Interleukin-1 mediates the behavioral hyperalgesia produced by lithium chloride and endotoxin

A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

1941 • 3,174 citations

Interleukin-1 and interleukin-1 antagonism

1991 • 2,276 citations

Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence

1993 • 2,006 citations

Biology of interleukin 1

1988 • 1,547 citations

Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist

1990 • 1,095 citations

Sickness behavior as a new target for drug development

1992 • 866 citations

Brainstem Control of Spinal Pain-Transmission Neurons

1978 • 820 citations

Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro

1991 • 729 citations

Interleukin-1β as a potent hyperalgesic agent antagonized by a tripeptide analogue

1988 • 618 citations

Interleukin 1 induces prolonged L-arginine-dependent cyclic guanosine monophosphate and nitrite production in rat vascular smooth muscle cells.

1991 • 403 citations

Appearance of interleukin-1 in macrophages and in ramified microglia in the brain of endotoxin-treated rats: a pathway for the induction of non-specific symptoms of sickness?

1992 • 337 citations

Functions and mechanisms of interleukin 1 in the brain

1991 • 325 citations

Different receptor mechanisms mediate the pyrogenic and behavioral effects of interleukin 1.

1992 • 319 citations

Endotoxin-induced activation of cerebral catecholamine and serotonin metabolism: comparison with interleukin-1.

1992 • 300 citations

Brain macrophages synthesize interleukin‐1 and interleukin‐1 mRNAs in vitro

1988 • 286 citations

The interleukins ¹

1989 • 276 citations

The intrathecal administration of excitatory amino acid receptor antagonists selectively attenuated carrageenan-induced behavioral hyperalgesia in rats

1992 • 242 citations

An IL-1 inhibitor from human monocytes. Production and characterization of biologic properties.

1989 • 208 citations

Contribution of protein kinase C to central sensitization and persistent pain following tissue injury

1992 • 182 citations

Convulsants induce interleukin-1β messenger RNA in rat brain

1990 • 158 citations

Arachidonic Acid Increases Inositol Phospholipid Metabolism and Glutamate Release in Synaptosomes Prepared from Hippocampal Tissue

1990 • 132 citations

Antagonism at the glycine site on the NMDA receptor reduces spinal nociception in the rat

1991 • 126 citations

Is there a facilitating component to central pain modulation?

1992 • 99 citations

Interleukin-1 induces analgesia in mice by a central action

1988 • 97 citations

Involvement of spinal opioid systems in footshock-induced analgesia: Antagonism by naloxone is possible only before induction of analgesia

1982 • 62 citations

Parallel activation of multiple spinal opiate systems appears to mediate ‘non-opiate’ stress-induced analgesias

1992 • 60 citations

Autoradiographic analysis of 125I-substance P binding in rat spinal cord following chronic constriction injury of the sciatic nerve

1992 • 51 citations

Role of Symbol and opiate receptors in nociception during and after ischaemia in rats

1992 • 49 citations

Vagal modulation of nociception

1992 • 47 citations

Interleukin-1 potentiates bradykinin- and TNFα-induced PGE2 release

1989 • 35 citations

Endogenous pain facilitory systems Antianalgesia and hyperalgesia

1992 • 30 citations