Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/β-catenin signaling pathway in hepatocellular carcinoma cells

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AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

2000 • 943 citations

Zebrafish Prickle, a Modulator of Noncanonical Wnt/Fz Signaling, Regulates Gastrulation Movements

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Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis

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The plasma membrane

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Expression Pattern of Wnt Signaling Components in the Adult Intestine

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The Wnt signaling pathway and its role in tumor development

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Transformation by Wnt family proteins correlates with regulation of beta-catenin.

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A transcriptional response to Wnt protein in human embryonic carcinoma cells

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New targets of β-catenin signaling in the liver are involved in the glutamine metabolism

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β-catenin mutation and overexpression in hepatocellular carcinoma

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Genetics of hepatocellular tumors

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Liver-targeted disruption ofApcin mice activates β-catenin signaling and leads to hepatocellular carcinomas

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Differential Transformation of Mammary Epithelial Cells by Wnt Genes

1994 • 305 citations

β-Catenin Mutations Are Associated with a Subset of Low-Stage Hepatocellular Carcinoma Negative for Hepatitis B Virus and with Favorable Prognosis

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Functional consequences of frizzled-7 receptor overexpression in human hepatocellular carcinoma

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Wnt signaling in lung cancer

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Differential transformation of mammary epithelial cells by Wnt genes.

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Non-canonical Wnt signalling and regulation of gastrulation movements

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Overexpression of orphan G-protein–coupled receptor, Gpr49, in human hepatocellular carcinomas with β-catenin mutations

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Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain.

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Wnt7b Activates Canonical Signaling in Epithelial and Vascular Smooth Muscle Cells through Interactions with Fzd1, Fzd10, and LRP5

2005 • 187 citations

Hepatomegaly in transgenic mice expressing an oncogenic form of beta-catenin.

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Restoration of Wnt-7a Expression Reverses Non-small Cell Lung Cancer Cellular Transformation through Frizzled-9-mediated Growth Inhibition and Promotion of Cell Differentiation

2005 • 162 citations

New aspects of diagnosis and therapy of hepatocellular carcinoma

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Tbx3 Is a Downstream Target of the Wnt/β-Catenin Pathway and a Critical Mediator of β-Catenin Survival Functions in Liver Cancer

2007 • 154 citations

Oncogenic role of the frizzled-7/β-catenin pathway in hepatocellular carcinoma

2005 • 151 citations

Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins.

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Pathway Specificity by the Bifunctional Receptor Frizzled Is Determined by Affinity for Wingless

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Wnt11 controls cell contact persistence by local accumulation of Frizzled 7 at the plasma membrane

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A novel frizzled gene identified in human esophageal carcinoma mediates APC/β-catenin signals

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Beta‐catenin accumulation in the progression of human hepatocarcinogenesis correlates with loss of E‐cadherin and accumulation of p53, but not with expression of conventional WNT‐1 target genes

2003 • 114 citations

Wnt signaling in hepatocellular carcinoma: Analysis of mutation and expression of beta‐catenin, T‐cell factor‐4 and glycogen synthase kinase 3‐beta genes

2003 • 108 citations

Promoter methylation of the secreted frizzled‐related protein 1 gene SFRP1 is frequent in hepatocellular carcinoma

2006 • 104 citations

CTNNB1 mutations and β‐catenin protein accumulation in human hepatocellular carcinomas associated with high exposure to aflatoxin B1†

2001 • 96 citations

HDPR1, a novel inhibitor of the WNT/β-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencing

2004 • 92 citations

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

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Up-regulation of Frizzled-7 (FZD7) in human gastric cancer

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Molecular cloning and characterization of human WNT3

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Activation of β-catenin provides proliferative and invasive advantages in c-myc /TGF-α hepatocarcinogenesis promoted by phenobarbital

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Frizzled/WNT signalling: the insidious promoter of tumour growth and progression

2004 • 50 citations

Expression of potential β-catenin targets, cyclin D1, c-Jun, c-Myc, E-cadherin, and EGFR in chemically induced hepatocellular neoplasms from B6C3F1 mice

2003 • 48 citations

In vitro RNA interference against β-catenin inhibits the proliferation of pediatric hepatic tumors

2006 • 46 citations

Coordinated expression of cyclin D1 and LEF‐1/TCF transcription factor is restricted to a subset of hepatocellular carcinoma

2005 • 30 citations

Molecular Cloning and Chromosomal Localization to 17q21 of the Human WNT3 Gene

1993 • 25 citations