Sensitizing effects and mechanisms of desensitization in regulation of the in vivo response to TNF

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Tumor Necrosis Factor (Cachectin) as an Essential Mediator in Murine Cerebral Malaria

1987 • 749 citations

Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host disease.

1987 • 609 citations

Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D-galactosamine-treated mice.

1987 • 560 citations

Synergy between tumor necrosis factor and bacterial products causes hemorrhagic necrosis and lethal shock in normal mice.

1988 • 260 citations

Possible roles of tumor necrosis factor in the pathology of malaria.

1987 • 195 citations

Biology of the interferon system

1983 • 192 citations

Down regulation of the receptors for tumor necrosis factor by interleukin 1 and 4 beta-phorbol-12-myristate-13-acetate.

1987 • 181 citations

Sensitization and desensitization to lethal effects of tumor necrosis factor and IL-1.

1988 • 179 citations

Tumor necrosis factor induction by Sendai virus.

1986 • 177 citations

Preparations of lymphotoxin induce resistance to their own cytotoxic effect.

1984 • 168 citations

MECHANISMS OF ENDOTOXIN TOLERANCE

1963 • 153 citations

Mechanisms of endotoxin tolerance. V. Specificity of the early and late phases of pyrogenic tolerance.

1969 • 118 citations

Tumor necrosis factor and related cytotoxins

1987 • 79 citations

Use of monoclonal antibodies to a human cytotoxin for its isolation and for examining the self-induction of resistance to this protein.

1985 • 71 citations

Early endotoxin tolerance is associated with alterations in bone marrow-derived macrophage precursor pools.

1985 • 62 citations

Mechanisms of Endotoxin Tolerance

1969 • 60 citations

Human tumor necrosis factor-alpha kills herpesvirus-infected but not normal cells.

1986 • 60 citations

Increase of vulnerability to lymphotoxin in cells infected by vesicular stomatitis virus and its further augmentation by interferon

1985 • 49 citations

Enhanced release of lymphotoxins by interferon-treated cells

1983 • 20 citations

Demonstration of α-lymphotoxin in human rejected renal allografts

1981 • 17 citations

Regulation of the Response to Tumor Necrosis Factor

2015 • 5 citations