Immune activation: the role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

1988 • 5,129 citations

Secretory products of macrophages.

1987 • 2,670 citations

Biological basis of the behavior of sick animals

1988 • 2,123 citations

Fever: Role of Pyrogens and Cryogens

1991 • 1,240 citations

Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve

1987 • 1,000 citations

Interleukin-1 Type II Receptor: A Decoy Target for IL-1 That Is Regulated by IL-4

1993 • 972 citations

Effect of Neuropeptides on Production of Inflammatory Cytokines by Human Monocytes

1988 • 929 citations

Biologically active products of stimulated liver macrophages (Kupffer cells)

1990 • 926 citations

Sickness behavior as a new target for drug development

1992 • 866 citations

Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo.

1992 • 842 citations

Interleukin-1 Immunoreactive Innervation of the Human Hypothalamus

1988 • 771 citations

Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro

1991 • 729 citations

A functional anatomical analysis of central pathways subserving the effects of interleukin-1 on stress-related neuroendocrine neurons

1994 • 679 citations

Cytokine-to-brain communication: A review & analysis of alternative mechanisms

1995 • 579 citations

The immune system as a sensory organ.

1984 • 555 citations

Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immune-brain communication

1995 • 510 citations

Characterization of cytokine-induced hyperalgesia

1994 • 506 citations

Peripheral administration of lipopolysaccharide induces the expression of cytokine transcripts in the brain and pituitary of mice

1994 • 502 citations

Staining of glial fibrillary acidic protein (GFAP) in lumbar spinal cord increases following a sciatic nerve constriction injury

1991 • 396 citations

Recent advances in the cellular and molecular biology of mast cells

1989 • 366 citations

The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat

1994 • 340 citations

Unilateral inflammation of the hindpaw in rats as a model of prolonged noxious stimulation: Alterations in behavior and nociceptive thresholds

1988 • 338 citations

Appearance of interleukin-1 in macrophages and in ramified microglia in the brain of endotoxin-treated rats: a pathway for the induction of non-specific symptoms of sickness?

1992 • 337 citations

Interleukin‐8 as a mediator of sympathetic pain

1991 • 333 citations

Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase.

1991 • 326 citations

Neural and biochemical mediators of endotoxin and stress-induced c-fos expression in the rat brain

1994 • 323 citations

Psychoneuroimmunology: The interface between behavior, brain, and immunity.

1994 • 315 citations

A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor.

1990 • 292 citations

Neurocircuitry of illness-induced hyperalgesia

1994 • 288 citations

Psychoneuroimmunology: The interface between behavior, brain, and immunity.

1994 • 281 citations

Bradykinin initiates cytokine‐mediated inflammatory hyperalgesia

1993 • 279 citations

Lipopolysaccharide induces sickness behaviour in rats by a vagal mediated mechanism.

1994 • 276 citations

Involvement of the cystine transport system xc- in the macrophage-induced glutamate-dependent cytotoxicity to neurons.

1994 • 267 citations

Induction of tumor necrosis factor-α mRNA in the brain after peripheral endotoxin treatment: comparison with interleukin-1 family and interleukin-6

1993 • 262 citations

Immobilization stress induces interleukin-1β mRNA in the rat hypothalamus

1991 • 258 citations

Degranulation of human mast cells induces an endothelial antigen central to leukocyte adhesion.

1989 • 252 citations

The role of nitric oxide in the development and maintenance of the hyperalgesia produced by intraplantar injection of carrageenan in the rat

1994 • 230 citations

A complete regulatory loop between the immune and neuroendocrine systems.

1985 • 227 citations

Mechanisms of tumor necrosis factor-α (TNF-α) hyperalgesia

1995 • 222 citations

Role of peri-axonal inflammation in the development of thermal hyperalgesia and guarding behavior in a rat model of neuropathic pain

1995 • 219 citations

Brain interleukin 1 gene expression induced by peripheral lipopolysaccharide administration

1992 • 217 citations

Interleukin 1 receptor blockade attenuates the host inflammatory response.

1990 • 216 citations

Interleukin-1 mediates the behavioral hyperalgesia produced by lithium chloride and endotoxin

1993 • 214 citations

Injury-Related Behavior and Neuronal Plasticity: an Evolutionary Perspective on Sensitization, Hyperalgesia, and Analgesia

1994 • 199 citations

Synergy between tumor necrosis factor α and interleukin-1 in the induction of sickness behavior in mice

1994 • 199 citations

Possible chemical contribution from chromic gut sutures produces disorders of pain sensation like those seen in man

1993 • 197 citations

Interleukin-1β induced corticosterone elevation and hypothalamic NE depletion is vagally mediated

1995 • 196 citations

Cutaneous hyperalgesia induced by peripheral injection of interleukin-1β in the rat

1994 • 193 citations

Neuroanatomy and Physiology of Abdominal Vagal Afferents

2020 • 192 citations

Fever: Causes and consequences

1993 • 188 citations

Localization of type I interleukin-1 receptor mRNA in the rat brain

1994 • 183 citations

Systemic interleukin-1 induces early and late patterns of c-fos mRNA expression in brain

1994 • 169 citations

Characterization of vagal innervation to the rat celiac, suprarenal and mesenteric ganglia

1993 • 160 citations

Natural and recombinant human IL-1 receptor antagonists block the effects of IL-1 on bone resorption and prostaglandin production.

1990 • 154 citations

Mast Cell and Myofibroblast in Wound Healing

1993 • 143 citations

Intracerebroventricular injection of interleukin-1β induces hyperalgesia in rats

1993 • 142 citations

GFAP Expression in Lumbar Spinal Cord of Naive and Neuropathic Rats Treated with MK-801

1994 • 141 citations

Peptidergic pathway in human skin and rat peritoneal mast cell activation

1994 • 133 citations

The Role of Interleukins and Nitric Oxide in the Mediation of Inflammatory Pain and its Control by Peripheral Analgesics

1993 • 131 citations

IL-1 induces IL-1. IV. IFN-gamma suppresses IL-1 but not lipopolysaccharide-induced transcription of IL-1.

1990 • 128 citations

A nitric oxide synthase inhibitor reduces inflammation, down-regulates inflammatory cytokines and enhances interleukin-10 production in carrageenin-induced oedema in mice.

1994 • 122 citations

Differential effects of central and peripheral injection of interleukin-1β on brain c-fos expression and neuroendocrine functions

1992 • 119 citations

Activation of adult human derived microglia by myelin phagocytosis in vitro

1994 • 112 citations

Low pH-induced release of calcitonin gene-related peptide from capsaicin-sensitive sensory nerves: Mechanism of action and biological response

1991 • 111 citations

Blockade of cytokine induced conditioned taste aversion by subdiaphragmatic vagotomy: further evidence for vagal mediation of immune-brain communication

1995 • 111 citations

Intramuscular gold decreases cytokine expression and macrophage numbers in the rheumatoid synovial membrane.

1994 • 109 citations

Involvement of capsaicin-sensitive neurones in hyperalgesia and enhanced opioid antinociception in inflammation

1990 • 100 citations

Substance P enhances the secretion of tumor necrosis factor-alpha from neuroglial cells stimulated with lipopolysaccharide.

1994 • 96 citations

Chapter 28 Endogenous pyrogens in the CNS: role in the febrile response

1992 • 94 citations

The response of central glia to peripheral nerve injury

1993 • 94 citations

Subcutaneous formalin produces centrifugal hyperalgesia at a non-injected site via the NMDA-nitric oxide cascade

1994 • 94 citations

Rat Schwann cells produce interleukin-1

1991 • 91 citations

Acute and conditioned hyperalgesic responses to illness

1994 • 87 citations

Interleukin-1 in adrenal chromaffin cells

1989 • 87 citations

Intracerebroventricular injection of interleukin-1β enhances nociceptive neuronal responses of the trigeminal nucleus caudalis in rats

1994 • 77 citations

ApoE genotype and familial Alzheimer's disease: a possible influence on age of onset in APP717 Val → Ile mutated families

1995 • 77 citations

Pharmacology of Interleukin-1 Actions in the Brain

1994 • 75 citations

Tumor necrosis factor-alpha and fever after peripheral inflammation in the rat

1994 • 71 citations

Illness-induced hyperalgesia is mediated by a spinal NMDA-nitric oxide cascade

1994 • 71 citations

Illness-induced hyperalgesia is mediated by spinal neuropeptides and excitatory amino acids

1994 • 70 citations

Endogenous tachykinins play a role in IL-1-induced neutrophil accumulation: involvement of NK-1 receptors.

1993 • 70 citations

The effect of antirheumatic drugs on interleukin 1 (IL-1) activity and IL-1 and IL-1 inhibitor production by human monocytes.

1990 • 68 citations

Arthritis and mast cell activation

1990 • 64 citations

Distribution and axonal relations of macrophages in a neuroma

1993 • 61 citations

Substance P, Cytokines, and Arthritis

1990 • 59 citations

Neural: Mediation of food aversions and anorexia induced by tumor necrosis factor and tumors

1996 • 57 citations

Structural Types of Spinal Cord Marginal (Lamina I) Neurons Projecting to the Nucleus of the Tractus Solitarius in the Rat

1993 • 57 citations

Role of Cytokines in Infection‐Induced Stressa

1993 • 56 citations

Interleukin‐1‐like immunoreactiveity in pripheral tissues

1987 • 56 citations

Induction of a cellular defense reaction is accompanied by an increase in sensory neuron excitability in Aplysia

1994 • 55 citations

Mechanisms of activation of the pituitary-adrenal axis by tissue injury in the rat

1994 • 49 citations

Neurophysiological and endocrine consequences of immune activity

1989 • 45 citations

Capsaicin effects on non-neuronal plasma membranes

1991 • 43 citations

Inhibition of production of macrophage-derived angiogenic activity by the anti-rheumatic agents gold sodium thiomalate and auranofin

1988 • 42 citations

Cytokines Modulate the Inflammatory Response and Change Permissiveness to Neuronal Adhesion in Injured Mammalian Central Nervous System

1994 • 40 citations

Biological properties of human skin mast cells

1991 • 38 citations

Lipopolysaccharide induces fever and decreases tail flick latency in awake rats

1993 • 36 citations

Structure of cells and nerve endings in abdominal vagal paraganglia of the rat

1976 • 35 citations

A STUDY OF CHEMICALLY INDUCED ACUTE INFLAMMATION IN THE SKIN OF THE RAT

1977 • 34 citations

ACTH response induced in capsaicin‐desensitized rats by intravenous injection of interleukin‐1 or prostaglandin E.

1994 • 33 citations

Effects of colchicine applied to the peripheral nerve on the thermal hyperalgesia evoked with chronic nerve constriction

1993 • 33 citations

The effect of capsaicin application on mast cells in normal human skin

1991 • 32 citations

Neural influences on synovial mast cell density in rat

1990 • 31 citations

Invertebrate cytokines II: release of interleukin-1-like molecules from tunicate hemocytes stimulated with zymosan.

1992 • 30 citations

Interleukin-1α expression is inducible by cholinergic stimulation in the rat adrenal gland

1992 • 29 citations

A behaviorally active dose of lipopolysaccharide increases sensory neuropeptides levels in mouse spinal cord

1994 • 27 citations

Transection or electrical stimulation of the hypoglossal nerve increases glial fibrillary acidic protein immunoreactivity in the hypoglossal nucleus

1989 • 26 citations

Inhibitory effect of morphine on granulocyte stimulation by tumor necrosis factor and substance P

1994 • 26 citations

Brain regions involved in the development of acute phase responses accompanying fever in rabbits.

1989 • 24 citations

Alterations in macrophage collagenase secretion induced by gold sodium thiomalate

1986 • 21 citations

Mast Cell Response to Formaldehyde

1992 • 21 citations

Pharmacologic modulation of TNF production by endotoxin stimulated macrophages:In vitro andin vivo effects of auranofin and other chrysotherapeutic compounds

1989 • 19 citations

Mast Cells and Their Mediators in Immediate and Delayed Immune Reactions

1991 • 17 citations

Suppression of macrophage function by suture materials and anastomotic recurrence of Crohn's disease

1993 • 16 citations

Effect of indomethacin on the growth of colon cancer cells in syngeneic rats

1984 • 14 citations

Neurokinin‐Induced Generation of Interleukin‐1 in a Macrophage Cell Line

1988 • 13 citations

Immunoglobulin E, Mast Cells, Endogenous Antigens, and Arthritis

1991 • 9 citations