More efficient peptide binding to MHC class II molecules during cathepsin B digestion of Ii than after Ii release

Binding of immunogenic peptides to Ia histocompatibility molecules

1985 • 1,209 citations

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

1990 • 486 citations

Isolation and characterization of antigen-la complexes involved in T cell recognition

1986 • 470 citations

The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route

1990 • 445 citations

Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment

1990 • 377 citations

Role for intracellular proteases in the processing and transport of class II HLA antigens.

1988 • 336 citations

Membrane insertion and oligomeric assembly of HLA-DR histocompatibility antigens

1982 • 308 citations

Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways

1990 • 303 citations

Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules.

1991 • 234 citations

Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes.

1992 • 219 citations

Structural model of HLA-DR1 restricted T cell antigen recognition

1988 • 172 citations

Peptide binding inhibits protein aggregation of invariant-chain free class II dimers and promotes surface expression of occupied molecules

1993 • 157 citations

Biosynthesis and glycosylation of the invariant chain associated with HLA-DR antigens.

1982 • 155 citations

Identification of proteases that process distinct epitopes on the same protein.

1989 • 147 citations

Characterization of endogenous peptides bound to purified HLA-DR molecules and their absence from invariant chain-associated alpha beta dimers.

1993 • 145 citations

Antigen presentation enhanced by the alternatively spliced invariant chain gene product p41

1992 • 124 citations

A human Ia cytoplasmic determinant located on multiple forms of invariant chain (gamma, gamma 2, gamma 3).

1984 • 119 citations

Different roles for thiol and aspartyl proteases in antigen presentation of ovalbumin.

1990 • 113 citations

Binding to Ia protects an immunogenic peptide from proteolytic degradation.

1989 • 113 citations

The invariant chain of murine ia antigens: Its glycosylation, abundance and subcellular localization

1981 • 108 citations

Specificity of monoclonal antibodies directed against human and murine class II histocompatibility antigens as analyzed by binding to HLA-deletion mutant cell lines

1985 • 106 citations

HLA B37 determines an influenza A virus nucleoprotein epitope recognized by cytotoxic T lymphocytes.

1986 • 100 citations

Role of cathepsin D in antigen presentation of ovalbumin.

1992 • 93 citations

Selective inhibition of antigen presentation to cloned T cells by protease inhibitors

1989 • 84 citations

Invariant chain retains MHC class II molecules in the endocytic pathway.

1993 • 73 citations

Cathepsin B cleavage of Ii from class II MHC alpha- and beta-chains.

1991 • 68 citations

Inhibition by leupeptin and antipain of the intracellular proteolysis of Ii

1989 • 66 citations

Invariant chain alters the malignant phenotype of MHC class II+ tumor cells.

1992 • 61 citations

Proteolytic enzymes: A practical approach

1990 • 17 citations

Kinetics of Ii synthesis, processing, and turnover in n-butyrate-treated Burkitt's lymphoma cell lines which express or do not express class II antigens and in hairy leukemic cells.

1985 • 12 citations

Binding of radioiodinated influenza virus peptides to class I MHC molecules and to other cellular proteins as analyzed by gel filtration and photoaffinity labeling

1991 • 8 citations