Manipulation of local and systemic host defence in the prevention of perioperative sepsis

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

1991 • 1,950 citations

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

1991 • 1,880 citations

Detection of Circulating Tumor Necrosis Factor after Endotoxin Administration

1988 • 1,711 citations

Treatment of Gram-Negative Bacteremia and Septic Shock with HA-1A Human Monoclonal Antibody against Endotoxin

1991 • 1,611 citations

Multiple Organ Failure Pathophysiology and Potential Future Therapy

1992 • 1,398 citations

Early Enteral Feeding, Compared With Parenteral, Reduces Postoperative Septic Complications The Results of a Meta-Analysis

1992 • 1,384 citations

Multiple-Organ Failure

1985 • 1,314 citations

Perioperative Total Parenteral Nutrition in Surgical Patients

1991 • 1,201 citations

Treatment of Gram-Negative Bacteremia and Shock with Human Antiserum to a MutantEscherichia coli

1982 • 1,062 citations

Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production.

1993 • 945 citations

Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group

1994 • 920 citations

Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo.

1992 • 842 citations

Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors.

1992 • 832 citations

Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia.

1993 • 821 citations

Interleukin 10 protects mice from lethal endotoxemia.

1993 • 807 citations

Is Glutamine a Conditionally Essential Amino Acid?

2009 • 802 citations

Clinical and Metabolic Efficacy of Glutamine-supplemented Parenteral Nutrition after Bone Marrow Transplantation

1992 • 763 citations

A Controlled Clinical Trial of E5 Murine Monoclonal IgM Antibody to Endotoxin in the Treatment of Gram-Negative Sepsis

1991 • 741 citations

Total parenteral nutrition promotes bacterial translocation from the gut

1989 • 740 citations

Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro

1991 • 729 citations

Regulation of the immune response by prostaglandins

1983 • 717 citations

Benefits of Immediate Jejunostomy Feeding after Major Abdominal Trauma???A Prospective, Randomized Study

1986 • 717 citations

Recombinant Human Interleukin 1 Receptor Antagonist in the Treatment of Patients With Sepsis Syndrome

1994 • 714 citations

Oral (n-3) Fatty Acid Supplementation Suppresses Cytokine Production and Lymphocyte Proliferation: Comparison between Young and Older Women

1991 • 704 citations

Effect of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor on Chemotherapy-Induced Myelosuppression

1988 • 689 citations

Biological properties of interleukin 10

1992 • 656 citations

The gut: a central organ after surgical stress.

1988 • 595 citations

Interleukin 1 receptor antagonist. A new member of the interleukin 1 family.

1991 • 589 citations

Postoperative infection and natural killer cell function following blood transfusion in patients undergoing elective colorectal surgery

1992 • 565 citations

Enteral nutrition with supplemental arginine, RNA, and omega-3 fatty acids in patients after operation: immunologic, metabolic, and clinical outcome.

1992 • 544 citations

Cytokine appearance in human endotoxemia and primate bacteremia.

1988 • 528 citations

Tumor necrosis factor-α

1991 • 508 citations

Glutamine Utilization by the Small Intestine

1982 • 495 citations

Initial evaluation of human recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome: A randomized, open-label, placebocontrolled multicenter trial

1994 • 488 citations

Tumor necrosis factor and interleukin-1 serum levels during severe sepsis in humans

1989 • 485 citations

Immune and Metabolic Effects of Arginine in the Surgical Patient

1988 • 436 citations

Beneficial Effects of Aggressive Protein Feeding in Severely Burned Children

1980 • 419 citations

Endotoxemia and Bacteremia During Hemorrhagic Shock The Link Between Trauma and Sepsis?

1988 • 391 citations

Hemorrhagic Shock Induces Bacterial Translocation from the Gut

1988 • 390 citations

The Effect of Parenteral Nutrition on Gastrointestinal Immunity

1985 • 347 citations

Monocyte HLA-DR antigen expression characterizes clinical outcome in the trauma patient

1990 • 347 citations

Clinical significance of translocation.

1994 • 333 citations

Arginine stimulates wound healing and immune function in elderly human beings.

1993 • 314 citations

Immunologic Abnormalities in Patients Receiving Multiple Blood Transfusions

1984 • 311 citations

A Prospective Randomized Trial of Total Parenteral Nutrition After Major Pancreatic Resection for Malignancy

1994 • 303 citations

Soluble cytokine receptors: their role in immunoregulation

1991 • 289 citations

Allelic polymorphisms of human Fc gamma receptor IIA and Fc gamma receptor IIIB. Independent mechanisms for differences in human phagocyte function.

1992 • 288 citations

Maintenance of Small Bowel Mucosa with Glutamine‐Enriched Parenteral Nutrition

1989 • 286 citations

The Genetic Mapping of a Defective Lps Response Gene in C3H/HeJ Mice

1978 • 284 citations

Total Parenteral Nutrition and Bowel Rest Modify the Metabolic Response to Endotoxin in Humans

1989 • 270 citations

Role of the neutrophil in adult respiratory distress syndrome

1993 • 263 citations

Changes in major histocompatibility complex class II expression in monocytes and T cells of patients developing infection after surgery

1993 • 261 citations

Host Resistance in Sepsis and Trauma

1975 • 259 citations

Detrimental effects of perioperative blood transfusion

1995 • 223 citations

Blood transfusion and infectious complications following colorectal cancer surgery

1988 • 220 citations

Hemorrhagic shock-induced bacterial translocation is reduced by xanthine oxidase inhibition or inactivation.

1988 • 207 citations

The Clinical Evaluation of New Drugs for Sepsis

1993 • 202 citations

A systematic study of host defense processes in badly injured patients.

1986 • 182 citations

The gut as source of sepsis after hemorrhagic shock

1988 • 180 citations

A randomized prospective clinical trial to determine the efficacy of interferon-γ in severely injured patients

1992 • 176 citations

Colony-Stimulating Factors and Host Defense

1989 • 155 citations

Postoperative Enteral vs Parenteral Nutrition

1986 • 154 citations

The effect of glutamine-enriched TPN on gut immune cellularity

1992 • 145 citations

Gut barrier function and the surgeon

1990 • 142 citations

Improvement in immune function in ICU patients by enteral nutrition supplemented with arginine, RNA, and menhaden oil is independent of nitrogen balance.

1991 • 138 citations

Macrophage activation by granulocyte/macrophage colony-stimulating factor. Priming for enhanced release of tumor necrosis factor-alpha and prostaglandin E2.

1989 • 136 citations

A Phase II Multicenter, Double-blind, Randomized, Placebo-Controlled Study of Three Dosages of an Immunomodulator (PGG-Glucan) in High-Risk Surgical Patients

1994 • 136 citations

Effect of dietary protein and amino acids on immune function

1990 • 136 citations

Effect of Interferon Gamma on Infection-Related Death in Patients With Severe Injuries

1994 • 129 citations

Human neutrophil bactericidal/permeability-increasing protein reduces mortality rate from endotoxin challenge

1994 • 122 citations

Immunomodulatory mechanisms of arginine.

1988 • 121 citations

Biological variation in the development of sepsis after surgery or trauma

1993 • 119 citations

Bacterial translocation: the influence of dietary variables.

1994 • 119 citations

A Controlled Trial of HA-1A in a Canine Model of Gram-negative Septic Shock

1993 • 117 citations

Recombinant Human Tumor Necrosis Factor Produces Hemodynamic Changes Characteristic of Sepsis and Endotoxemia

1989 • 115 citations

Tumor necrosis factor-alpha blockade prevents neutrophil CD18 receptor upregulation and attenuates acute lung injury in porcine sepsis without inhibition of neutrophil oxygen radical generation.

1993 • 114 citations

Polymorphonuclear Leukocyte Activation

1993 • 113 citations

Role of delayed hypersensitivity in predicting postoperative morbidity and mortality

1979 • 109 citations

Effect of Blood Transfusions on Immune Function

1987 • 108 citations

Involvement of class II MHC molecules in the LPS-induction of IL-1/TNF secretions by human monocytes. Quantitative differences at the polymorphic level.

1989 • 108 citations

Increase in National Hospital Discharge Survey Rates for Septicemia— United States, 1979-1987

1990 • 108 citations

Effects of different lipid emulsions on lymphocyte function during total parenteral nutrition

1991 • 97 citations

Immunologic Effects of Arginine Supplementation in Tumor-bearing and Non-tumor-bearing Hosts

1990 • 96 citations

Effect of indomethacin in vivo on humoral and cellular immunity in humans

1978 • 95 citations

TREATMENT OF INTRA-ABDOMINAL INFECTION WITH GRANULOCYTE COLONY-STIMULATING FACTOR

1992 • 93 citations

The Cytokine Network in the Critically Ill

1992 • 86 citations

Prevention and treatment of endotoxin and sepsis lethality with recombinant human tumor necrosis factor.

1989 • 85 citations

Therapeutic efficacy of granulocyte colony-stimulating factor alone and in combination with antibiotics against Pseudomonas aeruginosa infections in mice

1990 • 82 citations

Postoperative enteral versus parenteral nutritional support in gastrointestinal surgery

1985 • 77 citations

Intravenous lipid emulsions and host defense — a critical review

1991 • 70 citations

Introduction of new technology into critical care practice

1993 • 69 citations

Effect of Transfusion on Immune Function in a Traumatized Animal Model

1987 • 66 citations

Recombinant Human Granulocyte Colony-Stimulating Factor and Pseudomonas Burn Wound Sepsis

1988 • 64 citations

Postoperative depression of host resistance: determinants and effect of peripheral protein-sparing therapy.

1982 • 64 citations

Arginine, protein malnutrition, and cancer

1988 • 62 citations

The Route of Feeding Influences Injury Responses

1990 • 62 citations

Prophylactic administration of interleukin-2 protects mice from lethal challenge with gram-negative bacteria

1987 • 59 citations

Interferon-gamma attenuates hemorrhage-induced suppression of macrophage and splenocyte functions and decreases susceptibility to sepsis.

1992 • 59 citations

Maintenance of Skeletal Muscle Intracellular Glutamine during Standard Surgical Trauma

1985 • 59 citations

Role of Tumor Necrosis Factor in Sepsis and Acute Lung injury

1989 • 57 citations

Glutamine-containing dipeptides as infusion substrates in the septic state.

1989 • 50 citations

Immunotherapy of endotoxemia and septicemia

1993 • 49 citations

Effect of Blood Transfusion on Antigen Presentation Function and on Interleukin 2 Generation

1988 • 48 citations

Effect of Blood Transfusions on Macrophage-Lymphocyte Interaction in an Animal Model

1986 • 44 citations

Factors affecting the stability of L-glutamine in solution

1991 • 40 citations

Clinical Kidney Transplantation

1973 • 28 citations

Intestinal glutamine metabolism during critical illness: a surgical perspective.

1990 • 26 citations

Immunomodulators in the treatment of peritonitis in burned and malnourished animals.

1984 • 24 citations

The enhancement of host defenses against infection--search for the Holy Grail?

1986 • 22 citations

Immunological Alterations Following Simple Hemorrhage

1989 • 19 citations

Adjuvant biological response modifiers after major surgery or trauma

1995 • 17 citations

Nutrition and Inflammatory Events: Highly Unsaturated Fatty Acids ( -3 vs -6) in Surgical Injury

1992 • 15 citations

The effect of route of nutrient administration on the secretory immune system.

1985 • 14 citations

Glutamine-enriched total parenteral nutrition supports gut metabolism

1989 • 10 citations

Composition and functional consequences of fiber and glutamine supplementation of enteral diets

1989 • 8 citations

Transfusion-induced enhancement of prostaglandin and thromboxane release in prospective kidney graft recipients.

1985 • 7 citations

Influence of thymopentin on postsurgical immune deficiency: a clinical pilot study.

1987 • 7 citations

Anti-endotoxin therapy and the management of sepsis

1992 • 5 citations

Gut consumption of intravenously administered fuels.

1984 • 4 citations

Cytokine protection against tumor necrosis factor lethality

1989 • 3 citations

Sensitizing effects and mechanisms of desensitization in regulation of the in vivo response to TNF

1988 • 1 citations

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