Mechanism and regulation of antigen processing by cathepsin B

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

A hypothetical model of the foreign antigen binding site of Class II histocompatibility molecules

1988 • 1,161 citations

Proteinases in mammalian cells and tissues

1978 • 981 citations

The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity.

1991 • 595 citations

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

1990 • 486 citations

Infectious vaccinia virus recombinants that express hepatitis B virus surface antigen

1983 • 422 citations

Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment

1990 • 377 citations

Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways

1990 • 303 citations

Homology of amino acid sequences of rat liver cathepsins B and H with that of papain.

1983 • 231 citations

Novel epoxysuccinyl peptides A selective inhibitor of cathepsin B, in vivo

1991 • 213 citations

Antigen processing for presentation by class II major histocompatibility complex requires cleavage by cathepsin E

1992 • 207 citations

Human T cell response to the surface antigen of hepatitis B virus (HBsAg). Endosomal and nonendosomal processing pathways are accessible to both endogenous and exogenous antigen.

1988 • 180 citations

Participation of cathepsin B in processing of antigen presentation to MHC class II

1993 • 87 citations

Selective inhibition of antigen presentation to cloned T cells by protease inhibitors

1989 • 84 citations

The generation of immunogenic peptides can be selectively increased or decreased by proteolytic enzyme inhibitors.

1991 • 75 citations

Selective inhibition of antigen presentation to cloned T cells by protease inhibitors.

1988 • 61 citations

Antigen presentation to HLA class II-restricted measles virus-specific T-cell clones can occur in the absence of the invariant chain.

1988 • 58 citations

Inhibitions of Cathepsin B and Cathepsin L by E-64 In Vivo. II. Incorporation of [3H]E-64 into Rat Liver Lysosomes In Vivo1

1982 • 44 citations

Two genetically identical antigen-presenting cell clones display heterogeneity in antigen processing.

1989 • 43 citations

Amino acid sequence of rat liver cathepsin L

1988 • 32 citations

Molecular Basis of Intracellular Regulation of Thiol Proteinase Inhibitors

1985 • 29 citations

Binding of T cell receptor to major histocompatibility complex class II‐peptide complexes at the single‐cell level results in the induction of antigen unresponsiveness (anergy)

1992 • 28 citations

Immunological Studies on Cathepsins B and H from Rat Liver1

1982 • 22 citations

Mechanisms and regulation of lysosomal proteolysis.

1989 • 21 citations

Different Functional Share of Individual Lysosomal Cathepsins in Normal and Pathological Conditions

1993 • 10 citations