Characterization of cytokine-induced hyperalgesia

A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

1941 • 3,174 citations

Secretory products of macrophages.

1987 • 2,670 citations

Chronic catheterization of the spinal subarachnoid space

1976 • 2,244 citations

Biologically active products of stimulated liver macrophages (Kupffer cells)

1990 • 926 citations

Sickness behavior as a new target for drug development

1992 • 866 citations

Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo.

1992 • 842 citations

DIOGENES SYNDROME

1975 • 685 citations

Interleukin-1β as a potent hyperalgesic agent antagonized by a tripeptide analogue

1988 • 618 citations

Neutrophil chemotactic factor produced by lipopolysaccharide (LPS)-stimulated human blood mononuclear leukocytes: partial characterization and separation from interleukin 1 (IL 1).

1987 • 613 citations

Cells of the hepatic sinusoid

1989 • 589 citations

Visualization and characterization of interleukin 1 receptors in brain.

1987 • 451 citations

Heterogeneity of rat liver and spleen macrophages in gadolinium chloride–induced elimination and repopulation

1992 • 363 citations

Interleukin 1: the first interleukin

1990 • 342 citations

Bidirectional transport of interleukin-1 alpha across the blood-brain barrier

1989 • 323 citations

The central distribution of the cervical vagus nerve and gastric afferent and efferent projections in the rat

1982 • 294 citations

A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor.

1990 • 292 citations

Neurocircuitry of illness-induced hyperalgesia

1994 • 288 citations

Antagonism of stimulation-produced analgesia by p-CPA, a serotonin synthesis inhibitor

1972 • 284 citations

Synthesis of interleukin 1/endogenous pyrogen in the brain of endotoxin-treated mice: a step in fever induction?

1984 • 279 citations

The interleukins ¹

1989 • 276 citations

Modulation of IL-1-induced neutrophil migration by dexamethasone and lipocortin 1.

1993 • 223 citations

Interleukin-1 mediates the behavioral hyperalgesia produced by lithium chloride and endotoxin

1993 • 214 citations

Suppression of fever after lesions of the anteroventral third ventricle in guinea pigs

1983 • 212 citations

Neuroanatomy and Physiology of Abdominal Vagal Afferents

2020 • 192 citations

Occurrence of interleukin-1 in cerebrospinal fluid of the conscious cat

1988 • 178 citations

In the Rat, Interleukin- lα and -β Stimulate Adrenocorticotropin and Catecholamine Release*

1989 • 174 citations

Behavioural effects of peripherally injected interleukin-1: role of prostaglandins

1991 • 143 citations

Migration of neutrophils across endothelial monolayers is stimulated by treatment of the monolayers with interleukin-1 or tumor necrosis factor-alpha.

1989 • 135 citations

Electron microscopic study of Kupffer-cell phagocytosis blockade induced by gadolinium chloride.

1980 • 132 citations

Interleukin-1 enhances pain reflexes. Mediation through increased prostaglandin E2 levels

1988 • 114 citations

Interleukin-1 induces analgesia in mice by a central action

1988 • 97 citations

Characterization of interleukin-1 and interleukin-6 production by hepatic endothelial cells and macrophages

1993 • 96 citations

Subcutaneous formalin produces centrifugal hyperalgesia at a non-injected site via the NMDA-nitric oxide cascade

1994 • 94 citations

Role of the Kupffer cells in local and systemic immune responses

1981 • 92 citations

Acute and conditioned hyperalgesic responses to illness

1994 • 87 citations

Interleukin-1 in adrenal chromaffin cells

1989 • 87 citations

Androgen-dependent vasopressinergic neurotransmission attenuates interleukin-1-induced sickness behavior

1991 • 85 citations

STUDY ON THE POSSIBLE ENTRY OF BACTERIAL ENDOTOXIN AND PROSTAGLANDIN E₂ INTO THE CENTRAL NERVOUS SYSTEM FROM THE BLOOD

1979 • 81 citations

A light and electron microscopic examination of the vagal hepatic branch of the rat

1987 • 78 citations

Inhibition by neuropeptides of interleukin‐1β‐induced, prostaglandin‐independent hyperalgesia

1989 • 77 citations

THE FATE OF 32P-LABELLED BACTERIAL LIPOPOLYSACCHARIDE IN LABORATORY ANIMALS

1956 • 74 citations

Involvement of spinal opioid systems in footshock-induced analgesia: Antagonism by naloxone is possible only before induction of analgesia

1982 • 62 citations

Excessive gastric retention by vagotomized rats and rabbits given a solid diet

1977 • 61 citations

Properties of Interleukin-1 as a complete secretagogue for human neutrophils

1985 • 58 citations

Interleukin‐1‐like immunoreactiveity in pripheral tissues

1987 • 56 citations

Phagocytosis of Particulate Activators of the Alternative Complement Pathway: Effects of Fibronectin

1986 • 50 citations

Conditioned responses to a taste conditioned stimulus paired with lithium chloride administration.

1990 • 47 citations

Human neutrophil activation with interleukin-1

1987 • 46 citations

Conditioned responses to a taste conditioned stimulus paired with lithium chloride administration.

1990 • 46 citations

Corticotropin releasing hormone, interleukin-1α, and tumor necrosis factor-α share characteristics of stress mediators

1991 • 39 citations

Hyperalgesia and Allodynia

1993 • 31 citations

Interleukin-1α expression is inducible by cholinergic stimulation in the rat adrenal gland

1992 • 29 citations

Intraperitoneal administration of recombinant human interleukin-1β inhibits osmotic thirst in the rat

1992 • 28 citations

Delta opiate receptors mediate tail-shock induced antinociception at supraspinal levels

1992 • 24 citations

Observations on the development of cerebellar afferents in Xenopus laevis

1987 • 16 citations

Tumor Necrosis Factor Alpha and Interleukin‐1 Alpha Increase Pain Thresholds in the Rat

1992 • 13 citations

A new mechanism of action of dipyrone: blockade of the release of a nociceptive factor from macrophages.

1988 • 12 citations

The immune-hypothalamo-pituitary adrenal axis: Its role in immunoregulation and tolerance to self-antigens

1992 • 9 citations

Radiographic studies of the effect of benoxaprofen on bone damage in the adjuvant arthritic rat.

1982 • 8 citations

Interleukin-1 mimics the hyperalgesia induced by a factor obtained by macrophage lysis.

1988 • 8 citations

Location of interleukin-1 in the nervous system

1992 • 8 citations

Lithium chloride produces illness-induced analgesia

1988 • 7 citations

Stimulation of Human Polymorphonuclear Leukocytes by Recombinant Human Interleukin-1β

1992 • 6 citations

Sympathetically Maintained Pain

1994 • 4 citations

Inhibition of interleukin-1 (IL-1) enhanced pain reflexes in the rabbit by CGP 28238

1991 • 1 citations