Signal-Transduction Therapy. A Novel Approach to Disease Management

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1993 • 1,961 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

1991 • 1,479 citations

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1994 • 1,249 citations

Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C

1989 • 1,126 citations

A potent specific pure antiestrogen with clinical potential.

1991 • 1,111 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis.

1989 • 961 citations

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1993 • 879 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops.

1992 • 689 citations

Cyclosporin A, FK-506, and Rapamycin: Pharmacologic Probes of Lymphocyte Signal Transduction

1992 • 675 citations

Benzodiazepine Peptidomimetics: Potent Inhibitors of Ras Farnesylation In Animal Cells

1993 • 631 citations

Altered Growth of Human Colon Cancer Cell Lines Disrupted at Activated Ki- ras

1993 • 627 citations

Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors

1989 • 607 citations

Blocking of EGF-Dependent Cell Proliferation by EGF Receptor Kinase Inhibitors

1988 • 593 citations

Selective Inhibition of ras -Dependent Transformation by a Farnesyltransferase Inhibitor

1993 • 578 citations

The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling

1993 • 524 citations

Differential responses of human tumor cell lines to anti-p185HER2 monoclonal antibodies

1993 • 501 citations

Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alpha.

1992 • 500 citations

Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts.

1993 • 430 citations

Antitumor Effects of Doxorubicin in Combination With Anti-epidermal Growth Factor Receptor Monoclonal Antibodies

1993 • 422 citations

A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and In vitro anti‐proliferative as well as In vivo anti‐tumor activity

1989 • 414 citations

tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors.

1992 • 410 citations

Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies

1985 • 408 citations

Prevention of Lipopolysaccharide-Induced Lethal Toxicity by Tyrosine Kinase Inhibitors

1994 • 339 citations

Immunophilin-sensitive protein phosphatase action in cell signaling pathways

1992 • 338 citations

Tyrphostins: tyrosine kinase blockers as novel antiproliferative agents and dissectors of signal transduction

1992 • 323 citations

Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages.

1991 • 318 citations

Lipopolysaccharide induces activation of CD14-associated protein tyrosine kinase p53/56lyn.

1993 • 307 citations

Monoclonal antibody therapy of human cancer: Taking the HER2 protooncogene to the clinic

1991 • 296 citations

Investigation of a new pure antiestrogen (ICI 182780) in women with primary breast cancer.

1994 • 289 citations

Epidermal‐Growth‐Factor‐Dependent Activation of the Src‐Family Kinases

1994 • 287 citations

Recent research on the biological activity of suramin.

1993 • 281 citations

Involvement of pp60c-src with two major signaling pathways in human breast cancer.

1994 • 273 citations

Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation.

1994 • 272 citations

Efficient reversion of simian sarcoma virus-transformation and inhibition of growth factor-induced mitogenesis by suramin.

1986 • 270 citations

Tyrphostins. II. Heterocyclic and .alpha.-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases

1991 • 260 citations

Isolation of a Novel Tyrosine Kinase Inhibitor, Lavendustin A, from Streptomyces griseolavendus

1989 • 249 citations

Inhibition of tumor growth by a monoclonal antibody reactive with an oncogene-encoded tumor antigen.

1986 • 231 citations

A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization.

1991 • 227 citations

Peptidomimetic inhibitors of Ras farnesylation and function in whole cells.

1993 • 222 citations

Mechanistic aspects of the opposing effects of monoclonal antibodies to the ERBB2 receptor on tumor growth.

1991 • 208 citations

The potential of protein kinase C as A target for anticancer treatment

1993 • 200 citations

Selective inhibition of the epidermal growth factor and HER2/neu receptors by tyrphostins

1993 • 200 citations

MCF7/LCC2: a 4-hydroxytamoxifen resistant human breast cancer variant that retains sensitivity to the steroidal antiestrogen ICI 182,780.

1993 • 195 citations

Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection

1991 • 191 citations

TREATMENT OF EARLY BREAST CANCER

1978 • 156 citations

Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells.

1993 • 155 citations

Therapeutic potential of chimeric and murine anti-(epidermal growth factor receptor) antibodies in a metastasis model for human melanoma

1993 • 144 citations

Preclinical evaluation of bryostatin as an anticancer agent against several murine tumor cell lines: in vitro versus in vivo activity.

1992 • 133 citations

Suramin, an Active Drug for Prostate Cancer: Interim Observations in a Phase I Trial

1993 • 133 citations

Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity induces K562 to differentiate

1993 • 133 citations

L651582: A Novel Antiproliferative and Antimetastasis Agent

1990 • 132 citations

Malignant epithelial cells in primary human lung carcinomas coexpress in vivo platelet-derived growth factor (PDGF) and PDGF receptor mRNAs and their protein products.

1992 • 122 citations

Induction of apoptosis--new targets for cancer chemotherapy.

1992 • 121 citations

Monoclonal antibodies directed to the erbB-2 receptor inhibit in vivo tumour cell growth

1993 • 119 citations

Demethoxyviridin and wortmannin block phospholipase C and D activation in the human neutrophil

1991 • 118 citations

In vivo efficacy of a novel inhibitor of selected signal transduction pathways including calcium, arachidonate, and inositol phosphates.

1992 • 116 citations

Inhibition of glioma cell growth by a truncated platelet-derived growth factor-beta receptor.

1994 • 116 citations

Inhibition of smooth muscle cell proliferation by an antisense oligodeoxynucleotide targeting the messenger RNA encoding proliferating cell nuclear antigen.

1992 • 114 citations

The tyrosine kinase inhibitor tyrphostin blocks the cellular actions of nerve growth factor

1993 • 113 citations

Membrane-interactive lipids as experimental anticancer drugs

1991 • 112 citations

Circumvention of tamoxifen resistance by the pure anti‐estrogen ICI 182, 780

1993 • 111 citations

The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice.

1991 • 111 citations

4,5-Dianilinophthalimide: a protein-tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity.

1994 • 101 citations

Calcium-mediated signal transduction: biology, biochemistry, and therapy

1994 • 100 citations

The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release.

1991 • 100 citations

Structure-function analysis of signal and growth inhibition by carboxyamido-triazole, CAI.

1994 • 99 citations

Selective interactions of transforming and normal abl proteins with ATP, tyrosine-copolymer substrates, and tyrphostins.

1992 • 99 citations

Expression of Platelet‐Derived Growth Factor Receptors is Induced on Connective Tissue Cells During Chronic Synovial Inflammation

1988 • 94 citations

Successful treatment of murine melanoma with bryostatin 1.

1991 • 94 citations

Proline isomerases at the crossroads of protein folding, signal transduction, and immunosuppression.

1992 • 93 citations

Potentiation of the activity of 1-beta-D-arabinofuranosylcytosine by the protein kinase C activator bryostatin 1 in HL-60 cells: association with enhanced fragmentation of mature DNA.

1992 • 91 citations

Pathogenesis of Pulmonary Fibrosis in Interstitial Lung Disease: Alveolar Macrophage PDGF(B) Gene Activation and Up-regulation by Interferon Gamma

1991 • 91 citations

Antioestrogens in the management of hormone-dependent cancer

1988 • 86 citations

Tyrphostin induced growth inhibition: correlation with effect on p210bcr-abl autokinase activity in K562 chronic myelogenous leukemia.

1994 • 83 citations

Tyrphostin induced growth inhibition

1994 • 78 citations

Amplification of alpha-platelet-derived growth factor receptor gene lacking an exon coding for a portion of the extracellular region in a primary brain tumor of glial origin.

1992 • 76 citations

The protein kinase C inhibitor CGP 41251, a staurosporine derivative with antitumor activity, reverses multidrug resistance

1994 • 73 citations

Sensitization of human cervical carcinoma cells to cis-diamminedichloroplatinum(II) by bryostatin 1.

1992 • 73 citations

Differential inhibition of the epidermal growth factor-, platelet-derived growth factor-, and protein kinase C-mediated signal transduction pathways by the staurosporine derivative CGP 41251.

1992 • 72 citations

Kinetics of inhibition by tyrphostins of the tyrosine kinase activity of the epidermal growth factor receptor and analysis by a new computer program.

1994 • 70 citations

Expression of growth factor receptors in human brain tumours

1991 • 68 citations

Activation of phospholipase C in human B cells is dependent on tyrosine phosphorylation.

1991 • 68 citations

Protein kinase inhibitor, staurosporine, induces a mature neuronal phenotype in SH‐SY5Y human neuroblastoma cells through an α‐, β‐, and ζ‐protein kinase C‐independent pathway

1993 • 58 citations

Activation and growth of murine tumor-specific T-cells which have in vivo activity with bryostatin 1.

1992 • 54 citations

Phase II trial of suramin in patients with advanced renal cell carcinoma: treatment results, pharmacokinetics, and tumor growth factor expression.

1992 • 53 citations

Reversion of autocrine transformation by a dominant negative platelet-derived growth factor mutant.

1993 • 52 citations

Inhibition of Human Lung Cancer Cell Line Growth by an Anti-p185^HER2 Antibody

1993 • 50 citations

The Bryostatins

1991 • 49 citations

Tumor-suppressor function of muscarinic acetylcholine receptors is associated with activation of receptor-operated calcium influx.

1993 • 46 citations

Residues crucial for Ras interaction with GDP-GTP exchangers.

1993 • 45 citations

Differential pathways (phospholipase C and phospholipase D) of bradykinin-induced biphasic 1,2-diacylglycerol formation in non-transformed and K-ras-transformed NIH-3T3 fibroblasts. Involvement of intracellular Ca2+ oscillations in phosphatidylcholine breakdown

1992 • 43 citations

Tyrphostins. 3. Structure-activity relationship studies of .alpha.-substituted benzylidenemalononitrile 5-S-aryltyrphostins

1993 • 41 citations

Cellular ras activity and tumor cell proliferation

1987 • 38 citations

Protein kinase C modulation.

1992 • 38 citations

Suramin: an anticancer drug with unique biological effects

1993 • 36 citations

Tamoxifen modulation of cisplatin cytotoxicity in human malignancies

1993 • 35 citations

Coexpression of platelet-derived growth factor (PDGF) B chain and PDGF B-type receptor in human gliomas

1991 • 34 citations

Oncogenes: cause or consequence in the development of glial tumors

1992 • 32 citations

The Growth Regulation of Keratinocytes

1992 • 29 citations

Tyrosine phosphorylation is an essential event in the stimulation of B lymphocytes by Staphylococcus aureus Cowan I.

1991 • 25 citations

Intracellular retention of membrane-anchored v-sis protein abrogates autocrine signal transduction.

1992 • 24 citations

Inhibition of pancreatic cancer cell growth in vitro by the tyrphostin group of tyrosine kinase inhibitors

1993 • 22 citations

Tyrosine kinase signal transduction in rheumatoid synovitis

1992 • 20 citations

Tyrosine kinase receptor — nuclear protooncogene interactions in breast cancer

1991 • 20 citations

Steroid Hormone Agonists and Antagonists in the Treatment of Cancer

1992 • 19 citations

Expression of the epidermal growth factor receptor gene in human brain metastases

1992 • 17 citations

Activation of phosphoipase D by platelet-derived growth factor (PDGF) in rat C6 glioma cells: Possible role in mitogenic signal transduction

1992 • 17 citations

Tamoxifen therapy in breast cancer control worldwide.

1993 • 17 citations

Nitroreductases and glutathione transferases that act on 4-nitroquinoline 1-oxide and their differential induction by butylated hydroxyanisole in mice.

1992 • 14 citations

Cyclosporine A, Fk-506, And Rapamycin: Pharmacological Probes Of Lymphocyte Signal Transduction

1992 • 13 citations

Tamoxifen enhances the cytotoxic effects of the nitrosourea fotemustine. Results on human melanoma cell lines

1993 • 12 citations

Platelet-derived growth factor and proliferative glomerulonephritis.

1993 • 12 citations

Arylamides of hydroxylated isoquinolines as protein-tyrosine kinase inhibitors

1992 • 11 citations

The use of immunotoxins for cancer therapy

1993 • 10 citations

Reversal of Transformed Phenotypes by Antisense fos

1992 • 8 citations

Workshop on suramin with emphasis on prostate cancer: Re-evaluation of response criteria

1993 • 7 citations