Beta‐catenin accumulation in the progression of human hepatocarcinogenesis correlates with loss of E‐cadherin and accumulation of p53, but not with expression of conventional WNT‐1 target genes

β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

1999 • 3,566 citations

Wnt signaling and cancer

2000 • 3,215 citations

A gene hypermethylation profile of human cancer.

2001 • 2,043 citations

The Hedgehog and Wnt signalling pathways in cancer

2001 • 1,374 citations

Terminology of nodular hepatocellular lesions

1995 • 1,105 citations

Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas

1998 • 1,085 citations

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein.

1995 • 1,025 citations

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

2000 • 943 citations

Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors.

1987 • 895 citations

The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene

1999 • 738 citations

The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors

1999 • 679 citations

β-Catenin Regulates the Expression of the Matrix Metalloproteinase-7 in Human Colorectal Cancer

1999 • 665 citations

The Collagen-binding A-domains of Integrins α1β1 and α2β1Recognize the Same Specific Amino Acid Sequence, GFOGER, in Native (Triple-helical) Collagens

2000 • 636 citations

Siah-1, SIP, and Ebi Collaborate in a Novel Pathway for β-Catenin Degradation Linked to p53 Responses

2001 • 586 citations

E-cadherin binding prevents β-catenin nuclear localization and β-catenin/LEF-1-mediated transactivation

1999 • 526 citations

P53, cell cycle control and apoptosis: Implications for cancer

1995 • 467 citations

The adenomatous polyposis coli (APC) tumor suppressor

1997 • 446 citations

Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3.

1998 • 441 citations

Siah-1 Mediates a Novel β-Catenin Degradation Pathway Linking p53 to the Adenomatous Polyposis Coli Protein

2001 • 416 citations

A Putative Catenin–Cadherin System Mediates Morphogenesis of the Caenorhabditis elegans Embryo

1998 • 399 citations

Beta-catenin mutations in human prostate cancer.

1998 • 368 citations

β-catenin mutation and overexpression in hepatocellular carcinoma

2001 • 347 citations

Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma.

1994 • 327 citations

Two Members of the Tcf Family Implicated in Wnt/β-Catenin Signaling during Embryogenesis in the Mouse

1998 • 314 citations

Nuclear Accumulation of Mutated β-Catenin in Hepatocellular Carcinoma Is Associated with Increased Cell Proliferation

1999 • 297 citations

Nuclear Overexpression of the Oncoprotein β-Catenin in Colorectal Cancer is Localized Predominantly at the Invasion Front

1998 • 296 citations

Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes.

2002 • 295 citations

β-Catenin Mutations Are Associated with a Subset of Low-Stage Hepatocellular Carcinoma Negative for Hepatitis B Virus and with Favorable Prognosis

2000 • 292 citations

β-Catenin Mutations Are Frequent in Human Hepatocellular Carcinomas Associated with Hepatitis C Virus Infection

1999 • 275 citations

The E-cadherin gene is silenced by CpG methylation in human hepatocellular carcinomas

1997 • 254 citations

Excess beta -catenin promotes accumulation of transcriptionally active p53

1999 • 236 citations

The Invasion Front of Human Colorectal Adenocarcinomas Shows Co-Localization of Nuclear β-Catenin, Cyclin D1, and p16INK4A and Is a Region of Low Proliferation

2001 • 215 citations

Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation

2001 • 209 citations

Overexpression of β-Catenin Induces Apoptosis Independent of Its Transactivation Function with LEF-1 or the Involvement of Major G1 Cell Cycle Regulators

2000 • 203 citations

Genetic Aspects of Hepatocellular Carcinogenesis

1999 • 193 citations

Histological Typing of Tumours of the Liver

1994 • 174 citations

Immunoreactive e-cadherin, alpha-catenin,beta-catenin, and gamma-catenin proteins in hepatocellular carcinoma: Relationships with tumor grade, clinicopathologic parameters, and patients' survival

2000 • 167 citations

Expression of Nuclear β-Catenin and c-myc Is Correlated with Tumor Size but Not with Proliferative Activity of Colorectal Adenomas

2000 • 166 citations

Frequent down-regulation of E-cadherin by genetic and epigenetic changes in the malignant progression of hepatocellular carcinomas.

2001 • 146 citations

Altered expression of E-cadherin in hepatocellular carcinoma: Correlations with genetic alterations, β-catenin expression, and clinical features

2002 • 146 citations

Amplification of c-<i>myc</i> in Hepatocellular Carcinoma: Correlation with Clinicopathologic Features, Proliferative Activity and p53 Overexpression

1999 • 139 citations

Induction of the primary dorsalizing center in Xenopus by the Wnt/GSK/β-catenin signaling pathway, but not by Vg1, Activin or Noggin

1997 • 137 citations

Regulation of Lef-mediated Transcription and p53-dependent Pathway by Associating β-Catenin with CBP/p300

2000 • 116 citations

Expression of mutant nuclear β-catenin correlates with non-invasive hepatocellular carcinoma, absence of portal vein spread, and good prognosis

2001 • 114 citations

β‐Catenin Accumulation and Mutation of Exon 3 of the β‐Catenin Gene in Hepatocellular Carcinoma

1999 • 105 citations

More Than One Way to Skin a Catenin

2001 • 103 citations

c-myc amplification in hepatocellular carcinoma predicts unfavorable prognosis.

1996 • 83 citations

Helicobacter pylori genotyping in gastric adenocarcinoma and MALT lymphoma by multiplex PCR analyses of paraffin wax embedded tissues

2003 • 80 citations

Disrupted IGF2 promoter control by silencing of promoter P1 in human hepatocellular carcinoma.

1997 • 80 citations

Tumor heterogeneity in small hepatocellular carcinoma: Analysis of tumor cell proliferation, expression and mutation of p53 AND ?-catenin

2001 • 75 citations

Absence of APC gene mutation in the mutation cluster region in hepatocellular carcinoma

1998 • 29 citations