A Mechanism of Repression by Acute Myeloid Leukemia-1, the Target of Multiple Chromosomal Translocations in Acute Leukemia

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation

1997 • 4,191 citations

Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts

1997 • 4,168 citations

Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development

1997 • 2,784 citations

Mutations Involving the Transcription Factor CBFA1 Cause Cleidocranial Dysplasia

1997 • 1,463 citations

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.

1991 • 897 citations

Fusion Between Transcription Factor CBFβ/PEBP2β and a Myosin Heavy Chain in Acute Myeloid Leukemia

1993 • 760 citations

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia.

1995 • 738 citations

PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene.

1993 • 621 citations

Co-activators and co-repressors in the integration of transcriptional responses

1998 • 606 citations

Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt

1992 • 582 citations

The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion

1995 • 563 citations

Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions.

1995 • 546 citations

Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt

1992 • 494 citations

Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

1998 • 468 citations

ETO, a Target of t(8;21) in Acute Leukemia, Interacts with the N-CoR and mSin3 Corepressors

1998 • 442 citations

Cloning and Characterization of Subunits of the T-Cell Receptor and Murine Leukemia Virus Enhancer Core-Binding Factor

1993 • 425 citations

AML1, AML2, and AML3, the Human Members of the runt domain Gene-Family: cDNA Structure, Expression, and Chromosomal Localization

1994 • 403 citations

CCAAT Enhancer-Binding Protein (C/EBP) and AML1 (CBFα2) Synergistically Activate the Macrophage Colony-Stimulating Factor Receptor Promoter

1996 • 399 citations

The t(8;21) Fusion Protein Interferes with AML-1B-Dependent Transcriptional Activation

1995 • 391 citations

AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia

1995 • 346 citations

Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia.

1994 • 335 citations

Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation

1998 • 308 citations

The Drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system.

1990 • 299 citations

The t(12;21) Translocation Converts AML-1B from an Activator to a Repressor of Transcription

1996 • 284 citations

The t(8;21) Fusion Product, AML-1–ETO, Associates with C/EBP-α, Inhibits C/EBP-α-Dependent Transcription, and Blocks Granulocytic Differentiation

1998 • 280 citations

Groucho-Dependent and -Independent Repression Activities of Runt Domain Proteins

1997 • 253 citations

Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-α transcription factors

1997 • 251 citations

Multiple Functional Domains of AML1: PU.1 and C/EBPα Synergize with Different Regions of AML1

1998 • 218 citations

GAL4 fusion vectors for expression in yeast or mammalian cells

1992 • 213 citations

PEBP2 alpha B/mouse AML1 consists of multiple isoforms that possess differential transactivation potentials.

1994 • 204 citations

Intrinsic Transcriptional Activation-Inhibition Domains of the Polyomavirus Enhancer Binding Protein 2/Core Binding Factor α Subunit Revealed in the Presence of the β Subunit

1998 • 197 citations

Patterning of cells in the Drosophila eye by Lozenge, which shares homologous domains with AML1.

1996 • 187 citations

Parathyroid Hormone Regulates the Rat Collagenase-3 Promoter in Osteoblastic Cells through the Cooperative Interaction of the Activator Protein-1 Site and the runt Domain Binding Sequence

1998 • 173 citations

Both TEL and AML-1 Contribute Repression Domains to the t(12;21) Fusion Protein

1999 • 163 citations

Cloning, mapping and expression of PEBP2αC, a third gene encoding the mammalian Runt domain

1995 • 160 citations

Transactivation of the Moloney murine leukemia virus and T-cell receptor beta-chain enhancers by cbf and ets requires intact binding sites for both proteins

1995 • 153 citations

Isolation of the Drosophila segmentation gene runt and analysis of its expression during embryogenesis.

1988 • 135 citations

The corepressor N-CoR and its variants RIP13a and RIP13 1 directly interact with the basal transcription factors TFIIB, TAFII32 and TAFII70

1998 • 128 citations

Transcriptional Repression by the SMRT-mSin3 Corepressor: Multiple Interactions, Multiple Mechanisms, and a Potential Role for TFIIB

1998 • 127 citations

Distinct roles for P-CREB and LEF-1 in TCR alpha enhancer assembly and activation on chromatin templates in vitro.

1997 • 117 citations

c-Myb and Core-Binding Factor/PEBP2 Display Functional Synergy but Bind Independently to Adjacent Sites in the T-Cell Receptor δ Enhancer

1995 • 115 citations

Functional domains of the t(8;21) fusion protein, AML-1/ETO.

1995 • 113 citations

Role of histone deacetylases in acute leukemia

1998 • 65 citations

Three distinct domains in TEL-AML1 are required for transcriptional repression of the IL-3 promoter

1999 • 58 citations