Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation

Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation

1997 • 4,191 citations

Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts

1997 • 4,168 citations

Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development

1997 • 2,784 citations

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

1995 • 2,059 citations

AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis

1996 • 1,885 citations

Histone acetylation and transcriptional regulatory mechanisms

1998 • 1,793 citations

A transcriptional co-repressor that interacts with nuclear hormone receptors

1995 • 1,744 citations

Requirement of Transcription Factor PU.1 in the Development of Multiple Hematopoietic Lineages

1994 • 1,506 citations

Mutations Involving the Transcription Factor CBFA1 Cause Cleidocranial Dysplasia

1997 • 1,463 citations

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.

1996 • 1,195 citations

Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice

1997 • 929 citations

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.

1991 • 897 citations

Fusion Between Transcription Factor CBFβ/PEBP2β and a Myosin Heavy Chain in Acute Myeloid Leukemia

1993 • 760 citations

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia.

1995 • 738 citations

Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia.

1993 • 658 citations

The CBFβ Subunit Is Essential for CBFα2 (AML1) Function In Vivo

1996 • 630 citations

Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators

1993 • 589 citations

Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt

1992 • 582 citations

TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis.

1995 • 566 citations

The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion

1995 • 563 citations

Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions.

1995 • 546 citations

Regulation of LEF-1/TCF transcription factors by Wnt and other signals

1999 • 537 citations

A WW domain-containing Yes-associated protein (YAP) is a novel transcriptional co-activator

1999 • 534 citations

ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex

1998 • 525 citations

The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript.

1993 • 523 citations

Therapeutic Targeting of Transcription in Acute Promyelocytic Leukemia by Use of an Inhibitor of Histone Deacetylase

1998 • 517 citations

Molecular Cloning and Characterization of PEBP2β, the Heterodimeric Partner of a Novel Drosophila runt-Related DNA Binding Protein PEBP2α

1993 • 504 citations

Aberrant Recruitment of the Nuclear Receptor Corepressor-Histone Deacetylase Complex by the Acute Myeloid Leukemia Fusion Partner ETO

1998 • 500 citations

Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt

1992 • 494 citations

Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions.

1993 • 484 citations

Histone acetylation: chromatin in action

1997 • 475 citations

Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

1998 • 468 citations

ETO, a Target of t(8;21) in Acute Leukemia, Interacts with the N-CoR and mSin3 Corepressors

1998 • 442 citations

Runt homology domain proteins in osteoblast differentiation: AML3/CBFA1 is a major component of a bone-specific complex

1997 • 441 citations

The Drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates

1990 • 430 citations

Cloning and Characterization of Subunits of the T-Cell Receptor and Murine Leukemia Virus Enhancer Core-Binding Factor

1993 • 425 citations

Biallelic and Heterozygous Point Mutations in the Runt Domain of theAML1/PEBP2B Gene Associated With Myeloblastic Leukemias

1999 • 408 citations

AML1, AML2, and AML3, the Human Members of the runt domain Gene-Family: cDNA Structure, Expression, and Chromosomal Localization

1994 • 403 citations

CCAAT Enhancer-Binding Protein (C/EBP) and AML1 (CBFα2) Synergistically Activate the Macrophage Colony-Stimulating Factor Receptor Promoter

1996 • 399 citations

The t(8;21) Fusion Protein Interferes with AML-1B-Dependent Transcriptional Activation

1995 • 391 citations

Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product.

1994 • 390 citations

Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta.

1996 • 382 citations

Inhibition of DNA replication factor RPA by p53

1993 • 380 citations

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene

1997 • 362 citations

Expression of a Knocked-In AML1-ETO Leukemia Gene Inhibits the Establishment of Normal Definitive Hematopoiesis and Directly Generates Dysplastic Hematopoietic Progenitors

1998 • 362 citations

The WRPW Motif of the Hairy-Related Basic Helix-Loop-Helix Repressor Proteins Acts as a 4-Amino-Acid Transcription Repression and Protein-Protein Interaction Domain

1996 • 344 citations

Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia.

1994 • 335 citations

The acidic transcriptional activation domains of VP16 and p53 bind the cellular replication protein A and stimulate in vitro BPV-1 DNA replication

1993 • 329 citations

PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2 beta/CBF beta proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells.

1994 • 315 citations

Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation

1998 • 308 citations

The Drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system.

1990 • 299 citations

Failure of Embryonic Hematopoiesis andLethal Hemorrhages in Mouse Embryos Heterozygousfor a Knocked-In Leukemia Gene CBFB–MYH11

1996 • 296 citations

PU.1 (Spi-1) and C/EBPα Regulate Expression of the Granulocyte-Macrophage Colony-Stimulating Factor Receptor α Gene

1995 • 287 citations

ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function.

1997 • 286 citations

The t(12;21) Translocation Converts AML-1B from an Activator to a Repressor of Transcription

1996 • 284 citations

The t(8;21) Fusion Product, AML-1–ETO, Associates with C/EBP-α, Inhibits C/EBP-α-Dependent Transcription, and Blocks Granulocytic Differentiation

1998 • 280 citations

Expression of a Knocked-In AML1-ETO Leukemia Gene Inhibits the Establishment of Normal Definitive Hematopoiesis and Directly Generates Dysplastic Hematopoietic Progenitors

1998 • 280 citations

Groucho-Dependent and -Independent Repression Activities of Runt Domain Proteins

1997 • 253 citations

Two Domains Unique to Osteoblast-Specific Transcription Factor Osf2/Cbfa1 Contribute to Its Transactivation Function and Its Inability To Heterodimerize with Cbfβ

1998 • 253 citations

A Mechanism of Repression by Acute Myeloid Leukemia-1, the Target of Multiple Chromosomal Translocations in Acute Leukemia

2000 • 246 citations

The Tissue-Specific Nuclear Matrix Protein, NMP-2, Is a Member of the AML/PEBP2/Runt Domain Transcription Factor Family: Interactions with the Osteocalcin Gene Promoter

1995 • 245 citations

Dual Bar homeo box genes of Drosophila required in two photoreceptor cells, R1 and R6, and primary pigment cells for normal eye development.

1992 • 237 citations

An acute myeloid leukemia gene, AML1, regulates hemopoietic myeloid cell differentiation and transcriptional activation antagonistically by two alternative spliced forms.

1995 • 232 citations

Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor.

1993 • 229 citations

The Partner Gene of AML1 in t(16;21) Myeloid Malignancies Is a Novel Member of the MTG8(ETO) Family

1998 • 226 citations

Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains

1999 • 225 citations

Proviral insertions induce the expression of bone-specific isoforms of PEBP2αA (CBFA1): Evidence for a new myc collaborating oncogene

1997 • 218 citations

Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer

1990 • 218 citations

Multiple Functional Domains of AML1: PU.1 and C/EBPα Synergize with Different Regions of AML1

1998 • 218 citations

The transactivator proteins VP16 and GAL4 bind replication factor A

1993 • 216 citations

The AML1/ETO fusion protein blocks transactivation of the GM-CSF promoter by AML1B.

1995 • 212 citations

Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1).

1994 • 207 citations

The MYND Motif Is Required for Repression of Basal Transcription from the Multidrug Resistance 1 Promoter by the t(8;21) Fusion Protein

1998 • 197 citations

Purification of core-binding factor, a protein that binds the conserved core site in murine leukemia virus enhancers.

1992 • 194 citations

The AML1/ETO fusion protein activates transcription of BCL-2

1996 • 191 citations

Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor

1997 • 190 citations

Patterning of cells in the Drosophila eye by Lozenge, which shares homologous domains with AML1.

1996 • 187 citations

Mutation of the core or adjacent LVb elements of the Moloney murine leukemia virus enhancer alters disease specificity.

1990 • 178 citations

Human TAFII105 Is a Cell Type–Specific TFIID Subunit Related to hTAFII130

1996 • 169 citations

Positive and negative regulation of granulocyte-macrophage colony- stimulating factor promoter activity by AML1-related transcription factor, PEBP2

1995 • 165 citations

Both TEL and AML-1 Contribute Repression Domains to the t(12;21) Fusion Protein

1999 • 163 citations

The AML1-MTG8 Leukemic Fusion Protein Forms a Complex with a Novel Member of the MTG8(ETO/CDR) Family, MTGR1

1998 • 160 citations

Regulation of the T-cell receptor delta enhancer by functional cooperation between c-Myb and core-binding factors.

1994 • 154 citations

Transactivation of the Moloney murine leukemia virus and T-cell receptor beta-chain enhancers by cbf and ets requires intact binding sites for both proteins

1995 • 153 citations

Mouse MRP8 and MRP14, two intracellular calcium-binding proteins associated with the development of the myeloid lineage

1992 • 141 citations

The Drosophila segmentation gene runt acts as a position-specific numerator element necessary for the uniform expression of the sex-determining gene Sex-lethal.

1991 • 139 citations

DEAF-1, a novel protein that binds an essential region in a Deformed response element.

1996 • 138 citations

Synergistic up-regulation of the myeloid-specific promoter for the macrophage colony-stimulating factor receptor by AML1 and the t(8;21) fusion protein may contribute to leukemogenesis.

1996 • 137 citations

The Leukemic Protein Core Binding Factor β (CBFβ)–Smooth-Muscle Myosin Heavy Chain Sequesters CBFα2 into Cytoskeletal Filaments and Aggregates

1998 • 133 citations

Molecular cloning and analysis of two subunits of the human TFIID complex: hTAF _II 130 and hTAF _II 100

1996 • 130 citations

AML1A and AML1B can transactivate the human IL-3 promoter.

1997 • 130 citations

Functional and Physical Interactions between AML1 Proteins and an ETS Protein, MEF: Implications for the Pathogenesis of t(8;21)-Positive Leukemias

1999 • 129 citations

The ets Family Member Tel Binds to the Fli-1 Oncoprotein and Inhibits Its Transcriptional Activity

1998 • 126 citations

Identification of homeotic target genes in Drosophila melanogaster including nervy, a proto-oncogene homologue.

1995 • 126 citations

TLE, the Human Homolog of Groucho, Interacts with AML1 and Acts as a Repressor of AML1-Induced Transactivation

1998 • 123 citations

Histone acetylation: A possible mechanism for the inheritance of cell memory at mitosis

1997 • 121 citations

AML-2 is a potential target for transcriptional regulation by the t(8;21) and t(12;21) fusion proteins in acute leukemia.

1996 • 118 citations

Involvement of the AML1 gene in the t(3;21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis

1993 • 116 citations

The inv(16) encodes an acute myeloid leukemia 1 transcriptional corepressor

1999 • 114 citations

Functional domains of the t(8;21) fusion protein, AML-1/ETO.

1995 • 113 citations

A phorbol ester response element within the human T-cell receptor beta-chain enhancer.

1992 • 103 citations

Indistinguishable nuclear factor binding to functional core sites of the T-cell receptor delta and murine leukemia virus enhancers.

1992 • 102 citations

Expression and function of the Drosophila gene runt in early stages of neural development

1991 • 102 citations

Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain.

1999 • 100 citations

Growth inhibition and induction of differentiation of t(8;21) acute myeloid leukemia cells by the DNA-binding domain of PEBP2 and the AML1/MTG8(ETO)-specific antisense oligonucleotide.

1994 • 100 citations

Specific transcription factors stimulate simian virus 40 and polyomavirus origins of DNA replication.

1992 • 99 citations

The murine myeloperoxidase promoter contains several functional elements, one of which binds a cell type-restricted transcription factor, myeloid nuclear factor 1 (MyNF1).

1993 • 98 citations

A Large Variety of Alternatively Spliced and Differentially Expressed mRNAs Are Encoded by the Human Acute Myeloid Leukemia Gene AML1

1996 • 96 citations

Drosophila Homologs of the Proto-Oncogene Product PEBP2/CBFβ Regulate the DNA-Binding Properties of Runt

1996 • 91 citations

Dosage requirements for runt in the segmentation of Drosophila embryos

1986 • 91 citations

Negative regulation of granulocytic differentiation in the myeloid precursor cell line 32Dcl3 byear-2, a mammalian homolog ofDrosophila seven-up, and a chimeric leukemogenic gene,AML1/ETO(MTG8)

1998 • 88 citations

ETO and AML1 phosphoproteins are expressed in CD34+ hematopoietic progenitors: implications for t(8;21) leukemogenesis and monitoring residual disease

1996 • 88 citations

Cytoplasmic Sequestration of the Polyomavirus Enhancer Binding Protein 2 (PEBP2)/Core Binding Factor α (CBFα) Subunit by the Leukemia-Related PEBP2/CBFβ-SMMHC Fusion Protein Inhibits PEBP2/CBF-Mediated Transactivation

1998 • 84 citations

Modulation of TEL transcription activity by interaction with the ubiquitin-conjugating enzyme UBC9

1999 • 80 citations

A Novel Transcript Encoding an N-Terminally Truncated AML1/PEBP2αB Protein Interferes with Transactivation and Blocks Granulocytic Differentiation of 32Dcl3 Myeloid Cells

1997 • 79 citations

Gap gene properties of the pair-rule gene runt during Drosophila segmentation

1994 • 76 citations

Transcriptional regulation during myelopoiesis.

1997 • 74 citations

The PEBP2 β MYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasia

1998 • 72 citations

Solution structure of core binding factor beta and map of the CBF alpha binding site.

1999 • 72 citations

Identification of human granzyme B promoter regulatory elements interacting with activated T-cell-specific proteins: implication of Ikaros and CBF binding sites in promoter activation.

1995 • 72 citations

Control of segmental asymmetry in Drosophila embryos

1993 • 68 citations

Indirect and Direct Disruption of Transcriptional Regulation in Cancer: E2F and AML-1

1995 • 61 citations

ETS-Core Binding Factor: a Common Composite Motif in Antigen Receptor Gene Enhancers

1998 • 61 citations

Three distinct domains in TEL-AML1 are required for transcriptional repression of the IL-3 promoter

1999 • 58 citations

The t(8;21) translocation is not consistently associated with high Bcl-2 expression in de novo acute myeloid leukemias of adults.

1998 • 50 citations

In vivo interactions of the Drosophila Hairy and Runt transcriptional repressors with target promoters.

1996 • 47 citations

The Capacity of Polyomavirus Enhancer Binding Protein 2αB (AML1/Cbfa2) To Stimulate Polyomavirus DNA Replication Is Related to Its Affinity for the Nuclear Matrix

1998 • 41 citations

Pair-rule expression of the Drosophila fushi tarazu gene: a nuclear receptor response element mediates the opposing regulatory effects of runt and hairy

1995 • 40 citations

AML1a but not AML1b inhibits erythroid differentiation induced by sodium butyrate and enhances the megakaryocytic differentiation of K562 leukemia cells.

1997 • 39 citations

Premature expression of the macrophage colony-stimulating factor receptor on a multipotential stem cell line does not alter differentiation lineages controlled by stromal cells used for coculture.

1991 • 34 citations

Functional analysis of the individual enhancer core sequences of polyomavirus: cell-specific uncoupling of DNA replication from transcription.

1988 • 26 citations

The AML1 Gene in the 8;21 and 3;21 Translocations in Chronic and Acute Myeloid Leukemia

1994 • 15 citations