Epitope dominance: evidence for reciprocal determinant spreading to glutamic acid decarboxylase in non‐obese diabetic mice

Immunological Memory and Protective Immunity: Understanding Their Relation

1996 • 1,771 citations

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

1992 • 1,200 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

Induction of T _H 1 and T _H 2 Immunity in Neonatal Mice

1996 • 671 citations

Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading

1997 • 558 citations

Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis.

1995 • 522 citations

Determinant spreading and the dynamics of the autoimmune T-cell repertoire

1993 • 467 citations

Immunological Aspects of Experimental Allergic Encephalomyelitis and Multiple Sclerosis

1995 • 381 citations

Interferon Expression in the Pancreases of Patients With Type I Diabetes

1995 • 244 citations

Complete Freund's adjuvant-induced T cells prevent the development and adoptive transfer of diabetes in nonobese diabetic mice.

1993 • 176 citations

Determinant Spreading of T Helper Cell 2 (Th2) Responses to Pancreatic Islet Autoantigens

1997 • 134 citations

Immunization With the Larger Isoform of Mouse Glutamic Acid Decarboxylase (GAD67) Prevents Autoimmune Diabetes in NOD Mice

1994 • 128 citations

Quantitative thresholds of MHC class II I-E expressed on hemopoietically derived antigen-presenting cells in transgenic NOD/Lt mice determine level of diabetes resistance and indicate mechanism of protection.

1996 • 101 citations

Gamma‐interferon causes a selective induction of the lysosomal proteases, cathepsins B and L, in macrophages

1995 • 93 citations

Characterization of T Lymphocytes Infiltrating Human Pancreas Allograft Affected by Isletitis and Recurrent Diabetes

1992 • 93 citations

A Peptide-binding Motif for I-Ag7, the Class II Major Histocompatibility Complex (MHC) Molecule of NOD and Biozzi AB/H Mice

1997 • 90 citations

Molecular characterization of the diabetes-associated mouse MHC class II protein, I-Ag7

1997 • 81 citations

Localization and quantitation of expression of two glutamate decarboxylase genes in pancreatic beta-cells and other peripheral tissues of mouse and rat.

1993 • 80 citations

Identification of a major I-Ek-restricted determinant of hen egg lysozyme: limitations of lymph node proliferation studies in defining immunodominance and crypticity.

1995 • 69 citations

Independent genetic regulation of T-cell and antigen-presenting cell participation in autoimmune islet inflammation.

1998 • 69 citations

Destructive proteolysis by cysteine proteases in antigen presentation of ovalbumin

1995 • 63 citations

Cathepsin D, but not cathepsin B, releases T cell stimulatory fragments from lysozyme that are functional in the context of multiple murine class II MHC molecules

1994 • 62 citations

Antigen Based Therapies to Prevent Diabetes in NOD Mice

1996 • 55 citations

Differential expression of GAD65 and GAD67 in human, rat, and mouse pancreatic islets

1993 • 52 citations

Immunization with the larger isoform of mouse glutamic acid decarboxylase (GAD67) prevents autoimmune diabetes in NOD mice

1994 • 49 citations

Characterization of Novel T-cell Epitopes on 65kDa and 67kDa Glutamic Acid Decarboxylase Relevant in Autoimmune Responses in NOD Mice

1998 • 45 citations

IFN-γ increases cathepsin H mRNA levels in mouse macrophages

1995 • 36 citations

Localization and quantitation of expression of two glutamate decarboxylase genes in pancreatic beta-cells and other peripheral tissues of mouse and rat

1993 • 36 citations

Disruption of the determinant hierarchy on a self-MHC peptide: concomitant tolerance induction to the dominant determinant and priming to the cryptic self-determinant

1994 • 34 citations

The nature of cryptic epitopes within the self-antigen myelin basic protein

1996 • 34 citations

Responses of NOD Congenic Mice to a Glutamic Acid Decarboxylase-derived Peptide

1994 • 26 citations

Mechanism and regulation of antigen processing by cathepsin B

1994 • 24 citations

More efficient peptide binding to MHC class II molecules during cathepsin B digestion of Ii than after Ii release

1994 • 21 citations

Characterization of immunodominant peptide determinants of iddm-associated autoantigens in the nod mouse

1997 • 13 citations