Wnt signaling in disease and in development

β-catenin is a target for the ubiquitin–proteasome pathway

1997 • 2,461 citations

Identification of FAP Locus Genes from Chromosome 5q21

1991 • 2,358 citations

Wnt proteins are lipid-modified and can act as stem cell growth factors

2003 • 2,209 citations

LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development

2001 • 2,203 citations

Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism

2002 • 1,942 citations

Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

1991 • 1,890 citations

High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5

2002 • 1,577 citations

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

1998 • 1,548 citations

A new member of the frizzled family from Drosophila functions as a Wingless receptor

1996 • 1,489 citations

Caught up in a Wnt storm: Wnt signaling in cancer

2003 • 1,473 citations

The Hedgehog and Wnt signalling pathways in cancer

2001 • 1,374 citations

A Mutation in the LDL Receptor–Related Protein 5 Gene Results in the Autosomal Dominant High–Bone-Mass Trait

2002 • 1,279 citations

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3.

1996 • 1,156 citations

Canonical Wnt signals are essential for homeostasis of the intestinal epithelium

2003 • 982 citations

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

2000 • 943 citations

arrow encodes an LDL-receptor-related protein essential for Wingless signalling

2000 • 870 citations

Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β

1998 • 850 citations

Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling Pathway

2001 • 826 citations

Drosophila Tcf and Groucho interact to repress Wingless signalling activity

1998 • 722 citations

Axin-mediated CKI phosphorylation of β-catenin at Ser 45: a molecular switch for the Wnt pathway

2002 • 698 citations

Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1

2003 • 614 citations

The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates

2000 • 596 citations

Wnt/Wingless Signaling Requires BCL9/Legless-Mediated Recruitment of Pygopus to the Nuclear β-Catenin-TCF Complex

2002 • 548 citations

A β-catenin/XTcf-3 complex binds to thesiamois promoter to regulate dorsal axis specification in Xenopus

1997 • 527 citations

Direct Binding of the PDZ Domain of Dishevelled to a Conserved Internal Sequence in the C-Terminal Region of Frizzled

2003 • 498 citations

Axin, a Negative Regulator of the Wnt Signaling Pathway, Directly Interacts with Adenomatous Polyposis Coli and Regulates the Stabilization of β-Catenin

1998 • 489 citations

The Transcriptional Coactivator Cbp Interacts with β-Catenin to Activate Gene Expression

2000 • 468 citations

Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains

2001 • 453 citations

A functional interaction between the histone deacetylase Rpd3 and the corepressor Groucho in Drosophila development

1999 • 441 citations

The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation

2001 • 440 citations

The human F box protein β-Trcp associates with the Cul1/Skp1 complex and regulates the stability of β-catenin

1999 • 432 citations

β-Trcp couples β-catenin phosphorylation-degradation and regulates Xenopus axis formation

1999 • 385 citations

Biochemical characterization of Wnt-Frizzled interactions using a soluble, biologically active vertebrate Wnt protein

1999 • 351 citations

Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4

2003 • 316 citations

Homozygous WNT3 Mutation Causes Tetra-Amelia in a Large Consanguineous Family

2004 • 307 citations

Wg/Wnt Signal Can Be Transmitted through Arrow/LRP5,6 and Axin Independently of Zw3/Gsk3β Activity

2003 • 289 citations

A new nuclear component of the Wnt signalling pathway

2002 • 287 citations

Pygopus, a nuclear PHD-finger protein required for Wingless signaling inDrosophila

2002 • 236 citations

Crystal structure of a β-catenin/Axin complex suggests a mechanism for the β-catenin destruction complex

2003 • 234 citations

Structural basis of the Axin–adenomatous polyposis coli interaction

2000 • 203 citations

Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila

2002 • 199 citations

Deletion of an Amino-Terminal Sequence Stabilizes β-Catenin In Vivo and Promotes Hyperphosphorylation of the Adenomatous Polyposis Coli Tumor Suppressor Protein

1996 • 186 citations

A Functional Interaction

2001 • 6 citations