Injury-Related Behavior and Neuronal Plasticity: an Evolutionary Perspective on Sensitization, Hyperalgesia, and Analgesia

The genetical theory of natural selection

1930 • 17,330 citations

The expression of the emotions in man and animals.

1872 • 11,160 citations

Pain Mechanisms: A New Theory

1965 • 10,272 citations

On the origin of species by means of natural selection, or, The preservation of favoured races in the struggle for life /

1859 • 7,255 citations

Helplessness: On Depression, Development, and Death

1975 • 6,201 citations

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

1988 • 5,129 citations

The Organization of Behavior; A Neuropsychological Theory

1950 • 5,058 citations

Exaptation—a Missing Term in the Science of Form

1982 • 4,836 citations

The Organization of Behavior: A Neuropsychological Theory

1950 • 4,130 citations

Nebraska Symposium on Motivation: 1955

1957 • 4,104 citations

Behavioural Ecology: An Evolutionary Approach

1992 • 3,875 citations

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

1992 • 3,001 citations

Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones

1984 • 2,822 citations

Evolution and Tinkering

1977 • 2,509 citations

Habituation: A model phenomenon for the study of neuronal substrates of behavior.

1966 • 2,489 citations

The formalin test: an evaluation of the method

1992 • 2,414 citations

The Integrative Action of the Nervous System

1907 • 2,278 citations

Evidence for a central component of post-injury pain hypersensitivity

1983 • 2,103 citations

Habituation: A dual-process theory.

1970 • 2,096 citations

Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence

1993 • 2,006 citations

Induction of c-fos-like protein in spinal cord neurons following sensory stimulation

1987 • 1,975 citations

The induction and maintenance of central sensitization is dependent on N -methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states

1991 • 1,963 citations

Bodily Changes in Pain, Hunger, Fear, and Rage.

1917 • 1,959 citations

A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury

1990 • 1,819 citations

The Ecology and Evolution of Inducible Defenses

1990 • 1,712 citations

Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice

1992 • 1,458 citations

Inhibition of Postsynaptic PKC or CaMKII Blocks Induction But Not Expression of LTP

1989 • 1,335 citations

Conditioning and Associative Learning

1984 • 1,327 citations

Diffuse noxious inhibitory controls (DNIC). I. Effects on dorsal horn convergent neurones in the rat

1979 • 1,325 citations

Hilgard and Marquis' Conditioning and learning

1961 • 1,301 citations

Effects of cAMP Simulate a Late Stage of LTP in Hippocampal CA1 Neurons

1993 • 1,212 citations

The Challenge of Pain

1996 • 1,198 citations

Animal behavior. An evolutionary approach

1978 • 1,175 citations

Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice

1992 • 1,138 citations

Peripheral nerve injury triggers central sprouting of myelinated afferents

1992 • 1,073 citations

Peripheral and spinal mechanisms of nociception.

1987 • 1,025 citations

An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation

1989 • 1,015 citations

Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.

1987 • 1,012 citations

Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.

1969 • 1,011 citations

Nitric oxide (NO) and nociceptive processing in the spinal cord

1993 • 958 citations

Defence in animals: A survey of anti-predator defences

1974 • 954 citations

Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms

1991 • 942 citations

Activity-dependent neuronal plasticity following tissue injury and inflammation

1992 • 933 citations

Peripheral and central mechanisms of cutaneous hyperalgesia

1992 • 896 citations

Different voltage-dependent thresholds for inducing long-term depression and long-term potentiation in slices of rat visual cortex

1990 • 893 citations

Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following c fibre stimulation.

1987 • 836 citations

Sensory Biology of Aquatic Animals

1988 • 821 citations

A perceptual-defensive-recuperative model of fear and pain

1980 • 811 citations

The Ethology of Predation

1976 • 797 citations

Organization of Endogenous Opiate and Nonopiate Pain Control Systems

1982 • 793 citations

Painful neuropathy: altered central processing maintained dynamically by peripheral input

1992 • 770 citations

A Critical Period for Macromolecular Synthesis in Long-Term Heterosynaptic Facilitation in Aplysia

1986 • 767 citations

Diffuse noxious inhibitory controls (DNIC). II. Lack of effect on non-convergent neurones, supraspinal involvement and theoretical implications

1979 • 765 citations

Aversive Conditioning and Learning

1971 • 764 citations

Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation

1990 • 741 citations

The Dawn of Darwinian Medicine

1991 • 707 citations

Behavioral Studies of Pavlovian Conditioning

1988 • 692 citations

A stimulus-response analysis of anxiety and its role as a reinforcing agent.

1939 • 686 citations

Dynamic receptive field plasticity in rat spinal cord dorsal horn following C-primary afferent input

1987 • 667 citations

Evidence for involvement ofN-methylaspartate receptors in ‘wind-up’ of class 2 neurones in the dorsal horn of the rat

1987 • 666 citations

Sensory afferent impulses originate from dorsal root ganglia as well as from the periphery in normal and nerve injured rats

1983 • 658 citations

Bradykinin and inflammatory pain

1993 • 652 citations

Conditioned fear as revealed by magnitude of startle response to an auditory stimulus.

1951 • 649 citations

A Cellular Mechanism of Classical Conditioning in Aplysia : Activity-Dependent Amplification of Presynaptic Facilitation

1983 • 620 citations

Interleukin-1β as a potent hyperalgesic agent antagonized by a tripeptide analogue

1988 • 618 citations

Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: Evidence for a regulatory function of nerve growth factor in vivo

1992 • 603 citations

Adrenergic Excitation of Cutaneous Pain Receptors Induced by Peripheral Nerve Injury

1991 • 599 citations

Ethoexperimental Approaches to the Biology of Emotion

1988 • 567 citations

Predator-Induced Life-History Shifts in a Freshwater Snail

1990 • 567 citations

Specific modalities and receptive fields of sensory neurons in CNS of the leech.

1968 • 564 citations

Responses of Single Dorsal Cord Cells to Peripheral Cutaneous Unmyelinated Fibres

1965 • 564 citations

Nitric Oxide And Carbon Monoxide Produce Activity-Dependent Long-Term Synaptic Enhancement in Hippocampus

1993 • 562 citations

Relative effectiveness of C primary afferent fibers of different origins in evoking a prolonged facilitation of the flexor reflex in the rat

1986 • 561 citations

Nerve growth factor-induced hyperalgesia in the neonatal and adult rat

1993 • 560 citations

Pain Sensations and Reactions

1953 • 553 citations

Spatially Resolved Dynamics of cAMP and Protein Kinase A Subunits in Aplysia Sensory Neurons

1993 • 549 citations

Enkephalin inhibits release of substance P from sensory neurons in culture and decreases action potential duration.

1979 • 546 citations

Nerve growth factor and nociception

1993 • 530 citations

Neuronal Correlates of Habituation and Dishabituation of the Gill-Withdrawal Reflex in Aplysia

1970 • 529 citations

C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia

1994 • 528 citations

Cellular analysis of associative learning.

1987 • 524 citations

Long-term potentiation and long-term depression of primary afferent neurotransmission in the rat spinal cord

1993 • 521 citations

Evidence for spinal N-methyl-d-aspartate receptor involvement in prolonged chemical nociception in the rat

2016 • 516 citations

Synaptic Facilitation and Behavioral Sensitization in Aplysia : Possible Role of Serotonin and Cyclic AMP

1976 • 515 citations

Further evidence for ‘pain-related’ behaviours in a model of unilateral peripheral mononeuropathy

1990 • 504 citations

Expression of c‐fos protein in interneurons and projection neurons of the rat spinal cord in response to noxious somatic, articular, and visceral stimulation

1989 • 500 citations

Peptides and the primary afferent nociceptor

1993 • 486 citations

Neuronal Mechanisms of Habituation and Dishabituation of the Gill-Withdrawal Reflex in Aplysia

1970 • 477 citations

Evidence for spinalN-methyl-d-aspartate receptor involvement in prolonged chemical nociception in the rat

1990 • 458 citations

What is the signal for chromatolysis?

1970 • 454 citations

Excitatory and inhibitory amino acids and peptide-induced responses in acutely isolated rat spinal dorsal horn neurons

1989 • 436 citations

Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: stimulus specificity, behavioral parameters and opioid receptor binding

1988 • 435 citations

Body and Brain: A Trophic Theory of Neural Connections

1992 • 426 citations

The effects of a non-competitive NMDA receptor antagonist, MK-801, on behavioral hyperalgesia and dorsal horn neuronal activity in rats with unilateral inflammation

1992 • 422 citations

Properties of afferent nerve impulses originating from a neuroma

1974 • 422 citations

Morphological Basis of Long-Term Habituation and Sensitization in Aplysia

1983 • 420 citations

Neural mechanisms of startle behavior

1987 • 420 citations

Spontaneous discharge originates in the dorsal root ganglion at the onset of a painful peripheral neuropathy in the rat

1992 • 419 citations

The Developing Brain

1992 • 419 citations

The Emergence of Animals the Cambrian Breakthrough

1990 • 411 citations

Unsuccessful Predation and Evolution

1982 • 406 citations

Cellular neurophysiological approaches in the study of learning.

1968 • 403 citations

Invertebrate Learning and Memory: From Behavior to Molecules

1986 • 403 citations

Neural Mechanisms of Startle Behavior

1984 • 397 citations

Evolution and Learning

2013 • 396 citations

Bradykinin as a pain mediator: receptors are localized to sensory neurons, and antagonists have analgesic actions.

1988 • 396 citations

Learning to Modulate Transmitter Release: Themes and Variations in Synaptic Plasticity

1993 • 395 citations

Expansion of receptive fields of spinal lamina I projection neurons in rats with unilateral adjuvant-induced inflammation: the contribution of dorsal horn mechanisms

1989 • 395 citations

Associative Conditioning of Single Sensory Neurons Suggests a Cellular Mechanism for Learning

1983 • 393 citations

Presynaptic modulation of voltage-dependent Ca ²⁺ current: Mechanism for behavioral sensitization in Aplysia californica

1978 • 385 citations

Cat Behavior: The Predatory and Social Behavior of Domestic and Wild Cats

1979 • 377 citations

Modulation of an NCAM-Related Adhesion Molecule with Long-Term Synaptic Plasticity in Aplysia

1992 • 377 citations

Chronic fear produced by unpredictable electric shock.

1968 • 373 citations

Synaptic transmission: A bidirectional and self-modifiable form of cell-cell communication

1993 • 371 citations

The role of NMDA and non-NMDA excitatory amino acid receptors in the excitation of primate spinothalamic tract neurons by mechanical, chemical, thermal, and electrical stimuli

1992 • 370 citations

Handbook of clinical and experimental hypnosis

1967 • 369 citations

Presynaptic Facilitation as a Mechanism for Behavioral Sensitization in Aplysia

1976 • 369 citations

Onset of a painful peripheral neuropathy in rat: a partial and differential deafferentation and spontaneous discharge in A beta and A delta primary afferent neurons

1992 • 367 citations

The characterization and modelling of antipredator defensive behavior

1990 • 356 citations

Hormonal Control of Behavior: Amines and the Biasing of Behavioral Output in Lobsters

1988 • 355 citations

Activation of cAMP-Responsive genes by stimuli that produce long-term facilitation in aplysia sensory neurons

1993 • 353 citations

Psychophysiology of experimentally induced pain

1993 • 351 citations

Sensory Ecology: How Organisms Acquire and Respond to Information

1992 • 351 citations

Serotonin modulates a specific potassium current in the sensory neurons that show presynaptic facilitation in Aplysia.

1982 • 350 citations

The Genetical Theory of Natural Selection

1932 • 347 citations

On the relation of injury to pain the John J. Bonica Lecture

1979 • 346 citations

Sensory Neurons: Diversity, Development and Plasticity

1993 • 344 citations

Sensory ecology: How organisms acquire and respond to information

1993 • 344 citations

Time course of mechanosensitivity changes in articular afferents during a developing experimental arthritis

1988 • 336 citations

Myelinated afferent fibres innervating the primate skin and their response to noxious stimuli

1968 • 335 citations

Monosynaptic connections made by the sensory neurons of the gill- and siphon-withdrawal reflex in Aplysia participate in the storage of long-term memory for sensitization

1985 • 334 citations

Interleukin‐8 as a mediator of sympathetic pain

1991 • 333 citations

Activity-Dependent Regulation of Conductances in Model Neurons

1993 • 332 citations

Bradykinin and serotonin effects on various types of cutaneous nerve fibres

1974 • 331 citations

Insect defenses: adaptive mechanisms and strategies of prey and predators

1991 • 326 citations

The growth-associated protein gap-43 appears in dorsal root ganglion cells and in the dorsal horn of the rat spinal cord following peripheral nerve injury

1990 • 324 citations

Involvement of nitric oxide in spinally mediated hyperalgesia in the mouse

1992 • 320 citations

Two modes of cutaneous reinnervation following peripheral nerve injury

1979 • 319 citations

Postoperative orthopaedic pain — the effect of opiate premedication and local anaesthetic blocks

1988 • 316 citations

Serotonin-Mediated Endocytosis of apCAM: an Early Step of Learning-Related Synaptic Growth in Aplysia

1992 • 313 citations

Na+ channel immunolocalization in peripheral mammalian axons and changes following nerve injury and neuroma formation

1993 • 312 citations

Short-term changes in neural activity and behaviour

1971 • 307 citations

Evolution and escalation, an ecological history of life

1988 • 305 citations

The NMDA-receptor antagonist CPP abolishes neurogenic ‘wind-up pain’ after intrathecal administration in humans

1992 • 302 citations

Bodily Changes in Pain, Hunger, Fear and Rage.

1929 • 302 citations

Spinal pharmacology of thermal hyperesthesia induced by constriction injury of sciatic nerve. Excitatory amino acid antagonists

1992 • 301 citations

Electrophysiological evidence for a role of nitric oxide in prolonged chemical nociception in the rat

1992 • 298 citations

Substance P and calcitonin gene-related peptide synergistically modulate the gain of the nociceptive flexor withdrawal reflex in the rat

1986 • 292 citations

Long-term memory in Aplysia modulates the total number of varicosities of single identified sensory neurons.

1988 • 291 citations

Marked increase in nitric oxide synthase mRNA in rat dorsal root ganglia after peripheral axotomy: in situ hybridization and functional studies.

1992 • 289 citations

Intrathecal MK-801 and local nerve anesthesia synergistically reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy

1992 • 286 citations

Depletion of serotonin in the nervous system of Aplysia reduces the behavioral enhancement of gill withdrawal as well as the heterosynaptic facilitation produced by tail shock

1989 • 283 citations

EVIDENCE FOR DIFFERENT MECHANISMS OF PRIMARY AND SECONDARY HYPERALGESIA FOLLOWING HEAT INJURY TO THE GLABROUS SKIN

1984 • 282 citations

Axotomy-induced alterations in the electrophysiological characteristics of neurons

1990 • 282 citations

Psychological and Neural Mechanisms of Pain

1988 • 282 citations

Enhancement of spinothalamic neuron responses to chemical and mechanical stimuli following combined micro-iontophoretic application of n-methyl-d-aspartic acid and substance P

1991 • 281 citations

Peripheral Nerve Regeneration

1990 • 279 citations

Inflammation near the nerve cell body enhances axonal regeneration

1991 • 279 citations

Long term alterations in the excitability of the flexion reflex produced by peripheral tissue injury in the chronic decerebrate rat

1984 • 274 citations

Dynamic alterations in the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat spinal cord

1990 • 272 citations

Activity‐Dependent Changes in Rat Ventral Horn Neurons in vitro; Summation of Prolonged Afferent Evoked Postsynaptic Depolarizations Produce a D‐2‐Amino‐5‐Phosphonovaleric Acid Sensitive Windup

1990 • 270 citations

Cross-excitation in dorsal root ganglia of nerve-injured and intact rats

1990 • 270 citations

Differential activation of spinal cord dynorphin and enkephalin neurons during hyperalgesia: evidence using cDNA hybridization

1988 • 268 citations

Caenorhabditis elegans: A new model system for the study of learning and memory

1990 • 266 citations

Evidence that endogenous beta nerve growth factor is responsible for the collateral sprouting, but not the regeneration, of nociceptive axons in adult rats.

1987 • 265 citations

Cyclic AMP-dependent protein kinase closes the serotonin-sensitive K+channels of Aplysia sensory neurones in cell-free membrane patches

1985 • 265 citations

cAMP Evokes Long-Term Facilitation in Aplysia Sensory Neurons That Requires New Protein Synthesis

1988 • 265 citations

Two endogenous neuropeptides modulate the gill and siphon withdrawal reflex in Aplysia by presynaptic facilitation involving cAMP-dependent closure of a serotonin-sensitive potassium channel.

1984 • 261 citations

From metapsychology to molecular biology: explorations into the nature of anxiety

1983 • 260 citations

Excitatory amino acid receptors and nociceptive neurotransmission in rat spinal cord

1990 • 259 citations

Body and brain: A trophic theory of neural connections

1989 • 259 citations

The Deer and the Tiger: A Study of Wildlife in India

1968 • 257 citations

The development of the action potential mechanism of amphibian neurons isolated in culture.

1976 • 257 citations

Stimulation of craniofacial muscle afferents induces prolonged facilitatory effects in trigeminal nociceptive brain-stem neurones

1992 • 253 citations

Roles of PKA and PKC in facilitation of evoked and spontaneous transmitter release at depressed and nondepressed synapses in aplysia sensory neurons

1992 • 253 citations

Primary afferent-evoked synaptic responses and slow potential generation in rat substantia gelatinosa neurons in vitro

1989 • 252 citations

Long-term increase in the levels of c-jun mRNA and jun protein-like immunoreactivity in motor and sensory neurons following axon damage

1991 • 249 citations

Lesion-Induced Neuronal Plasticity in Sensorimotor Systems

1981 • 247 citations

The spectrum of fiber loss in a model of neuropathic pain in the rat: an electron microscopic study

1991 • 247 citations

An Ecological Theory for the Sudden Origin of Multicellular Life in the Late Precambrian

1973 • 246 citations

The escape behavior of the cockroachPeriplaneta americana

1978 • 242 citations

Morphine-sensitive and morphine-insensitive actions of C-fibre input on the rat spinal cord

1986 • 240 citations

Inhibitor of protein synthesis blocks longterm behavioral sensitization in the isolated gill‐withdrawal reflex of Aplysia

1989 • 240 citations

Ongoing activity in peripheral nerve: Injury discharge

1974 • 240 citations

Modulation of neuropathic pain behavior in rats by spinal disinhibition and NMDA receptor blockade of injury discharge

1991 • 236 citations

Differential roles of NMDA and non-NMDA receptor activation in induction and maintenance of thermal hyperalgesia in rats with painful peripheral mononeuropathy

1992 • 236 citations

Dynorphin expression and Fos-like immunoreactivity following inflammation induced hyperalgesia are colocalized in spinal cord neurons

1991 • 235 citations

Nerve growth activities in rat peripheral nerve

1982 • 235 citations

Selective expression of Jun proteins following axotomy and axonal transport block in peripheral nerves in the rat: evidence for a role in the regeneration process

1991 • 235 citations

Mechanoafferent neurons innervating tail of Aplysia. I. Response properties and synaptic connections

1983 • 234 citations

A molecular mechanism for long-term sensitization in Aplysia

1987 • 234 citations

Sensitization of the acoustic startle reflex by footshock.

1989 • 233 citations

Changing patterns of c-fos induction in spinal neurons following thermal cutaneous stimulation in the rat

1990 • 231 citations

Sensory biology of aquatic animals

1989 • 230 citations

Target-Dependent Structural Changes Accompanying Long-Term Synaptic Facilitation in Aplysia Neurons

1990 • 230 citations

The Deer and the Tiger: a Study of Wildlife in India

1967 • 227 citations

Pain Sensations and Reactions

1953 • 227 citations

Sensory Neurons; Diversity, Development and Plasticity

1994 • 226 citations

Enhancement of synaptic transmission by dendritic potentials in chromatolysed motoneurones of the cat

1970 • 225 citations

THE AFFERENT NERVOUS SYSTEM FROM A NEW ASPECT

1905 • 221 citations

Enhanced responses of spinothalamic tract neurons to excitatory amino acids accompany capsaicin-induced sensitization in the monkey

1992 • 220 citations

Mechanically insensitive afferents (MIAs) in cutaneous nerves of monkey

1991 • 219 citations

Expression of GAP-43, a rapidly transported growth-associated protein, and class II beta tubulin, a slowly transported cytoskeletal protein, are coordinated in regenerating neurons

1989 • 217 citations

Death Feigning by Ducks in Response to Predation by Red Foxes (Vulpes fulva)

1975 • 216 citations

Facilitatory transmitter causes a selective and prolonged increase in adenosine 3':5'-monophosphate in sensory neurons mediating the gill and siphon withdrawal reflex in Aplysia

1982 • 215 citations

An Analysis of Dishabituation and Sensitization of The Gill-Withdrawal Reflex In Aplysia

1971 • 213 citations

Natural Enemies: The Population Biology of Predators, Parasites and Diseases

1992 • 209 citations

Regulatory subunits of cAMP-dependent protein kinases are degraded after conjugation to ubiquitin: a molecular mechanism underlying long-term synaptic plasticity.

1993 • 208 citations

Inhibitor of adenosine 3':5'-monophosphate-dependent protein kinase blocks presynaptic facilitation in Aplysia

1982 • 207 citations

Associative conditioning analog selectively increases cAMP levels of tail sensory neurons in Aplysia.

1985 • 206 citations

Factors influencing peripheral nerve stimulation produced inhibition of primate spinothalamic tract cells

1984 • 202 citations

Is contiguity detection in classical conditioning a system or a cellular property? Learning in Aplysia suggests a possible molecular site

1988 • 202 citations

Neurogenetic Dissection of Learning and Short-Term Memory in Drosophila

1988 • 202 citations

The transcription factors c-JUN, JUN D and CREB, but not FOS and KROX-24, are differentially regulated in axotomized neurons following transection of rat sciatic nerve

1992 • 199 citations

The Initial Processing of Pain and Its Descending Control: Spinal and Trigeminal Systems

1992 • 198 citations

Responses of spinothalamic tract cells to mechanical and thermal stimulation of skin in rats with experimental peripheral neuropathy

1992 • 197 citations

Identified serotonergic neurons LCB1 and RCB1 in the cerebral ganglia of Aplysia produce presynaptic facilitation of siphon sensory neurons

1989 • 196 citations

Mechanoafferent neurons innervating tail of Aplysia. II. Modulation by sensitizing stimulation

1983 • 194 citations

Enhancement of the responses of ascending tract cells in the cat spinal cord by acute inflammation of the knee joint

1987 • 192 citations

Short-Term and Long-Term Plasticity and Physiological Differentiation of Crustacean Motor Synapses

1986 • 192 citations

Sensory Functions of the Skin in Primates

1976 • 190 citations

Do insects feel pain? — A biological view

1984 • 189 citations

Cutaneous hyperalgesia: contributions of the peripheral and central nervous systems to the increase in pain sensitivity after injury

1987 • 188 citations

Short-Term Changes in Neural Activity and Behaviour

1972 • 188 citations

Proximate and Developmental Aspects of Antipredator Behavior

1993 • 187 citations

Hyperalgesia and allodynia

1992 • 186 citations

Identification of Mauthner-initiated response patterns in goldfish: Evidence from simultaneous cinematography and electrophysiology

1981 • 186 citations

Parasites and the Evolution of Host Social Behavior

1993 • 186 citations

Receptive fields and response properties of mechanoreceptor neurons innervating siphon skin and mantle shelf in Aplysia.

1974 • 183 citations

Contribution of protein kinase C to central sensitization and persistent pain following tissue injury

1992 • 182 citations

Inhibitors of protein and RNA synthesis block structural changes that accompany long-term heterosynaptic plasticity in Aplysia

1992 • 181 citations

Simulation of synaptic depression, posttetanic potentiation, and presynaptic facilitation of synaptic potentials from sensory neurons mediating gill-withdrawal reflex in Aplysia

1985 • 181 citations

Evolutionary and comparative aspects of nociception

1988 • 181 citations

Behavioral Dissociation of Dishabituation, Sensitization, and Inhibition in Aplysia

1988 • 180 citations

CELLULAR RESPONSES TO AXOTOMY AND TO RELATED PROCEDURES

1974 • 179 citations

Characterization of a Pathway for Ciliary Neurotrophic Factor Signaling to the Nucleus

1993 • 177 citations

Receptive fields of rat lamina 1 projection cells move to incorporate a nearby region of injury

1984 • 176 citations

Genetic Dissection of Behavior in Paramecium

1975 • 173 citations

Long-Term Sensitization in Aplysia : Biophysical Correlates in Tail Sensory Neurons

1987 • 171 citations

Neuronal inhibition by the peptide FMRFamide involves opening of S K+ channels

1987 • 170 citations

Enhancement by histamine of NMDA-mediated synaptic transmission in the hippocampus

1993 • 169 citations

Additional component in the cellular mechanism of presynaptic facilitation contributes to behavioral dishabituation in Aplysia.

1986 • 168 citations

Presynaptic Inhibition: Transmitter and Ionic Mechanisms

1979 • 168 citations

The role of injury discharge in the induction of neuropathic pain behavior in rats

1991 • 167 citations

Associative Learning in Aplysia : Evidence for Conditioned Fear in an Invertebrate

1981 • 165 citations

Evolution and Learning

1991 • 164 citations

Frequency-dependent release of peptide cotransmitters from identified cholinergic motor neurons in Aplysia.

1989 • 162 citations

Up-regulation of opioid gene expression in spinal cord evoked by experimental nerve injuries and inflammation

1991 • 161 citations

Neural changes in acute arthritis in monkeys. I. Parallel enhancement of responses of spinothalamic tract neurons to mechanical stimulation and excitatory amino acids

1992 • 161 citations

Bacterial behaviour

1975 • 160 citations

Evidence for the involvement of opioid neuropeptides in the adherence and migration of immunocompetent invertebrate hemocytes.

1989 • 160 citations

Conditioned fear-induced opiate analgesia on the Formalin test: Evidence for two aversive motivational systems

1982 • 159 citations

Unresponsive afferent nerve fibres in the sural nerve of the rat.

1991 • 159 citations

Invertebrate Neuropeptides: Native and Naturalized

1983 • 158 citations

THE LOCAL EXTENSION OF NERVE FIBRES INTO DENERVATED AREAS OF SKIN

1941 • 156 citations

Nerve growth factor: acceleration of the rate of wound healing in mice.

1980 • 155 citations

Origin and early evolution of the Metazoa

1993 • 154 citations

Parallel processing of short‐term memory for sensitization in Aplysia

1988 • 153 citations

Autonomous Developmental Control of Human Embryonic Globin Gene Switching in Transgenic Mice

1990 • 151 citations

Chemically stimulated feeding behavior in marine animals

1986 • 150 citations

Time course of structural changes at identified sensory neuron synapses during long-term sensitization in Aplysia

1989 • 150 citations

5-HT modulates protein synthesis and the expression of specific proteins during long-term facilitation in aplysia sensory neurons

1989 • 149 citations

Psychological and Neural Mechanisms of Pain

1988 • 146 citations

Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model

1991 • 145 citations

Physiology and morphology of multireceptive neurons with C-afferent fiber inputs in the deep dorsal horn of the rat lumbar spinal cord

1987 • 144 citations

Sensory input and central excitation and inhibition in the blowfly.

1965 • 141 citations

Tail autotomy, functional conflicts and their resolution by a salamander

1977 • 140 citations

The effect of carrageenan-induced inflammation on the sensitivity of unmyelinated skin nociceptors in the rat

1987 • 140 citations

Evidence that axoplasmic transport of trophic factors is involved in the regulation of peripheral nerve fields in salamanders

1973 • 138 citations

Odors released by stressed rats produce opioid analgesia in unstressed rats.

1985 • 138 citations

The effect of epidermal growth factor on wound healing in mice

1982 • 137 citations

Evolution in Nervous Systems

1991 • 136 citations

Effect of salivary glands on wound contraction in mice

1979 • 135 citations

Odors released by stressed rats produce opioid analgesia in unstressed rats.

1985 • 135 citations

Responses of spinothalamic tract neurons to mechanical and thermal stimuli in an experimental model of peripheral neuropathy in primates

1992 • 134 citations

Intracellular Injection of cAMP Induces a Long-Term Reduction of Neuronal K ⁺ Currents

1988 • 134 citations

Combined application of excitatory amino acids and substance P produces long-lasting changes in responses of primate spinothalamic tract neurons

1993 • 134 citations

Spinal substance p and N-methyl-d-aspartate receptors are coactivated in the induction of central sensitization of the nociceptive flexor reflex

1992 • 133 citations

Tail shock produces inhibition as well as sensitization of the siphon-withdrawal reflex of Aplysia: possible behavioral role for presynaptic inhibition mediated by the peptide Phe-Met-Arg-Phe-NH2.

1987 • 133 citations

Serotonergic modulation of two potassium currents in the pleural sensory neurons of Aplysia

1989 • 133 citations

Contributions of Two Types of Calcium Channels to Synaptic Transmission and Plasticity

1990 • 132 citations

Pain and hyperalgesia after intradermal injection of bradykinin in humans

1991 • 132 citations

Persistent and transcriptionally-dependent increase in protein phosphorylation in long-term facilitation ofAplysia sensory neurons

1989 • 131 citations

Ciliary neurotrophic factor prevents retrograde neuronal death in the adult central nervous system.

1993 • 130 citations

Distributed processing of sensory information in the leech. II. Identification of interneurons contributing to the local bending reflex

1990 • 128 citations

Is large myelinated fiber loss associated with hyperalgesia in a model of experimental peripheral neuropathy in the rat?

1993 • 127 citations

The postshock activity burst

1982 • 127 citations

5-Hydroxytryptamine and Related Indolealkylamines

1966 • 127 citations

Potentiation of muscle contraction: a possible modulatory function of an identified serotonergic cell in Aplysia

1975 • 125 citations

Serotonin produces long-term changes in the excitability of Aplysia sensory neurons in culture that depend on new protein synthesis

1987 • 123 citations

Serotonin and octopamine have opposite modulatory effects on the crayfish's lateral giant escape reaction

1983 • 122 citations

Intracellular responses of dorsal horn cells to cutaneous and sural nerve A and C fiber stimuli

1971 • 121 citations

Hebbian induction of long-term potentiation of Aplysia sensorimotor synapses: partial requirement for activation of an NMDA-related receptor

1994 • 120 citations

Long-term sensitization in Aplysia increases the number of presynaptic contacts onto the identified gill motor neuron L7.

1988 • 120 citations

Natural enemies: The population biology of predators, parasites and diseases

1993 • 119 citations

Long-Term Facilitation in Aplysia Involves Increase in Transmitter Release

1988 • 119 citations

Afferent neurons mediating escape swimming of the marine mollusc,Tritonia

1976 • 119 citations

Facilitatory transmitters and cAMP can modulate accommodation as well as transmitter release in Aplysia sensory neurons: Evidence for parallel processing in a single cell

1986 • 119 citations

Action-potential duration and the modulation of transmitter release from the sensory neurons of Aplysia in presynaptic facilitation and behavioral sensitization

1986 • 118 citations

Synaptic Transmission: Long-Lasting Potentiation by a Postsynaptic Mechanism

1976 • 118 citations

Sensitization of nociceptive cutaneous nerve fibers from the rat's tail by noxious mechanical stimulation

1987 • 117 citations

Mechanisms of pain arising from articular tissues

1991 • 116 citations

Multiple sensory neuronal correlates of site-specific sensitization in Aplysia

1987 • 116 citations

Membrane responses and changes in cAMP levels in Aplysia sensory neurons produced by serotonin, tryptamine, FMRFamide and small cardioactive peptideB (SCPB)

1985 • 116 citations

Facilitatory role of calcitonin gene-related peptide (CGRP) on excitation induced by substance P (SP) and noxious stimuli in rat spinal dorsal horn neurons. An iontophoretic study in vivo

1991 • 113 citations

Classical conditioning in Aplysia californica.

1979 • 112 citations

Involvement of protein kinase C in serotonin-induced spike broadening and synaptic facilitation in sensorimotor connections of Aplysia

1992 • 112 citations

Effects of spinal kappa-opioid receptor agonists on the responsiveness of nociceptive superficial dorsal horn neurons

1991 • 110 citations

Octopamine—a neurohormone with presynaptic activity-dependent effects at crayfish neuromuscular junctions

1983 • 108 citations

A comparative study of the changes in receptive-field properties of multireceptive and nocireceptive rat dorsal horn neurons following noxious mechanical stimulation

1989 • 108 citations

Subthreshold components of the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat lumbar spinal cord

1989 • 107 citations

Neuronal organization of escape swimming inTritonia

1977 • 107 citations

Hundreds of neurons in the Aplysia abdominal ganglion are active during the gill-withdrawal reflex.

1989 • 106 citations

Brief exposure to a natural predator, the short-tailed weasel, induces benzodiazepine-sensitive analgesia in white-footed mice

1988 • 105 citations

Physiological consequences of a peptide cotransmitter in a crayfish nerve-muscle preparation

1987 • 104 citations

The development of chronic mechanical hyperalgesia, autotomy and collateral sprouting following sciatic nerve section in rat

1989 • 103 citations

The role of neurokinin and N-methyl-d-aspartate receptors in synaptic transmission from capsaicin-sensitive primary afferents in the rat spinal cord in vitro

1993 • 102 citations

Sensory cells in the spinal cord of the sea lamprey

1971 • 102 citations

Sensitizing stimuli cause translocation of protein kinase C in Aplysia sensory neurons.

1990 • 102 citations

cAMP modulates multiple K+ currents, increasing spike duration and excitability in Aplysia sensory neurons.

1992 • 102 citations

Membrane properties and conduction velocity in sensory neurones following central or peripheral axotomy

1977 • 102 citations

Differential effects of cAMP and serotonin on membrane current, action-potential duration, and excitability in somata of pleural sensory neurons of Aplysia

1990 • 102 citations

Ontogeny of Prey-Killing Behavior in Canidae

1969 • 101 citations

Peripheral inflammation is associated with increased dynorphin immunoreactivity in both projection and local circuit neurons in the superficial dorsal horn of the rat lumbar spinal cord

1989 • 99 citations

Spatiotemporal Distribution of Ca²⁺ Following Axotomy and Throughout the Recovery Process of Cultured Aplysia Neurons

1993 • 99 citations

Distribution of serotonin-immunoreactive cell bodies and processes in the abdominal ganglion of mature Aplysia

1985 • 98 citations

Facilitation of the responses of primate spinothalamic cells to cold and to tactile stimuli by noxious heating of the skin

1982 • 98 citations

Basic fibroblast growth factor in the hypoglossal system: Specific retrograde transport, trophic, and lesion‐related responses

1992 • 97 citations

Electrical Properties of Insect Neurones with Spiking and Non-Spiking Somata: Normal, Axotomized, and Colchicine-Treated Neurones

1979 • 97 citations

Resealing of the proximal and distal cut ends of transected axons: Electrophysiological and ultrastructural analysis

1993 • 97 citations

Learning of Leg Position by Headless Insects

1962 • 97 citations

Prolonged C-fibre mediated facilitation of the flexion reflex in the rat is not due to changes in afferent terminal or motoneurone excitability

1986 • 96 citations

Pharmacological Dissociation of Modulatory Effects of Serotonin in Aplysia Sensory Neurons

1991 • 96 citations

Site-specific sensitization of defensive reflexes in Aplysia: a simple model of long-term hyperalgesia

1987 • 95 citations

Distribution of serotonin-immunoreactivity in juvenile Aplysia

1984 • 94 citations

Electrical Responses of Insect Central Neurons: Augmentation by Nerve Section or Colchicine

1972 • 94 citations

Pseudo-conditioning without paired stimulation encountered in attempted backward conditioning.

1938 • 94 citations

Calcium and the control of synaptic strength by learning

1981 • 92 citations

A reflex behavior mediated by monosynaptic connections between hair afferents and motoneurons in the larval tobacco hornworm,Manduca sexta

1987 • 92 citations

Serotonin immunoreactivity of neurons in the gastropod Aplysia californica

1986 • 92 citations

Similar Neuronal Alterations Induced by Axonal Injury And Learning in Aplysia

1991 • 91 citations

Modulation of a transient K+ current in the pleural sensory neurons of Aplysia by serotonin and cAMP: implications for spike broadening.

1992 • 90 citations

P<scp>art</scp> VIII. P<scp>sychopharmacological and</scp> B<scp>iological</scp> E<scp>ffects</scp> O<scp>f</scp> O<scp>pioid</scp> P<scp>eptides</scp> I<scp>n</scp> A<scp>nimals</scp>: THE ROLE OF ENDORPHINS IN STRESS‐INDUCED ANALGESIA

1982 • 89 citations

Hundreds of neurons in the Aplysia abdominal ganglion are active during the gill-withdrawal reflex

1989 • 89 citations

On the Ability of Prey to Recognize Predators

1980 • 89 citations

Contribution of polysynaptic pathways in the mediation and plasticity of Aplysia gill and siphon withdrawal reflex: evidence for differential modulation

1992 • 88 citations

Behavioral choice and habituation in the marine mollusk Pleurobranchaea californica MacFarland (Gastropoda, Opisthobranchia)

1971 • 87 citations

The Effect of Toe Clipping on Survival in Fowler's Toad (Bufo woodhousei fowleri)

1972 • 87 citations

Functional and structural changes in mammalian sympathetic neurones following colchicine application to post‐ganglionic nerves.

1976 • 85 citations

Behavioural and Mechanosensory Neurone Responses to Skin Stimulation in Leeches

1982 • 85 citations

Dorsal root potentials and afferent input to the spinal cord in rats with an experimental peripheral neuropathy

1992 • 85 citations

Effects of stimulus frequency and intensity on habituation and sensitization in acute spinal cat

1969 • 85 citations

Long-term sensitization training in Aplysia leads to an increase in the expression of BiP, the major protein chaperon of the ER.

1992 • 85 citations

Effect of neurokinin A, substance P and calcitonin gene related peptide in peripheral hyperalgesia in the rat paw

1991 • 85 citations

Modification of the responses of primate spinothalamic neurons to mechanical stimulation by excitatory amino acids and an N-methyl-d-aspartate antagonist

1991 • 84 citations

Tachykinins modulate multiple ionic conductances in voltage-clamped rat spinal dorsal horn neurons

1989 • 83 citations

Directional control and the functional organization of defensive responses inAplysia

1986 • 83 citations

Inking in Aplysia californica. III. Two different synaptic conductance mechanisms for triggering central program for inking

1977 • 83 citations

Blockade of retrograde axonal transport delays the onset of metabolic and morphologic changes induced by axotomy

1982 • 82 citations

Long-term potentiation of Aplysia sensorimotor synapses in cell culture: regulation by postsynaptic voltage

1994 • 82 citations

Long-Term sensitization training in Aplysia leads to an increase in calreticulin, a major presynaptic calcium-binding protein

1992 • 80 citations

Prolonged noxious mechanical stimulation of the rat's tail: responses and encoding properties of dorsal horn neurones.

1988 • 80 citations

The contributions of protein kinase A and protein kinase C to the actions of 5-HT on the L-type Ca2+ current of the sensory neurons in Aplysia

1993 • 79 citations

Spinal c-fos induction by sensory stimulation in neonatal rats

1990 • 78 citations

The problems of evolution

1985 • 78 citations

Impulse Activity Evokes Precocious Sprouting of Nociceptive Nerves into Denervated Skin

1984 • 78 citations

Dishabituation and sensitization emerge as separate processes during development in Aplysia

1988 • 77 citations

The dorsal cell, one class of primary sensory neuron in the lamprey spinal cord. I. Touch, pressure but no nociception — a physiological study

1988 • 76 citations

Preliminary observations on escape swimming and giant neurons in Aglantha digitale (Hydromedusae: Trachylina)

1980 • 76 citations

Long-Term Synaptic Changes Produced by a Cellular Analog of Classical Conditioning in Aplysia

1990 • 76 citations

Collateral sprouting in skin and sensory recovery after nerve injury in man

1987 • 76 citations

Protein synthesis during acquisition of long-term facilitation is needed for the persistent loss of regulatory subunits of the Aplysia cAMP-dependent protein kinase.

1990 • 76 citations

Long-term enhancement produced by activity-dependent modulation of Aplysia sensory neurons

1985 • 75 citations

cAMP induces long-term morphological changes in sensory neurons ofAplysia

1991 • 75 citations

A quantitative analysis of 2-D gels identifies proteins in which labeling is increased following long-term sensitization in Aplysia

1988 • 75 citations

Electrophysiological characteristics of hamster dorsal root ganglion cells and their response to axotomy

1988 • 75 citations

Imaging terminals of Aplysia sensory neurons demonstrates role of enhanced Ca2+ influx in presynaptic facilitation

1993 • 74 citations

Strychnine-enhanced transsynaptic degeneration of dorsal horn neurons in rats with an experimental painful peripheral neuropathy

1989 • 74 citations

Activity-dependent potentiation of recurrent inhibition: a mechanism for dynamic gain control in the siphon withdrawal reflex of Aplysia

1993 • 73 citations

Selective activation of Ca(2+)-activated PKCs in Aplysia neurons by 5- HT

1992 • 72 citations

A signal sequence mediates the retrograde transport of proteins from the axon periphery to the cell body and then into the nucleus

1992 • 71 citations

Expanded receptive fields of cutaneous mechanoreceptor cells after single neurone deletion in leech central nervous system.

1982 • 71 citations

The central representation of an aversive event maintains the opioid and nonopioid forms of analgesia.

1987 • 71 citations

Facilitatory and inhibitory transmitters modulate calcium influx during action potentials in Aplysia sensory neurons

1990 • 70 citations

Suppression of C-fibre discharges upon repeated heat stimulation may explain characteristics of concomitant pain sensations

1984 • 70 citations

Peripheral modulation of mechanosensitivity in primary afferent neurons

1987 • 68 citations

Central nervous sensitization and dishabituation of reflex action in an insect by the neuromodulator octopamine

1984 • 66 citations

Identification and initial characterization of a cluster of command and pattern-generating neurons underlying respiratory pumping in Aplysia californica

1983 • 66 citations

Neurite outgrowth and selection of new electrical connections by adult Helisoma neurons

1982 • 66 citations

Normal and precocious sprouting of heat nociceptors in the skin of adult rats

1987 • 65 citations

Parametric studies of the response decrement produced by mechanical stimuli in the protozoan, Stentor coeruleus

1969 • 64 citations

Modulation of a steady-state Ca2+-activated, K+ current in tail sensory neurons of Aplysia: role of serotonin and cAMP

1989 • 64 citations

Classical conditioning, sensitization and habituation in the spinal cat

1975 • 64 citations

Identified facilitator neurons L29 and L28 are excited by cutaneous stimuli used in dishabituation, sensitization, and classical conditioning of Aplysia

1989 • 64 citations

A regulatory subunit of the cAMP-dependent protein kinase down-regulated in aplysia sensory neurons during long-term sensitization

1992 • 63 citations

Mediators of the Inflammatory Process

1990 • 63 citations

Spider leg autotomy induced by prey venom injection: An adaptive response to “pain”?

1983 • 63 citations

Antibacterial properties of saliva: Role in maternal periparturient grooming and in licking wounds

1990 • 62 citations

Interactions between excitatory amino acids and tachykinins in the rat spinal dorsal horn

1993 • 62 citations

Effects of central or peripheral axotomy on membrane properties of sensory neurones in the petrosal ganglion of the cat.

1987 • 62 citations

Long‐term facilitation and long‐term adaptation at synapses of a crayfish phasic motoneuron

1985 • 62 citations

Distribution and axonal relations of macrophages in a neuroma

1993 • 61 citations

Frog neurobiology: a handbook

1977 • 61 citations

Pharmacology of the effects of bradykinin, serotonin, and histamine on the release of calcitonin gene-related peptide from C-fiber terminals in the rat trachea

1993 • 60 citations

Two Functional Effects of Decreased Conductance EPSP's: Synaptic Augmentation and Increased Electrotonic Coupling

1976 • 60 citations

The effects of phorbol ester on slowly conducting afferents of the cat's knee joint

1993 • 60 citations

Neuromuscular transmission in a primitive insect: Modulation by octopamine, and catch-like tension

1984 • 60 citations

Distribution of the growth associated protein GAP-43 in the central processes of axotomized primary afferents in the adult rat spinal cord; presence of growth cone-like structures

1991 • 59 citations

Two forms of sensitization of the local bending reflex of the medicinal leech

1991 • 59 citations

Branch-specific heterosynaptic facilitation in Aplysia siphon sensory cells

1984 • 58 citations

Selective modulation of spike duration by serotonin and the neuropeptides, FMRFamide, SCPB, buccalin and myomodulin in different classes of mechanoafferent neurons in the cerebral ganglion of Aplysia

1989 • 58 citations

Role of serotonin and cyclic AMP on facilitation of the fast conducting system activity in the leechHirudo Medicinalis

1982 • 57 citations

Differential effects of serotonin depletion on sensitization and dishabituation in the leech, Hirudo medicinalis

1992 • 57 citations

Participation of excitatory amino acid receptors in the slow excitatory synaptic transmission in rat spinal dorsal horn

1991 • 56 citations

Excitation and Conduction in Immature Nerve Fibers of the Developing Chick

1957 • 56 citations

The initial stages of neural regeneration are dependent upon intracellular calcium levels

1992 • 56 citations

Differential effects of serotonin, FMRFamide, and small cardioactive peptide on multiple, distributed processes modulating sensorimotor synaptic transmission in Aplysia

1992 • 55 citations

Evidence for opioid and non-opioid forms of stress-induced analgesia in the snail, Cepaea nemoralis

1987 • 55 citations

Induction of a cellular defense reaction is accompanied by an increase in sensory neuron excitability in Aplysia

1994 • 55 citations

An ethological model for the study of activation and interaction of pain, memory and defensive systems in the attacked mouse. Role of endogenous opioids

1990 • 55 citations

Stress Induced Analgesia plays an adaptive role in the organization of behavioral responding

1988 • 54 citations

Alterations in membrane potential after axotomy at different distances from the soma of an identified neuron and the effect of depolarization on neurite outgrowth and calcium channel expression

1993 • 54 citations

Cyclic adenosine 3′5′-monophosphate potentiates excitatory amino acid and synaptic responses of rat spinal dorsal horn neurons

1992 • 54 citations

Injury-induced vesiculation and membrane redistribution in squid giant axon

1990 • 52 citations

Involvement of pedal peptide in locomotion in Aplysia: Modulation of foot muscle contractions

1990 • 52 citations

Selective short- and long-term effects of serotonin, small cardioactive peptide, and tetanic stimulation on sensorimotor synapses of Aplysia in culture

1990 • 51 citations

Behavioral recovery associated with central nervous system regeneration in the snailMelampus

1985 • 51 citations

Evidence That the Loss of Homeostatic Signals Induces Regeneration-Associated Alterations in Neuronal Gene Expression

1993 • 50 citations

Pain, suffering, and anxiety in animals and humans

1991 • 50 citations

Rapid amplification and facilitation of mechanosensory discharge in Aplysia by noxious stimulation

1993 • 48 citations

Nonuniform expression of habituation in the activity of distinct classes of neurons in the Aplysia abdominal ganglion

1993 • 47 citations

Dynorphin A: in vivo release in the spinal cord of the cat

1990 • 46 citations

The central representation of an aversive event maintains the opioid and nonopioid forms of analgesia.

1987 • 46 citations

448-Detector optical recording system: development and application to Aplysia gill-withdrawal reflex

1992 • 46 citations

A Functional, Cellular, and Evolutionary Model of Nociceptive Plasticity in Aplysia

1991 • 45 citations

Axonal sprouting and laminin appearance after destruction of glial sheaths.

1993 • 43 citations

Boyd's Textbook of Pathology

1991 • 43 citations

Sensitization of the crayfish lateral giant escape reaction

1986 • 42 citations

Facilitation at neuromuscular junctions: contribution to habituation and dishabituation of the Aplysia gill withdrawal reflex.

1977 • 41 citations

Postsynaptic mechanism of withdrawal reflex sensitization in the snail

1983 • 41 citations

Stimuli that produce sensitization lead to elevation of cyclic AMP levels in tail sensory neurons ofAplysia

1986 • 40 citations

Connectivity of identified central synapses in the cricket is normal following regeneration and blockade of presynaptic activity

1991 • 40 citations

A motor neuron‐specific epitope and the low‐affinity nerve growth factor receptor display reciprocal patterns of during development, axotomy, and regeneration

1993 • 40 citations

An arthropod NMDA receptor

1991 • 40 citations

Slow depolarization produced by associative conditioning of Aplysia sensory neurons may enhance Ca2+ entry

1983 • 40 citations

Distribution and morphology of nociceptive cells in the CNS of three species of leeches

1984 • 40 citations

Induction of heat shock protein 70 mRNA in adult hamster facial nuclear groups following axotomy of the facial nerve

1989 • 39 citations

Endogenous axoplasmic proteins and proteins containing nuclear localization signal sequences use the retrograde axonal transport/nuclear import pathway in Aplysia neurons

1993 • 39 citations

Chemically and electrically coupled interneurons mediate respiratory pumping in Aplysia

1989 • 39 citations

Evidence that fine primary afferent axons innervate a wider territory in the superficial dorsal horn following peripheral axotomy

1992 • 38 citations

Characteristics of instinctive behaviour and learning in reflex activity of the frog

1963 • 38 citations

Information storage in the nervous system of Aplysia: specific proteins affected by serotonin and cAMP.

1989 • 38 citations

Serotoninergic varicosities make synaptic contacts with pleural sensory neurons of Aplysia

1991 • 38 citations

Intracellular stimulation of sensory cells elicits swimming activity in the medicinal leech

1987 • 37 citations

Transient, axotomy‐induced changes in the membrane properties of crayfish central neurones.

1981 • 37 citations

Comparative analysis of hyperexcitability and synaptic facilitation induced by nerve injury in two populations of mechanosensory neurones of Aplysia californica

1994 • 37 citations

Receptive Fields and Properties of A New Cluster Of Mechanoreceptor Neurons Innervating the Mantle Region and the Branchial Cavity of the Marine MolluskAplysia California

1991 • 35 citations

Nonhabituation processes affect stimulus specificity of response habituation in the crab Chasmagnathus granulatus.

1991 • 35 citations

Fatigue and adaptation in unmyelinated (C) polymodal nociceptors to mechanical and thermal stimuli applied to the monkey's face

1976 • 35 citations

Functional uncoupling of inhibitory interneurons plays an important role in short-term sensitization of Aplysia gill and siphon withdrawal reflex

1993 • 34 citations

The effects of opioid and FMRF-amide peptides on thermal behavior in the snail

1985 • 34 citations

Neuronal modulation of foot and body-wall contractions in Aplysia californica

1992 • 33 citations

Neural mechanisms of hyperalgesia

1992 • 33 citations

Increased synthesis of cyclic AMP and short-term plastic changes in the segmental ganglia of the LeechHirudo medicinalis

1982 • 33 citations

Nerve growth factor accelerates the early cellular events associated with wound healing

1985 • 33 citations

Post-tetanic potentiation inAplysia sensory neurons

1984 • 33 citations

Associative aspects of conditioned analgesia evoked by a discrete CS

1985 • 32 citations

Biochemical correlates of short-term sensitization in Aplysia: temporal analysis of adenylate cyclase stimulation in a perfused-membrane preparation.

1987 • 32 citations

Chapter 9 Synaptic plasticity and behavioral modifications in the marine mollusk Aplysia

1990 • 32 citations

Morphology and odor sensitivity of regenerated snail tentacles

1983 • 31 citations

Self-Actualization in Junior High Students: A Pilot Study

1993 • 31 citations

Tail pinch and handling facilitate feeding behavior in Aplysia

1981 • 29 citations

Catalepsy Induced by Body Pinch: Relation to Stress‐Induced Analgesia

1986 • 29 citations

Developmental assembly of learning in Aplysia

1989 • 28 citations

Differential expression of pseudoconditioning and sensitization by siphon responses in Aplysia: novel response selection after training

1988 • 28 citations

The effect of selective desalivation on wound healing in mice

1991 • 28 citations

Motor controls of opaline secretion in Aplysia californica

1980 • 28 citations

Collateral sprouting of nociceptive C-fibers after cut or capsaicin treatment of the sciatic nerve in adult rats

1988 • 28 citations

Modulation of mechanosensory threshold in Aplysia by serotonin, small cardioactive peptideB (SCPB), FMRFamide, acetylcholine, and dopamine

1989 • 27 citations

Non-associative behavioural modifications in the polychaete Nereis diversicolor

1966 • 27 citations

Nonhabituation processes affect stimulus specificity of response habituation in the crab Chasmagnathus granulatus..

1991 • 26 citations

Chemocommunication among prey and predator species

1986 • 25 citations

Crayfish Escape Behaviour: Commands for Fast Movement Inhibit Postural Tone and Reflexes, and Prevent Habituation of Slow Reflexes

1979 • 25 citations

Serotonin mimics tail shock in producing transient inhibition in the siphon withdrawal reflex of Aplysia

1991 • 25 citations

Response to axotomy of an identified leech neuron, in vivo and in culture

1984 • 25 citations

Sprouting and retraction of neurites by undamaged adult molluscan neurons

1984 • 25 citations

Neuroethological studies of reflex plasticity in intact Aplysia.

1984 • 24 citations

Conspecific Wounding in Free-Ranging R. Norvegicus From Stable and Unstable Populations

1985 • 23 citations

Evolution of Abilities to Regenerate Neurons in Central Nervous Systems

1980 • 23 citations

Plasticity in the Somatosensory System of Developing and Mature Mammals — The Effects of Injury to the Central and Peripheral Nervous System

1991 • 22 citations

Humoral factors released during trauma ofAplysia body wall

1989 • 22 citations

Neuroethological studies of reflex plasticity in intact Aplysia..

1984 • 22 citations

Boyd’s Textbook of Pathology

1991 • 20 citations

Response-specific inhibition during general facilitation of defensive responses in Aplysia..

1994 • 20 citations

Predator–Prey Relationships

2017 • 19 citations

Classical Conditioning Alters the Efficacy of Identified Gill Motor Neurones in Producing Gill Withdrawal Movements in Aplysia

1988 • 19 citations

Activity-dependent depression of mechanosensory discharge in Aplysia

1993 • 19 citations

Serotonin acts in the synaptic region of sensory neruons in Aplysia to enhance transmitter release

1989 • 19 citations

Regeneration of afferent axons into discrete tracts within peripheral nerves in the leech

1987 • 19 citations

Common set of proteins inAplysia sensory neurons affected by an in vitro analogue of long-term sensitization training, 5-HT and cAMP

1991 • 18 citations

Formation of Pseudo-Conditioned Responses in the Cat

1940 • 18 citations

Forward conditioning, backward conditioning, pseudoconditioning, and adaptation to the conditioned stimulus.

1941 • 18 citations

Localization of brain function and neurochemical correlates of learning in the mud crab, Eurypanopeus depressus (Decapoda)

1983 • 18 citations

The Effects of Microenvironment on the Redifferentiation of Regenerating Neurones: Neurite Architecture, Acetylcholine Receptors and Ca2+ Channel Distribution

1987 • 17 citations

Humoral factors released during trauma ofAplysia body wall

1989 • 17 citations

Analysis of decreased conductance serotonergic response in Aplysia ink motor neurons

1985 • 17 citations

Regeneration of an identified central neuron in the cricket. II. Electrical and morphological responses of the soma

1983 • 17 citations

Membrane properties of primary sensory neurones of the cat after peripheral reinnervation.

1988 • 16 citations

Changes of ornithine decarboxylase activity in dorsal root ganglion cells after axon injury: Possible relationship to alterations in neuronal chromatin

1987 • 16 citations

Axotomy-induced ornithine decarboxylase activity in the mouse dorsal root ganglion is inhibited by the vinca alkaloids

1988 • 16 citations

New Growth Elicited in Adult Leech Mechanosensory Neurones by Peripheral Axon Damage

1989 • 16 citations

Trophic regulation of action potential in bullfrog sympathetic neurones

1992 • 16 citations

Neuromodulatory effects of acetylcholine and serotonin on the sensitivity of leech mechanoreceptors

1991 • 14 citations

Early Changes in Nuclear Proteins Following Axotomy

1990 • 13 citations

On the presence and localization of epidermal and nerve growth factors in human whole saliva

1989 • 12 citations

Effect of conditioned stimulus intensity on visually conditioned heart rate change in the pigeon: A sensitization mechanism.

1974 • 11 citations

Neurobiological Background of Pain and Analgesia: The Attempt at Revaluation According to Position of the Organism's Adaptive Activity

1990 • 11 citations

Collateral sprouting of sensory axons in the hairy skin of the trunk: a morphological study in adult rats

1987 • 11 citations

Spontaneous Activity in Afferent and Efferent Fibers after Chronic Axotomy: Response to Potassium Channel Blockade

1988 • 10 citations

The impact of shock on reactivity to a tactile stimulus

1990 • 10 citations

Selection for central excitation in Drosophila melanogaster.

1985 • 10 citations

Delayed-onset sensitization emerges after dishabituation in developing Aplysia

1992 • 9 citations

The reappearance of a developmental stage-specific antigen in adult regenerating neurons of the cockroach

1989 • 7 citations

Selection for central excitation in Drosophila melanogaster..

1985 • 7 citations

Adaptive Pain Inhibition in Murine Resiiient-Intruder Interactions

1988 • 7 citations

Habituation, sensitization and the effect of serotonin on the eyestalk withdrawal reflex of Cancer magister

1990 • 6 citations

Differential time course of the response to axotomy induced by cut or crush in the leech AP cell

1986 • 6 citations

Predators and predation: the struggle for life in the animal world

1990 • 5 citations

"Simple" nervous systems: An international symposium

1975 • 4 citations

Neurophysiological properties of primary touch sensitive neurones in the gastropod molluscLymnaea stagnalis (L.)

1975 • 3 citations

Why Sadie Licks Her Wounds

1988 • 2 citations

Electrophysiological and neurochemical investigation of longterm sensitization in snails

1988 • 1 citations