Biological properties of interleukin 10

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

1991 • 3,812 citations

IL-10 inhibits cytokine production by activated macrophages.

1991 • 2,919 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1987 • 2,492 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

1991 • 1,950 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

1991 • 1,880 citations

Cachectin and tumour necrosis factor as two sides of the same biological coin

1986 • 1,659 citations

Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes.

1992 • 1,259 citations

Macrophage deactivation by interleukin 10.

1991 • 1,253 citations

Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI

1990 • 1,155 citations

Heterogeneity of Cytokine Secretion Patterns and Functions of Helper T Cells

1989 • 1,122 citations

Human TH1 and TH2 subsets: doubt no more

1991 • 1,103 citations

The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice.

1983 • 810 citations

The Role of Helper T Cell Products in Mouse B Cell Differentiation and Isotype Regulation

1988 • 764 citations

Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.

1991 • 752 citations

IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages.

1992 • 709 citations

Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies.

1984 • 652 citations

Interleukin 10 and transforming growth factor beta cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A.

1992 • 641 citations

The LY‐1B Cell Lineage

1986 • 603 citations

Progenitors for Ly-1 B cells are distinct from progenitors for other B cells.

1985 • 599 citations

Dendritic Cells: Features and Functions

1980 • 585 citations

Long-Term Human B Cell Lines Dependent on Interleukin-4 and antibody to CD40

1991 • 554 citations

Expression of Interleukin-10 Activity by Epstein-Barr Virus Protein BCRF1

1990 • 539 citations

Ly‐1 B (B‐1) cells are the main source of B cell‐derived interleukin 10

1992 • 525 citations

Interleukin 10: a novel stimulatory factor for mast cells and their progenitors.

1991 • 514 citations

Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells.

1990 • 487 citations

Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae.

1981 • 477 citations

Increased expression of Ia antigens on resting B cells: an additional role for B-cell growth factor.

1984 • 438 citations

IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity.

1992 • 422 citations

IL-10: a novel cytotoxic T cell differentiation factor.

1991 • 391 citations

IL-10, a novel growth cofactor for mature and immature T cells.

1990 • 371 citations

Interleukin 10 and interferon gamma regulation of experimental Trypanosoma cruzi infection.

1992 • 364 citations

Many of the IgA producing plasma cells in murine gut are derived from self-replenishing precursors in the peritoneal cavity

1989 • 351 citations

Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10

1990 • 347 citations

Anti-IL-6 monoclonal antibodies protect against lethal Escherichia coli infection and lethal tumor necrosis factor-alpha challenge in mice.

1990 • 343 citations

The CD5 B Cell

1989 • 327 citations

Expansion and functional activity of Ly‐1⁺ B cells upon transfer of peritoneal cells into allotype‐congenic, newborn mice

1987 • 318 citations

Treatment of Visceral Leishmaniasis with Pentavalent Antimony and Interferon Gamma

1990 • 313 citations

Production of IL-10 by CD4+ T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth infection.

1991 • 312 citations

The CBA/N Mouse Strain: An Experimental Model Illustration the Influence of the X-Chromosome on Immunity

1982 • 305 citations

Normal, Autoimmune, and Malignant CD5+ B Cells: The LY-1 B Lineage?

1988 • 302 citations

Interleukin-induced increase in Ia expression by normal mouse B cells.

1984 • 293 citations

Development and Physiology of LY‐1 B and its Human Homolog, LEU‐1 B

1986 • 269 citations

Isolation of monoclonal antibodies specific for IL-4, IL-5, IL-6, and a new Th2-specific cytokine (IL-10), cytokine synthesis inhibitory factor, by using a solid phase radioimmunoadsorbent assay.

1990 • 247 citations

IL-10, T lymphocyte inhibitor of human blood cell production of IL-1 and tumor necrosis factor.

1992 • 229 citations

Differential effects of IL-4 and IL-10 on IL-2-induced IFN-γ synthesis and lymphokine-activated killer activity

1992 • 210 citations

Autoantibodies and the physiological role of immunoglobulins

1983 • 203 citations

All T15 Id-positive antibodies (but not the majority of V_HT15⁺ antibodies) are produced by peritoneal CD5⁺ B lymphocytes

1990 • 197 citations

Continuous anti-interleukin 10 antibody administration depletes mice of Ly-1 B cells but not conventional B cells.

1992 • 197 citations

Large numbers of cells in normal mice produce antibody components of isologous erythrocytes

1974 • 178 citations

Functional characterization of monoclonal auto‐antiidiotype antibodies isolated from the early B cell repertoire of BALB/c mice

1986 • 139 citations

Murine monoclonal anti-DNA autoantibodies bind to endogenous bacteria.

1985 • 122 citations

In vivo suppression of perinatal multispecific B cells results in a distortion of the adult B cell repertoire

1986 • 115 citations

In Vitro Responses of CBA/N Mice: Spleen Cells of Mice with an X-Linked Defect that Precludes Immune Responses to Several Thymus-Independent Antigens Can Respond to TNP-Lipopolysaccharide

1976 • 113 citations

Susceptibility of CBA/N Mice to Infection with Salmonella Typhimurium: Influence of the X-Linked Gene Controlling B Lymphocyte Function

1979 • 105 citations

Identification of a novel thymocyte growth-promoting factor derived from B cell lymphomas

1990 • 88 citations

Interleukin-4 enhances anti-IgM stimulation of B cells by improving cell viability and by increasing the sensitivity of b cells to the anti-IgM signal

1991 • 51 citations

Defective Resistance to Plasmodium Yoelii in CBA/N Mice

1979 • 39 citations

Idiotypic Multireactivity of ‘Natural’ Antibodies

1987 • 27 citations

Single cell studies on the role of B-cell stimulatory factor 1 in B-cell activation.

1987 • 17 citations

An alternative pathway of induction of lymphokine production by T lymphocyte clones.

1989 • 16 citations

The mutual selective influences of T- and B-cell repertoires: The idiotypic net (AT) work

1986 • 8 citations