Overexpression of human aspartyl (asparaginyl) beta-hydroxylase is associated with malignant transformation.

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1991 • 1,693 citations

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.

1996 • 717 citations

Solution Structure of a Pair of Calcium-Binding Epidermal Growth Factor-like Domains: Implications for the Marfan Syndrome and Other Genetic Disorders

1996 • 437 citations

Key residues involved in calcium-binding motifs in EGF-like domains

1991 • 282 citations

Risk factors and clinical presentation of hepatobiliary carcinoma in patients with primary sclerosing cholangitis: A case-control study

1998 • 276 citations

Transcriptional Coregulators in Development

1999 • 242 citations

Notch signalling pathway and human diseases

1998 • 190 citations

Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in hepatocellular carcinoma and cholangiocarcinoma.

1996 • 142 citations

Overexpression of Human Insulin Receptor Substrate 1 Induces Cellular Transformation with Activation of Mitogen-Activated Protein Kinases

1996 • 88 citations

cDNA cloning and expression of bovine aspartyl (asparaginyl) beta-hydroxylase.

1992 • 85 citations

Aspartyl beta-hydroxylase: in vitro hydroxylation of a synthetic peptide based on the structure of the first growth factor-like domain of human factor IX.

1989 • 77 citations

Bovine liver aspartyl beta-hydroxylase. Purification and characterization

1991 • 58 citations

A fully active catalytic domain of bovine aspartyl (asparaginyl) beta-hydroxylase expressed in Escherichia coli: characterization and evidence for the identification of an active-site region in vertebrate alpha-ketoglutarate-dependent dioxygenases.

1994 • 56 citations

Partial purification and characterization of bovine liver aspartyl beta-hydroxylase.

1990 • 51 citations

Site-Directed Mutagenesis of Residues in a Conserved Region of Bovine Aspartyl (Asparaginyl) β-Hydroxylase: Evidence That Histidine 675 Has a Role in Binding Fe²⁺

1996 • 48 citations

Cell-surface changes associated with transformation of human hepatocytes to the malignant phenotype.

1988 • 42 citations

Cloning and characterization of a thermolabile v-src gene for use in reversible transformation of mammalian cells.

1992 • 33 citations

Multisite Monoclonal Immunoassay for Dengue Viruses: Detection of Viraemic Human Sera and Interference by Heterologous Antibody

1986 • 24 citations

Factor IX Fukuoka. Substitution of ASN92 by His in the second epidermal growth factor-like domain results in defective interaction with factors VIIa/X.

1993 • 22 citations