 • 1,402 citations

Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor

1995 • 1,400 citations

Regulation of transcription by MAP kinase cascades

1996 • 1,330 citations

[2] Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members

1991 • 1,225 citations

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

1997 • 1,190 citations

Crystal structure of the Src family tyrosine kinase Hck

1997 • 1,165 citations

Protein Kinase C Isotypes Controlled by Phosphoinositide 3-Kinase Through the Protein Kinase PDK1

1998 • 1,118 citations

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1994 • 1,071 citations

Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

1998 • 1,050 citations

Phosphoinositide 3-kinases: A conserved family of signal transducers

1997 • 944 citations

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

1997 • 929 citations

Phosphorylation and Activation of p70 ^s6k by PDK1

1998 • 835 citations

Activation of RET as a Dominant Transforming Gene by Germline Mutations of MEN2A and MEN2B

1995 • 826 citations

Inhibition of Stat1-mediated gene activation by PIAS1

1998 • 760 citations

A family of proteins that inhibit signalling through tyrosine kinase receptors

1997 • 648 citations

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.

1996 • 636 citations

Activation of the Sire-family tyrosine kinase Hck by SH3 domain displacement

1997 • 601 citations

Targeted disruption ofSHIPleads to hemopoietic perturbations, lung pathology, and a shortened life span

1998 • 566 citations

p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity.

1996 • 429 citations

Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation.

1994 • 369 citations

Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases.

1993 • 354 citations

Ras-Independent Growth Factor Signaling by Transcription Factor Tyrosine Phosphorylation

1993 • 345 citations

The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early xenopus development

1995 • 330 citations

Cloning of p97/Gab2, the Major SHP2-Binding Protein in Hematopoietic Cells, Reveals a Novel Pathway for Cytokine-Induced Gene Activation

1998 • 313 citations

Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin.

1994 • 302 citations

Lineage Commitment and Maturation in Hematopoietic Cells: The Case for Extrinsic Regulation

1998 • 243 citations

Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3′-kinase SH2 domains: a model for SH2-mediated receptor-target interactions.

1992 • 241 citations

Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor.

1993 • 238 citations

Identification of a Second SH2-Domain-Containing Protein Closely Related to the Phosphatidylinositol Polyphosphate 5-Phosphatase SHIP

1997 • 232 citations

Anti-Colony-Stimulating Factor-1 Antibody Staining in Primary Breast Adenocarcinomas Correlates With Marked Inflammatory Cell Infiltrates and Prognosis

1994 • 226 citations

Do Stem Cells Play Dice?

1998 • 212 citations

Socs1 binds to multiple signalling proteins and suppresses Steel factor-dependent proliferation

1999 • 205 citations

Identification of Major Binding Proteins and Substrates for the SH2-Containing Protein Tyrosine Phosphatase SHP-1 in Macrophages

1998 • 201 citations

CSF-1 signal transduction

1997 • 201 citations

Regulation of Colony-Stimulating Factor 1 Receptor Signaling by the SH2 Domain-Containing Tyrosine Phosphatase SHPTP1

1996 • 199 citations

Sequence Requirements for Binding of Src Family Tyrosine Kinases to Activated Growth Factor Receptors

1995 • 186 citations

Correction by CSF-1 of defects in the osteopetrotic op/op mouse suggests local, developmental, and humoral requirements for this growth factor.

1991 • 183 citations

Colony stimulating factor 1 is required for mammary gland development during pregnancy.

1994 • 177 citations

Do Stem Cells Play Dice?

1998 • 171 citations

Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1

1996 • 168 citations

Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor.

1990 • 167 citations

A Novel SH2-Containing Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase (SHIP2) Is Constitutively Tyrosine Phosphorylated and Associated With src Homologous and Collagen Gene (SHC) in Chronic Myelogenous Leukemia Progenitor Cells

1999 • 156 citations

Src kinases and not JAKs activate STATs during IL-3 induced myeloid cell proliferation

1998 • 151 citations

A Novel SH2-Containing Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase (SHIP2) Is Constitutively Tyrosine Phosphorylated and Associated With src Homologous and Collagen Gene (SHC) in Chronic Myelogenous Leukemia Progenitor Cells

1999 • 128 citations

CSF-1 deficiency in mice results in abnormal brain development

1996 • 128 citations

CSF-1 and its receptor in breast carcinomas and neoplasms of the female reproductive tract

1997 • 121 citations

Shc Interaction with Src Homology 2 Domain Containing Inositol Phosphatase (SHIP) in VivoRequires the Shc-Phosphotyrosine Binding Domain and Two Specific Phosphotyrosines on SHIP

1997 • 121 citations

A binary complex of the catalytic subunit of cAMP-dependent protein kinase and adenosine further defines conformational flexibility

1997 • 119 citations

Colony-stimulating factor 1-induced STAT1 and STAT3 activation is accompanied by phosphorylation of Tyk2 in macrophages and Tyk2 and JAK1 in fibroblasts

1995 • 119 citations

Identification of PTP1C Mutation as the Genetic Defect in Motheaten and Viable Motheaten Mice: A Step toward Defining the Roles of Protein Tyrosine Phosphatases in the Regulation of Hemopoietic Cell Differentiation and Function

1994 • 116 citations

Guidebook to cytokines and their receptors

1995 • 106 citations

Sequential activation of phoshatidylinositol 3-kinase and phospholipase C-γ2 by the M-CSF receptor is necessary for differentiation signaling

1997 • 102 citations

Mona, a novel hematopoietic-specific adaptor interacting with the macrophage colony-stimulating factor receptor, is implicated in monocyte/macrophage development

1998 • 95 citations

CSF-1 stimulated multiubiquitination of the CSF-1 receptor and of Cbl follows their tyrosine phosphorylation and association with other signaling proteins

1999 • 90 citations

Ligand activation causes a phosphorylation-dependent change in platelet-derived growth factor receptor conformation.

1988 • 84 citations

The Human SHIP Gene Is Differentially Expressed in Cell Lineages of the Bone Marrow and Blood

1997 • 83 citations

BIT, an immune antigen receptor‐like molecule in the brain¹

1997 • 82 citations

Interleukin-3 Induces the Association of the Inositol 5-Phosphatase SHIP with SHP2

1997 • 81 citations

The phosphatidylinositol polyphosphate 5-phosphatase SHIP and the protein tyrosine phosphatase SHP-2 form a complex in hematopoietic cells which can be regulated by BCR/ABL and growth factors

1997 • 81 citations

Uncoupling of the proliferation and differentiation signals mediated by the murine macrophage colony-stimulating factor receptor expressed in myeloid FDC-P1 cells.

1995 • 76 citations

Shp-2 has a positive regulatory role in ES cell differentiation and proliferation

1998 • 75 citations

The biology and action of colony stimulating factor-1

1992 • 72 citations

Identification of the ligand-binding regions in the macrophage colony-stimulating factor receptor extracellular domain.

1993 • 70 citations

Formation of STAT5-containing DNA Binding Complexes in Response to Colony-stimulating Factor-1 and Platelet-derived Growth Factor

1996 • 69 citations

c-fms expression is a molecular marker of human acute myeloid leukemias

1988 • 68 citations

c-Src Activates both STAT1 and STAT3 in PDGF-Stimulated NIH3T3 Cells

1997 • 68 citations

The SH2 Domain-containing Inositol 5′-Phosphatase (SHIP) Recruits the p85 Subunit of Phosphoinositide 3-Kinase during FcγRIIb1-mediated Inhibition of B Cell Receptor Signaling

1999 • 64 citations

Catalytic Activities of Glycogenin Additional to Autocatalytic Self-glucosylation

1995 • 63 citations

Macrophage Colony-Stimulating Factor-Induced Tyrosine Phosphorylation of c-fms Proteins Expressed in FDC-P1 and BALB/c 3T3 Cells

1990 • 60 citations

Characterization of a Novel Tyrosine Phosphorylated 100-kDa Protein That Binds to SHP-2 and Phosphatidylinositol 3′-Kinase in Myeloid Cells

1997 • 58 citations

Tyrosine 706 and 807 phosphorylation site mutants in the murine colony-stimulating factor-1 receptor are unaffected in their ability to bind or phosphorylate phosphatidylinositol-3 kinase but show differential defects in their ability to induce early response gene transcription.

1991 • 56 citations

A Novel Spliced Form of SH2-Containing Inositol Phosphatase Is Expressed During Myeloid Development

1999 • 56 citations

The Role of CSF‐1 in Normal and Neoplastic Breast Physiology

1999 • 53 citations

Independent regulation of invasion and anchorage-independent growth by different autophosphorylation sites of the macrophage colony-stimulating factor 1 receptor.

1996 • 52 citations

Identification of a second Grb2 binding site in the v-Fms tyrosine kinase

1997 • 52 citations

Requirement for Y706 of the murine (or Y708 of the human) CSF-1 receptor for STAT1 activation in response to CSF-1.

1996 • 52 citations

c-fms expression is a molecular marker of human acute myeloid leukemias

1988 • 51 citations

Purification and Molecular Cloning of SH2- and SH3-Containing Inositol Polyphosphate-5-Phosphatase, Which Is Involved in the Signaling Pathway of Granulocyte-Macrophage Colony-Stimulating Factor, Erythropoietin, and Bcr-Abl

1997 • 46 citations

Induced expression of c-fms in normal hematopoietic cells shows evidence for both conservation and lineage restriction of signal transduction in response to macrophage colony-stimulating factor

1994 • 46 citations

Identification of a Novel, Tissue-Specific Calpainhtra-3;a Human Homologue of theCaenorhabditis elegansSex Determination Gene

1997 • 37 citations

Phosphorylation of Tyrosine 992, 1068, and 1086 Is Required for Conformational Change of the Human Epidermal Growth Factor Receptor C-Terminal Tail

1999 • 33 citations

Tyrosine Phosphorylation of the Juxtamembrane Domain of the v-Fms Oncogene Product Is Required for Its Association with a 55-kDa Protein

1996 • 30 citations

The Role of CSF-1 in Normal and Neoplastic Breast Physiology

1999 • 28 citations

Macrophage colony-stimulating factor-induced tyrosine phosphorylation of c-fms proteins expressed in FDC-P1 and BALB/c 3T3 cells.

1990 • 23 citations

Tyrosine 807 of the v-Fms oncogene product controls cell morphology and association with p120RasGAP

1995 • 22 citations