Neoplastic Transformation Induced by Insulin Receptor Substrate-1 Overexpression Requires an Interaction with Both Grb2 and Syp Signaling Molecules

Protein modules and signalling networks

1995 • 2,447 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

The insulin signaling system.

1994 • 1,733 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1992 • 1,358 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation.

1992 • 1,030 citations

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1993 • 876 citations

Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells

1987 • 657 citations

The Function of GRB2 in Linking the Insulin Receptor to Ras Signaling Pathways

1993 • 629 citations

Insulin-like growth factors and cancer

1992 • 622 citations

Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor.

1993 • 554 citations

The insulin-like growth factor I receptor: a key to tumor growth?

1995 • 549 citations

Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts.

1994 • 527 citations

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

1994 • 477 citations

IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85.

1992 • 471 citations

Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1.

1993 • 452 citations

Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation.

1990 • 404 citations

The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp

1993 • 384 citations

Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation.

1994 • 369 citations

Expression and function of IRS-1 in insulin signal transmission.

1992 • 331 citations

Insulin-like Growth Factors and Cancer

1995 • 321 citations

The IRS-1 signaling system

1994 • 310 citations

Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin.

1994 • 302 citations

Stimulatory Effects of Yeast and Mammalian 14-3-3 Proteins on the Raf Protein Kinase

1994 • 299 citations

Binding of the Ras Activator Son of Sevenless to Insulin Receptor Substrate-1 Signaling Complexes

1993 • 298 citations

Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor.

1994 • 292 citations

Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling.

1995 • 263 citations

Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction.

1994 • 240 citations

Oncogenes and the strategy of growth factors

1994 • 232 citations

Role of IRS-1-GRB-2 complexes in insulin signaling.

1994 • 215 citations

Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells.

1993 • 207 citations

Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins.

1994 • 205 citations

Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor I receptor mutant.

1994 • 195 citations

Direct interaction between Shc and the platelet-derived growth factor beta-receptor.

1994 • 176 citations

The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors.

1992 • 174 citations

Signal transduction pathways from insulin receptors to Ras. Analysis by mutant insulin receptors.

1994 • 116 citations

Functional expression of insulin receptor substrate-1 is required for insulin-stimulated mitogenic signaling.

1993 • 116 citations

Cloning and increased expression of an insulin receptor substrate-1-like gene in human hepatocellular carcinoma

1994 • 101 citations

Binding of NCK to SOS and Activation of ras-Dependent Gene Expression

1995 • 94 citations

Overexpression of Human Insulin Receptor Substrate 1 Induces Cellular Transformation with Activation of Mitogen-Activated Protein Kinases

1996 • 88 citations

The SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels.

1992 • 85 citations

Ethanol Impairs Insulin Receptor Substrate-1-Mediated Signal Transduction during Rat Liver Regeneration

1994 • 67 citations

Expression and phosphorylation of insulin receptor substrate 1 during rat liver regeneration.

1993 • 61 citations

Expression of insulin receptor substrate-1 in hepatocytes: an investigation using monoclonal antibodies

1994 • 13 citations